Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IC37_LEIDO

TriTrypDb:

LdBPK_242280.1 , LdCL_240028400 , LDHU3_24.2800

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005635	nuclear envelope	4	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1

Expansion

Sequence features

A0A3Q8IC37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.696
CLV_NRD_NRD_1	177	179	PF00675	0.708
CLV_NRD_NRD_1	65	67	PF00675	0.533
CLV_PCSK_KEX2_1	123	125	PF00082	0.696
CLV_PCSK_KEX2_1	177	179	PF00082	0.708
CLV_PCSK_KEX2_1	192	194	PF00082	0.762
CLV_PCSK_KEX2_1	50	52	PF00082	0.571
CLV_PCSK_KEX2_1	65	67	PF00082	0.423
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.791
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.560
CLV_PCSK_PC7_1	46	52	PF00082	0.566
CLV_PCSK_SKI1_1	10	14	PF00082	0.625
CLV_PCSK_SKI1_1	115	119	PF00082	0.784
CLV_PCSK_SKI1_1	167	171	PF00082	0.726
DEG_SPOP_SBC_1	109	113	PF00917	0.591
DOC_CKS1_1	185	190	PF01111	0.573
DOC_MAPK_gen_1	175	185	PF00069	0.565
DOC_MAPK_gen_1	65	74	PF00069	0.549
DOC_PP1_RVXF_1	178	185	PF00149	0.495
DOC_PP2B_LxvP_1	170	173	PF13499	0.532
DOC_USP7_MATH_1	110	114	PF00917	0.513
DOC_USP7_MATH_1	159	163	PF00917	0.541
DOC_USP7_MATH_1	21	25	PF00917	0.721
DOC_USP7_MATH_1	214	218	PF00917	0.540
DOC_USP7_MATH_1	27	31	PF00917	0.705
DOC_USP7_MATH_1	49	53	PF00917	0.759
DOC_WW_Pin1_4	184	189	PF00397	0.574
DOC_WW_Pin1_4	222	227	PF00397	0.529
DOC_WW_Pin1_4	23	28	PF00397	0.748
DOC_WW_Pin1_4	88	93	PF00397	0.728
DOC_WW_Pin1_4	94	99	PF00397	0.520
LIG_14-3-3_CanoR_1	101	109	PF00244	0.500
LIG_14-3-3_CanoR_1	193	199	PF00244	0.532
LIG_14-3-3_CanoR_1	218	222	PF00244	0.553
LIG_BIR_II_1	1	5	PF00653	0.825
LIG_BRCT_BRCA1_1	140	144	PF00533	0.583
LIG_EH1_1	237	245	PF00400	0.598
LIG_FHA_1	218	224	PF00498	0.553
LIG_FHA_1	74	80	PF00498	0.451
LIG_FHA_2	184	190	PF00498	0.508
LIG_GBD_Chelix_1	194	202	PF00786	0.665
LIG_GBD_Chelix_1	82	90	PF00786	0.338
LIG_LIR_Apic_2	93	98	PF02991	0.498
LIG_NRBOX	85	91	PF00104	0.430
LIG_PDZ_Class_1	242	247	PF00595	0.601
LIG_SH2_CRK	95	99	PF00017	0.490
LIG_SH3_3	151	157	PF00018	0.469
LIG_SH3_3	182	188	PF00018	0.572
LIG_SUMO_SIM_par_1	219	225	PF11976	0.534
LIG_SUMO_SIM_par_1	85	91	PF11976	0.373
LIG_ULM_U2AF65_1	65	70	PF00076	0.736
MOD_CDK_SPK_2	23	28	PF00069	0.679
MOD_CDK_SPK_2	94	99	PF00069	0.438
MOD_CDK_SPxxK_3	222	229	PF00069	0.524
MOD_CDK_SPxxK_3	94	101	PF00069	0.504
MOD_CK1_1	122	128	PF00069	0.560
MOD_CK1_1	208	214	PF00069	0.523
MOD_CK1_1	217	223	PF00069	0.554
MOD_CK1_1	225	231	PF00069	0.454
MOD_CK2_1	183	189	PF00069	0.510
MOD_CK2_1	194	200	PF00069	0.493
MOD_CK2_1	94	100	PF00069	0.541
MOD_Cter_Amidation	175	178	PF01082	0.675
MOD_GlcNHglycan	127	130	PF01048	0.802
MOD_GlcNHglycan	148	151	PF01048	0.746
MOD_GlcNHglycan	207	210	PF01048	0.799
MOD_GlcNHglycan	43	46	PF01048	0.595
MOD_GlcNHglycan	6	9	PF01048	0.564
MOD_GlcNHglycan	92	95	PF01048	0.768
MOD_GSK3_1	10	17	PF00069	0.720
MOD_GSK3_1	148	155	PF00069	0.523
MOD_GSK3_1	2	9	PF00069	0.777
MOD_GSK3_1	23	30	PF00069	0.765
MOD_GSK3_1	90	97	PF00069	0.543
MOD_NEK2_1	232	237	PF00069	0.524
MOD_PIKK_1	143	149	PF00454	0.580
MOD_PIKK_1	21	27	PF00454	0.749
MOD_PKA_2	122	128	PF00069	0.572
MOD_PKA_2	176	182	PF00069	0.542
MOD_PKA_2	217	223	PF00069	0.509
MOD_PKA_2	27	33	PF00069	0.728
MOD_Plk_4	208	214	PF00069	0.515
MOD_Plk_4	217	223	PF00069	0.542
MOD_ProDKin_1	184	190	PF00069	0.572
MOD_ProDKin_1	222	228	PF00069	0.523
MOD_ProDKin_1	23	29	PF00069	0.749
MOD_ProDKin_1	88	94	PF00069	0.732
MOD_SUMO_rev_2	42	52	PF00179	0.724
TRG_ER_diArg_1	177	180	PF00400	0.511
TRG_ER_diArg_1	64	66	PF00400	0.746
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A422MRD3	Trypanosoma rangeli	36%	100%
A4HDT0	Leishmania braziliensis	74%	100%
A4I128	Leishmania infantum	99%	100%
E9AX65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAB1	Leishmania major	86%	100%