Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IC18_LEIDO

TriTrypDb:

LdBPK_212220.1 , LdCL_210027900 , LDHU3_21.2630

Length:

647

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8IC18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.397
CLV_C14_Caspase3-7	270	274	PF00656	0.404
CLV_C14_Caspase3-7	474	478	PF00656	0.593
CLV_NRD_NRD_1	156	158	PF00675	0.540
CLV_NRD_NRD_1	249	251	PF00675	0.446
CLV_NRD_NRD_1	283	285	PF00675	0.480
CLV_NRD_NRD_1	359	361	PF00675	0.502
CLV_NRD_NRD_1	386	388	PF00675	0.613
CLV_NRD_NRD_1	81	83	PF00675	0.624
CLV_PCSK_FUR_1	117	121	PF00082	0.513
CLV_PCSK_FUR_1	79	83	PF00082	0.503
CLV_PCSK_KEX2_1	119	121	PF00082	0.455
CLV_PCSK_KEX2_1	156	158	PF00082	0.540
CLV_PCSK_KEX2_1	249	251	PF00082	0.551
CLV_PCSK_KEX2_1	27	29	PF00082	0.576
CLV_PCSK_KEX2_1	282	284	PF00082	0.504
CLV_PCSK_KEX2_1	358	360	PF00082	0.497
CLV_PCSK_KEX2_1	386	388	PF00082	0.625
CLV_PCSK_KEX2_1	623	625	PF00082	0.498
CLV_PCSK_KEX2_1	81	83	PF00082	0.624
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.455
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.560
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.389
CLV_PCSK_PC1ET2_1	623	625	PF00082	0.538
CLV_PCSK_PC7_1	355	361	PF00082	0.599
CLV_PCSK_SKI1_1	107	111	PF00082	0.595
CLV_PCSK_SKI1_1	144	148	PF00082	0.541
CLV_PCSK_SKI1_1	24	28	PF00082	0.543
CLV_PCSK_SKI1_1	326	330	PF00082	0.540
CLV_PCSK_SKI1_1	410	414	PF00082	0.590
CLV_PCSK_SKI1_1	544	548	PF00082	0.693
DEG_APCC_DBOX_1	43	51	PF00400	0.566
DEG_Nend_UBRbox_1	1	4	PF02207	0.484
DEG_SPOP_SBC_1	403	407	PF00917	0.568
DEG_SPOP_SBC_1	503	507	PF00917	0.597
DOC_ANK_TNKS_1	282	289	PF00023	0.482
DOC_CYCLIN_RxL_1	407	417	PF00134	0.538
DOC_MAPK_gen_1	44	52	PF00069	0.570
DOC_MAPK_MEF2A_6	589	597	PF00069	0.414
DOC_PP2B_LxvP_1	412	415	PF13499	0.556
DOC_PP2B_LxvP_1	50	53	PF13499	0.589
DOC_PP2B_LxvP_1	590	593	PF13499	0.436
DOC_USP7_MATH_1	194	198	PF00917	0.546
DOC_USP7_MATH_1	36	40	PF00917	0.505
DOC_USP7_MATH_1	392	396	PF00917	0.511
DOC_USP7_MATH_1	435	439	PF00917	0.583
DOC_USP7_MATH_1	458	462	PF00917	0.604
DOC_USP7_MATH_1	466	470	PF00917	0.593
DOC_USP7_MATH_1	550	554	PF00917	0.574
DOC_USP7_MATH_1	558	562	PF00917	0.565
DOC_USP7_MATH_1	583	587	PF00917	0.658
DOC_WW_Pin1_4	109	114	PF00397	0.594
DOC_WW_Pin1_4	17	22	PF00397	0.560
DOC_WW_Pin1_4	171	176	PF00397	0.578
DOC_WW_Pin1_4	249	254	PF00397	0.515
DOC_WW_Pin1_4	415	420	PF00397	0.642
DOC_WW_Pin1_4	431	436	PF00397	0.538
DOC_WW_Pin1_4	451	456	PF00397	0.538
DOC_WW_Pin1_4	495	500	PF00397	0.684
DOC_WW_Pin1_4	554	559	PF00397	0.594
DOC_WW_Pin1_4	573	578	PF00397	0.662
DOC_WW_Pin1_4	61	66	PF00397	0.660
LIG_14-3-3_CanoR_1	107	116	PF00244	0.444
LIG_14-3-3_CanoR_1	426	430	PF00244	0.629
LIG_14-3-3_CanoR_1	567	575	PF00244	0.500
LIG_14-3-3_CanoR_1	66	75	PF00244	0.549
LIG_Actin_WH2_2	591	607	PF00022	0.394
LIG_BRCT_BRCA1_1	497	501	PF00533	0.674
LIG_BRCT_BRCA1_1	606	610	PF00533	0.422
LIG_FHA_1	441	447	PF00498	0.786
LIG_FHA_1	516	522	PF00498	0.568
LIG_FHA_1	62	68	PF00498	0.629
LIG_FHA_2	252	258	PF00498	0.442
LIG_FHA_2	574	580	PF00498	0.549
LIG_Integrin_isoDGR_2	490	492	PF01839	0.622
LIG_LIR_Nem_3	90	96	PF02991	0.561
LIG_MYND_1	301	305	PF01753	0.694
LIG_NRBOX	542	548	PF00104	0.547
LIG_NRBOX	594	600	PF00104	0.454
LIG_NRBOX	628	634	PF00104	0.526
LIG_Pex14_1	215	219	PF04695	0.343
LIG_SH2_STAP1	634	638	PF00017	0.430
LIG_SH2_STAT3	45	48	PF00017	0.470
LIG_SH2_STAT3	98	101	PF00017	0.465
LIG_SH2_STAT5	218	221	PF00017	0.530
LIG_SH2_STAT5	453	456	PF00017	0.536
LIG_SH2_STAT5	96	99	PF00017	0.541
LIG_SH3_3	169	175	PF00018	0.541
LIG_SH3_3	188	194	PF00018	0.484
LIG_SH3_3	452	458	PF00018	0.601
LIG_SH3_3	50	56	PF00018	0.539
LIG_SH3_3	577	583	PF00018	0.521
LIG_SH3_CIN85_PxpxPR_1	431	436	PF14604	0.536
LIG_SUMO_SIM_anti_2	594	599	PF11976	0.513
LIG_SUMO_SIM_par_1	48	55	PF11976	0.602
LIG_SxIP_EBH_1	514	523	PF03271	0.549
LIG_TRAF2_1	102	105	PF00917	0.488
LIG_TRAF2_1	237	240	PF00917	0.397
LIG_TRAF2_1	259	262	PF00917	0.409
LIG_TRAF2_1	396	399	PF00917	0.610
LIG_TRAF2_1	87	90	PF00917	0.550
LIG_WRC_WIRS_1	129	134	PF05994	0.414
LIG_WRC_WIRS_1	230	235	PF05994	0.486
MOD_CDC14_SPxK_1	252	255	PF00782	0.504
MOD_CDK_SPK_2	17	22	PF00069	0.560
MOD_CDK_SPK_2	431	436	PF00069	0.676
MOD_CDK_SPK_2	61	66	PF00069	0.646
MOD_CDK_SPxK_1	249	255	PF00069	0.509
MOD_CDK_SPxxK_3	17	24	PF00069	0.468
MOD_CDK_SPxxK_3	415	422	PF00069	0.549
MOD_CK1_1	149	155	PF00069	0.420
MOD_CK1_1	197	203	PF00069	0.472
MOD_CK1_1	29	35	PF00069	0.741
MOD_CK1_1	456	462	PF00069	0.630
MOD_CK1_1	561	567	PF00069	0.643
MOD_CK1_1	570	576	PF00069	0.654
MOD_CK1_1	68	74	PF00069	0.517
MOD_CK2_1	196	202	PF00069	0.683
MOD_CK2_1	251	257	PF00069	0.512
MOD_CK2_1	392	398	PF00069	0.562
MOD_Cter_Amidation	79	82	PF01082	0.476
MOD_DYRK1A_RPxSP_1	451	455	PF00069	0.639
MOD_GlcNHglycan	148	151	PF01048	0.537
MOD_GlcNHglycan	179	182	PF01048	0.743
MOD_GlcNHglycan	196	199	PF01048	0.534
MOD_GlcNHglycan	244	247	PF01048	0.394
MOD_GlcNHglycan	28	31	PF01048	0.768
MOD_GlcNHglycan	289	293	PF01048	0.739
MOD_GlcNHglycan	306	309	PF01048	0.461
MOD_GlcNHglycan	38	42	PF01048	0.532
MOD_GlcNHglycan	388	391	PF01048	0.567
MOD_GlcNHglycan	393	397	PF01048	0.571
MOD_GlcNHglycan	422	425	PF01048	0.671
MOD_GlcNHglycan	431	434	PF01048	0.769
MOD_GlcNHglycan	438	441	PF01048	0.583
MOD_GlcNHglycan	486	489	PF01048	0.702
MOD_GlcNHglycan	493	496	PF01048	0.656
MOD_GlcNHglycan	506	509	PF01048	0.491
MOD_GlcNHglycan	560	563	PF01048	0.592
MOD_GlcNHglycan	569	572	PF01048	0.622
MOD_GSK3_1	11	18	PF00069	0.569
MOD_GSK3_1	167	174	PF00069	0.583
MOD_GSK3_1	193	200	PF00069	0.479
MOD_GSK3_1	249	256	PF00069	0.544
MOD_GSK3_1	402	409	PF00069	0.617
MOD_GSK3_1	425	432	PF00069	0.670
MOD_GSK3_1	436	443	PF00069	0.609
MOD_GSK3_1	449	456	PF00069	0.566
MOD_GSK3_1	473	480	PF00069	0.643
MOD_GSK3_1	491	498	PF00069	0.654
MOD_GSK3_1	550	557	PF00069	0.639
MOD_GSK3_1	558	565	PF00069	0.692
MOD_GSK3_1	61	68	PF00069	0.643
MOD_GSK3_1	632	639	PF00069	0.505
MOD_N-GLC_1	477	482	PF02516	0.609
MOD_NEK2_1	517	522	PF00069	0.545
MOD_NEK2_1	604	609	PF00069	0.412
MOD_NEK2_1	632	637	PF00069	0.506
MOD_NEK2_2	11	16	PF00069	0.578
MOD_NEK2_2	550	555	PF00069	0.560
MOD_PIKK_1	173	179	PF00454	0.559
MOD_PIKK_1	334	340	PF00454	0.513
MOD_PIKK_1	562	568	PF00454	0.610
MOD_PIKK_1	583	589	PF00454	0.543
MOD_PKA_1	386	392	PF00069	0.510
MOD_PKA_2	15	21	PF00069	0.490
MOD_PKA_2	167	173	PF00069	0.553
MOD_PKA_2	386	392	PF00069	0.510
MOD_PKA_2	425	431	PF00069	0.625
MOD_PKA_2	435	441	PF00069	0.628
MOD_PKA_2	471	477	PF00069	0.595
MOD_PKA_2	491	497	PF00069	0.524
MOD_PKA_2	604	610	PF00069	0.520
MOD_PKA_2	65	71	PF00069	0.595
MOD_Plk_1	11	17	PF00069	0.577
MOD_Plk_1	256	262	PF00069	0.435
MOD_Plk_1	272	278	PF00069	0.495
MOD_Plk_1	466	472	PF00069	0.662
MOD_Plk_2-3	128	134	PF00069	0.416
MOD_Plk_2-3	346	352	PF00069	0.466
MOD_Plk_4	272	278	PF00069	0.539
MOD_ProDKin_1	109	115	PF00069	0.591
MOD_ProDKin_1	17	23	PF00069	0.560
MOD_ProDKin_1	171	177	PF00069	0.581
MOD_ProDKin_1	249	255	PF00069	0.509
MOD_ProDKin_1	415	421	PF00069	0.646
MOD_ProDKin_1	431	437	PF00069	0.539
MOD_ProDKin_1	451	457	PF00069	0.539
MOD_ProDKin_1	495	501	PF00069	0.686
MOD_ProDKin_1	554	560	PF00069	0.595
MOD_ProDKin_1	573	579	PF00069	0.662
MOD_ProDKin_1	61	67	PF00069	0.653
MOD_SUMO_for_1	3	6	PF00179	0.531
TRG_DiLeu_BaEn_1	104	109	PF01217	0.429
TRG_DiLeu_BaEn_1	628	633	PF01217	0.524
TRG_DiLeu_BaEn_4	345	351	PF01217	0.524
TRG_DiLeu_LyEn_5	628	633	PF01217	0.524
TRG_ER_diArg_1	156	158	PF00400	0.491
TRG_ER_diArg_1	21	24	PF00400	0.558
TRG_ER_diArg_1	248	250	PF00400	0.426
TRG_ER_diArg_1	281	284	PF00400	0.492
TRG_ER_diArg_1	359	362	PF00400	0.549
TRG_ER_diArg_1	79	82	PF00400	0.624
TRG_NES_CRM1_1	42	55	PF08389	0.606
TRG_NLS_MonoExtC_3	357	362	PF00514	0.391
TRG_NLS_MonoExtN_4	355	362	PF00514	0.388
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	544	549	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	582	587	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	624	628	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRK6	Leptomonas seymouri	43%	68%
A0A3R7MG27	Trypanosoma rangeli	28%	85%
A4HLC7	Leishmania braziliensis	69%	100%
E9AVI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QBZ8	Leishmania major	89%	100%