DEK_C domain-containing protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IC32_LEIDO

TriTrypDb:

LdBPK_141320.1 , LdCL_140019100 , LDHU3_14.1660

Length:

302

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IC32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC32

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	5
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	5

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	5
GO:0003677	DNA binding	4	5
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	5
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0097159	organic cyclic compound binding	2	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.508
CLV_NRD_NRD_1	197	199	PF00675	0.459
CLV_NRD_NRD_1	60	62	PF00675	0.362
CLV_PCSK_KEX2_1	144	146	PF00082	0.565
CLV_PCSK_KEX2_1	197	199	PF00082	0.345
CLV_PCSK_KEX2_1	59	61	PF00082	0.352
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.565
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.534
CLV_PCSK_SKI1_1	197	201	PF00082	0.337
CLV_PCSK_SKI1_1	207	211	PF00082	0.360
CLV_PCSK_SKI1_1	246	250	PF00082	0.412
CLV_PCSK_SKI1_1	61	65	PF00082	0.462
CLV_PCSK_SKI1_1	81	85	PF00082	0.513
DEG_SPOP_SBC_1	266	270	PF00917	0.458
DOC_MAPK_MEF2A_6	95	103	PF00069	0.472
DOC_PP2B_LxvP_1	118	121	PF13499	0.456
DOC_SPAK_OSR1_1	126	130	PF12202	0.407
DOC_USP7_MATH_1	134	138	PF00917	0.699
DOC_USP7_MATH_1	166	170	PF00917	0.649
DOC_USP7_MATH_1	174	178	PF00917	0.535
DOC_USP7_MATH_1	184	188	PF00917	0.378
DOC_USP7_MATH_1	281	285	PF00917	0.659
DOC_USP7_MATH_1	63	67	PF00917	0.435
DOC_WW_Pin1_4	128	133	PF00397	0.521
DOC_WW_Pin1_4	138	143	PF00397	0.568
DOC_WW_Pin1_4	200	205	PF00397	0.423
DOC_WW_Pin1_4	268	273	PF00397	0.550
DOC_WW_Pin1_4	296	301	PF00397	0.539
LIG_14-3-3_CanoR_1	126	132	PF00244	0.527
LIG_14-3-3_CanoR_1	216	220	PF00244	0.395
LIG_Actin_WH2_2	75	93	PF00022	0.552
LIG_BIR_II_1	1	5	PF00653	0.630
LIG_FHA_1	113	119	PF00498	0.375
LIG_FHA_2	201	207	PF00498	0.413
LIG_FHA_2	215	221	PF00498	0.314
LIG_FHA_2	271	277	PF00498	0.630
LIG_LIR_Nem_3	194	199	PF02991	0.379
LIG_LIR_Nem_3	66	70	PF02991	0.349
LIG_SH2_CRK	196	200	PF00017	0.350
LIG_SH3_1	145	151	PF00018	0.547
LIG_SH3_1	159	165	PF00018	0.539
LIG_SH3_3	126	132	PF00018	0.556
LIG_SH3_3	140	146	PF00018	0.715
LIG_SH3_3	159	165	PF00018	0.632
LIG_SH3_3	280	286	PF00018	0.551
LIG_SH3_3	294	300	PF00018	0.488
LIG_TRAF2_1	2	5	PF00917	0.545
LIG_TRAF2_1	218	221	PF00917	0.437
LIG_WRC_WIRS_1	64	69	PF05994	0.428
MOD_CDC14_SPxK_1	141	144	PF00782	0.655
MOD_CDK_SPxK_1	138	144	PF00069	0.625
MOD_CDK_SPxxK_3	138	145	PF00069	0.586
MOD_CDK_SPxxK_3	200	207	PF00069	0.408
MOD_CK1_1	177	183	PF00069	0.524
MOD_CK1_1	268	274	PF00069	0.609
MOD_CK2_1	103	109	PF00069	0.481
MOD_CK2_1	157	163	PF00069	0.567
MOD_CK2_1	214	220	PF00069	0.401
MOD_CK2_1	270	276	PF00069	0.639
MOD_CK2_1	281	287	PF00069	0.525
MOD_Cter_Amidation	57	60	PF01082	0.496
MOD_GlcNHglycan	168	171	PF01048	0.596
MOD_GlcNHglycan	177	180	PF01048	0.488
MOD_GlcNHglycan	182	185	PF01048	0.404
MOD_GlcNHglycan	273	276	PF01048	0.653
MOD_GlcNHglycan	283	286	PF01048	0.607
MOD_GSK3_1	134	141	PF00069	0.510
MOD_GSK3_1	180	187	PF00069	0.622
MOD_GSK3_1	235	242	PF00069	0.361
MOD_GSK3_1	24	31	PF00069	0.540
MOD_GSK3_1	261	268	PF00069	0.485
MOD_GSK3_1	271	278	PF00069	0.561
MOD_NEK2_1	127	132	PF00069	0.544
MOD_NEK2_1	267	272	PF00069	0.536
MOD_NEK2_1	289	294	PF00069	0.568
MOD_NEK2_2	63	68	PF00069	0.331
MOD_PKA_2	215	221	PF00069	0.379
MOD_ProDKin_1	128	134	PF00069	0.521
MOD_ProDKin_1	138	144	PF00069	0.570
MOD_ProDKin_1	200	206	PF00069	0.425
MOD_ProDKin_1	268	274	PF00069	0.553
MOD_ProDKin_1	296	302	PF00069	0.541
MOD_SUMO_rev_2	152	160	PF00179	0.544
TRG_DiLeu_BaEn_4	220	226	PF01217	0.477
TRG_ENDOCYTIC_2	196	199	PF00928	0.347
TRG_ER_diArg_1	196	198	PF00400	0.478
TRG_NLS_Bipartite_1	144	162	PF00514	0.657
TRG_NLS_MonoExtC_3	157	162	PF00514	0.557
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C3	Leptomonas seymouri	60%	88%
A0A1X0NNS7	Trypanosomatidae	33%	73%
A0A422MT09	Trypanosoma rangeli	40%	81%
A4H7U4	Leishmania braziliensis	77%	95%
A4HW70	Leishmania infantum	100%	100%
C9ZSU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	99%
E9APX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QFL0	Leishmania major	95%	100%
V5AW13	Trypanosoma cruzi	41%	83%