Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger multi-pass transmembrane protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IC46_LEIDO

TriTrypDb:

LdBPK_242360.1 , LdCL_240029200 , LDHU3_24.2920

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8IC46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC46

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016409	palmitoyltransferase activity	5	8
GO:0016417	S-acyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	8
GO:0019707	protein-cysteine S-acyltransferase activity	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.316
CLV_NRD_NRD_1	190	192	PF00675	0.281
CLV_NRD_NRD_1	249	251	PF00675	0.302
CLV_NRD_NRD_1	261	263	PF00675	0.333
CLV_PCSK_FUR_1	188	192	PF00082	0.316
CLV_PCSK_FUR_1	259	263	PF00082	0.426
CLV_PCSK_KEX2_1	165	167	PF00082	0.316
CLV_PCSK_KEX2_1	190	192	PF00082	0.278
CLV_PCSK_KEX2_1	249	251	PF00082	0.316
CLV_PCSK_KEX2_1	259	261	PF00082	0.390
CLV_PCSK_PC7_1	255	261	PF00082	0.345
CLV_PCSK_SKI1_1	190	194	PF00082	0.273
CLV_PCSK_SKI1_1	210	214	PF00082	0.545
CLV_PCSK_SKI1_1	255	259	PF00082	0.302
CLV_PCSK_SKI1_1	262	266	PF00082	0.371
CLV_PCSK_SKI1_1	270	274	PF00082	0.337
DEG_APCC_DBOX_1	190	198	PF00400	0.516
DOC_CYCLIN_yClb1_LxF_4	93	99	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.374
DOC_MAPK_gen_1	260	271	PF00069	0.599
DOC_MAPK_MEF2A_6	110	118	PF00069	0.424
DOC_MAPK_MEF2A_6	262	271	PF00069	0.630
DOC_MAPK_NFAT4_5	270	278	PF00069	0.609
DOC_PP1_RVXF_1	268	275	PF00149	0.613
DOC_PP2B_LxvP_1	18	21	PF13499	0.374
DOC_PP4_FxxP_1	143	146	PF00568	0.448
DOC_USP7_MATH_1	7	11	PF00917	0.438
LIG_14-3-3_CanoR_1	249	258	PF00244	0.505
LIG_Actin_WH2_2	233	251	PF00022	0.414
LIG_Actin_WH2_2	95	112	PF00022	0.379
LIG_BRCT_BRCA1_1	139	143	PF00533	0.414
LIG_FHA_1	236	242	PF00498	0.353
LIG_FHA_2	1	7	PF00498	0.445
LIG_FHA_2	251	257	PF00498	0.545
LIG_LIR_Apic_2	140	146	PF02991	0.414
LIG_LIR_Gen_1	124	135	PF02991	0.373
LIG_LIR_Nem_3	124	130	PF02991	0.373
LIG_LIR_Nem_3	205	209	PF02991	0.369
LIG_LIR_Nem_3	223	228	PF02991	0.357
LIG_LIR_Nem_3	68	74	PF02991	0.343
LIG_LIR_Nem_3	9	14	PF02991	0.286
LIG_NRBOX	203	209	PF00104	0.374
LIG_NRBOX	236	242	PF00104	0.398
LIG_Pex14_1	11	15	PF04695	0.314
LIG_Pex14_1	274	278	PF04695	0.696
LIG_Pex14_2	31	35	PF04695	0.500
LIG_PTB_Apo_2	200	207	PF02174	0.314
LIG_PTB_Apo_2	25	32	PF02174	0.374
LIG_PTB_Apo_2	91	98	PF02174	0.361
LIG_PTB_Phospho_1	200	206	PF10480	0.374
LIG_SH2_CRK	15	19	PF00017	0.411
LIG_SH2_STAP1	138	142	PF00017	0.374
LIG_SH2_STAP1	15	19	PF00017	0.353
LIG_SH2_STAT5	108	111	PF00017	0.455
LIG_SH2_STAT5	127	130	PF00017	0.192
LIG_SH2_STAT5	163	166	PF00017	0.545
LIG_SH2_STAT5	179	182	PF00017	0.371
LIG_SH2_STAT5	206	209	PF00017	0.401
LIG_SH2_STAT5	74	77	PF00017	0.320
LIG_SUMO_SIM_par_1	63	68	PF11976	0.313
LIG_TRAF2_1	3	6	PF00917	0.421
LIG_TYR_ITIM	125	130	PF00017	0.414
MOD_CK1_1	49	55	PF00069	0.700
MOD_CK2_1	250	256	PF00069	0.516
MOD_GlcNHglycan	151	154	PF01048	0.407
MOD_GSK3_1	137	144	PF00069	0.375
MOD_GSK3_1	147	154	PF00069	0.543
MOD_N-GLC_1	202	207	PF02516	0.374
MOD_NEK2_1	137	142	PF00069	0.405
MOD_NEK2_1	40	45	PF00069	0.635
MOD_PIKK_1	40	46	PF00454	0.616
MOD_Plk_1	202	208	PF00069	0.374
MOD_Plk_4	112	118	PF00069	0.447
MOD_Plk_4	202	208	PF00069	0.401
TRG_ENDOCYTIC_2	127	130	PF00928	0.374
TRG_ENDOCYTIC_2	15	18	PF00928	0.341
TRG_ENDOCYTIC_2	73	76	PF00928	0.334
TRG_ER_diArg_1	188	191	PF00400	0.487
TRG_ER_diArg_1	248	250	PF00400	0.516
TRG_ER_diArg_1	258	261	PF00400	0.584
TRG_ER_diArg_1	53	56	PF00400	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ8	Leptomonas seymouri	61%	99%
A0A1X0NW18	Trypanosomatidae	36%	100%
A4HDT8	Leishmania braziliensis	85%	100%
E9AH93	Leishmania infantum	100%	100%
E9AX73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QAA3	Leishmania major	92%	100%