Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)
by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 2 |
Forrest at al. (procyclic) | no | yes: 4 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 51 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 5 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | yes | yes: 41, no: 9 |
NetGPI | no | yes: 0, no: 50 |
Term | Name | Level | Count |
---|---|---|---|
GO:0016020 | membrane | 2 | 51 |
GO:0110165 | cellular anatomical entity | 1 | 51 |
GO:0005737 | cytoplasm | 2 | 4 |
GO:0018995 | host cellular component | 2 | 4 |
GO:0033643 | host cell part | 3 | 4 |
GO:0033646 | host intracellular part | 4 | 4 |
GO:0033647 | host intracellular organelle | 5 | 4 |
GO:0033648 | host intracellular membrane-bounded organelle | 6 | 4 |
GO:0042025 | host cell nucleus | 7 | 4 |
Related structures:
AlphaFold database: A0A3Q8IC44
Term | Name | Level | Count |
---|---|---|---|
GO:0006508 | proteolysis | 4 | 51 |
GO:0006807 | nitrogen compound metabolic process | 2 | 51 |
GO:0007155 | cell adhesion | 2 | 51 |
GO:0008152 | metabolic process | 1 | 51 |
GO:0009987 | cellular process | 1 | 51 |
GO:0019538 | protein metabolic process | 3 | 51 |
GO:0043170 | macromolecule metabolic process | 3 | 51 |
GO:0044238 | primary metabolic process | 2 | 51 |
GO:0071704 | organic substance metabolic process | 2 | 51 |
GO:1901564 | organonitrogen compound metabolic process | 3 | 51 |
GO:0009966 | regulation of signal transduction | 4 | 4 |
GO:0010646 | regulation of cell communication | 4 | 4 |
GO:0010749 | regulation of nitric oxide mediated signal transduction | 6 | 4 |
GO:0023051 | regulation of signaling | 3 | 4 |
GO:0035821 | modulation of process of another organism | 2 | 4 |
GO:0044003 | modulation by symbiont of host process | 3 | 4 |
GO:0044068 | modulation by symbiont of host cellular process | 4 | 4 |
GO:0044081 | modulation by symbiont of host nitric oxide-mediated signal transduction | 5 | 4 |
GO:0044403 | biological process involved in symbiotic interaction | 2 | 4 |
GO:0044419 | biological process involved in interspecies interaction between organisms | 1 | 4 |
GO:0044501 | modulation of signal transduction in another organism | 3 | 4 |
GO:0048583 | regulation of response to stimulus | 3 | 4 |
GO:0050789 | regulation of biological process | 2 | 4 |
GO:0050794 | regulation of cellular process | 3 | 4 |
GO:0051701 | biological process involved in interaction with host | 3 | 4 |
GO:0052027 | modulation by symbiont of host signal transduction pathway | 4 | 4 |
GO:0065007 | biological regulation | 1 | 4 |
GO:0075130 | modulation by symbiont of host protein kinase-mediated signal transduction | 5 | 4 |
GO:1902531 | regulation of intracellular signal transduction | 5 | 4 |
Term | Name | Level | Count |
---|---|---|---|
GO:0003824 | catalytic activity | 1 | 51 |
GO:0004175 | endopeptidase activity | 4 | 51 |
GO:0004222 | metalloendopeptidase activity | 5 | 51 |
GO:0005488 | binding | 1 | 51 |
GO:0008233 | peptidase activity | 3 | 51 |
GO:0008237 | metallopeptidase activity | 4 | 51 |
GO:0016787 | hydrolase activity | 2 | 51 |
GO:0043167 | ion binding | 2 | 51 |
GO:0043169 | cation binding | 3 | 51 |
GO:0046872 | metal ion binding | 4 | 51 |
GO:0140096 | catalytic activity, acting on a protein | 2 | 51 |
GO:0008047 | enzyme activator activity | 3 | 4 |
GO:0008160 | protein tyrosine phosphatase activator activity | 6 | 4 |
GO:0019208 | phosphatase regulator activity | 3 | 4 |
GO:0019211 | phosphatase activator activity | 4 | 4 |
GO:0019888 | protein phosphatase regulator activity | 4 | 4 |
GO:0030234 | enzyme regulator activity | 2 | 4 |
GO:0072542 | protein phosphatase activator activity | 5 | 4 |
GO:0098772 | molecular function regulator activity | 1 | 4 |
GO:0140677 | molecular function activator activity | 2 | 4 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 120 | 124 | PF00656 | 0.190 |
CLV_NRD_NRD_1 | 277 | 279 | PF00675 | 0.401 |
CLV_NRD_NRD_1 | 569 | 571 | PF00675 | 0.567 |
CLV_PCSK_KEX2_1 | 139 | 141 | PF00082 | 0.552 |
CLV_PCSK_KEX2_1 | 277 | 279 | PF00082 | 0.406 |
CLV_PCSK_KEX2_1 | 569 | 571 | PF00082 | 0.567 |
CLV_PCSK_PC1ET2_1 | 139 | 141 | PF00082 | 0.541 |
CLV_PCSK_SKI1_1 | 132 | 136 | PF00082 | 0.489 |
CLV_PCSK_SKI1_1 | 140 | 144 | PF00082 | 0.531 |
CLV_PCSK_SKI1_1 | 247 | 251 | PF00082 | 0.538 |
DEG_APCC_DBOX_1 | 526 | 534 | PF00400 | 0.306 |
DEG_SPOP_SBC_1 | 3 | 7 | PF00917 | 0.605 |
DOC_CYCLIN_yCln2_LP_2 | 105 | 111 | PF00134 | 0.270 |
DOC_MAPK_gen_1 | 277 | 285 | PF00069 | 0.316 |
DOC_PP2B_LxvP_1 | 331 | 334 | PF13499 | 0.359 |
DOC_PP4_FxxP_1 | 181 | 184 | PF00568 | 0.377 |
DOC_PP4_FxxP_1 | 418 | 421 | PF00568 | 0.221 |
DOC_PP4_FxxP_1 | 427 | 430 | PF00568 | 0.256 |
DOC_SPAK_OSR1_1 | 125 | 129 | PF12202 | 0.194 |
DOC_USP7_MATH_1 | 463 | 467 | PF00917 | 0.234 |
DOC_USP7_MATH_1 | 483 | 487 | PF00917 | 0.279 |
DOC_WW_Pin1_4 | 520 | 525 | PF00397 | 0.381 |
LIG_14-3-3_CanoR_1 | 10 | 15 | PF00244 | 0.620 |
LIG_14-3-3_CanoR_1 | 118 | 126 | PF00244 | 0.203 |
LIG_14-3-3_CanoR_1 | 277 | 286 | PF00244 | 0.205 |
LIG_14-3-3_CanoR_1 | 405 | 409 | PF00244 | 0.290 |
LIG_14-3-3_CanoR_1 | 482 | 490 | PF00244 | 0.274 |
LIG_14-3-3_CanoR_1 | 507 | 512 | PF00244 | 0.365 |
LIG_14-3-3_CanoR_1 | 56 | 62 | PF00244 | 0.352 |
LIG_14-3-3_CanoR_1 | 573 | 581 | PF00244 | 0.545 |
LIG_14-3-3_CanoR_1 | 63 | 68 | PF00244 | 0.291 |
LIG_14-3-3_CanoR_1 | 97 | 105 | PF00244 | 0.360 |
LIG_APCC_ABBA_1 | 152 | 157 | PF00400 | 0.377 |
LIG_APCC_ABBA_1 | 346 | 351 | PF00400 | 0.357 |
LIG_APCC_ABBA_1 | 445 | 450 | PF00400 | 0.261 |
LIG_APCC_ABBA_1 | 467 | 472 | PF00400 | 0.381 |
LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.665 |
LIG_BRCT_BRCA1_1 | 259 | 263 | PF00533 | 0.332 |
LIG_BRCT_BRCA1_1 | 533 | 537 | PF00533 | 0.381 |
LIG_eIF4E_1 | 426 | 432 | PF01652 | 0.187 |
LIG_EVH1_1 | 418 | 422 | PF00568 | 0.178 |
LIG_FHA_1 | 100 | 106 | PF00498 | 0.306 |
LIG_FHA_1 | 154 | 160 | PF00498 | 0.304 |
LIG_FHA_1 | 187 | 193 | PF00498 | 0.290 |
LIG_FHA_1 | 214 | 220 | PF00498 | 0.282 |
LIG_FHA_1 | 244 | 250 | PF00498 | 0.343 |
LIG_FHA_1 | 278 | 284 | PF00498 | 0.213 |
LIG_FHA_1 | 343 | 349 | PF00498 | 0.372 |
LIG_FHA_1 | 401 | 407 | PF00498 | 0.352 |
LIG_FHA_1 | 426 | 432 | PF00498 | 0.194 |
LIG_FHA_1 | 506 | 512 | PF00498 | 0.364 |
LIG_FHA_1 | 521 | 527 | PF00498 | 0.226 |
LIG_FHA_1 | 575 | 581 | PF00498 | 0.503 |
LIG_FHA_2 | 128 | 134 | PF00498 | 0.309 |
LIG_GBD_Chelix_1 | 581 | 589 | PF00786 | 0.530 |
LIG_LIR_Apic_2 | 179 | 184 | PF02991 | 0.360 |
LIG_LIR_Gen_1 | 239 | 249 | PF02991 | 0.335 |
LIG_LIR_Gen_1 | 256 | 267 | PF02991 | 0.210 |
LIG_LIR_Gen_1 | 303 | 311 | PF02991 | 0.376 |
LIG_LIR_Gen_1 | 466 | 474 | PF02991 | 0.268 |
LIG_LIR_Gen_1 | 77 | 85 | PF02991 | 0.187 |
LIG_LIR_Nem_3 | 195 | 200 | PF02991 | 0.357 |
LIG_LIR_Nem_3 | 239 | 244 | PF02991 | 0.335 |
LIG_LIR_Nem_3 | 256 | 262 | PF02991 | 0.210 |
LIG_LIR_Nem_3 | 436 | 441 | PF02991 | 0.277 |
LIG_LIR_Nem_3 | 466 | 470 | PF02991 | 0.274 |
LIG_LIR_Nem_3 | 492 | 496 | PF02991 | 0.296 |
LIG_LIR_Nem_3 | 77 | 81 | PF02991 | 0.187 |
LIG_PDZ_Class_2 | 584 | 589 | PF00595 | 0.520 |
LIG_Pex14_1 | 388 | 392 | PF04695 | 0.371 |
LIG_Pex14_2 | 259 | 263 | PF04695 | 0.321 |
LIG_PTB_Apo_2 | 191 | 198 | PF02174 | 0.367 |
LIG_REV1ctd_RIR_1 | 261 | 269 | PF16727 | 0.202 |
LIG_SH2_CRK | 241 | 245 | PF00017 | 0.332 |
LIG_SH2_CRK | 341 | 345 | PF00017 | 0.381 |
LIG_SH2_CRK | 441 | 445 | PF00017 | 0.267 |
LIG_SH2_CRK | 493 | 497 | PF00017 | 0.346 |
LIG_SH2_GRB2like | 519 | 522 | PF00017 | 0.274 |
LIG_SH2_PTP2 | 548 | 551 | PF00017 | 0.377 |
LIG_SH2_PTP2 | 78 | 81 | PF00017 | 0.277 |
LIG_SH2_SRC | 548 | 551 | PF00017 | 0.377 |
LIG_SH2_STAP1 | 241 | 245 | PF00017 | 0.338 |
LIG_SH2_STAP1 | 509 | 513 | PF00017 | 0.381 |
LIG_SH2_STAT3 | 509 | 512 | PF00017 | 0.367 |
LIG_SH2_STAT5 | 200 | 203 | PF00017 | 0.361 |
LIG_SH2_STAT5 | 306 | 309 | PF00017 | 0.347 |
LIG_SH2_STAT5 | 426 | 429 | PF00017 | 0.366 |
LIG_SH2_STAT5 | 441 | 444 | PF00017 | 0.212 |
LIG_SH2_STAT5 | 542 | 545 | PF00017 | 0.377 |
LIG_SH2_STAT5 | 548 | 551 | PF00017 | 0.317 |
LIG_SH2_STAT5 | 78 | 81 | PF00017 | 0.350 |
LIG_SH3_3 | 396 | 402 | PF00018 | 0.190 |
LIG_SH3_3 | 416 | 422 | PF00018 | 0.238 |
LIG_SH3_3 | 441 | 447 | PF00018 | 0.253 |
LIG_Sin3_3 | 576 | 583 | PF02671 | 0.520 |
LIG_TRAF2_1 | 205 | 208 | PF00917 | 0.260 |
LIG_TRAF2_1 | 536 | 539 | PF00917 | 0.241 |
LIG_TYR_ITIM | 76 | 81 | PF00017 | 0.317 |
LIG_WRC_WIRS_1 | 464 | 469 | PF05994 | 0.181 |
MOD_CDK_SPxxK_3 | 520 | 527 | PF00069 | 0.386 |
MOD_CK1_1 | 2 | 8 | PF00069 | 0.632 |
MOD_CK1_1 | 203 | 209 | PF00069 | 0.465 |
MOD_CK1_1 | 317 | 323 | PF00069 | 0.420 |
MOD_CK1_1 | 342 | 348 | PF00069 | 0.274 |
MOD_CK1_1 | 404 | 410 | PF00069 | 0.289 |
MOD_CK1_1 | 468 | 474 | PF00069 | 0.268 |
MOD_CK1_1 | 531 | 537 | PF00069 | 0.341 |
MOD_CK1_1 | 77 | 83 | PF00069 | 0.262 |
MOD_CK2_1 | 357 | 363 | PF00069 | 0.470 |
MOD_CK2_1 | 532 | 538 | PF00069 | 0.296 |
MOD_Cter_Amidation | 567 | 570 | PF01082 | 0.567 |
MOD_GlcNHglycan | 316 | 319 | PF01048 | 0.394 |
MOD_GlcNHglycan | 341 | 344 | PF01048 | 0.343 |
MOD_GlcNHglycan | 435 | 438 | PF01048 | 0.332 |
MOD_GlcNHglycan | 516 | 519 | PF01048 | 0.402 |
MOD_GlcNHglycan | 534 | 537 | PF01048 | 0.209 |
MOD_GlcNHglycan | 71 | 74 | PF01048 | 0.425 |
MOD_GSK3_1 | 243 | 250 | PF00069 | 0.375 |
MOD_GSK3_1 | 253 | 260 | PF00069 | 0.294 |
MOD_GSK3_1 | 400 | 407 | PF00069 | 0.325 |
MOD_GSK3_1 | 501 | 508 | PF00069 | 0.320 |
MOD_GSK3_1 | 528 | 535 | PF00069 | 0.337 |
MOD_GSK3_1 | 99 | 106 | PF00069 | 0.306 |
MOD_N-GLC_1 | 192 | 197 | PF02516 | 0.179 |
MOD_N-GLC_1 | 383 | 388 | PF02516 | 0.386 |
MOD_N-GLC_1 | 455 | 460 | PF02516 | 0.200 |
MOD_N-GLC_1 | 520 | 525 | PF02516 | 0.315 |
MOD_NEK2_1 | 253 | 258 | PF00069 | 0.398 |
MOD_PK_1 | 10 | 16 | PF00069 | 0.614 |
MOD_PK_1 | 265 | 271 | PF00069 | 0.180 |
MOD_PK_1 | 465 | 471 | PF00069 | 0.215 |
MOD_PK_1 | 507 | 513 | PF00069 | 0.348 |
MOD_PKA_1 | 277 | 283 | PF00069 | 0.186 |
MOD_PKA_2 | 117 | 123 | PF00069 | 0.250 |
MOD_PKA_2 | 277 | 283 | PF00069 | 0.186 |
MOD_PKA_2 | 404 | 410 | PF00069 | 0.335 |
MOD_PKA_2 | 57 | 63 | PF00069 | 0.312 |
MOD_Plk_1 | 265 | 271 | PF00069 | 0.256 |
MOD_Plk_1 | 528 | 534 | PF00069 | 0.324 |
MOD_Plk_2-3 | 133 | 139 | PF00069 | 0.370 |
MOD_Plk_4 | 265 | 271 | PF00069 | 0.290 |
MOD_Plk_4 | 74 | 80 | PF00069 | 0.199 |
MOD_Plk_4 | 83 | 89 | PF00069 | 0.279 |
MOD_ProDKin_1 | 520 | 526 | PF00069 | 0.462 |
MOD_SUMO_rev_2 | 175 | 184 | PF00179 | 0.329 |
TRG_DiLeu_BaLyEn_6 | 427 | 432 | PF01217 | 0.191 |
TRG_ENDOCYTIC_2 | 241 | 244 | PF00928 | 0.408 |
TRG_ENDOCYTIC_2 | 306 | 309 | PF00928 | 0.407 |
TRG_ENDOCYTIC_2 | 341 | 344 | PF00928 | 0.462 |
TRG_ENDOCYTIC_2 | 441 | 444 | PF00928 | 0.357 |
TRG_ENDOCYTIC_2 | 493 | 496 | PF00928 | 0.440 |
TRG_ENDOCYTIC_2 | 548 | 551 | PF00928 | 0.458 |
TRG_ENDOCYTIC_2 | 78 | 81 | PF00928 | 0.317 |
TRG_ER_diArg_1 | 276 | 278 | PF00400 | 0.215 |
TRG_Pf-PMV_PEXEL_1 | 47 | 51 | PF00026 | 0.291 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0N1IL11 | Leptomonas seymouri | 35% | 90% |
A0A0S4IUT6 | Bodo saltans | 31% | 72% |
A0A0S4IUU1 | Bodo saltans | 30% | 89% |
A0A0S4IYM3 | Bodo saltans | 30% | 81% |
A0A1L8HYT7 | Xenopus laevis | 24% | 82% |
A0A1X0NDG7 | Trypanosomatidae | 30% | 90% |
A0A1X0NDJ3 | Trypanosomatidae | 29% | 81% |
A0A1X0NDK2 | Trypanosomatidae | 32% | 100% |
A0A1X0NDK7 | Trypanosomatidae | 29% | 82% |
A0A1X0NDK9 | Trypanosomatidae | 28% | 100% |
A0A1X0NDM7 | Trypanosomatidae | 30% | 91% |
A0A1X0NDU8 | Trypanosomatidae | 28% | 88% |
A0A1X0NE71 | Trypanosomatidae | 29% | 100% |
A0A1X0NER9 | Trypanosomatidae | 32% | 92% |
A0A1X0NET7 | Trypanosomatidae | 33% | 100% |
A0A1X0NEX7 | Trypanosomatidae | 32% | 90% |
A0A1X0NEZ6 | Trypanosomatidae | 29% | 90% |
A0A1X0NF32 | Trypanosomatidae | 29% | 100% |
A0A1X0NF41 | Trypanosomatidae | 30% | 96% |
A0A1X0NFJ0 | Trypanosomatidae | 31% | 100% |
A0A1X0NFK3 | Trypanosomatidae | 31% | 88% |
A0A1X0NFS0 | Trypanosomatidae | 28% | 68% |
A0A1X0NFU4 | Trypanosomatidae | 30% | 72% |
A0A1X0NFZ9 | Trypanosomatidae | 32% | 100% |
A0A1X0NG20 | Trypanosomatidae | 30% | 95% |
A0A1X0NGP3 | Trypanosomatidae | 30% | 69% |
A0A1X0NGY3 | Trypanosomatidae | 29% | 77% |
A0A1X0NGZ3 | Trypanosomatidae | 31% | 98% |
A0A1X0NH86 | Trypanosomatidae | 30% | 67% |
A0A1X0NHP4 | Trypanosomatidae | 30% | 100% |
A0A1X0NHP6 | Trypanosomatidae | 27% | 100% |
A0A1X0NHQ6 | Trypanosomatidae | 30% | 100% |
A0A1X0NI38 | Trypanosomatidae | 28% | 67% |
A0A1X0NI74 | Trypanosomatidae | 28% | 79% |
A0A1X0NII4 | Trypanosomatidae | 29% | 70% |
A0A1X0NIJ6 | Trypanosomatidae | 31% | 100% |
A0A1X0NIZ3 | Trypanosomatidae | 33% | 100% |
A0A1X0NJS3 | Trypanosomatidae | 30% | 90% |
A0A1X0NJU4 | Trypanosomatidae | 28% | 68% |
A0A1X0NK66 | Trypanosomatidae | 31% | 89% |
A0A1X0NKJ8 | Trypanosomatidae | 29% | 79% |
A0A1X0NKW9 | Trypanosomatidae | 30% | 100% |
A0A1X0NME2 | Trypanosomatidae | 30% | 94% |
A0A1X0NMK3 | Trypanosomatidae | 26% | 100% |
A0A1X0NMK7 | Trypanosomatidae | 35% | 100% |
A0A1X0NMV0 | Trypanosomatidae | 29% | 80% |
A0A1X0NN43 | Trypanosomatidae | 29% | 82% |
A0A1X0NNK8 | Trypanosomatidae | 28% | 89% |
A0A1X0NP64 | Trypanosomatidae | 29% | 66% |
A0A1X0NPW0 | Trypanosomatidae | 29% | 92% |
A0A1X0NQJ5 | Trypanosomatidae | 34% | 100% |
A0A1X0NQM4 | Trypanosomatidae | 33% | 100% |
A0A1X0NQN3 | Trypanosomatidae | 34% | 100% |
A0A1X0NQU4 | Trypanosomatidae | 33% | 91% |
A0A1X0NQW6 | Trypanosomatidae | 31% | 100% |
A0A1X0NRF3 | Trypanosomatidae | 32% | 88% |
A0A1X0NRY8 | Trypanosomatidae | 34% | 100% |
A0A1X0NU16 | Trypanosomatidae | 36% | 98% |
A0A1X0NUR2 | Trypanosomatidae | 33% | 80% |
A0A1X0NV28 | Trypanosomatidae | 35% | 100% |
A0A1X0NVC3 | Trypanosomatidae | 30% | 86% |
A0A1X0NVE0 | Trypanosomatidae | 29% | 75% |
A0A1X0NW07 | Trypanosomatidae | 26% | 94% |
A0A1X0NX94 | Trypanosomatidae | 28% | 91% |
A0A1X0NX98 | Trypanosomatidae | 31% | 73% |
A0A1X0NXB6 | Trypanosomatidae | 29% | 84% |
A0A1X0NXH6 | Trypanosomatidae | 31% | 81% |
A0A1X0NXQ4 | Trypanosomatidae | 28% | 87% |
A0A1X0NXR7 | Trypanosomatidae | 32% | 78% |
A0A1X0NY94 | Trypanosomatidae | 33% | 100% |
A0A1X0NYE3 | Trypanosomatidae | 28% | 94% |
A0A1X0NYE7 | Trypanosomatidae | 31% | 100% |
A0A1X0NYN2 | Trypanosomatidae | 33% | 100% |
A0A1X0NYN4 | Trypanosomatidae | 27% | 83% |
A0A1X0NYS5 | Trypanosomatidae | 34% | 98% |
A0A1X0NYZ2 | Trypanosomatidae | 38% | 100% |
A0A1X0NZ46 | Trypanosomatidae | 28% | 100% |
A0A1X0NZ63 | Trypanosomatidae | 28% | 92% |
A0A1X0NZN6 | Trypanosomatidae | 27% | 90% |
A0A1X0P055 | Trypanosomatidae | 35% | 99% |
A0A1X0P0C4 | Trypanosomatidae | 30% | 100% |
A0A1X0P154 | Trypanosomatidae | 28% | 98% |
A0A1X0P331 | Trypanosomatidae | 34% | 100% |
A0A1X0P3K0 | Trypanosomatidae | 27% | 81% |
A0A1X0P3S2 | Trypanosomatidae | 27% | 100% |
A0A1X0P4L8 | Trypanosomatidae | 30% | 100% |
A0A1X0P4Y5 | Trypanosomatidae | 27% | 92% |
A0A1X0P544 | Trypanosomatidae | 30% | 92% |
A0A1X0P5J0 | Trypanosomatidae | 32% | 86% |
A0A1X0P7K5 | Trypanosomatidae | 28% | 66% |
A0A1X0P7R3 | Trypanosomatidae | 35% | 100% |
A0A1X0P8B4 | Trypanosomatidae | 31% | 100% |
A0A1X0P9Z4 | Trypanosomatidae | 30% | 100% |
A0A1X0PB04 | Trypanosomatidae | 32% | 100% |
A0A3Q8I8N3 | Leishmania donovani | 87% | 100% |
A0A3Q8I8P8 | Leishmania donovani | 88% | 100% |
A0A3Q8I8S6 | Leishmania donovani | 81% | 100% |
A0A3Q8I8S9 | Leishmania donovani | 88% | 100% |
A0A3Q8IAZ8 | Leishmania donovani | 86% | 100% |
A0A3Q8IC35 | Leishmania donovani | 87% | 100% |
A0A3Q8IH61 | Leishmania donovani | 91% | 100% |
A0A3Q8IIN4 | Leishmania donovani | 35% | 93% |
A0A3R7JT49 | Trypanosoma rangeli | 34% | 70% |
A0A3R7JTB6 | Trypanosoma rangeli | 32% | 84% |
A0A3R7JV87 | Trypanosoma rangeli | 33% | 100% |
A0A3R7K7T9 | Trypanosoma rangeli | 33% | 98% |
A0A3R7K9S1 | Trypanosoma rangeli | 33% | 100% |
A0A3R7KLR6 | Trypanosoma rangeli | 31% | 92% |
A0A3R7KMY2 | Trypanosoma rangeli | 34% | 88% |
A0A3R7LFC4 | Trypanosoma rangeli | 33% | 87% |
A0A3R7LFZ4 | Trypanosoma rangeli | 33% | 100% |
A0A3R7LWG1 | Trypanosoma rangeli | 32% | 100% |
A0A3R7LX11 | Trypanosoma rangeli | 35% | 100% |
A0A3R7M1R8 | Trypanosoma rangeli | 32% | 100% |
A0A3R7M574 | Trypanosoma rangeli | 33% | 92% |
A0A3R7M5K4 | Trypanosoma rangeli | 35% | 100% |
A0A3R7M7N6 | Trypanosoma rangeli | 33% | 86% |
A0A3R7MTS2 | Trypanosoma rangeli | 34% | 100% |
A0A3R7MW36 | Trypanosoma rangeli | 32% | 100% |
A0A3R7MXF4 | Trypanosoma rangeli | 34% | 96% |
A0A3R7N1W7 | Trypanosoma rangeli | 34% | 100% |
A0A3R7N289 | Trypanosoma rangeli | 33% | 81% |
A0A3R7N7I3 | Trypanosoma rangeli | 36% | 100% |
A0A3R7NTI8 | Trypanosoma rangeli | 34% | 100% |
A0A3R7R2J4 | Trypanosoma rangeli | 32% | 91% |
A0A3R7R5R1 | Trypanosoma rangeli | 34% | 98% |
A0A3R7R818 | Trypanosoma rangeli | 30% | 100% |
A0A3S5H6G0 | Leishmania donovani | 88% | 98% |
A0A3S5IQY2 | Trypanosoma rangeli | 36% | 100% |
A0A3S7WR43 | Leishmania donovani | 87% | 98% |
A0A3S7WR46 | Leishmania donovani | 88% | 98% |
A0A3S7WR60 | Leishmania donovani | 87% | 98% |
A0A3S7X192 | Leishmania donovani | 36% | 100% |
A0A422MP17 | Trypanosoma rangeli | 35% | 100% |
A0A422MRQ6 | Trypanosoma rangeli | 36% | 79% |
A0A422MU95 | Trypanosoma rangeli | 35% | 100% |
A0A422MVF5 | Trypanosoma rangeli | 33% | 100% |
A0A422MVS3 | Trypanosoma rangeli | 34% | 100% |
A0A422MW99 | Trypanosoma rangeli | 31% | 79% |
A0A422MZ47 | Trypanosoma rangeli | 36% | 100% |
A0A422MZG4 | Trypanosoma rangeli | 35% | 100% |
A0A422N361 | Trypanosoma rangeli | 33% | 100% |
A0A422N7Q6 | Trypanosoma rangeli | 34% | 91% |
A0A422NDS2 | Trypanosoma rangeli | 31% | 100% |
A0A422NDT3 | Trypanosoma rangeli | 31% | 100% |
A0A422NP82 | Trypanosoma rangeli | 37% | 100% |
A4H626 | Leishmania braziliensis | 58% | 100% |
A4H627 | Leishmania braziliensis | 57% | 100% |
A4H630 | Leishmania braziliensis | 62% | 100% |
A4H631 | Leishmania braziliensis | 57% | 100% |
A4H632 | Leishmania braziliensis | 62% | 100% |
A4H633 | Leishmania braziliensis | 58% | 100% |
A4H634 | Leishmania braziliensis | 62% | 100% |
A4H635 | Leishmania braziliensis | 63% | 100% |
A4H636 | Leishmania braziliensis | 60% | 100% |
A4H637 | Leishmania braziliensis | 63% | 100% |
A4H638 | Leishmania braziliensis | 70% | 100% |
A4H639 | Leishmania braziliensis | 67% | 100% |
A4H640 | Leishmania braziliensis | 62% | 100% |
A4H6D3 | Leishmania braziliensis | 60% | 100% |
A4H6D5 | Leishmania braziliensis | 59% | 100% |
A4H6D7 | Leishmania braziliensis | 57% | 100% |
A4H6D8 | Leishmania braziliensis | 57% | 100% |
A4H6D9 | Leishmania braziliensis | 57% | 100% |
A4H6E0 | Leishmania braziliensis | 57% | 100% |
A4H6E1 | Leishmania braziliensis | 58% | 100% |
A4H6E2 | Leishmania braziliensis | 60% | 100% |
A4H6E3 | Leishmania braziliensis | 59% | 100% |
A4H6E4 | Leishmania braziliensis | 60% | 100% |
A4H6E5 | Leishmania braziliensis | 68% | 100% |
A4HJI2 | Leishmania braziliensis | 36% | 100% |
A4HUF6 | Leishmania infantum | 86% | 100% |
A4HUF8 | Leishmania infantum | 88% | 100% |
A4HUF9 | Leishmania infantum | 80% | 100% |
A4HUG0 | Leishmania infantum | 90% | 100% |
A4I6X5 | Leishmania infantum | 36% | 100% |
C9ZUT5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 36% | 100% |
D0A1R8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 100% |
D0A7S8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 31% | 87% |
D0A855 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 37% | 95% |
E9AHH5 | Leishmania infantum | 37% | 100% |
E9AN53 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 74% | 100% |
E9AN54 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 78% | 100% |
E9AN55 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 75% | 100% |
E9AN56 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 73% | 100% |
E9AN57 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 80% | 100% |
E9AZL8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 37% | 100% |
E9B1Z9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
O62446 | Caenorhabditis elegans | 24% | 89% |
P08148 | Leishmania major | 80% | 98% |
P15706 | Leishmania chagasi | 88% | 98% |
P23223 | Leishmania donovani | 90% | 100% |
P43150 | Leishmania mexicana | 73% | 91% |
Q00689 | Leishmania guyanensis | 63% | 95% |
Q06031 | Crithidia fasciculata | 51% | 90% |
Q27673 | Leishmania amazonensis | 77% | 99% |
Q29AK2 | Drosophila pseudoobscura pseudoobscura | 23% | 86% |
Q4Q662 | Leishmania major | 35% | 100% |
Q4Q8L3 | Leishmania major | 38% | 100% |
Q4QHG9 | Leishmania major | 80% | 100% |
Q4QHH0 | Leishmania major | 78% | 100% |
Q4QHH1 | Leishmania major | 80% | 100% |
Q4QHH2 | Leishmania major | 80% | 100% |
Q61YG1 | Caenorhabditis briggsae | 24% | 89% |
Q6LA77 | Leishmania infantum | 88% | 100% |
Q8MNZ1 | Leishmania tropica | 78% | 90% |
Q9VH19 | Drosophila melanogaster | 23% | 86% |
V5A303 | Trypanosoma cruzi | 37% | 100% |
V5A359 | Trypanosoma cruzi | 36% | 100% |
V5A488 | Trypanosoma cruzi | 33% | 73% |
V5AII7 | Trypanosoma cruzi | 37% | 100% |
V5AN34 | Trypanosoma cruzi | 35% | 100% |
V5APQ4 | Trypanosoma cruzi | 33% | 74% |
V5AX72 | Trypanosoma cruzi | 33% | 80% |
V5B5M0 | Trypanosoma cruzi | 34% | 80% |
V5BAL3 | Trypanosoma cruzi | 38% | 100% |
V5BAN1 | Trypanosoma cruzi | 33% | 75% |
V5BD39 | Trypanosoma cruzi | 39% | 100% |
V5BLT3 | Trypanosoma cruzi | 33% | 93% |
V5CI97 | Trypanosoma cruzi | 32% | 92% |
V5D358 | Trypanosoma cruzi | 33% | 69% |