Ferric reductase transmembrane protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ferric reductase transmembrane protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IC17_LEIDO

TriTrypDb:

LdCL_300025800 , LDHU3_30.2780

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8IC17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC17

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0140575	transmembrane monodehydroascorbate reductase activity	3	10
GO:0005488	binding	1	1
GO:0020037	heme binding	4	1
GO:0046906	tetrapyrrole binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.553
CLV_PCSK_KEX2_1	106	108	PF00082	0.371
CLV_PCSK_KEX2_1	24	26	PF00082	0.557
CLV_PCSK_PC1ET2_1	106	108	PF00082	0.371
CLV_PCSK_PC7_1	20	26	PF00082	0.504
CLV_PCSK_SKI1_1	97	101	PF00082	0.388
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.418
DOC_PP1_SILK_1	93	98	PF00149	0.396
DOC_PP2B_LxvP_1	99	102	PF13499	0.418
DOC_PP4_MxPP_1	142	145	PF00568	0.329
DOC_WW_Pin1_4	23	28	PF00397	0.754
LIG_14-3-3_CanoR_1	111	121	PF00244	0.399
LIG_Actin_WH2_2	6	22	PF00022	0.694
LIG_FHA_1	118	124	PF00498	0.398
LIG_FHA_1	148	154	PF00498	0.429
LIG_LIR_Gen_1	60	69	PF02991	0.315
LIG_LIR_Nem_3	60	64	PF02991	0.330
LIG_LIR_Nem_3	80	84	PF02991	0.155
LIG_LYPXL_yS_3	68	71	PF13949	0.327
LIG_MYND_2	144	148	PF01753	0.249
LIG_NRBOX	95	101	PF00104	0.334
LIG_SH2_CRK	61	65	PF00017	0.353
LIG_SH2_STAP1	138	142	PF00017	0.445
LIG_SH2_STAT5	61	64	PF00017	0.389
LIG_SH2_STAT5	98	101	PF00017	0.589
LIG_SH3_2	102	107	PF14604	0.589
LIG_SH3_3	99	105	PF00018	0.564
LIG_SUMO_SIM_par_1	118	124	PF11976	0.380
LIG_TRFH_1	98	102	PF08558	0.561
LIG_TYR_ITIM	59	64	PF00017	0.389
LIG_WRC_WIRS_1	43	48	PF05994	0.483
LIG_WRC_WIRS_1	78	83	PF05994	0.405
LIG_WW_3	31	35	PF00397	0.541
MOD_CK1_1	115	121	PF00069	0.177
MOD_CK1_1	73	79	PF00069	0.218
MOD_CK2_1	23	29	PF00069	0.668
MOD_GlcNHglycan	117	120	PF01048	0.330
MOD_GSK3_1	117	124	PF00069	0.423
MOD_GSK3_1	143	150	PF00069	0.389
MOD_GSK3_1	73	80	PF00069	0.301
MOD_NEK2_1	147	152	PF00069	0.391
MOD_PKA_2	13	19	PF00069	0.531
MOD_Plk_4	143	149	PF00069	0.318
MOD_Plk_4	42	48	PF00069	0.536
MOD_Plk_4	73	79	PF00069	0.349
MOD_Plk_4	82	88	PF00069	0.382
MOD_Plk_4	91	97	PF00069	0.315
MOD_ProDKin_1	23	29	PF00069	0.749
MOD_SUMO_rev_2	11	19	PF00179	0.660
TRG_ENDOCYTIC_2	61	64	PF00928	0.365
TRG_ENDOCYTIC_2	68	71	PF00928	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JNM4	Bodo saltans	26%	70%
A0A1X0P2F3	Trypanosomatidae	23%	67%
A0A3R7RSY6	Trypanosoma rangeli	28%	69%
A4HID6	Leishmania braziliensis	64%	100%
A4I5N2	Leishmania infantum	99%	100%
E9B0X7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q789	Leishmania major	89%	100%
V5BPF8	Trypanosoma cruzi	24%	69%