Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC49_LEIDO

TriTrypDb:

LdCL_220010000 , LDHU3_22.0680

Length:

728

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IC49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC49

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0007165	signal transduction	2	1
GO:0035556	intracellular signal transduction	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004707	MAP kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.657
CLV_C14_Caspase3-7	311	315	PF00656	0.498
CLV_C14_Caspase3-7	644	648	PF00656	0.509
CLV_NRD_NRD_1	601	603	PF00675	0.331
CLV_NRD_NRD_1	9	11	PF00675	0.705
CLV_PCSK_FUR_1	7	11	PF00082	0.677
CLV_PCSK_KEX2_1	448	450	PF00082	0.299
CLV_PCSK_KEX2_1	601	603	PF00082	0.331
CLV_PCSK_KEX2_1	626	628	PF00082	0.287
CLV_PCSK_KEX2_1	77	79	PF00082	0.374
CLV_PCSK_KEX2_1	9	11	PF00082	0.705
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.299
CLV_PCSK_PC1ET2_1	626	628	PF00082	0.287
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.374
CLV_PCSK_SKI1_1	322	326	PF00082	0.298
CLV_PCSK_SKI1_1	346	350	PF00082	0.299
CLV_PCSK_SKI1_1	424	428	PF00082	0.299
CLV_PCSK_SKI1_1	529	533	PF00082	0.446
CLV_PCSK_SKI1_1	563	567	PF00082	0.236
CLV_PCSK_SKI1_1	601	605	PF00082	0.287
CLV_PCSK_SKI1_1	626	630	PF00082	0.331
CLV_Separin_Metazoa	417	421	PF03568	0.299
DEG_SCF_FBW7_2	581	588	PF00400	0.331
DEG_SPOP_SBC_1	134	138	PF00917	0.620
DEG_SPOP_SBC_1	209	213	PF00917	0.502
DEG_SPOP_SBC_1	255	259	PF00917	0.608
DEG_SPOP_SBC_1	551	555	PF00917	0.303
DOC_CDC14_PxL_1	389	397	PF14671	0.299
DOC_CYCLIN_RxL_1	596	608	PF00134	0.287
DOC_MAPK_gen_1	346	355	PF00069	0.351
DOC_MAPK_gen_1	388	397	PF00069	0.309
DOC_MAPK_gen_1	4	14	PF00069	0.552
DOC_MAPK_gen_1	487	496	PF00069	0.358
DOC_MAPK_HePTP_8	385	397	PF00069	0.299
DOC_MAPK_MEF2A_6	388	397	PF00069	0.299
DOC_MAPK_MEF2A_6	490	498	PF00069	0.358
DOC_PP1_RVXF_1	323	330	PF00149	0.351
DOC_PP1_RVXF_1	331	338	PF00149	0.269
DOC_PP2B_LxvP_1	443	446	PF13499	0.358
DOC_PP2B_LxvP_1	680	683	PF13499	0.463
DOC_PP4_FxxP_1	566	569	PF00568	0.304
DOC_USP7_MATH_1	124	128	PF00917	0.680
DOC_USP7_MATH_1	134	138	PF00917	0.573
DOC_USP7_MATH_1	19	23	PF00917	0.641
DOC_USP7_MATH_1	210	214	PF00917	0.590
DOC_USP7_MATH_1	255	259	PF00917	0.594
DOC_USP7_MATH_1	38	42	PF00917	0.480
DOC_USP7_MATH_1	552	556	PF00917	0.325
DOC_USP7_MATH_1	660	664	PF00917	0.584
DOC_USP7_UBL2_3	73	77	PF12436	0.349
DOC_WW_Pin1_4	126	131	PF00397	0.667
DOC_WW_Pin1_4	256	261	PF00397	0.647
DOC_WW_Pin1_4	262	267	PF00397	0.610
DOC_WW_Pin1_4	286	291	PF00397	0.756
DOC_WW_Pin1_4	36	41	PF00397	0.611
DOC_WW_Pin1_4	540	545	PF00397	0.299
DOC_WW_Pin1_4	547	552	PF00397	0.299
DOC_WW_Pin1_4	581	586	PF00397	0.311
DOC_WW_Pin1_4	605	610	PF00397	0.287
DOC_WW_Pin1_4	665	670	PF00397	0.636
LIG_14-3-3_CanoR_1	125	130	PF00244	0.622
LIG_14-3-3_CanoR_1	20	27	PF00244	0.650
LIG_14-3-3_CanoR_1	31	40	PF00244	0.575
LIG_14-3-3_CanoR_1	428	436	PF00244	0.299
LIG_14-3-3_CanoR_1	470	475	PF00244	0.358
LIG_14-3-3_CanoR_1	627	634	PF00244	0.287
LIG_14-3-3_CanoR_1	700	708	PF00244	0.453
LIG_14-3-3_CanoR_1	9	15	PF00244	0.648
LIG_Actin_WH2_2	336	351	PF00022	0.287
LIG_Actin_WH2_2	407	422	PF00022	0.299
LIG_AP2alpha_1	639	643	PF02296	0.369
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BRCT_BRCA1_1	127	131	PF00533	0.529
LIG_BRCT_BRCA1_1	184	188	PF00533	0.530
LIG_deltaCOP1_diTrp_1	407	411	PF00928	0.299
LIG_eIF4E_1	390	396	PF01652	0.299
LIG_FHA_1	127	133	PF00498	0.607
LIG_FHA_1	357	363	PF00498	0.347
LIG_FHA_1	573	579	PF00498	0.331
LIG_FHA_1	608	614	PF00498	0.304
LIG_FHA_2	107	113	PF00498	0.657
LIG_FHA_2	138	144	PF00498	0.617
LIG_FHA_2	429	435	PF00498	0.299
LIG_FHA_2	575	581	PF00498	0.337
LIG_FHA_2	582	588	PF00498	0.303
LIG_FHA_2	606	612	PF00498	0.287
LIG_FHA_2	627	633	PF00498	0.331
LIG_FHA_2	694	700	PF00498	0.423
LIG_Integrin_isoDGR_2	684	686	PF01839	0.471
LIG_LIR_Apic_2	387	393	PF02991	0.299
LIG_LIR_Apic_2	564	569	PF02991	0.304
LIG_LIR_Gen_1	185	196	PF02991	0.524
LIG_LIR_Gen_1	314	324	PF02991	0.348
LIG_LIR_Gen_1	587	598	PF02991	0.287
LIG_LIR_Nem_3	160	165	PF02991	0.380
LIG_LIR_Nem_3	185	191	PF02991	0.530
LIG_LIR_Nem_3	314	319	PF02991	0.395
LIG_LIR_Nem_3	394	400	PF02991	0.299
LIG_LIR_Nem_3	410	414	PF02991	0.299
LIG_LIR_Nem_3	438	443	PF02991	0.358
LIG_LIR_Nem_3	58	62	PF02991	0.405
LIG_LIR_Nem_3	584	589	PF02991	0.299
LIG_Pex14_1	600	604	PF04695	0.287
LIG_Pex14_2	639	643	PF04695	0.369
LIG_SH2_CRK	48	52	PF00017	0.424
LIG_SH2_CRK	590	594	PF00017	0.287
LIG_SH2_NCK_1	165	169	PF00017	0.455
LIG_SH2_NCK_1	703	707	PF00017	0.464
LIG_SH2_STAP1	703	707	PF00017	0.419
LIG_SH2_STAP1	81	85	PF00017	0.490
LIG_SH2_STAT5	162	165	PF00017	0.379
LIG_SH2_STAT5	226	229	PF00017	0.384
LIG_SH2_STAT5	233	236	PF00017	0.405
LIG_SH2_STAT5	240	243	PF00017	0.427
LIG_SH2_STAT5	245	248	PF00017	0.290
LIG_SH2_STAT5	384	387	PF00017	0.351
LIG_SH2_STAT5	53	56	PF00017	0.432
LIG_SH2_STAT5	703	706	PF00017	0.424
LIG_SH3_3	214	220	PF00018	0.568
LIG_SH3_3	284	290	PF00018	0.733
LIG_SH3_3	631	637	PF00018	0.331
LIG_SH3_3	95	101	PF00018	0.516
LIG_SUMO_SIM_anti_2	610	618	PF11976	0.290
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.391
LIG_SUMO_SIM_par_1	10	15	PF11976	0.551
LIG_SUMO_SIM_par_1	154	160	PF11976	0.354
LIG_SUMO_SIM_par_1	60	67	PF11976	0.368
LIG_TRAF2_1	376	379	PF00917	0.358
LIG_TRAF2_1	502	505	PF00917	0.331
LIG_TRAF2_1	585	588	PF00917	0.331
LIG_UBA3_1	439	448	PF00899	0.299
LIG_WRC_WIRS_1	408	413	PF05994	0.299
MOD_CDK_SPK_2	286	291	PF00069	0.678
MOD_CK1_1	133	139	PF00069	0.557
MOD_CK1_1	15	21	PF00069	0.627
MOD_CK1_1	190	196	PF00069	0.547
MOD_CK1_1	2	8	PF00069	0.586
MOD_CK1_1	204	210	PF00069	0.597
MOD_CK1_1	22	28	PF00069	0.585
MOD_CK1_1	300	306	PF00069	0.639
MOD_CK1_1	41	47	PF00069	0.449
MOD_CK1_1	473	479	PF00069	0.236
MOD_CK1_1	538	544	PF00069	0.388
MOD_CK1_1	550	556	PF00069	0.229
MOD_CK1_1	663	669	PF00069	0.612
MOD_CK2_1	444	450	PF00069	0.333
MOD_CK2_1	581	587	PF00069	0.331
MOD_CK2_1	605	611	PF00069	0.287
MOD_CK2_1	626	632	PF00069	0.331
MOD_CK2_1	665	671	PF00069	0.595
MOD_CK2_1	693	699	PF00069	0.424
MOD_GlcNHglycan	132	135	PF01048	0.649
MOD_GlcNHglycan	17	20	PF01048	0.647
MOD_GlcNHglycan	184	187	PF01048	0.709
MOD_GlcNHglycan	203	206	PF01048	0.714
MOD_GlcNHglycan	21	24	PF01048	0.606
MOD_GlcNHglycan	212	215	PF01048	0.551
MOD_GlcNHglycan	217	220	PF01048	0.476
MOD_GlcNHglycan	274	277	PF01048	0.644
MOD_GlcNHglycan	310	313	PF01048	0.644
MOD_GlcNHglycan	368	371	PF01048	0.323
MOD_GlcNHglycan	421	424	PF01048	0.299
MOD_GlcNHglycan	479	482	PF01048	0.358
MOD_GlcNHglycan	540	543	PF01048	0.287
MOD_GlcNHglycan	566	569	PF01048	0.331
MOD_GlcNHglycan	643	646	PF01048	0.557
MOD_GlcNHglycan	662	665	PF01048	0.494
MOD_GlcNHglycan	676	679	PF01048	0.476
MOD_GSK3_1	106	113	PF00069	0.684
MOD_GSK3_1	126	133	PF00069	0.475
MOD_GSK3_1	15	22	PF00069	0.697
MOD_GSK3_1	204	211	PF00069	0.623
MOD_GSK3_1	250	257	PF00069	0.560
MOD_GSK3_1	299	306	PF00069	0.677
MOD_GSK3_1	32	39	PF00069	0.565
MOD_GSK3_1	380	387	PF00069	0.299
MOD_GSK3_1	473	480	PF00069	0.236
MOD_GSK3_1	534	541	PF00069	0.329
MOD_GSK3_1	547	554	PF00069	0.270
MOD_GSK3_1	564	571	PF00069	0.216
MOD_GSK3_1	656	663	PF00069	0.604
MOD_N-GLC_1	297	302	PF02516	0.650
MOD_N-GLC_1	380	385	PF02516	0.299
MOD_NEK2_1	12	17	PF00069	0.644
MOD_NEK2_1	132	137	PF00069	0.640
MOD_NEK2_1	229	234	PF00069	0.316
MOD_NEK2_1	254	259	PF00069	0.669
MOD_NEK2_1	29	34	PF00069	0.505
MOD_NEK2_1	419	424	PF00069	0.300
MOD_NEK2_1	462	467	PF00069	0.299
MOD_NEK2_1	615	620	PF00069	0.331
MOD_PIKK_1	38	44	PF00454	0.618
MOD_PIKK_1	535	541	PF00454	0.358
MOD_PK_1	10	16	PF00069	0.553
MOD_PKA_1	626	632	PF00069	0.287
MOD_PKA_2	124	130	PF00069	0.640
MOD_PKA_2	15	21	PF00069	0.674
MOD_PKA_2	303	309	PF00069	0.636
MOD_PKA_2	419	425	PF00069	0.299
MOD_PKA_2	55	61	PF00069	0.436
MOD_PKA_2	626	632	PF00069	0.287
MOD_PKA_2	654	660	PF00069	0.506
MOD_Plk_1	114	120	PF00069	0.570
MOD_Plk_1	2	8	PF00069	0.553
MOD_Plk_1	380	386	PF00069	0.299
MOD_Plk_4	106	112	PF00069	0.645
MOD_Plk_4	229	235	PF00069	0.320
MOD_Plk_4	380	386	PF00069	0.299
MOD_Plk_4	615	621	PF00069	0.417
MOD_Plk_4	688	694	PF00069	0.553
MOD_Plk_4	92	98	PF00069	0.447
MOD_ProDKin_1	126	132	PF00069	0.667
MOD_ProDKin_1	256	262	PF00069	0.648
MOD_ProDKin_1	286	292	PF00069	0.756
MOD_ProDKin_1	36	42	PF00069	0.608
MOD_ProDKin_1	540	546	PF00069	0.299
MOD_ProDKin_1	547	553	PF00069	0.299
MOD_ProDKin_1	581	587	PF00069	0.311
MOD_ProDKin_1	605	611	PF00069	0.287
MOD_ProDKin_1	665	671	PF00069	0.634
MOD_SUMO_rev_2	555	565	PF00179	0.327
TRG_DiLeu_BaEn_1	611	616	PF01217	0.287
TRG_ENDOCYTIC_2	226	229	PF00928	0.341
TRG_ENDOCYTIC_2	233	236	PF00928	0.367
TRG_ENDOCYTIC_2	245	248	PF00928	0.290
TRG_ENDOCYTIC_2	48	51	PF00928	0.438
TRG_ENDOCYTIC_2	589	592	PF00928	0.287
TRG_ER_diArg_1	463	466	PF00400	0.402
TRG_ER_diArg_1	6	9	PF00400	0.693
TRG_ER_diArg_1	600	602	PF00400	0.331
TRG_Pf-PMV_PEXEL_1	700	705	PF00026	0.408

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU16	Leptomonas seymouri	51%	100%
A4HC95	Leishmania braziliensis	77%	100%
A4HZS7	Leishmania infantum	99%	100%
E9AVN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QBU7	Leishmania major	93%	100%