Leucine Rich repeats (2 copies) family protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein light chain, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC25_LEIDO

TriTrypDb:

LdBPK_241050.1 , LdCL_240015500 , LDHU3_24.1230

Length:

210

Annotations

Annotations by Jardim et al.

Structural Proteins, dynein light chain

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3Q8IC25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.487
CLV_NRD_NRD_1	100	102	PF00675	0.293
CLV_NRD_NRD_1	21	23	PF00675	0.556
CLV_PCSK_KEX2_1	20	22	PF00082	0.564
CLV_PCSK_KEX2_1	208	210	PF00082	0.670
CLV_PCSK_SKI1_1	44	48	PF00082	0.625
CLV_PCSK_SKI1_1	85	89	PF00082	0.293
DEG_APCC_DBOX_1	19	27	PF00400	0.702
DOC_CDC14_PxL_1	184	192	PF14671	0.493
DOC_MAPK_gen_1	101	108	PF00069	0.493
DOC_MAPK_gen_1	189	198	PF00069	0.493
DOC_MAPK_gen_1	85	95	PF00069	0.493
DOC_MAPK_MEF2A_6	65	72	PF00069	0.618
DOC_PP2B_LxvP_1	106	109	PF13499	0.493
DOC_PP4_MxPP_1	50	53	PF00568	0.585
DOC_USP7_MATH_1	168	172	PF00917	0.565
LIG_BIR_II_1	1	5	PF00653	0.575
LIG_eIF4E_1	137	143	PF01652	0.507
LIG_FHA_1	72	78	PF00498	0.514
LIG_FHA_2	123	129	PF00498	0.507
LIG_FHA_2	145	151	PF00498	0.493
LIG_FHA_2	189	195	PF00498	0.487
LIG_FHA_2	53	59	PF00498	0.725
LIG_FHA_2	61	67	PF00498	0.668
LIG_LIR_Gen_1	117	124	PF02991	0.493
LIG_LIR_Gen_1	145	153	PF02991	0.528
LIG_LIR_Gen_1	178	188	PF02991	0.507
LIG_LIR_Nem_3	112	118	PF02991	0.493
LIG_LIR_Nem_3	145	149	PF02991	0.528
LIG_LIR_Nem_3	178	184	PF02991	0.507
LIG_LRP6_Inhibitor_1	95	101	PF00058	0.293
LIG_MAD2	44	52	PF02301	0.607
LIG_MYND_3	108	112	PF01753	0.549
LIG_NRP_CendR_1	208	210	PF00754	0.670
LIG_SH2_CRK	181	185	PF00017	0.507
LIG_SH2_NCK_1	118	122	PF00017	0.493
LIG_SH3_3	194	200	PF00018	0.507
LIG_SUMO_SIM_anti_2	158	164	PF11976	0.507
LIG_TRAF2_1	175	178	PF00917	0.524
LIG_TRAF2_1	29	32	PF00917	0.655
LIG_TRAF2_1	39	42	PF00917	0.572
LIG_UBA3_1	183	189	PF00899	0.507
LIG_UBA3_1	47	56	PF00899	0.573
MOD_CK1_1	171	177	PF00069	0.589
MOD_CK1_1	2	8	PF00069	0.690
MOD_CK2_1	142	148	PF00069	0.495
MOD_CK2_1	172	178	PF00069	0.507
MOD_CK2_1	3	9	PF00069	0.550
MOD_CK2_1	60	66	PF00069	0.690
MOD_GlcNHglycan	171	174	PF01048	0.388
MOD_GSK3_1	168	175	PF00069	0.565
MOD_N-GLC_2	154	156	PF02516	0.293
MOD_NEK2_1	1	6	PF00069	0.624
MOD_NEK2_1	114	119	PF00069	0.499
MOD_NEK2_1	136	141	PF00069	0.502
MOD_NEK2_1	142	147	PF00069	0.493
MOD_NEK2_1	169	174	PF00069	0.574
MOD_NEK2_1	30	35	PF00069	0.625
MOD_NEK2_1	70	75	PF00069	0.493
MOD_Plk_1	59	65	PF00069	0.642
MOD_Plk_2-3	60	66	PF00069	0.690
MOD_SUMO_for_1	109	112	PF00179	0.508
TRG_DiLeu_BaEn_1	42	47	PF01217	0.592
TRG_ENDOCYTIC_2	118	121	PF00928	0.493
TRG_ENDOCYTIC_2	179	182	PF00928	0.493
TRG_ER_diArg_1	19	22	PF00400	0.580
TRG_ER_diArg_1	208	210	PF00400	0.670
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.293

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A096MJZ0	Rattus norvegicus	43%	100%
A0A0N1PBU3	Leptomonas seymouri	89%	100%
A0A0S4JQV7	Bodo saltans	70%	99%
A0A1X0NVY4	Trypanosomatidae	79%	100%
A0A3R7LR73	Trypanosoma rangeli	78%	100%
A4HDF9	Leishmania braziliensis	93%	100%
A4I0U0	Leishmania infantum	100%	100%
D0A771	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
D0A8W7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	73%
E9ATS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	67%
E9AWU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q05A62	Mus musculus	43%	100%
Q28G94	Xenopus tropicalis	43%	100%
Q2KID4	Bos taurus	44%	100%
Q4LDG9	Homo sapiens	43%	100%
Q4QAN0	Leishmania major	99%	100%
Q641R9	Xenopus laevis	43%	100%
Q6DHB1	Danio rerio	45%	100%
Q8T888	Ciona intestinalis	43%	100%
Q9XHH2	Chlamydomonas reinhardtii	48%	100%