Zinc-finger_protein_conserved/GeneDB:LmjF.30.2360

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IC39_LEIDO

TriTrypDb:

LdBPK_302370.1 , LdCL_300029200 , LDHU3_30.3210

Length:

546

Annotations

Annotations by Jardim et al.

Metal Binding, Conserved zinc-finger

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8IC39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC39

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0008270	zinc ion binding	6	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0046914	transition metal ion binding	5	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	254	258	PF00656	0.446
CLV_C14_Caspase3-7	473	477	PF00656	0.659
CLV_NRD_NRD_1	246	248	PF00675	0.473
CLV_NRD_NRD_1	264	266	PF00675	0.432
CLV_NRD_NRD_1	33	35	PF00675	0.298
CLV_NRD_NRD_1	487	489	PF00675	0.590
CLV_PCSK_KEX2_1	119	121	PF00082	0.441
CLV_PCSK_KEX2_1	246	248	PF00082	0.550
CLV_PCSK_KEX2_1	264	266	PF00082	0.548
CLV_PCSK_KEX2_1	295	297	PF00082	0.600
CLV_PCSK_KEX2_1	33	35	PF00082	0.298
CLV_PCSK_KEX2_1	487	489	PF00082	0.590
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.441
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.600
CLV_PCSK_PC7_1	115	121	PF00082	0.452
CLV_PCSK_SKI1_1	247	251	PF00082	0.489
CLV_PCSK_SKI1_1	4	8	PF00082	0.424
CLV_PCSK_SKI1_1	418	422	PF00082	0.592
DEG_APCC_DBOX_1	245	253	PF00400	0.471
DEG_APCC_DBOX_1	264	272	PF00400	0.539
DEG_COP1_1	455	465	PF00400	0.495
DOC_ANK_TNKS_1	119	126	PF00023	0.425
DOC_CKS1_1	376	381	PF01111	0.581
DOC_CYCLIN_yClb1_LxF_4	379	384	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.283
DOC_CYCLIN_yCln2_LP_2	376	382	PF00134	0.509
DOC_MAPK_MEF2A_6	170	179	PF00069	0.423
DOC_PP1_RVXF_1	379	385	PF00149	0.451
DOC_PP1_RVXF_1	495	501	PF00149	0.425
DOC_PP4_FxxP_1	44	47	PF00568	0.261
DOC_USP7_MATH_1	538	542	PF00917	0.415
DOC_WW_Pin1_4	366	371	PF00397	0.691
DOC_WW_Pin1_4	375	380	PF00397	0.527
DOC_WW_Pin1_4	480	485	PF00397	0.480
LIG_14-3-3_CanoR_1	211	215	PF00244	0.483
LIG_14-3-3_CanoR_1	246	250	PF00244	0.492
LIG_14-3-3_CanoR_1	296	304	PF00244	0.568
LIG_14-3-3_CanoR_1	353	360	PF00244	0.682
LIG_14-3-3_CanoR_1	381	385	PF00244	0.406
LIG_14-3-3_CanoR_1	4	12	PF00244	0.332
LIG_14-3-3_CanoR_1	432	438	PF00244	0.464
LIG_Actin_WH2_2	387	404	PF00022	0.420
LIG_Actin_WH2_2	494	512	PF00022	0.438
LIG_APCC_ABBA_1	102	107	PF00400	0.356
LIG_APCC_ABBA_1	166	171	PF00400	0.423
LIG_BRCT_BRCA1_1	130	134	PF00533	0.511
LIG_BRCT_BRCA1_1	40	44	PF00533	0.395
LIG_BRCT_BRCA1_1	444	448	PF00533	0.494
LIG_FHA_1	174	180	PF00498	0.529
LIG_FHA_1	27	33	PF00498	0.355
LIG_FHA_1	381	387	PF00498	0.456
LIG_FHA_1	481	487	PF00498	0.463
LIG_FHA_1	5	11	PF00498	0.299
LIG_FHA_1	506	512	PF00498	0.340
LIG_FHA_2	287	293	PF00498	0.499
LIG_FHA_2	325	331	PF00498	0.586
LIG_FHA_2	421	427	PF00498	0.411
LIG_KLC1_Yacidic_2	70	74	PF13176	0.451
LIG_LIR_Apic_2	41	47	PF02991	0.264
LIG_LIR_Gen_1	217	227	PF02991	0.426
LIG_LIR_Gen_1	228	239	PF02991	0.412
LIG_LIR_Gen_1	419	429	PF02991	0.464
LIG_LIR_Gen_1	70	77	PF02991	0.604
LIG_LIR_Nem_3	217	223	PF02991	0.427
LIG_LIR_Nem_3	228	234	PF02991	0.410
LIG_LIR_Nem_3	314	319	PF02991	0.500
LIG_LIR_Nem_3	419	424	PF02991	0.473
LIG_LIR_Nem_3	445	451	PF02991	0.420
LIG_LIR_Nem_3	70	75	PF02991	0.553
LIG_PDZ_Class_2	541	546	PF00595	0.394
LIG_Rb_pABgroove_1	496	504	PF01858	0.367
LIG_SH2_CRK	502	506	PF00017	0.557
LIG_SH2_NCK_1	220	224	PF00017	0.426
LIG_SH2_PTP2	72	75	PF00017	0.409
LIG_SH2_SRC	64	67	PF00017	0.439
LIG_SH2_SRC	72	75	PF00017	0.484
LIG_SH2_STAP1	216	220	PF00017	0.562
LIG_SH2_STAT3	162	165	PF00017	0.334
LIG_SH2_STAT5	105	108	PF00017	0.382
LIG_SH2_STAT5	162	165	PF00017	0.352
LIG_SH2_STAT5	267	270	PF00017	0.543
LIG_SH2_STAT5	482	485	PF00017	0.544
LIG_SH2_STAT5	72	75	PF00017	0.493
LIG_SH3_3	532	538	PF00018	0.274
LIG_SUMO_SIM_anti_2	540	546	PF11976	0.366
LIG_SUMO_SIM_par_1	317	323	PF11976	0.610
MOD_CDK_SPxK_1	375	381	PF00069	0.542
MOD_CDK_SPxxK_3	480	487	PF00069	0.419
MOD_CK1_1	128	134	PF00069	0.602
MOD_CK1_1	26	32	PF00069	0.363
MOD_CK1_1	355	361	PF00069	0.727
MOD_CK1_1	456	462	PF00069	0.507
MOD_CK2_1	191	197	PF00069	0.523
MOD_CK2_1	270	276	PF00069	0.517
MOD_CK2_1	286	292	PF00069	0.431
MOD_CK2_1	317	323	PF00069	0.693
MOD_CK2_1	49	55	PF00069	0.501
MOD_GlcNHglycan	116	119	PF01048	0.475
MOD_GlcNHglycan	254	257	PF01048	0.439
MOD_GlcNHglycan	313	316	PF01048	0.443
MOD_GlcNHglycan	350	353	PF01048	0.636
MOD_GlcNHglycan	354	357	PF01048	0.599
MOD_GlcNHglycan	405	408	PF01048	0.467
MOD_GlcNHglycan	92	95	PF01048	0.551
MOD_GSK3_1	210	217	PF00069	0.592
MOD_GSK3_1	270	277	PF00069	0.496
MOD_GSK3_1	34	41	PF00069	0.392
MOD_GSK3_1	348	355	PF00069	0.606
MOD_GSK3_1	440	447	PF00069	0.478
MOD_GSK3_1	452	459	PF00069	0.538
MOD_N-GLC_1	274	279	PF02516	0.500
MOD_N-GLC_1	348	353	PF02516	0.705
MOD_N-GLC_1	358	363	PF02516	0.718
MOD_N-GLC_1	38	43	PF02516	0.448
MOD_N-GLC_1	513	518	PF02516	0.494
MOD_NEK2_1	127	132	PF00069	0.588
MOD_NEK2_1	150	155	PF00069	0.380
MOD_NEK2_1	173	178	PF00069	0.570
MOD_NEK2_1	260	265	PF00069	0.475
MOD_NEK2_1	324	329	PF00069	0.586
MOD_NEK2_1	348	353	PF00069	0.728
MOD_NEK2_1	380	385	PF00069	0.426
MOD_NEK2_1	420	425	PF00069	0.502
MOD_NEK2_1	48	53	PF00069	0.447
MOD_PIKK_1	150	156	PF00454	0.365
MOD_PIKK_1	295	301	PF00454	0.641
MOD_PIKK_1	408	414	PF00454	0.496
MOD_PIKK_1	453	459	PF00454	0.538
MOD_PK_1	270	276	PF00069	0.474
MOD_PK_1	440	446	PF00069	0.477
MOD_PKA_1	295	301	PF00069	0.460
MOD_PKA_2	114	120	PF00069	0.552
MOD_PKA_2	210	216	PF00069	0.485
MOD_PKA_2	245	251	PF00069	0.474
MOD_PKA_2	252	258	PF00069	0.392
MOD_PKA_2	295	301	PF00069	0.620
MOD_PKA_2	352	358	PF00069	0.759
MOD_PKA_2	380	386	PF00069	0.414
MOD_PKA_2	77	83	PF00069	0.574
MOD_Plk_1	274	280	PF00069	0.470
MOD_Plk_1	322	328	PF00069	0.608
MOD_Plk_1	358	364	PF00069	0.603
MOD_Plk_1	390	396	PF00069	0.437
MOD_Plk_2-3	191	197	PF00069	0.557
MOD_Plk_2-3	334	340	PF00069	0.651
MOD_Plk_4	191	197	PF00069	0.488
MOD_Plk_4	210	216	PF00069	0.603
MOD_Plk_4	274	280	PF00069	0.546
MOD_Plk_4	390	396	PF00069	0.515
MOD_Plk_4	420	426	PF00069	0.424
MOD_Plk_4	444	450	PF00069	0.400
MOD_Plk_4	540	546	PF00069	0.334
MOD_ProDKin_1	366	372	PF00069	0.690
MOD_ProDKin_1	375	381	PF00069	0.515
MOD_ProDKin_1	480	486	PF00069	0.477
TRG_ENDOCYTIC_2	220	223	PF00928	0.426
TRG_ENDOCYTIC_2	502	505	PF00928	0.550
TRG_ENDOCYTIC_2	72	75	PF00928	0.583
TRG_ER_diArg_1	245	247	PF00400	0.586
TRG_ER_diArg_1	32	34	PF00400	0.346
TRG_ER_diArg_1	399	402	PF00400	0.576
TRG_ER_diArg_1	486	488	PF00400	0.578
TRG_ER_diArg_1	497	500	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9X5	Leptomonas seymouri	68%	99%
A0A0S4IQV6	Bodo saltans	45%	98%
A0A0S4JR35	Bodo saltans	25%	91%
A0A1X0P2R0	Trypanosomatidae	51%	95%
A0A3R7M632	Trypanosoma rangeli	53%	97%
A4HIG8	Leishmania braziliensis	82%	100%
A4I5R4	Leishmania infantum	100%	100%
C9ZR32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	97%
E9B109	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q757	Leishmania major	95%	100%
V5DCZ6	Trypanosoma cruzi	52%	97%