LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Isocitrate dehydrogenase [NADP]

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Isocitrate dehydrogenase [NADP]
Gene product:
isocitrate dehydrogenase [NADP], mitochondrial precursor, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IC24_LEIDO
TriTrypDb:
LdBPK_100310.1 , LdCL_100008400 , LDHU3_10.0440
Length:
435

Annotations

Annotations by Jardim et al.

Tricarboxylic acid cycle, Isocitrate dehydrogenase [NADP]

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IC24
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC24

Function

Biological processes
Term Name Level Count
GO:0006066 alcohol metabolic process 3 12
GO:0006082 organic acid metabolic process 3 12
GO:0006099 tricarboxylic acid cycle 3 12
GO:0006102 isocitrate metabolic process 5 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0019752 carboxylic acid metabolic process 5 12
GO:0043436 oxoacid metabolic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044281 small molecule metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:0072350 tricarboxylic acid metabolic process 6 12
GO:1901615 organic hydroxy compound metabolic process 3 12
GO:1902652 secondary alcohol metabolic process 4 12
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006739 NADP metabolic process 7 1
GO:0006753 nucleoside phosphate metabolic process 4 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0009117 nucleotide metabolic process 5 1
GO:0019362 pyridine nucleotide metabolic process 5 1
GO:0019637 organophosphate metabolic process 3 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0046483 heterocycle metabolic process 3 1
GO:0046496 nicotinamide nucleotide metabolic process 6 1
GO:0055086 nucleobase-containing small molecule metabolic process 3 1
GO:0072524 pyridine-containing compound metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0000287 magnesium ion binding 5 12
GO:0003824 catalytic activity 1 12
GO:0004448 isocitrate dehydrogenase [NAD(P)+] activity 5 12
GO:0004450 isocitrate dehydrogenase (NADP+) activity 6 12
GO:0005488 binding 1 12
GO:0016491 oxidoreductase activity 2 12
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 12
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0051287 NAD binding 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 423 427 PF00656 0.498
CLV_C14_Caspase3-7 73 77 PF00656 0.446
CLV_NRD_NRD_1 226 228 PF00675 0.246
CLV_NRD_NRD_1 3 5 PF00675 0.492
CLV_PCSK_KEX2_1 28 30 PF00082 0.435
CLV_PCSK_KEX2_1 3 5 PF00082 0.492
CLV_PCSK_KEX2_1 411 413 PF00082 0.302
CLV_PCSK_PC1ET2_1 28 30 PF00082 0.452
CLV_PCSK_PC1ET2_1 411 413 PF00082 0.302
CLV_PCSK_SKI1_1 126 130 PF00082 0.246
CLV_PCSK_SKI1_1 158 162 PF00082 0.246
CLV_PCSK_SKI1_1 28 32 PF00082 0.494
CLV_PCSK_SKI1_1 55 59 PF00082 0.235
CLV_PCSK_SKI1_1 75 79 PF00082 0.141
CLV_PCSK_SKI1_1 98 102 PF00082 0.235
DEG_Nend_Nbox_1 1 3 PF02207 0.526
DOC_CKS1_1 180 185 PF01111 0.435
DOC_MAPK_DCC_7 53 63 PF00069 0.435
DOC_MAPK_gen_1 227 233 PF00069 0.435
DOC_MAPK_gen_1 241 248 PF00069 0.435
DOC_MAPK_gen_1 91 97 PF00069 0.524
DOC_MAPK_JIP1_4 173 179 PF00069 0.492
DOC_MAPK_MEF2A_6 198 206 PF00069 0.443
DOC_MAPK_MEF2A_6 55 63 PF00069 0.435
DOC_PP1_RVXF_1 44 50 PF00149 0.435
DOC_PP2B_LxvP_1 56 59 PF13499 0.435
DOC_PP4_FxxP_1 134 137 PF00568 0.435
DOC_USP7_MATH_1 15 19 PF00917 0.685
DOC_USP7_MATH_1 184 188 PF00917 0.498
DOC_USP7_MATH_1 8 12 PF00917 0.569
DOC_USP7_UBL2_3 115 119 PF12436 0.445
DOC_WW_Pin1_4 100 105 PF00397 0.461
DOC_WW_Pin1_4 117 122 PF00397 0.435
DOC_WW_Pin1_4 179 184 PF00397 0.435
LIG_14-3-3_CanoR_1 17 26 PF00244 0.516
LIG_14-3-3_CanoR_1 46 52 PF00244 0.502
LIG_APCC_ABBA_1 57 62 PF00400 0.446
LIG_FHA_1 166 172 PF00498 0.446
LIG_FHA_1 189 195 PF00498 0.492
LIG_FHA_1 314 320 PF00498 0.458
LIG_FHA_1 349 355 PF00498 0.438
LIG_FHA_1 359 365 PF00498 0.435
LIG_FHA_1 395 401 PF00498 0.443
LIG_FHA_1 43 49 PF00498 0.441
LIG_FHA_2 101 107 PF00498 0.435
LIG_FHA_2 180 186 PF00498 0.474
LIG_FHA_2 188 194 PF00498 0.442
LIG_FHA_2 71 77 PF00498 0.446
LIG_LIR_Apic_2 132 137 PF02991 0.435
LIG_LIR_Gen_1 250 259 PF02991 0.437
LIG_LYPXL_yS_3 229 232 PF13949 0.460
LIG_MAD2 145 153 PF02301 0.435
LIG_Pex14_2 247 251 PF04695 0.435
LIG_SH2_PTP2 60 63 PF00017 0.460
LIG_SH2_SRC 60 63 PF00017 0.460
LIG_SH2_STAP1 255 259 PF00017 0.435
LIG_SH2_STAT3 255 258 PF00017 0.460
LIG_SH2_STAT5 25 28 PF00017 0.450
LIG_SH2_STAT5 60 63 PF00017 0.450
LIG_SH2_STAT5 67 70 PF00017 0.440
LIG_SH3_3 168 174 PF00018 0.450
LIG_SH3_3 177 183 PF00018 0.420
LIG_SH3_3 58 64 PF00018 0.435
LIG_SUMO_SIM_par_1 136 141 PF11976 0.537
LIG_SUMO_SIM_par_1 190 196 PF11976 0.478
LIG_SUMO_SIM_par_1 229 235 PF11976 0.435
LIG_TYR_ITIM 58 63 PF00017 0.442
LIG_TYR_ITIM 65 70 PF00017 0.425
LIG_WRC_WIRS_1 248 253 PF05994 0.435
LIG_WRC_WIRS_1 48 53 PF05994 0.457
MOD_CK1_1 18 24 PF00069 0.515
MOD_CK1_1 187 193 PF00069 0.537
MOD_CK1_1 350 356 PF00069 0.435
MOD_CK1_1 6 12 PF00069 0.648
MOD_CK2_1 100 106 PF00069 0.435
MOD_GlcNHglycan 185 189 PF01048 0.337
MOD_GlcNHglycan 407 410 PF01048 0.337
MOD_GlcNHglycan 5 8 PF01048 0.567
MOD_GSK3_1 117 124 PF00069 0.435
MOD_GSK3_1 15 22 PF00069 0.598
MOD_GSK3_1 184 191 PF00069 0.492
MOD_GSK3_1 231 238 PF00069 0.435
MOD_GSK3_1 346 353 PF00069 0.441
MOD_N-GLC_1 121 126 PF02516 0.235
MOD_NEK2_1 129 134 PF00069 0.446
MOD_NEK2_1 19 24 PF00069 0.484
MOD_NEK2_1 216 221 PF00069 0.443
MOD_NEK2_1 231 236 PF00069 0.413
MOD_NEK2_1 247 252 PF00069 0.435
MOD_NEK2_1 314 319 PF00069 0.435
MOD_NEK2_1 68 73 PF00069 0.439
MOD_NEK2_2 121 126 PF00069 0.435
MOD_PKA_1 3 9 PF00069 0.540
MOD_PKA_2 3 9 PF00069 0.540
MOD_Plk_1 42 48 PF00069 0.435
MOD_Plk_1 68 74 PF00069 0.446
MOD_Plk_2-3 323 329 PF00069 0.446
MOD_Plk_2-3 80 86 PF00069 0.531
MOD_Plk_4 129 135 PF00069 0.447
MOD_Plk_4 235 241 PF00069 0.435
MOD_Plk_4 314 320 PF00069 0.460
MOD_Plk_4 353 359 PF00069 0.435
MOD_Plk_4 9 15 PF00069 0.652
MOD_ProDKin_1 100 106 PF00069 0.461
MOD_ProDKin_1 117 123 PF00069 0.435
MOD_ProDKin_1 179 185 PF00069 0.435
MOD_SUMO_for_1 197 200 PF00179 0.452
MOD_SUMO_for_1 283 286 PF00179 0.537
MOD_SUMO_for_1 32 35 PF00179 0.537
MOD_SUMO_for_1 410 413 PF00179 0.537
MOD_SUMO_rev_2 317 327 PF00179 0.446
TRG_DiLeu_BaLyEn_6 270 275 PF01217 0.435
TRG_ENDOCYTIC_2 223 226 PF00928 0.451
TRG_ENDOCYTIC_2 229 232 PF00928 0.427
TRG_ENDOCYTIC_2 243 246 PF00928 0.341
TRG_ENDOCYTIC_2 60 63 PF00928 0.442
TRG_ENDOCYTIC_2 67 70 PF00928 0.425
TRG_ER_diArg_1 2 4 PF00400 0.494
TRG_Pf-PMV_PEXEL_1 273 277 PF00026 0.235

Homologs

Protein Taxonomy Sequence identity Coverage
A0A096P8D3 Ostreococcus tauri 32% 93%
A0A0N1I742 Leptomonas seymouri 88% 100%
A0A0S4IN25 Bodo saltans 65% 100%
A0A0S4JT83 Bodo saltans 73% 100%
A0A1X0NQ73 Trypanosomatidae 73% 96%
A0A1X0P451 Trypanosomatidae 66% 100%
A0A3R7NV25 Trypanosoma rangeli 75% 100%
A0A422NTJ0 Trypanosoma rangeli 65% 100%
A4H612 Leishmania braziliensis 92% 100%
A4HUD9 Leishmania infantum 100% 100%
C9ZVF6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 75% 100%
D0A5M9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
E9AN39 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O13285 Candida tropicalis 64% 100%
O13294 Candida tropicalis 64% 100%
O14254 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 62% 99%
O75874 Homo sapiens 65% 100%
O88844 Mus musculus 64% 100%
P21954 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 64% 100%
P33198 Sus scrofa 67% 100%
P41562 Rattus norvegicus 65% 100%
P41939 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 64% 100%
P48735 Homo sapiens 67% 96%
P50215 Sphingobium yanoikuyae 62% 100%
P50217 Solanum tuberosum 65% 100%
P50218 Nicotiana tabacum 65% 100%
P53982 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 61% 100%
P54071 Mus musculus 68% 96%
P56574 Rattus norvegicus 68% 96%
P65098 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 62% 100%
P79089 Aspergillus niger 61% 87%
P9WKL0 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 62% 100%
P9WKL1 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 62% 100%
Q04467 Bos taurus 65% 96%
Q06197 Glycine max 65% 100%
Q40345 Medicago sativa 67% 100%
Q4QHI7 Leishmania major 99% 100%
Q4R502 Macaca fascicularis 66% 96%
Q5R9C5 Pongo abelii 65% 100%
Q6XUZ5 Ovis aries 65% 100%
Q75JR2 Dictyostelium discoideum 62% 100%
Q75JR3 Dictyostelium discoideum 60% 100%
Q8LPJ5 Arabidopsis thaliana 66% 90%
Q9SLK0 Arabidopsis thaliana 64% 100%
Q9SRZ6 Arabidopsis thaliana 64% 100%
Q9XSG3 Bos taurus 64% 100%
Q9Z2K8 Microtus ochrogaster 65% 100%
Q9Z2K9 Microtus mexicanus 65% 100%
V5B9G3 Trypanosoma cruzi 74% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS