Ubiquinone biosynthesis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COQ9, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC23_LEIDO

TriTrypDb:

LdBPK_141120.1 , LdCL_140016900

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

A0A3Q8IC23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC23

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	11
GO:0006744	ubiquinone biosynthetic process	6	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0042180	cellular ketone metabolic process	3	11
GO:0042181	ketone biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901661	quinone metabolic process	4	11
GO:1901663	quinone biosynthetic process	5	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.474
CLV_NRD_NRD_1	176	178	PF00675	0.494
CLV_PCSK_KEX2_1	176	178	PF00082	0.494
CLV_PCSK_KEX2_1	232	234	PF00082	0.315
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.349
CLV_PCSK_SKI1_1	103	107	PF00082	0.536
CLV_PCSK_SKI1_1	115	119	PF00082	0.373
CLV_PCSK_SKI1_1	164	168	PF00082	0.463
CLV_PCSK_SKI1_1	176	180	PF00082	0.460
CLV_PCSK_SKI1_1	206	210	PF00082	0.437
CLV_PCSK_SKI1_1	259	263	PF00082	0.333
DEG_Nend_UBRbox_4	1	3	PF02207	0.576
DEG_SCF_FBW7_2	123	129	PF00400	0.270
DEG_SPOP_SBC_1	242	246	PF00917	0.384
DOC_CKS1_1	123	128	PF01111	0.262
DOC_CYCLIN_RxL_1	100	109	PF00134	0.518
DOC_CYCLIN_RxL_1	110	122	PF00134	0.378
DOC_MAPK_gen_1	232	238	PF00069	0.317
DOC_PP2B_LxvP_1	104	107	PF13499	0.499
DOC_USP7_MATH_1	183	187	PF00917	0.545
DOC_USP7_UBL2_3	206	210	PF12436	0.535
DOC_USP7_UBL2_3	22	26	PF12436	0.315
DOC_WW_Pin1_4	122	127	PF00397	0.269
DOC_WW_Pin1_4	3	8	PF00397	0.533
LIG_14-3-3_CanoR_1	164	169	PF00244	0.456
LIG_BRCT_BRCA1_1	51	55	PF00533	0.422
LIG_FHA_1	242	248	PF00498	0.423
LIG_FHA_1	256	262	PF00498	0.265
LIG_FHA_2	165	171	PF00498	0.453
LIG_LIR_Apic_2	216	222	PF02991	0.331
LIG_NRBOX	167	173	PF00104	0.469
LIG_PAM2_1	130	142	PF00658	0.449
LIG_PDZ_Class_1	265	270	PF00595	0.365
LIG_Pex14_2	204	208	PF04695	0.346
LIG_Pex14_2	55	59	PF04695	0.340
LIG_PTB_Apo_2	53	60	PF02174	0.476
LIG_SH2_CRK	146	150	PF00017	0.349
LIG_SH2_CRK	219	223	PF00017	0.331
LIG_SH2_CRK	240	244	PF00017	0.338
LIG_SH2_NCK_1	146	150	PF00017	0.349
LIG_SH2_SRC	139	142	PF00017	0.551
LIG_SH2_STAT5	139	142	PF00017	0.477
LIG_SH2_STAT5	230	233	PF00017	0.354
LIG_SUMO_SIM_anti_2	119	125	PF11976	0.428
LIG_SUMO_SIM_par_1	59	65	PF11976	0.310
LIG_TYR_ITIM	144	149	PF00017	0.363
LIG_TYR_ITIM	238	243	PF00017	0.331
LIG_Vh1_VBS_1	144	162	PF01044	0.430
LIG_WRC_WIRS_1	205	210	PF05994	0.461
MOD_CK1_1	213	219	PF00069	0.436
MOD_CK1_1	37	43	PF00069	0.502
MOD_CK1_1	91	97	PF00069	0.406
MOD_CK2_1	116	122	PF00069	0.390
MOD_CK2_1	164	170	PF00069	0.474
MOD_GlcNHglycan	132	135	PF01048	0.455
MOD_GlcNHglycan	189	192	PF01048	0.593
MOD_GlcNHglycan	201	204	PF01048	0.448
MOD_GlcNHglycan	215	218	PF01048	0.342
MOD_GlcNHglycan	80	83	PF01048	0.446
MOD_GSK3_1	183	190	PF00069	0.590
MOD_GSK3_1	255	262	PF00069	0.397
MOD_NEK2_1	154	159	PF00069	0.314
MOD_NEK2_1	204	209	PF00069	0.331
MOD_NEK2_1	34	39	PF00069	0.389
MOD_PIKK_1	249	255	PF00454	0.296
MOD_PIKK_1	49	55	PF00454	0.373
MOD_Plk_1	155	161	PF00069	0.325
MOD_Plk_1	47	53	PF00069	0.451
MOD_Plk_4	155	161	PF00069	0.417
MOD_Plk_4	204	210	PF00069	0.483
MOD_Plk_4	243	249	PF00069	0.295
MOD_ProDKin_1	122	128	PF00069	0.268
MOD_ProDKin_1	3	9	PF00069	0.524
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.443
TRG_ENDOCYTIC_2	146	149	PF00928	0.472
TRG_ENDOCYTIC_2	240	243	PF00928	0.338
TRG_ER_diArg_1	176	178	PF00400	0.494
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P430	Leptomonas seymouri	62%	100%
A0A1X0NP57	Trypanosomatidae	38%	97%
A0A422MQP2	Trypanosoma rangeli	38%	96%
A4H7Q9	Leishmania braziliensis	77%	100%
A4HW47	Leishmania infantum	99%	100%
C9ZSX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	88%
E9APV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QFN0	Leishmania major	92%	100%
Q8MKN0	Drosophila melanogaster	28%	83%
V5BEC0	Trypanosoma cruzi	38%	96%