LeishMANIAdb
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FYR C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
FYR C-terminal domain-containing protein
Gene product:
ISWI complex protein
Species:
Leishmania donovani
UniProt:
A0A3Q8IC42_LEIDO
TriTrypDb:
LdBPK_260830.1 * , LdCL_260014000 , LDHU3_26.1090
Length:
786

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 5
GO:0043226 organelle 2 5
GO:0043227 membrane-bounded organelle 3 5
GO:0043229 intracellular organelle 3 5
GO:0043231 intracellular membrane-bounded organelle 4 5
GO:0110165 cellular anatomical entity 1 5
GO:0031010 ISWI-type complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0070603 SWI/SNF superfamily-type complex 3 1
GO:0140513 nuclear protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1904949 ATPase complex 3 1

Expansion

Sequence features

A0A3Q8IC42
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC42

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 450 454 PF00656 0.804
CLV_C14_Caspase3-7 481 485 PF00656 0.674
CLV_C14_Caspase3-7 726 730 PF00656 0.689
CLV_C14_Caspase3-7 765 769 PF00656 0.736
CLV_C14_Caspase3-7 88 92 PF00656 0.538
CLV_C14_Caspase3-7 97 101 PF00656 0.468
CLV_NRD_NRD_1 108 110 PF00675 0.525
CLV_NRD_NRD_1 215 217 PF00675 0.705
CLV_NRD_NRD_1 242 244 PF00675 0.748
CLV_NRD_NRD_1 248 250 PF00675 0.759
CLV_NRD_NRD_1 288 290 PF00675 0.700
CLV_NRD_NRD_1 291 293 PF00675 0.688
CLV_NRD_NRD_1 325 327 PF00675 0.730
CLV_NRD_NRD_1 412 414 PF00675 0.727
CLV_NRD_NRD_1 417 419 PF00675 0.747
CLV_NRD_NRD_1 461 463 PF00675 0.752
CLV_NRD_NRD_1 465 467 PF00675 0.738
CLV_NRD_NRD_1 498 500 PF00675 0.731
CLV_NRD_NRD_1 610 612 PF00675 0.727
CLV_NRD_NRD_1 733 735 PF00675 0.740
CLV_PCSK_FUR_1 289 293 PF00082 0.759
CLV_PCSK_FUR_1 465 469 PF00082 0.750
CLV_PCSK_FUR_1 496 500 PF00082 0.710
CLV_PCSK_KEX2_1 215 217 PF00082 0.705
CLV_PCSK_KEX2_1 241 243 PF00082 0.765
CLV_PCSK_KEX2_1 248 250 PF00082 0.724
CLV_PCSK_KEX2_1 286 288 PF00082 0.750
CLV_PCSK_KEX2_1 291 293 PF00082 0.730
CLV_PCSK_KEX2_1 323 325 PF00082 0.728
CLV_PCSK_KEX2_1 416 418 PF00082 0.704
CLV_PCSK_KEX2_1 465 467 PF00082 0.695
CLV_PCSK_KEX2_1 498 500 PF00082 0.728
CLV_PCSK_KEX2_1 600 602 PF00082 0.699
CLV_PCSK_KEX2_1 609 611 PF00082 0.715
CLV_PCSK_KEX2_1 702 704 PF00082 0.578
CLV_PCSK_KEX2_1 738 740 PF00082 0.711
CLV_PCSK_PC1ET2_1 241 243 PF00082 0.765
CLV_PCSK_PC1ET2_1 286 288 PF00082 0.750
CLV_PCSK_PC1ET2_1 323 325 PF00082 0.728
CLV_PCSK_PC1ET2_1 467 469 PF00082 0.695
CLV_PCSK_PC1ET2_1 600 602 PF00082 0.699
CLV_PCSK_PC1ET2_1 702 704 PF00082 0.578
CLV_PCSK_PC1ET2_1 738 740 PF00082 0.753
CLV_PCSK_PC7_1 238 244 PF00082 0.766
CLV_PCSK_PC7_1 287 293 PF00082 0.761
CLV_PCSK_PC7_1 413 419 PF00082 0.742
CLV_PCSK_PC7_1 734 740 PF00082 0.758
CLV_PCSK_SKI1_1 102 106 PF00082 0.562
CLV_PCSK_SKI1_1 109 113 PF00082 0.473
CLV_PCSK_SKI1_1 242 246 PF00082 0.696
CLV_PCSK_SKI1_1 35 39 PF00082 0.462
CLV_PCSK_SKI1_1 715 719 PF00082 0.674
CLV_PCSK_SKI1_1 77 81 PF00082 0.561
DEG_APCC_DBOX_1 714 722 PF00400 0.592
DEG_COP1_1 484 492 PF00400 0.610
DEG_Nend_Nbox_1 1 3 PF02207 0.487
DEG_SCF_FBW7_1 221 226 PF00400 0.746
DEG_SPOP_SBC_1 11 15 PF00917 0.675
DEG_SPOP_SBC_1 190 194 PF00917 0.653
DEG_SPOP_SBC_1 37 41 PF00917 0.591
DOC_CYCLIN_yCln2_LP_2 555 561 PF00134 0.745
DOC_MAPK_DCC_7 339 348 PF00069 0.572
DOC_MAPK_gen_1 398 408 PF00069 0.729
DOC_MAPK_RevD_3 587 601 PF00069 0.666
DOC_PP2B_LxvP_1 126 129 PF13499 0.531
DOC_PP2B_LxvP_1 156 159 PF13499 0.560
DOC_PP2B_LxvP_1 371 374 PF13499 0.674
DOC_PP2B_LxvP_1 555 558 PF13499 0.664
DOC_PP4_FxxP_1 21 24 PF00568 0.658
DOC_SPAK_OSR1_1 706 710 PF12202 0.614
DOC_USP7_MATH_1 129 133 PF00917 0.557
DOC_USP7_MATH_1 168 172 PF00917 0.567
DOC_USP7_MATH_1 223 227 PF00917 0.768
DOC_USP7_MATH_1 237 241 PF00917 0.696
DOC_USP7_MATH_1 244 248 PF00917 0.691
DOC_USP7_MATH_1 258 262 PF00917 0.676
DOC_USP7_MATH_1 263 267 PF00917 0.597
DOC_USP7_MATH_1 318 322 PF00917 0.619
DOC_USP7_MATH_1 483 487 PF00917 0.785
DOC_USP7_MATH_1 510 514 PF00917 0.711
DOC_USP7_MATH_1 523 527 PF00917 0.722
DOC_USP7_MATH_1 728 732 PF00917 0.640
DOC_USP7_MATH_2 230 236 PF00917 0.846
DOC_USP7_UBL2_3 224 228 PF12436 0.772
DOC_USP7_UBL2_3 463 467 PF12436 0.725
DOC_WW_Pin1_4 217 222 PF00397 0.746
DOC_WW_Pin1_4 254 259 PF00397 0.711
DOC_WW_Pin1_4 299 304 PF00397 0.830
DOC_WW_Pin1_4 357 362 PF00397 0.614
DOC_WW_Pin1_4 529 534 PF00397 0.721
DOC_WW_Pin1_4 669 674 PF00397 0.719
DOC_WW_Pin1_4 776 781 PF00397 0.764
LIG_14-3-3_CanoR_1 191 196 PF00244 0.643
LIG_14-3-3_CanoR_1 242 252 PF00244 0.814
LIG_14-3-3_CanoR_1 35 44 PF00244 0.508
LIG_14-3-3_CanoR_1 556 562 PF00244 0.741
LIG_14-3-3_CanoR_1 734 740 PF00244 0.614
LIG_Actin_WH2_2 134 151 PF00022 0.515
LIG_APCC_ABBAyCdc20_2 23 29 PF00400 0.495
LIG_BRCT_BRCA1_1 513 517 PF00533 0.691
LIG_DCNL_PONY_1 1 4 PF03556 0.582
LIG_FHA_1 191 197 PF00498 0.682
LIG_FHA_1 260 266 PF00498 0.808
LIG_FHA_1 336 342 PF00498 0.599
LIG_FHA_1 345 351 PF00498 0.538
LIG_FHA_1 519 525 PF00498 0.788
LIG_FHA_1 71 77 PF00498 0.488
LIG_FHA_1 82 88 PF00498 0.458
LIG_FHA_2 440 446 PF00498 0.684
LIG_FHA_2 558 564 PF00498 0.724
LIG_FHA_2 714 720 PF00498 0.716
LIG_FHA_2 760 766 PF00498 0.669
LIG_FHA_2 86 92 PF00498 0.502
LIG_FHA_2 95 101 PF00498 0.525
LIG_FXI_DFP_1 116 120 PF00024 0.507
LIG_LIR_Apic_2 52 58 PF02991 0.710
LIG_LIR_Apic_2 547 553 PF02991 0.664
LIG_LIR_Gen_1 714 724 PF02991 0.614
LIG_LIR_Nem_3 381 387 PF02991 0.548
LIG_LIR_Nem_3 551 555 PF02991 0.777
LIG_LIR_Nem_3 714 720 PF02991 0.621
LIG_LRP6_Inhibitor_1 136 142 PF00058 0.512
LIG_LYPXL_yS_3 552 555 PF13949 0.676
LIG_MYND_1 369 373 PF01753 0.667
LIG_MYND_1 553 557 PF01753 0.670
LIG_Pex14_1 575 579 PF04695 0.614
LIG_SH2_CRK 55 59 PF00017 0.727
LIG_SH2_CRK 550 554 PF00017 0.696
LIG_SH2_STAT5 31 34 PF00017 0.460
LIG_SH2_STAT5 550 553 PF00017 0.653
LIG_SH2_STAT5 71 74 PF00017 0.573
LIG_SH2_STAT5 711 714 PF00017 0.703
LIG_SH2_STAT5 98 101 PF00017 0.540
LIG_SH3_3 22 28 PF00018 0.608
LIG_SH3_3 347 353 PF00018 0.722
LIG_SH3_3 366 372 PF00018 0.454
LIG_SH3_3 403 409 PF00018 0.722
LIG_SH3_3 527 533 PF00018 0.782
LIG_SH3_3 535 541 PF00018 0.821
LIG_SH3_3 551 557 PF00018 0.568
LIG_SH3_3 580 586 PF00018 0.628
LIG_SH3_3 667 673 PF00018 0.724
LIG_SH3_3 678 684 PF00018 0.676
LIG_SH3_4 463 470 PF00018 0.799
LIG_Sin3_3 485 492 PF02671 0.607
LIG_SUMO_SIM_anti_2 347 352 PF11976 0.618
LIG_SUMO_SIM_anti_2 716 722 PF11976 0.594
LIG_SUMO_SIM_par_1 266 273 PF11976 0.619
LIG_SUMO_SIM_par_1 344 349 PF11976 0.698
LIG_SUMO_SIM_par_1 557 563 PF11976 0.732
LIG_SUMO_SIM_par_1 688 693 PF11976 0.644
LIG_TRAF2_1 544 547 PF00917 0.711
MOD_CDK_SPK_2 219 224 PF00069 0.756
MOD_CDK_SPxxK_3 217 224 PF00069 0.838
MOD_CK1_1 103 109 PF00069 0.501
MOD_CK1_1 179 185 PF00069 0.590
MOD_CK1_1 194 200 PF00069 0.714
MOD_CK1_1 329 335 PF00069 0.756
MOD_CK1_1 357 363 PF00069 0.622
MOD_CK1_1 513 519 PF00069 0.782
MOD_CK1_1 59 65 PF00069 0.537
MOD_CK1_1 664 670 PF00069 0.758
MOD_CK1_1 672 678 PF00069 0.785
MOD_CK1_1 713 719 PF00069 0.609
MOD_CK1_1 776 782 PF00069 0.825
MOD_CK2_1 439 445 PF00069 0.684
MOD_CK2_1 513 519 PF00069 0.766
MOD_CK2_1 557 563 PF00069 0.732
MOD_CK2_1 776 782 PF00069 0.784
MOD_Cter_Amidation 700 703 PF01082 0.577
MOD_Cter_Amidation 732 735 PF01082 0.838
MOD_GlcNHglycan 102 105 PF01048 0.534
MOD_GlcNHglycan 171 174 PF01048 0.509
MOD_GlcNHglycan 225 228 PF01048 0.745
MOD_GlcNHglycan 265 268 PF01048 0.746
MOD_GlcNHglycan 356 359 PF01048 0.706
MOD_GlcNHglycan 446 452 PF01048 0.772
MOD_GlcNHglycan 478 481 PF01048 0.835
MOD_GlcNHglycan 484 488 PF01048 0.767
MOD_GlcNHglycan 58 61 PF01048 0.643
MOD_GlcNHglycan 663 666 PF01048 0.749
MOD_GlcNHglycan 667 670 PF01048 0.768
MOD_GlcNHglycan 725 728 PF01048 0.687
MOD_GlcNHglycan 774 778 PF01048 0.834
MOD_GSK3_1 190 197 PF00069 0.712
MOD_GSK3_1 198 205 PF00069 0.686
MOD_GSK3_1 2 9 PF00069 0.510
MOD_GSK3_1 206 213 PF00069 0.751
MOD_GSK3_1 215 222 PF00069 0.694
MOD_GSK3_1 232 239 PF00069 0.768
MOD_GSK3_1 244 251 PF00069 0.714
MOD_GSK3_1 254 261 PF00069 0.677
MOD_GSK3_1 270 277 PF00069 0.629
MOD_GSK3_1 325 332 PF00069 0.753
MOD_GSK3_1 374 381 PF00069 0.562
MOD_GSK3_1 437 444 PF00069 0.735
MOD_GSK3_1 661 668 PF00069 0.830
MOD_GSK3_1 669 676 PF00069 0.646
MOD_GSK3_1 690 697 PF00069 0.641
MOD_GSK3_1 709 716 PF00069 0.604
MOD_GSK3_1 81 88 PF00069 0.497
MOD_GSK3_1 94 101 PF00069 0.638
MOD_N-GLC_1 2 7 PF02516 0.587
MOD_N-GLC_1 722 727 PF02516 0.654
MOD_NEK2_1 176 181 PF00069 0.560
MOD_NEK2_1 195 200 PF00069 0.522
MOD_NEK2_1 2 7 PF00069 0.587
MOD_NEK2_1 362 367 PF00069 0.713
MOD_NEK2_1 38 43 PF00069 0.638
MOD_NEK2_1 571 576 PF00069 0.601
MOD_NEK2_1 690 695 PF00069 0.641
MOD_NEK2_1 72 77 PF00069 0.417
MOD_NEK2_1 85 90 PF00069 0.389
MOD_NEK2_2 318 323 PF00069 0.592
MOD_PIKK_1 198 204 PF00454 0.826
MOD_PIKK_1 206 212 PF00454 0.718
MOD_PIKK_1 38 44 PF00454 0.698
MOD_PIKK_1 690 696 PF00454 0.643
MOD_PK_1 248 254 PF00069 0.733
MOD_PKA_1 215 221 PF00069 0.704
MOD_PKA_1 242 248 PF00069 0.735
MOD_PKA_1 287 293 PF00069 0.723
MOD_PKA_1 324 330 PF00069 0.710
MOD_PKA_1 417 423 PF00069 0.844
MOD_PKA_1 702 708 PF00069 0.585
MOD_PKA_1 734 740 PF00069 0.614
MOD_PKA_2 190 196 PF00069 0.636
MOD_PKA_2 215 221 PF00069 0.719
MOD_PKA_2 237 243 PF00069 0.770
MOD_PKA_2 248 254 PF00069 0.709
MOD_PKA_2 287 293 PF00069 0.761
MOD_PKA_2 324 330 PF00069 0.710
MOD_PKA_2 417 423 PF00069 0.844
MOD_PKA_2 500 506 PF00069 0.723
MOD_PKA_2 658 664 PF00069 0.687
MOD_PKA_2 702 708 PF00069 0.585
MOD_PKA_2 733 739 PF00069 0.617
MOD_PKB_1 324 332 PF00069 0.835
MOD_Plk_1 2 8 PF00069 0.586
MOD_Plk_1 434 440 PF00069 0.706
MOD_Plk_1 483 489 PF00069 0.720
MOD_Plk_1 690 696 PF00069 0.643
MOD_Plk_1 713 719 PF00069 0.609
MOD_Plk_1 94 100 PF00069 0.573
MOD_Plk_2-3 29 35 PF00069 0.589
MOD_Plk_4 191 197 PF00069 0.764
MOD_Plk_4 265 271 PF00069 0.640
MOD_Plk_4 346 352 PF00069 0.671
MOD_Plk_4 6 12 PF00069 0.535
MOD_ProDKin_1 217 223 PF00069 0.743
MOD_ProDKin_1 254 260 PF00069 0.710
MOD_ProDKin_1 299 305 PF00069 0.829
MOD_ProDKin_1 357 363 PF00069 0.604
MOD_ProDKin_1 529 535 PF00069 0.724
MOD_ProDKin_1 669 675 PF00069 0.718
MOD_ProDKin_1 776 782 PF00069 0.763
MOD_SUMO_rev_2 472 478 PF00179 0.770
MOD_SUMO_rev_2 625 630 PF00179 0.807
MOD_SUMO_rev_2 95 104 PF00179 0.648
TRG_ENDOCYTIC_2 552 555 PF00928 0.676
TRG_ER_diArg_1 287 289 PF00400 0.764
TRG_ER_diArg_1 291 293 PF00400 0.709
TRG_ER_diArg_1 324 326 PF00400 0.729
TRG_ER_diArg_1 415 418 PF00400 0.746
TRG_ER_diArg_1 464 466 PF00400 0.731
TRG_ER_diArg_1 468 471 PF00400 0.737
TRG_ER_diArg_1 496 499 PF00400 0.713
TRG_ER_diArg_1 609 611 PF00400 0.715
TRG_NLS_MonoCore_2 322 327 PF00514 0.728
TRG_NLS_MonoCore_2 412 417 PF00514 0.697
TRG_NLS_MonoCore_2 461 466 PF00514 0.711
TRG_NLS_MonoExtC_3 412 417 PF00514 0.713
TRG_NLS_MonoExtC_3 461 466 PF00514 0.680
TRG_NLS_MonoExtN_4 238 245 PF00514 0.726
TRG_NLS_MonoExtN_4 463 470 PF00514 0.682
TRG_Pf-PMV_PEXEL_1 294 298 PF00026 0.763
TRG_Pf-PMV_PEXEL_1 706 710 PF00026 0.596

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAK0 Leptomonas seymouri 42% 98%
A4HEU2 Leishmania braziliensis 68% 98%
A4I217 Leishmania infantum 99% 100%
E9AY65 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4Q9A7 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS