LeishMANIAdb
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Choline dehydrogenase, like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline dehydrogenase, like protein
Gene product:
choline dehydrogenase, like protein
Species:
Leishmania donovani
UniProt:
A0A3Q8IC21_LEIDO
TriTrypDb:
LdBPK_211860.1 , LdCL_210024300 , LDHU3_21.2230
Length:
535

Annotations

Annotations by Jardim et al.

Amino acid metabolism, Choline dehydrogenase, like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 4
GO:0016020 membrane 2 3

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IC21
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC21

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0016491 oxidoreductase activity 2 12
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0050660 flavin adenine dinucleotide binding 4 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0008812 choline dehydrogenase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 190 192 PF00675 0.365
CLV_NRD_NRD_1 2 4 PF00675 0.659
CLV_NRD_NRD_1 259 261 PF00675 0.401
CLV_NRD_NRD_1 515 517 PF00675 0.535
CLV_NRD_NRD_1 54 56 PF00675 0.327
CLV_PCSK_FUR_1 154 158 PF00082 0.315
CLV_PCSK_KEX2_1 156 158 PF00082 0.315
CLV_PCSK_KEX2_1 2 4 PF00082 0.659
CLV_PCSK_KEX2_1 259 261 PF00082 0.401
CLV_PCSK_KEX2_1 514 516 PF00082 0.542
CLV_PCSK_PC1ET2_1 156 158 PF00082 0.365
CLV_PCSK_PC1ET2_1 514 516 PF00082 0.531
CLV_PCSK_SKI1_1 220 224 PF00082 0.397
CLV_PCSK_SKI1_1 284 288 PF00082 0.427
CLV_PCSK_SKI1_1 3 7 PF00082 0.697
CLV_PCSK_SKI1_1 511 515 PF00082 0.491
CLV_PCSK_SKI1_1 516 520 PF00082 0.607
DEG_APCC_DBOX_1 219 227 PF00400 0.380
DEG_Nend_UBRbox_1 1 4 PF02207 0.665
DOC_CKS1_1 101 106 PF01111 0.296
DOC_CKS1_1 84 89 PF01111 0.337
DOC_CYCLIN_RxL_1 159 169 PF00134 0.350
DOC_CYCLIN_RxL_1 217 225 PF00134 0.401
DOC_CYCLIN_yCln2_LP_2 228 234 PF00134 0.280
DOC_MAPK_gen_1 140 149 PF00069 0.337
DOC_MAPK_gen_1 438 445 PF00069 0.397
DOC_MAPK_gen_1 474 483 PF00069 0.337
DOC_MAPK_MEF2A_6 142 151 PF00069 0.401
DOC_MAPK_MEF2A_6 438 445 PF00069 0.350
DOC_PP1_RVXF_1 162 169 PF00149 0.389
DOC_USP7_MATH_1 184 188 PF00917 0.337
DOC_USP7_MATH_1 254 258 PF00917 0.350
DOC_USP7_MATH_1 29 33 PF00917 0.436
DOC_USP7_MATH_1 407 411 PF00917 0.420
DOC_WW_Pin1_4 100 105 PF00397 0.303
DOC_WW_Pin1_4 126 131 PF00397 0.337
DOC_WW_Pin1_4 166 171 PF00397 0.280
DOC_WW_Pin1_4 361 366 PF00397 0.408
DOC_WW_Pin1_4 437 442 PF00397 0.427
DOC_WW_Pin1_4 488 493 PF00397 0.337
DOC_WW_Pin1_4 83 88 PF00397 0.315
LIG_14-3-3_CanoR_1 140 145 PF00244 0.389
LIG_14-3-3_CanoR_1 284 293 PF00244 0.401
LIG_14-3-3_CanoR_1 341 347 PF00244 0.505
LIG_14-3-3_CanoR_1 402 411 PF00244 0.387
LIG_BRCT_BRCA1_1 16 20 PF00533 0.468
LIG_BRCT_BRCA1_1 168 172 PF00533 0.296
LIG_Clathr_ClatBox_1 265 269 PF01394 0.427
LIG_CSL_BTD_1 99 102 PF09270 0.401
LIG_deltaCOP1_diTrp_1 122 133 PF00928 0.292
LIG_eIF4E_1 431 437 PF01652 0.401
LIG_FHA_1 101 107 PF00498 0.296
LIG_FHA_1 115 121 PF00498 0.296
LIG_FHA_1 223 229 PF00498 0.358
LIG_FHA_1 269 275 PF00498 0.296
LIG_FHA_1 362 368 PF00498 0.371
LIG_FHA_1 43 49 PF00498 0.326
LIG_FHA_1 438 444 PF00498 0.339
LIG_FHA_1 470 476 PF00498 0.207
LIG_FHA_1 499 505 PF00498 0.397
LIG_FHA_1 529 535 PF00498 0.630
LIG_FHA_2 188 194 PF00498 0.358
LIG_FHA_2 203 209 PF00498 0.280
LIG_LIR_Apic_2 336 342 PF02991 0.465
LIG_LIR_Gen_1 143 152 PF02991 0.401
LIG_LIR_Gen_1 17 25 PF02991 0.396
LIG_LIR_Gen_1 348 356 PF02991 0.345
LIG_LIR_Gen_1 59 69 PF02991 0.427
LIG_LIR_LC3C_4 269 274 PF02991 0.427
LIG_LIR_Nem_3 169 175 PF02991 0.277
LIG_LIR_Nem_3 17 23 PF02991 0.396
LIG_LIR_Nem_3 348 353 PF02991 0.428
LIG_LIR_Nem_3 368 374 PF02991 0.436
LIG_LIR_Nem_3 440 445 PF02991 0.326
LIG_LIR_Nem_3 59 64 PF02991 0.401
LIG_MLH1_MIPbox_1 168 172 PF16413 0.315
LIG_PCNA_yPIPBox_3 215 227 PF02747 0.373
LIG_Pex14_2 168 172 PF04695 0.324
LIG_SH2_CRK 339 343 PF00017 0.441
LIG_SH2_CRK 61 65 PF00017 0.367
LIG_SH2_SRC 324 327 PF00017 0.490
LIG_SH2_STAP1 500 504 PF00017 0.401
LIG_SH2_STAT5 171 174 PF00017 0.401
LIG_SH2_STAT5 221 224 PF00017 0.275
LIG_SH2_STAT5 324 327 PF00017 0.490
LIG_SH2_STAT5 415 418 PF00017 0.289
LIG_SH2_STAT5 431 434 PF00017 0.391
LIG_SH2_STAT5 482 485 PF00017 0.296
LIG_SH2_STAT5 500 503 PF00017 0.245
LIG_SH3_1 438 444 PF00018 0.427
LIG_SH3_3 146 152 PF00018 0.337
LIG_SH3_3 390 396 PF00018 0.461
LIG_SH3_3 438 444 PF00018 0.427
LIG_SH3_3 96 102 PF00018 0.286
LIG_SUMO_SIM_anti_2 21 26 PF11976 0.401
LIG_SUMO_SIM_anti_2 269 276 PF11976 0.427
LIG_SUMO_SIM_par_1 264 271 PF11976 0.401
LIG_SUMO_SIM_par_1 44 50 PF11976 0.315
LIG_SUMO_SIM_par_1 500 506 PF11976 0.315
LIG_TRAF2_2 87 92 PF00917 0.401
LIG_UBA3_1 222 227 PF00899 0.315
LIG_WRC_WIRS_1 141 146 PF05994 0.401
MOD_CDK_SPK_2 100 105 PF00069 0.315
MOD_CDK_SPxxK_3 166 173 PF00069 0.280
MOD_CK1_1 129 135 PF00069 0.427
MOD_CK1_1 187 193 PF00069 0.323
MOD_CK1_1 276 282 PF00069 0.387
MOD_CK1_1 289 295 PF00069 0.219
MOD_CK1_1 345 351 PF00069 0.417
MOD_CK1_1 359 365 PF00069 0.385
MOD_CK1_1 491 497 PF00069 0.407
MOD_CK2_1 129 135 PF00069 0.335
MOD_CK2_1 187 193 PF00069 0.425
MOD_Cter_Amidation 154 157 PF01082 0.315
MOD_GlcNHglycan 245 248 PF01048 0.329
MOD_GlcNHglycan 275 278 PF01048 0.413
MOD_GlcNHglycan 281 284 PF01048 0.385
MOD_GlcNHglycan 29 32 PF01048 0.429
MOD_GlcNHglycan 405 408 PF01048 0.392
MOD_GlcNHglycan 455 459 PF01048 0.284
MOD_GSK3_1 342 349 PF00069 0.416
MOD_GSK3_1 355 362 PF00069 0.293
MOD_GSK3_1 374 381 PF00069 0.442
MOD_GSK3_1 403 410 PF00069 0.355
MOD_GSK3_1 484 491 PF00069 0.307
MOD_GSK3_1 494 501 PF00069 0.283
MOD_GSK3_1 60 67 PF00069 0.359
MOD_LATS_1 451 457 PF00433 0.330
MOD_N-GLC_1 166 171 PF02516 0.401
MOD_N-GLC_1 214 219 PF02516 0.365
MOD_N-GLC_1 248 253 PF02516 0.350
MOD_N-GLC_1 407 412 PF02516 0.427
MOD_NEK2_1 222 227 PF00069 0.337
MOD_NEK2_1 286 291 PF00069 0.295
MOD_NEK2_1 355 360 PF00069 0.423
MOD_NEK2_1 454 459 PF00069 0.366
MOD_NEK2_1 493 498 PF00069 0.318
MOD_NEK2_2 254 259 PF00069 0.427
MOD_NEK2_2 342 347 PF00069 0.446
MOD_PIKK_1 177 183 PF00454 0.359
MOD_PIKK_1 378 384 PF00454 0.484
MOD_PKA_2 243 249 PF00069 0.439
MOD_PKA_2 289 295 PF00069 0.448
MOD_PKA_2 317 323 PF00069 0.479
MOD_PKA_2 346 352 PF00069 0.464
MOD_Plk_1 207 213 PF00069 0.389
MOD_Plk_1 214 220 PF00069 0.336
MOD_Plk_1 268 274 PF00069 0.401
MOD_Plk_1 295 301 PF00069 0.418
MOD_Plk_1 484 490 PF00069 0.296
MOD_Plk_4 202 208 PF00069 0.310
MOD_Plk_4 268 274 PF00069 0.358
MOD_Plk_4 29 35 PF00069 0.364
MOD_Plk_4 42 48 PF00069 0.240
MOD_Plk_4 484 490 PF00069 0.282
MOD_ProDKin_1 100 106 PF00069 0.303
MOD_ProDKin_1 126 132 PF00069 0.337
MOD_ProDKin_1 166 172 PF00069 0.280
MOD_ProDKin_1 361 367 PF00069 0.401
MOD_ProDKin_1 437 443 PF00069 0.427
MOD_ProDKin_1 488 494 PF00069 0.337
MOD_ProDKin_1 83 89 PF00069 0.315
TRG_DiLeu_BaLyEn_6 281 286 PF01217 0.297
TRG_ENDOCYTIC_2 61 64 PF00928 0.401
TRG_ER_diArg_1 1 3 PF00400 0.663
TRG_ER_diArg_1 139 142 PF00400 0.382
TRG_ER_diArg_1 258 260 PF00400 0.401
TRG_ER_diArg_1 397 400 PF00400 0.480
TRG_NLS_MonoExtN_4 154 160 PF00514 0.365

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HUY3 Leptomonas seymouri 77% 100%
A0A0S4JLI4 Bodo saltans 40% 93%
A0A1X0NHH3 Trypanosomatidae 48% 100%
A0A248QE08 Chlorella variabilis 22% 82%
A0A3R7KBI5 Trypanosoma rangeli 50% 100%
A4HC08 Leishmania braziliensis 90% 100%
A4HZM3 Leishmania infantum 100% 100%
A5VPA6 Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512) 24% 97%
A6U6Y8 Sinorhizobium medicae (strain WSM419) 23% 97%
A6X2G7 Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) 24% 97%
A7N2P9 Vibrio campbellii (strain ATCC BAA-1116) 24% 94%
A9M9H8 Brucella canis (strain ATCC 23365 / NCTC 10854) 24% 97%
B0CKN4 Brucella suis (strain ATCC 23445 / NCTC 10510) 24% 97%
D0A120 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
E9AVE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q47944 Gluconobacter oxydans 23% 100%
Q4QC34 Leishmania major 96% 100%
Q7MF12 Vibrio vulnificus (strain YJ016) 24% 96%
Q8D3K2 Vibrio vulnificus (strain CMCP6) 24% 96%
Q8G1Z8 Brucella suis biovar 1 (strain 1330) 24% 97%
Q8YFY2 Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) 24% 97%
Q985M5 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 23% 97%
V5DIB3 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS