Programmed cell death protein 2, C-terminal putative domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Programmed cell death protein 2, C-terminal putative domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC20_LEIDO

TriTrypDb:

LdBPK_211190.1 , LdCL_210017000 , LDHU3_21.1420

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3Q8IC20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.526
CLV_NRD_NRD_1	363	365	PF00675	0.336
CLV_PCSK_KEX2_1	33	35	PF00082	0.526
CLV_PCSK_KEX2_1	363	365	PF00082	0.433
CLV_PCSK_KEX2_1	4	6	PF00082	0.653
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.653
CLV_PCSK_SKI1_1	224	228	PF00082	0.470
CLV_PCSK_SKI1_1	388	392	PF00082	0.678
CLV_PCSK_SKI1_1	401	405	PF00082	0.705
DOC_MAPK_DCC_7	222	231	PF00069	0.415
DOC_MAPK_gen_1	235	242	PF00069	0.397
DOC_MAPK_gen_1	363	369	PF00069	0.333
DOC_PP4_FxxP_1	230	233	PF00568	0.313
DOC_USP7_MATH_1	102	106	PF00917	0.663
DOC_USP7_MATH_1	138	142	PF00917	0.567
DOC_USP7_MATH_1	215	219	PF00917	0.434
DOC_USP7_MATH_1	290	294	PF00917	0.481
DOC_USP7_MATH_1	304	308	PF00917	0.405
DOC_USP7_MATH_1	317	321	PF00917	0.428
DOC_USP7_MATH_1	56	60	PF00917	0.493
DOC_USP7_MATH_1	72	76	PF00917	0.377
DOC_USP7_MATH_1	82	86	PF00917	0.354
DOC_WW_Pin1_4	14	19	PF00397	0.458
DOC_WW_Pin1_4	50	55	PF00397	0.412
LIG_14-3-3_CanoR_1	163	171	PF00244	0.654
LIG_14-3-3_CanoR_1	33	40	PF00244	0.439
LIG_14-3-3_CanoR_1	7	14	PF00244	0.421
LIG_14-3-3_CanoR_1	80	89	PF00244	0.419
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BIR_III_2	137	141	PF00653	0.548
LIG_FHA_1	114	120	PF00498	0.702
LIG_FHA_1	175	181	PF00498	0.544
LIG_FHA_1	251	257	PF00498	0.438
LIG_FHA_1	341	347	PF00498	0.307
LIG_FHA_1	364	370	PF00498	0.403
LIG_FHA_1	389	395	PF00498	0.623
LIG_FHA_2	146	152	PF00498	0.526
LIG_FHA_2	163	169	PF00498	0.491
LIG_FHA_2	323	329	PF00498	0.415
LIG_FHA_2	372	378	PF00498	0.672
LIG_FHA_2	397	403	PF00498	0.735
LIG_LIR_Apic_2	17	23	PF02991	0.565
LIG_LIR_Gen_1	186	197	PF02991	0.297
LIG_LIR_Gen_1	262	273	PF02991	0.350
LIG_LIR_Nem_3	186	192	PF02991	0.297
LIG_LIR_Nem_3	19	24	PF02991	0.466
LIG_LIR_Nem_3	262	268	PF02991	0.350
LIG_LIR_Nem_3	269	274	PF02991	0.367
LIG_LIR_Nem_3	340	344	PF02991	0.333
LIG_LIR_Nem_3	49	55	PF02991	0.442
LIG_NRBOX	399	405	PF00104	0.701
LIG_PDZ_Class_1	430	435	PF00595	0.575
LIG_SH2_CRK	271	275	PF00017	0.433
LIG_SH2_CRK	52	56	PF00017	0.575
LIG_SH2_PTP2	133	136	PF00017	0.503
LIG_SH2_SRC	133	136	PF00017	0.529
LIG_SH2_SRC	265	268	PF00017	0.433
LIG_SH2_STAP1	207	211	PF00017	0.418
LIG_SH2_STAP1	271	275	PF00017	0.433
LIG_SH2_STAT5	133	136	PF00017	0.503
LIG_SH2_STAT5	20	23	PF00017	0.519
LIG_SH2_STAT5	265	268	PF00017	0.298
LIG_SH2_STAT5	271	274	PF00017	0.298
LIG_SH2_STAT5	347	350	PF00017	0.389
LIG_SH2_STAT5	69	72	PF00017	0.335
LIG_SH2_STAT5	77	80	PF00017	0.376
LIG_SH3_3	115	121	PF00018	0.558
LIG_SH3_3	125	131	PF00018	0.427
LIG_SH3_3	141	147	PF00018	0.500
LIG_SH3_3	237	243	PF00018	0.395
LIG_TRAF2_1	105	108	PF00917	0.667
LIG_TRAF2_1	167	170	PF00917	0.626
LIG_TYR_ITIM	263	268	PF00017	0.313
LIG_WW_1	130	133	PF00397	0.469
MOD_CK1_1	164	170	PF00069	0.652
MOD_CK1_1	250	256	PF00069	0.450
MOD_CK1_1	269	275	PF00069	0.178
MOD_CK1_1	309	315	PF00069	0.348
MOD_CK1_1	318	324	PF00069	0.376
MOD_CK1_1	46	52	PF00069	0.404
MOD_CK2_1	102	108	PF00069	0.685
MOD_CK2_1	145	151	PF00069	0.512
MOD_CK2_1	164	170	PF00069	0.534
MOD_CK2_1	322	328	PF00069	0.415
MOD_CK2_1	396	402	PF00069	0.736
MOD_GlcNHglycan	217	220	PF01048	0.405
MOD_GlcNHglycan	249	252	PF01048	0.355
MOD_GlcNHglycan	308	311	PF01048	0.388
MOD_GlcNHglycan	317	320	PF01048	0.478
MOD_GlcNHglycan	58	61	PF01048	0.493
MOD_GlcNHglycan	74	77	PF01048	0.432
MOD_GSK3_1	304	311	PF00069	0.486
MOD_GSK3_1	318	325	PF00069	0.274
MOD_GSK3_1	388	395	PF00069	0.686
MOD_GSK3_1	46	53	PF00069	0.449
MOD_GSK3_1	54	61	PF00069	0.526
MOD_GSK3_1	72	79	PF00069	0.363
MOD_NEK2_2	342	347	PF00069	0.297
MOD_PIKK_1	291	297	PF00454	0.324
MOD_PIKK_1	46	52	PF00454	0.404
MOD_PKA_1	33	39	PF00069	0.510
MOD_PKA_1	363	369	PF00069	0.433
MOD_PKA_2	162	168	PF00069	0.656
MOD_PKA_2	33	39	PF00069	0.483
MOD_PKA_2	363	369	PF00069	0.480
MOD_PKA_2	6	12	PF00069	0.562
MOD_PKB_1	5	13	PF00069	0.571
MOD_Plk_1	174	180	PF00069	0.552
MOD_Plk_1	207	213	PF00069	0.386
MOD_Plk_1	269	275	PF00069	0.415
MOD_Plk_2-3	371	377	PF00069	0.654
MOD_Plk_4	16	22	PF00069	0.456
MOD_Plk_4	259	265	PF00069	0.326
MOD_Plk_4	43	49	PF00069	0.486
MOD_Plk_4	82	88	PF00069	0.468
MOD_ProDKin_1	14	20	PF00069	0.461
MOD_ProDKin_1	50	56	PF00069	0.431
MOD_SUMO_rev_2	220	229	PF00179	0.336
MOD_SUMO_rev_2	6	14	PF00179	0.495
TRG_DiLeu_BaEn_4	169	175	PF01217	0.674
TRG_DiLeu_LyEn_5	115	120	PF01217	0.624
TRG_ENDOCYTIC_2	133	136	PF00928	0.503
TRG_ENDOCYTIC_2	189	192	PF00928	0.357
TRG_ENDOCYTIC_2	265	268	PF00928	0.313
TRG_ENDOCYTIC_2	271	274	PF00928	0.313
TRG_ENDOCYTIC_2	52	55	PF00928	0.525
TRG_ER_diArg_1	192	195	PF00400	0.314
TRG_ER_diArg_1	32	34	PF00400	0.521
TRG_ER_diArg_1	362	364	PF00400	0.433
TRG_NES_CRM1_1	257	270	PF08389	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTP0	Leptomonas seymouri	68%	97%
A0A0S4JIG4	Bodo saltans	35%	100%
A0A1X0NZ44	Trypanosomatidae	44%	100%
A0A3S5IS34	Trypanosoma rangeli	44%	100%
A4HBV5	Leishmania braziliensis	78%	92%
D0A195	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AGW3	Leishmania infantum	98%	99%
E9AV79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QCA1	Leishmania major	93%	99%
V5AR10	Trypanosoma cruzi	44%	100%