Histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone deacetylase

Gene product:

histone deacetylase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC47_LEIDO

TriTrypDb:

LdBPK_241410.1 , LdCL_240019300 , LDHU3_24.1720

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8IC47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC47

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	14
GO:0006476	protein deacetylation	6	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016043	cellular component organization	3	14
GO:0016570	histone modification	5	14
GO:0016575	histone deacetylation	6	14
GO:0019538	protein metabolic process	3	14
GO:0035601	protein deacylation	5	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:0071840	cellular component organization or biogenesis	2	14
GO:0098732	macromolecule deacylation	5	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0080090	regulation of primary metabolic process	4	2
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004407	histone deacetylase activity	4	14
GO:0016787	hydrolase activity	2	14
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	14
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	14
GO:0019213	deacetylase activity	3	14
GO:0033558	protein lysine deacetylase activity	3	14
GO:0140096	catalytic activity, acting on a protein	2	14
GO:0005488	binding	1	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.487
CLV_C14_Caspase3-7	521	525	PF00656	0.544
CLV_NRD_NRD_1	246	248	PF00675	0.220
CLV_NRD_NRD_1	426	428	PF00675	0.365
CLV_NRD_NRD_1	488	490	PF00675	0.414
CLV_NRD_NRD_1	494	496	PF00675	0.423
CLV_NRD_NRD_1	82	84	PF00675	0.395
CLV_PCSK_FUR_1	486	490	PF00082	0.377
CLV_PCSK_KEX2_1	246	248	PF00082	0.220
CLV_PCSK_KEX2_1	426	428	PF00082	0.377
CLV_PCSK_KEX2_1	432	434	PF00082	0.365
CLV_PCSK_KEX2_1	488	490	PF00082	0.365
CLV_PCSK_KEX2_1	494	496	PF00082	0.389
CLV_PCSK_KEX2_1	513	515	PF00082	0.630
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.390
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.630
CLV_PCSK_SKI1_1	133	137	PF00082	0.288
CLV_PCSK_SKI1_1	246	250	PF00082	0.277
CLV_PCSK_SKI1_1	277	281	PF00082	0.251
CLV_PCSK_SKI1_1	326	330	PF00082	0.229
CLV_PCSK_SKI1_1	489	493	PF00082	0.434
CLV_PCSK_SKI1_1	495	499	PF00082	0.505
CLV_PCSK_SKI1_1	523	527	PF00082	0.504
DEG_APCC_DBOX_1	325	333	PF00400	0.435
DEG_SPOP_SBC_1	54	58	PF00917	0.527
DOC_ANK_TNKS_1	502	509	PF00023	0.484
DOC_CKS1_1	1	6	PF01111	0.496
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.555
DOC_MAPK_gen_1	432	440	PF00069	0.365
DOC_MAPK_MEF2A_6	254	262	PF00069	0.459
DOC_MAPK_MEF2A_6	406	415	PF00069	0.451
DOC_MAPK_MEF2A_6	432	440	PF00069	0.349
DOC_PP1_RVXF_1	460	467	PF00149	0.261
DOC_PP1_RVXF_1	82	89	PF00149	0.333
DOC_PP2B_LxvP_1	413	416	PF13499	0.395
DOC_PP4_FxxP_1	174	177	PF00568	0.413
DOC_PP4_FxxP_1	439	442	PF00568	0.456
DOC_USP7_MATH_1	177	181	PF00917	0.513
DOC_USP7_MATH_1	193	197	PF00917	0.478
DOC_USP7_MATH_1	199	203	PF00917	0.458
DOC_USP7_MATH_1	230	234	PF00917	0.416
DOC_USP7_MATH_1	328	332	PF00917	0.518
DOC_USP7_MATH_1	54	58	PF00917	0.536
DOC_USP7_MATH_1	64	68	PF00917	0.642
DOC_WW_Pin1_4	12	17	PF00397	0.744
DOC_WW_Pin1_4	23	28	PF00397	0.627
DOC_WW_Pin1_4	427	432	PF00397	0.566
DOC_WW_Pin1_4	44	49	PF00397	0.630
LIG_14-3-3_CanoR_1	133	140	PF00244	0.435
LIG_14-3-3_CanoR_1	277	282	PF00244	0.452
LIG_14-3-3_CanoR_1	326	336	PF00244	0.435
LIG_14-3-3_CanoR_1	49	54	PF00244	0.575
LIG_14-3-3_CterR_2	532	536	PF00244	0.541
LIG_APCC_ABBA_1	436	441	PF00400	0.331
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BRCT_BRCA1_1	166	170	PF00533	0.501
LIG_BRCT_BRCA1_1	30	34	PF00533	0.551
LIG_BRCT_BRCA1_1	452	456	PF00533	0.343
LIG_BRCT_BRCA1_2	166	172	PF00533	0.477
LIG_CaM_IQ_9	461	477	PF13499	0.383
LIG_eIF4E_1	98	104	PF01652	0.351
LIG_FHA_1	278	284	PF00498	0.451
LIG_FHA_1	364	370	PF00498	0.457
LIG_FHA_1	377	383	PF00498	0.404
LIG_FHA_1	433	439	PF00498	0.320
LIG_FHA_1	479	485	PF00498	0.431
LIG_FHA_1	64	70	PF00498	0.658
LIG_FHA_2	134	140	PF00498	0.435
LIG_FHA_2	519	525	PF00498	0.573
LIG_FHA_2	56	62	PF00498	0.625
LIG_GBD_Chelix_1	241	249	PF00786	0.251
LIG_GBD_Chelix_1	350	358	PF00786	0.213
LIG_Integrin_RGD_1	211	213	PF01839	0.277
LIG_LIR_Apic_2	173	177	PF02991	0.435
LIG_LIR_Gen_1	190	199	PF02991	0.435
LIG_LIR_Gen_1	233	243	PF02991	0.451
LIG_LIR_Nem_3	190	195	PF02991	0.433
LIG_LIR_Nem_3	233	238	PF02991	0.451
LIG_LIR_Nem_3	419	425	PF02991	0.312
LIG_PDZ_Class_2	531	536	PF00595	0.513
LIG_Pex14_2	170	174	PF04695	0.465
LIG_Pex14_2	188	192	PF04695	0.361
LIG_Pex14_2	286	290	PF04695	0.451
LIG_PTB_Apo_2	285	292	PF02174	0.413
LIG_Rb_LxCxE_1	202	215	PF01857	0.413
LIG_REV1ctd_RIR_1	476	484	PF16727	0.298
LIG_SH2_CRK	252	256	PF00017	0.477
LIG_SH2_PTP2	257	260	PF00017	0.519
LIG_SH2_SRC	98	101	PF00017	0.349
LIG_SH2_STAT5	148	151	PF00017	0.451
LIG_SH2_STAT5	257	260	PF00017	0.418
LIG_SH2_STAT5	321	324	PF00017	0.470
LIG_SH2_STAT5	414	417	PF00017	0.308
LIG_SH2_STAT5	87	90	PF00017	0.267
LIG_SH3_3	183	189	PF00018	0.413
LIG_SH3_3	307	313	PF00018	0.417
LIG_SH3_3	428	434	PF00018	0.391
LIG_SH3_3	441	447	PF00018	0.356
LIG_SH3_3	70	76	PF00018	0.551
LIG_SUMO_SIM_par_1	371	376	PF11976	0.432
LIG_TRAF2_1	136	139	PF00917	0.413
LIG_TRAF2_1	497	500	PF00917	0.436
LIG_TRAF2_1	59	62	PF00917	0.565
LIG_TYR_ITIM	255	260	PF00017	0.292
LIG_WRC_WIRS_1	322	327	PF05994	0.270
MOD_CDK_SPK_2	427	432	PF00069	0.445
MOD_CDK_SPK_2	44	49	PF00069	0.558
MOD_CDK_SPxK_1	427	433	PF00069	0.436
MOD_CK1_1	15	21	PF00069	0.641
MOD_CK1_1	23	29	PF00069	0.624
MOD_CK1_1	324	330	PF00069	0.279
MOD_CK1_1	44	50	PF00069	0.658
MOD_CK1_1	57	63	PF00069	0.483
MOD_CK1_1	92	98	PF00069	0.448
MOD_CK2_1	133	139	PF00069	0.240
MOD_CK2_1	23	29	PF00069	0.662
MOD_CK2_1	55	61	PF00069	0.529
MOD_Cter_Amidation	81	84	PF01082	0.420
MOD_GlcNHglycan	10	13	PF01048	0.578
MOD_GlcNHglycan	145	148	PF01048	0.233
MOD_GlcNHglycan	17	20	PF01048	0.548
MOD_GlcNHglycan	232	235	PF01048	0.290
MOD_GlcNHglycan	42	46	PF01048	0.601
MOD_GlcNHglycan	504	507	PF01048	0.519
MOD_GlcNHglycan	509	512	PF01048	0.732
MOD_GlcNHglycan	516	519	PF01048	0.605
MOD_GlcNHglycan	61	65	PF01048	0.683
MOD_GSK3_1	19	26	PF00069	0.639
MOD_GSK3_1	30	37	PF00069	0.501
MOD_GSK3_1	324	331	PF00069	0.305
MOD_GSK3_1	359	366	PF00069	0.328
MOD_GSK3_1	49	56	PF00069	0.568
MOD_GSK3_1	514	521	PF00069	0.714
MOD_GSK3_1	60	67	PF00069	0.534
MOD_GSK3_1	8	15	PF00069	0.711
MOD_LATS_1	131	137	PF00433	0.328
MOD_N-GLC_1	518	523	PF02516	0.547
MOD_NEK2_1	115	120	PF00069	0.239
MOD_NEK2_1	143	148	PF00069	0.249
MOD_NEK2_1	194	199	PF00069	0.288
MOD_NEK2_1	279	284	PF00069	0.292
MOD_NEK2_1	358	363	PF00069	0.292
MOD_NEK2_1	404	409	PF00069	0.505
MOD_NEK2_1	450	455	PF00069	0.352
MOD_NEK2_1	460	465	PF00069	0.262
MOD_NEK2_1	478	483	PF00069	0.349
MOD_NEK2_2	321	326	PF00069	0.270
MOD_PIKK_1	177	183	PF00454	0.393
MOD_PIKK_1	194	200	PF00454	0.166
MOD_PIKK_1	363	369	PF00454	0.328
MOD_PIKK_1	495	501	PF00454	0.574
MOD_PIKK_1	64	70	PF00454	0.645
MOD_PKA_1	432	438	PF00069	0.359
MOD_PKA_2	104	110	PF00069	0.239
MOD_PKA_2	299	305	PF00069	0.328
MOD_PKA_2	376	382	PF00069	0.270
MOD_PKA_2	432	438	PF00069	0.328
MOD_PKA_2	502	508	PF00069	0.584
MOD_PKA_2	54	60	PF00069	0.531
MOD_Plk_1	164	170	PF00069	0.332
MOD_Plk_1	212	218	PF00069	0.270
MOD_Plk_1	28	34	PF00069	0.623
MOD_Plk_1	89	95	PF00069	0.412
MOD_Plk_2-3	371	377	PF00069	0.242
MOD_Plk_4	328	334	PF00069	0.374
MOD_Plk_4	34	40	PF00069	0.498
MOD_Plk_4	376	382	PF00069	0.251
MOD_ProDKin_1	12	18	PF00069	0.744
MOD_ProDKin_1	23	29	PF00069	0.627
MOD_ProDKin_1	427	433	PF00069	0.558
MOD_ProDKin_1	44	50	PF00069	0.632
TRG_DiLeu_BaEn_1	190	195	PF01217	0.269
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.239
TRG_ENDOCYTIC_2	252	255	PF00928	0.296
TRG_ENDOCYTIC_2	257	260	PF00928	0.291
TRG_ENDOCYTIC_2	387	390	PF00928	0.239
TRG_ER_diArg_1	245	247	PF00400	0.249
TRG_ER_diArg_1	425	427	PF00400	0.343
TRG_ER_diArg_1	486	489	PF00400	0.513
TRG_ER_diArg_1	493	495	PF00400	0.613
TRG_NLS_MonoCore_2	512	517	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	254	259	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD3	Leptomonas seymouri	76%	100%
A0A0N1PD56	Leptomonas seymouri	25%	100%
A0A1X0NVQ2	Trypanosomatidae	69%	100%
A0A3S7WWE6	Leishmania donovani	40%	100%
A0A422N1V5	Trypanosoma rangeli	70%	100%
A4HBR4	Leishmania braziliensis	39%	100%
A4HDK5	Leishmania braziliensis	93%	100%
A4HZ67	Leishmania infantum	41%	100%
A4I0X6	Leishmania infantum	100%	100%
E9AV34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AWY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13298	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
O15379	Homo sapiens	34%	100%
O88895	Mus musculus	34%	100%
P56520	Gallus gallus	34%	100%
P64375	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	100%
P64376	Staphylococcus aureus (strain N315)	28%	100%
Q28DV3	Xenopus tropicalis	37%	100%
Q4QAJ4	Leishmania major	95%	100%
Q4QCE7	Leishmania major	39%	100%
Q4SFA0	Tetraodon nigroviridis	36%	100%
Q55FN5	Dictyostelium discoideum	38%	100%
Q5HF39	Staphylococcus aureus (strain COL)	28%	100%
Q5RB76	Pongo abelii	34%	100%
Q6G8J2	Staphylococcus aureus (strain MSSA476)	27%	100%
Q6GFX3	Staphylococcus aureus (strain MRSA252)	28%	100%
Q6IRL9	Xenopus laevis	34%	100%
Q6P6W3	Rattus norvegicus	34%	100%
Q7SXM0	Danio rerio	39%	100%
Q803C3	Danio rerio	34%	100%
Q8NW34	Staphylococcus aureus (strain MW2)	27%	100%
Q944K3	Arabidopsis thaliana	28%	100%
Q9BY41	Homo sapiens	35%	100%