Proteasome subunit alpha type

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome subunit alpha type-5, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC41_LEIDO

TriTrypDb:

LdBPK_212200.1 , LdCL_210027700 , LDHU3_21.2610

Length:

244

Annotations

Annotations by Jardim et al.

Proteasome, Proteasome subunit alpha type

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	yes	yes: 2
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	11
GO:0019773	proteasome core complex, alpha-subunit complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005829	cytosol	2	1
GO:0005839	proteasome core complex	3	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3Q8IC41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC41

PDB structure(s): 6qm7_E , 6qm7_S , 6qm8_E , 6qm8_S , 6tcz_e , 6td5_e

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0030163	protein catabolic process	4	12
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.340
CLV_PCSK_KEX2_1	129	131	PF00082	0.393
CLV_PCSK_KEX2_1	52	54	PF00082	0.326
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.393
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.326
CLV_PCSK_SKI1_1	187	191	PF00082	0.326
DEG_Nend_Nbox_1	1	3	PF02207	0.634
DOC_CKS1_1	229	234	PF01111	0.677
DOC_CKS1_1	40	45	PF01111	0.538
DOC_MAPK_gen_1	52	60	PF00069	0.569
DOC_MAPK_MEF2A_6	135	143	PF00069	0.526
DOC_PP2B_LxvP_1	58	61	PF13499	0.614
DOC_USP7_MATH_1	176	180	PF00917	0.625
DOC_USP7_MATH_1	237	241	PF00917	0.719
DOC_WW_Pin1_4	13	18	PF00397	0.526
DOC_WW_Pin1_4	208	213	PF00397	0.625
DOC_WW_Pin1_4	228	233	PF00397	0.760
DOC_WW_Pin1_4	39	44	PF00397	0.538
LIG_14-3-3_CanoR_1	10	16	PF00244	0.527
LIG_14-3-3_CanoR_1	100	104	PF00244	0.526
LIG_14-3-3_CanoR_1	187	192	PF00244	0.538
LIG_14-3-3_CanoR_1	53	59	PF00244	0.535
LIG_BRCT_BRCA1_1	119	123	PF00533	0.535
LIG_BRCT_BRCA1_1	133	137	PF00533	0.497
LIG_EH1_1	136	144	PF00400	0.526
LIG_FHA_1	114	120	PF00498	0.550
LIG_FHA_1	194	200	PF00498	0.584
LIG_FHA_1	55	61	PF00498	0.614
LIG_FHA_2	100	106	PF00498	0.526
LIG_FHA_2	161	167	PF00498	0.526
LIG_FHA_2	188	194	PF00498	0.527
LIG_FHA_2	229	235	PF00498	0.674
LIG_LIR_Apic_2	102	106	PF02991	0.526
LIG_LIR_LC3C_4	56	60	PF02991	0.537
LIG_RPA_C_Fungi	81	93	PF08784	0.384
LIG_SH2_STAP1	165	169	PF00017	0.368
LIG_SH2_STAP1	26	30	PF00017	0.368
LIG_SH2_STAT3	165	168	PF00017	0.368
LIG_SH2_STAT5	230	233	PF00017	0.744
LIG_SUMO_SIM_anti_2	216	221	PF11976	0.368
LIG_SUMO_SIM_par_1	195	200	PF11976	0.506
LIG_SUMO_SIM_par_1	56	63	PF11976	0.405
LIG_TRAF2_1	190	193	PF00917	0.384
LIG_WRC_WIRS_1	12	17	PF05994	0.368
MOD_CDK_SPxxK_3	13	20	PF00069	0.368
MOD_CK1_1	108	114	PF00069	0.490
MOD_CK1_1	179	185	PF00069	0.488
MOD_CK1_1	62	68	PF00069	0.484
MOD_CK2_1	1	7	PF00069	0.616
MOD_CK2_1	187	193	PF00069	0.391
MOD_CK2_1	228	234	PF00069	0.758
MOD_CK2_1	99	105	PF00069	0.368
MOD_Cter_Amidation	127	130	PF01082	0.369
MOD_GlcNHglycan	125	128	PF01048	0.403
MOD_GlcNHglycan	157	161	PF01048	0.368
MOD_GlcNHglycan	78	81	PF01048	0.372
MOD_GSK3_1	113	120	PF00069	0.403
MOD_GSK3_1	156	163	PF00069	0.372
MOD_GSK3_1	69	76	PF00069	0.337
MOD_LATS_1	91	97	PF00433	0.461
MOD_N-GLC_1	187	192	PF02516	0.384
MOD_NEK2_1	1	6	PF00069	0.620
MOD_NEK2_1	123	128	PF00069	0.391
MOD_NEK2_1	137	142	PF00069	0.353
MOD_NEK2_1	33	38	PF00069	0.368
MOD_NEK2_2	176	181	PF00069	0.384
MOD_OFUCOSY	112	117	PF10250	0.384
MOD_PIKK_1	93	99	PF00454	0.461
MOD_PKA_2	99	105	PF00069	0.368
MOD_Plk_1	117	123	PF00069	0.385
MOD_Plk_1	187	193	PF00069	0.390
MOD_Plk_2-3	105	111	PF00069	0.490
MOD_Plk_4	137	143	PF00069	0.379
MOD_Plk_4	176	182	PF00069	0.402
MOD_Plk_4	54	60	PF00069	0.347
MOD_Plk_4	73	79	PF00069	0.380
MOD_ProDKin_1	13	19	PF00069	0.368
MOD_ProDKin_1	208	214	PF00069	0.506
MOD_ProDKin_1	228	234	PF00069	0.758
MOD_ProDKin_1	39	45	PF00069	0.384
MOD_SUMO_rev_2	223	227	PF00179	0.755
TRG_DiLeu_BaEn_4	192	198	PF01217	0.384
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I1	Leptomonas seymouri	93%	100%
A0A0N0P4E6	Leptomonas seymouri	31%	100%
A0A0N0P7F8	Leptomonas seymouri	21%	81%
A0A0N1HVL0	Leptomonas seymouri	28%	96%
A0A0N1I173	Leptomonas seymouri	42%	100%
A0A0N1I278	Leptomonas seymouri	35%	99%
A0A0N1I2E0	Leptomonas seymouri	25%	98%
A0A0N1ILS9	Leptomonas seymouri	37%	92%
A0A0N1PBJ3	Leptomonas seymouri	38%	86%
A0A0S4INC9	Bodo saltans	30%	100%
A0A0S4IQU5	Bodo saltans	70%	92%
A0A0S4IU58	Bodo saltans	37%	100%
A0A0S4IWG0	Bodo saltans	33%	91%
A0A0S4IX63	Bodo saltans	25%	83%
A0A0S4IXL2	Bodo saltans	27%	95%
A0A0S4J6W0	Bodo saltans	22%	98%
A0A0S4JLA2	Bodo saltans	37%	87%
A0A1X0NHF3	Trypanosomatidae	38%	100%
A0A1X0NJ65	Trypanosomatidae	79%	100%
A0A1X0NMF1	Trypanosomatidae	31%	100%
A0A1X0NNS5	Trypanosomatidae	39%	85%
A0A1X0NNS8	Trypanosomatidae	22%	86%
A0A1X0NVU4	Trypanosomatidae	35%	99%
A0A1X0P5G1	Trypanosomatidae	28%	95%
A0A1X0P5Y6	Trypanosomatidae	23%	98%
A0A1X0P7U3	Trypanosomatidae	25%	78%
A0A1X0P853	Trypanosomatidae	34%	92%
A0A3Q8IB07	Leishmania donovani	42%	100%
A0A3Q8IFZ3	Leishmania donovani	36%	92%
A0A3Q8IIY4	Leishmania donovani	22%	81%
A0A3Q8IVH0	Leishmania donovani	28%	96%
A0A3R7KUN3	Trypanosoma rangeli	39%	85%
A0A3R7LAV3	Trypanosoma rangeli	35%	99%
A0A3R7MIT1	Trypanosoma rangeli	35%	92%
A0A3R7MZI3	Trypanosoma rangeli	25%	78%
A0A3S5H6I0	Leishmania donovani	35%	99%
A0A3S5H7H2	Leishmania donovani	31%	100%
A0A3S5IS75	Trypanosoma rangeli	31%	100%
A0A3S7WST4	Leishmania donovani	39%	86%
A0A422N1Q5	Trypanosoma rangeli	26%	96%
A0A422N8R3	Trypanosoma rangeli	77%	100%
A0A422N8U2	Trypanosoma rangeli	38%	100%
A0A422P146	Trypanosoma rangeli	24%	98%
A0A6L0XSJ0	Leishmania infantum	24%	98%
A0B5B1	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	28%	100%
A0RU86	Cenarchaeum symbiosum (strain A)	22%	100%
A0RXV1	Cenarchaeum symbiosum (strain A)	27%	100%
A1RSJ8	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	32%	100%
A1RTI7	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	33%	100%
A1RWY6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	35%	100%
A1RX71	Thermofilum pendens (strain DSM 2475 / Hrk 5)	31%	100%
A1XQU1	Sus scrofa	26%	88%
A2BN24	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	27%	100%
A2BN27	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	27%	100%
A2SS78	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	31%	100%
A2Y9X7	Oryza sativa subsp. indica	41%	98%
A2YVR7	Oryza sativa subsp. indica	40%	100%
A2YXU2	Oryza sativa subsp. indica	40%	98%
A2Z3I9	Oryza sativa subsp. indica	39%	98%
A3CUS9	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	29%	100%
A3CW55	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	42%	100%
A3DN21	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	27%	100%
A3DN27	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	32%	100%
A3MS44	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	30%	100%
A3MXQ6	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	30%	100%
A4FYA5	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	29%	100%
A4FZT6	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	45%	94%
A4H7J0	Leishmania braziliensis	38%	100%
A4H9T4	Leishmania braziliensis	35%	100%
A4HC34	Leishmania braziliensis	42%	100%
A4HFD7	Leishmania braziliensis	32%	100%
A4HLC5	Leishmania braziliensis	95%	100%
A4HN55	Leishmania braziliensis	29%	100%
A4HNE9	Leishmania braziliensis	23%	98%
A4HP20	Leishmania braziliensis	38%	100%
A4HP29	Leishmania braziliensis	22%	81%
A4HUT6	Leishmania infantum	35%	100%
A4HVX3	Leishmania infantum	39%	100%
A4HZI9	Leishmania infantum	100%	100%
A4I357	Leishmania infantum	31%	100%
A4IBS2	Leishmania infantum	28%	100%
A4IDD0	Leishmania infantum	36%	100%
A4IDD6	Leishmania infantum	22%	81%
A4WH05	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	30%	100%
A4WMZ0	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	32%	100%
A4YCU9	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	37%	100%
A4YIE0	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	28%	100%
A4YJ04	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	28%	100%
A5UJS2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	45%	98%
A5UM14	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	31%	100%
A6URN9	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	44%	94%
A6USJ3	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	29%	100%
A6UT20	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	28%	100%
A6VIP0	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	45%	94%
A6VK02	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	27%	100%
A7I841	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	29%	100%
A7I9C7	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	39%	100%
A8AA46	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	26%	100%
A8AB58	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	33%	100%
A8M8R5	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	31%	100%
A8MBW0	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	31%	100%
A9A2U7	Nitrosopumilus maritimus (strain SCM1)	29%	100%
A9A788	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	27%	100%
A9A846	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	45%	94%
B0R2T2	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	44%	96%
B0R4C8	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	25%	100%
B1L6S7	Korarchaeum cryptofilum (strain OPF8)	28%	100%
B1L6X8	Korarchaeum cryptofilum (strain OPF8)	22%	100%
B1YA36	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	31%	100%
B1YDJ0	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	32%	100%
B5IEE5	Aciduliprofundum boonei (strain DSM 19572 / T469)	25%	100%
B6YSH9	Thermococcus onnurineus (strain NA1)	44%	94%
B6YSW2	Thermococcus onnurineus (strain NA1)	34%	100%
B8D673	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	31%	100%
B8D683	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	30%	100%
B8GEZ3	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	39%	100%
B8GG66	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	30%	100%
B9LTS6	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	28%	100%
C3MQ16	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	29%	100%
C3MQ43	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	36%	100%
C3MRE5	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	29%	100%
C3MVD5	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	29%	100%
C3MVG1	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	36%	100%
C3MY41	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	29%	100%
C3MZI0	Sulfolobus islandicus (strain M.16.27)	29%	100%
C3N5N4	Sulfolobus islandicus (strain M.16.27)	29%	100%
C3N5R0	Sulfolobus islandicus (strain M.16.27)	36%	100%
C3N7K2	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	29%	100%
C3NE98	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	29%	100%
C3NEC6	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	36%	100%
C3NFX2	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	29%	100%
C3NHC6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	36%	100%
C3NHF1	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	29%	100%
C4KHB0	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	29%	100%
C4KHD9	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	36%	100%
C4KIR0	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	29%	100%
C5A2C2	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	43%	94%
C5A2D5	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	28%	100%
C5A7L1	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	32%	100%
C6A2V9	Thermococcus sibiricus (strain DSM 12597 / MM 739)	32%	100%
C6A3R1	Thermococcus sibiricus (strain DSM 12597 / MM 739)	29%	100%
C6A459	Thermococcus sibiricus (strain DSM 12597 / MM 739)	48%	94%
C7NQ99	Halorhabdus utahensis (strain DSM 12940 / JCM 11049 / AX-2)	27%	100%
C7NVQ4	Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541)	30%	100%
C7P6N4	Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86)	29%	100%
C9REN7	Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)	29%	100%
C9ZKV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZT49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	85%
C9ZYH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	98%
D0A0Z1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	99%
D0A0Z7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	92%
D0A305	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
D0A312	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	79%
D0A7M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	99%
D0KRX1	Saccharolobus solfataricus (strain 98/2)	29%	100%
D0KTH0	Saccharolobus solfataricus (strain 98/2)	29%	100%
D1Z199	Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / SANAE)	28%	100%
D2PDG6	Sulfolobus islandicus (strain L.D.8.5 / Lassen #2)	29%	100%
D2PK63	Sulfolobus islandicus (strain L.D.8.5 / Lassen #2)	29%	100%
D2RGT4	Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)	28%	100%
D2RQX3	Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / JCM 9101 / NCIMB 13204 / VKM B-1734 / 4k)	26%	100%
D2RUI0	Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / JCM 9101 / NCIMB 13204 / VKM B-1734 / 4k)	27%	100%
D3E0A3	Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1)	30%	100%
D3RX66	Ferroglobus placidus (strain DSM 10642 / AEDII12DO)	28%	100%
D3S8M7	Methanocaldococcus sp. (strain FS406-22)	28%	100%
D3SSQ6	Natrialba magadii (strain ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM 8861 / NBRC 102185 / NCIMB 2190 / MS3)	26%	100%
D4GYZ1	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	30%	100%
D5EAS6	Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)	33%	100%
E9ACZ6	Leishmania major	32%	100%
E9AFK8	Leishmania major	28%	100%
E9AFW0	Leishmania major	24%	98%
E9ANH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9APM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AST1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AST7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	81%
E9AVG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AVH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AYS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	98%
E9B6R2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B713	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	97%
F4JJE5	Arabidopsis thaliana	31%	100%
O13268	Gallus gallus	39%	98%
O14250	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	90%
O14818	Homo sapiens	39%	98%
O16811	Drosophila virilis	38%	99%
O16812	Drosophila virilis	40%	100%
O17586	Caenorhabditis elegans	27%	99%
O23708	Arabidopsis thaliana	39%	100%
O23710	Arabidopsis thaliana	27%	89%
O23712	Arabidopsis thaliana	37%	88%
O23714	Arabidopsis thaliana	25%	100%
O23715	Arabidopsis thaliana	33%	98%
O23717	Arabidopsis thaliana	27%	89%
O24030	Solanum lycopersicum	39%	94%
O24361	Spinacia oleracea	28%	90%
O24362	Spinacia oleracea	33%	98%
O24616	Arabidopsis thaliana	39%	98%
O24633	Arabidopsis thaliana	26%	100%
O24733	Thermococcus sp. (strain JCM 11816 / KS-1)	42%	94%
O26782	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	45%	98%
O27270	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	31%	100%
O29760	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	45%	99%
O35955	Mus musculus	30%	89%
O42265	Gallus gallus	34%	94%
O43063	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
O44156	Caenorhabditis elegans	32%	94%
O48551	Glycine max	34%	99%
O50110	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	100%
O55234	Mus musculus	26%	92%
O57983	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	27%	100%
O59219	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	46%	94%
O59770	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	96%
O70435	Mus musculus	34%	96%
O73672	Carassius auratus	38%	100%
O81146	Arabidopsis thaliana	34%	99%
O81147	Arabidopsis thaliana	34%	99%
O81148	Arabidopsis thaliana	39%	98%
O81149	Arabidopsis thaliana	60%	100%
O82530	Petunia hybrida	41%	98%
O94517	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O94579	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
O96788	Trypanosoma brucei rhodesiense	36%	92%
P0C8Y9	Oryza sativa subsp. indica	41%	98%
P0DKK3	Oryza sativa subsp. japonica	41%	98%
P0DKK4	Oryza sativa subsp. japonica	41%	98%
P12881	Drosophila melanogaster	32%	87%
P17220	Rattus norvegicus	36%	100%
P18053	Drosophila melanogaster	36%	92%
P18420	Rattus norvegicus	34%	93%
P18422	Rattus norvegicus	34%	96%
P21242	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	85%
P21243	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	97%
P21670	Rattus norvegicus	39%	93%
P22141	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P22769	Drosophila melanogaster	36%	98%
P23638	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	95%
P23639	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	98%
P24495	Xenopus laevis	37%	100%
P25043	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	93%
P25156	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	40%	100%
P25786	Homo sapiens	34%	93%
P25787	Homo sapiens	37%	100%
P25788	Homo sapiens	35%	96%
P25789	Homo sapiens	39%	93%
P28061	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	27%	100%
P28062	Homo sapiens	26%	88%
P28063	Mus musculus	25%	88%
P28064	Rattus norvegicus	26%	88%
P28066	Homo sapiens	58%	100%
P28074	Homo sapiens	24%	93%
P28075	Rattus norvegicus	26%	93%
P30186	Arabidopsis thaliana	39%	98%
P30655	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	90%
P30656	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	85%
P32379	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	94%
P34064	Rattus norvegicus	57%	100%
P34065	Gallus gallus	26%	95%
P34066	Arabidopsis thaliana	39%	88%
P34119	Dictyostelium discoideum	37%	98%
P34120	Dictyostelium discoideum	37%	98%
P40301	Drosophila melanogaster	35%	100%
P40302	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P40303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	96%
P40306	Homo sapiens	29%	89%
P48004	Rattus norvegicus	39%	96%
P49722	Mus musculus	36%	100%
P52427	Spinacia oleracea	42%	98%
P52428	Oryza sativa subsp. japonica	35%	90%
P57697	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	44%	96%
P60900	Homo sapiens	31%	99%
P60901	Rattus norvegicus	31%	99%
P70195	Mus musculus	24%	88%
P90513	Acanthamoeba castellanii	35%	97%
P92188	Trypanosoma cruzi	37%	92%
P93395	Nicotiana tabacum	26%	100%
Q09583	Caenorhabditis elegans	30%	98%
Q09682	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	98%
Q0J006	Oryza sativa subsp. japonica	39%	98%
Q0W2D6	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	27%	100%
Q10329	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	94%
Q10KF0	Oryza sativa subsp. japonica	40%	100%
Q12YV7	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	33%	100%
Q18GX3	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	29%	100%
Q18K08	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	41%	98%
Q24178	Drosophila melanogaster	36%	98%
Q27488	Caenorhabditis elegans	36%	100%
Q27562	Dictyostelium discoideum	33%	98%
Q27563	Dictyostelium discoideum	31%	98%
Q27575	Drosophila melanogaster	35%	97%
Q2FQL8	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	33%	100%
Q2NI68	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	29%	100%
Q2TBP0	Bos taurus	25%	88%
Q2YDE4	Bos taurus	31%	99%
Q32KL2	Bos taurus	25%	93%
Q3IPJ1	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	42%	96%
Q3IPX1	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	26%	100%
Q3T0T1	Bos taurus	30%	89%
Q3T0X5	Bos taurus	34%	93%
Q3T0Y5	Bos taurus	37%	100%
Q3T112	Bos taurus	25%	88%
Q3ZBG0	Bos taurus	39%	98%
Q3ZCK9	Bos taurus	39%	93%
Q42134	Arabidopsis thaliana	61%	100%
Q469M6	Methanosarcina barkeri (strain Fusaro / DSM 804)	42%	98%
Q46G14	Methanosarcina barkeri (strain Fusaro / DSM 804)	32%	100%
Q4JAA8	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	29%	100%
Q4JAY3	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	28%	100%
Q4JB24	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	34%	100%
Q4KM35	Rattus norvegicus	28%	89%
Q4Q1Q9	Leishmania major	21%	81%
Q4Q1R5	Leishmania major	38%	100%
Q4QC00	Leishmania major	99%	100%
Q4QC13	Leishmania major	42%	100%
Q4QFV4	Leishmania major	39%	100%
Q4QH56	Leishmania major	35%	100%
Q4R3H2	Macaca fascicularis	34%	93%
Q4R7D9	Macaca fascicularis	38%	98%
Q4R932	Macaca fascicularis	38%	93%
Q54DM7	Dictyostelium discoideum	37%	100%
Q54XM7	Dictyostelium discoideum	31%	98%
Q55G04	Dictyostelium discoideum	55%	100%
Q58634	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	29%	100%
Q58DU5	Bos taurus	34%	96%
Q59565	Methanosarcina thermophila	43%	99%
Q5E987	Bos taurus	58%	100%
Q5JDJ9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	33%	100%
Q5JHL8	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	31%	100%
Q5JIU9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	44%	94%
Q5R8S2	Pongo abelii	24%	93%
Q5RDH8	Pongo abelii	40%	98%
Q5REN2	Pongo abelii	34%	93%
Q5V1D4	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	46%	100%
Q5V1D5	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	27%	100%
Q5V2X8	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	45%	94%
Q5V4S6	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	26%	100%
Q5VRG3	Oryza sativa subsp. japonica	41%	98%
Q5W416	Canis lupus familiaris	26%	88%
Q60177	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	43%	93%
Q6L0W3	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	38%	100%
Q6L181	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	24%	100%
Q6LZD4	Methanococcus maripaludis (strain S2 / LL)	28%	100%
Q6M0L9	Methanococcus maripaludis (strain S2 / LL)	45%	94%
Q6YT00	Oryza sativa subsp. japonica	40%	98%
Q7DLS1	Arabidopsis thaliana	27%	89%
Q8L4A7	Arabidopsis thaliana	39%	100%
Q8LD27	Arabidopsis thaliana	25%	100%
Q8PTU1	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	42%	98%
Q8PZ04	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	30%	100%
Q8SQN7	Encephalitozoon cuniculi (strain GB-M1)	28%	100%
Q8SQP9	Encephalitozoon cuniculi (strain GB-M1)	26%	100%
Q8SRU3	Encephalitozoon cuniculi (strain GB-M1)	39%	100%
Q8SRU7	Encephalitozoon cuniculi (strain GB-M1)	33%	100%
Q8TAA3	Homo sapiens	38%	95%
Q8TJB5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	30%	100%
Q8TPX5	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	43%	99%
Q8TW10	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	30%	100%
Q8TYB7	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	49%	99%
Q8U0L6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	45%	94%
Q8U125	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	30%	100%
Q8U4C9	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	32%	100%
Q8UW64	Oryzias latipes	27%	100%
Q8X077	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	98%
Q8ZST5	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	34%	100%
Q8ZVM1	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	44%	100%
Q8ZYF2	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	31%	100%
Q94561	Entamoeba histolytica	55%	99%
Q95005	Caenorhabditis elegans	36%	96%
Q95008	Caenorhabditis elegans	52%	98%
Q95083	Drosophila melanogaster	55%	100%
Q975D1	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	28%	100%
Q975G5	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	35%	100%
Q975U8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	28%	100%
Q97AZ7	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	26%	100%
Q97BZ8	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	38%	100%
Q980L4	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	29%	100%
Q99436	Homo sapiens	25%	88%
Q9CWH6	Mus musculus	39%	98%
Q9DD33	Salmo salar	26%	100%
Q9GNZ8	Leishmania infantum	42%	100%
Q9GU37	Trypanosoma brucei brucei	24%	92%
Q9HR36	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	25%	100%
Q9JHW0	Rattus norvegicus	25%	88%
Q9LIP2	Arabidopsis thaliana	28%	89%
Q9LST6	Oryza sativa subsp. japonica	27%	100%
Q9LSU0	Oryza sativa subsp. japonica	29%	98%
Q9LSU1	Oryza sativa subsp. japonica	61%	100%
Q9LSU3	Oryza sativa subsp. japonica	32%	99%
Q9M4T8	Glycine max	60%	100%
Q9N599	Caenorhabditis elegans	39%	98%
Q9NDA2	Trypanosoma brucei brucei	34%	99%
Q9P992	Methanosarcina thermophila	30%	100%
Q9P996	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
Q9PT26	Oncorhynchus mykiss	24%	100%
Q9PTW9	Carassius auratus	40%	97%
Q9PVQ1	Xenopus laevis	40%	99%
Q9PVY6	Xenopus laevis	40%	98%
Q9QUM9	Mus musculus	31%	99%
Q9R1P0	Mus musculus	39%	93%
Q9R1P4	Mus musculus	34%	93%
Q9SXU1	Cicer arietinum	39%	98%
Q9U793	Trypanosoma brucei brucei	37%	100%
Q9UAB4	Leishmania donovani	24%	98%
Q9UT97	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	55%	99%
Q9UXC6	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	35%	100%
Q9UXF3	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	29%	100%
Q9V0N9	Pyrococcus abyssi (strain GE5 / Orsay)	31%	100%
Q9V122	Pyrococcus abyssi (strain GE5 / Orsay)	46%	94%
Q9V247	Pyrococcus abyssi (strain GE5 / Orsay)	28%	100%
Q9V2V5	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	43%	98%
Q9V2V6	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	42%	97%
Q9V5C6	Drosophila melanogaster	32%	96%
Q9VA12	Drosophila melanogaster	32%	97%
Q9XG77	Nicotiana tabacum	35%	99%
Q9XZG5	Trypanosoma brucei brucei	76%	99%
Q9XZJ4	Drosophila melanogaster	30%	100%
Q9YC01	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	39%	95%
Q9YER0	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	28%	100%
Q9YES4	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	30%	100%
Q9Z2U0	Mus musculus	39%	98%
Q9Z2U1	Mus musculus	58%	100%
V5AWB3	Trypanosoma cruzi	31%	100%
V5B1X4	Trypanosoma cruzi	78%	100%
V5B4E8	Trypanosoma cruzi	37%	92%
V5BCU3	Trypanosoma cruzi	29%	84%
V5BLX4	Trypanosoma cruzi	38%	100%
V5BU39	Trypanosoma cruzi	26%	78%
V5BW71	Trypanosoma cruzi	35%	78%