PSP1_C-inal_conserved_region_containing_protein_p utative/Pfam:PF04468

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC14_LEIDO

TriTrypDb:

LdBPK_100100.1 , LdCL_100006200 , LDHU3_10.0180

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IC14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	290	292	PF00675	0.289
CLV_NRD_NRD_1	339	341	PF00675	0.597
CLV_NRD_NRD_1	358	360	PF00675	0.701
CLV_NRD_NRD_1	88	90	PF00675	0.667
CLV_PCSK_FUR_1	337	341	PF00082	0.568
CLV_PCSK_KEX2_1	20	22	PF00082	0.585
CLV_PCSK_KEX2_1	336	338	PF00082	0.561
CLV_PCSK_KEX2_1	339	341	PF00082	0.591
CLV_PCSK_KEX2_1	357	359	PF00082	0.596
CLV_PCSK_KEX2_1	88	90	PF00082	0.667
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.608
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.620
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.615
CLV_PCSK_PC7_1	353	359	PF00082	0.673
CLV_PCSK_SKI1_1	133	137	PF00082	0.499
CLV_PCSK_SKI1_1	236	240	PF00082	0.574
CLV_PCSK_SKI1_1	292	296	PF00082	0.400
CLV_PCSK_SKI1_1	89	93	PF00082	0.670
DEG_Nend_UBRbox_3	1	3	PF02207	0.522
DEG_SCF_FBW7_1	69	75	PF00400	0.538
DOC_CKS1_1	69	74	PF01111	0.652
DOC_CYCLIN_RxL_1	86	95	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.345
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.587
DOC_MAPK_gen_1	133	141	PF00069	0.559
DOC_MAPK_gen_1	240	250	PF00069	0.361
DOC_MAPK_MEF2A_6	150	159	PF00069	0.513
DOC_MAPK_MEF2A_6	182	191	PF00069	0.520
DOC_PP2B_LxvP_1	276	279	PF13499	0.402
DOC_PP4_FxxP_1	166	169	PF00568	0.356
DOC_USP7_MATH_1	13	17	PF00917	0.525
DOC_USP7_MATH_1	24	28	PF00917	0.646
DOC_USP7_MATH_1	32	36	PF00917	0.413
DOC_USP7_MATH_1	79	83	PF00917	0.684
DOC_USP7_UBL2_3	134	138	PF12436	0.576
DOC_USP7_UBL2_3	236	240	PF12436	0.420
DOC_WW_Pin1_4	100	105	PF00397	0.601
DOC_WW_Pin1_4	215	220	PF00397	0.685
DOC_WW_Pin1_4	227	232	PF00397	0.653
DOC_WW_Pin1_4	41	46	PF00397	0.676
DOC_WW_Pin1_4	48	53	PF00397	0.680
DOC_WW_Pin1_4	68	73	PF00397	0.423
DOC_WW_Pin1_4	92	97	PF00397	0.609
LIG_14-3-3_CanoR_1	125	131	PF00244	0.583
LIG_14-3-3_CanoR_1	160	168	PF00244	0.495
LIG_14-3-3_CanoR_1	243	250	PF00244	0.453
LIG_14-3-3_CanoR_1	291	297	PF00244	0.317
LIG_APCC_ABBAyCdc20_2	88	94	PF00400	0.673
LIG_BRCT_BRCA1_1	34	38	PF00533	0.582
LIG_Clathr_ClatBox_1	174	178	PF01394	0.585
LIG_FHA_1	154	160	PF00498	0.513
LIG_FHA_1	163	169	PF00498	0.503
LIG_FHA_1	179	185	PF00498	0.433
LIG_FHA_1	308	314	PF00498	0.411
LIG_FHA_1	69	75	PF00498	0.599
LIG_FHA_2	218	224	PF00498	0.664
LIG_IBAR_NPY_1	23	25	PF08397	0.529
LIG_LIR_Apic_2	163	169	PF02991	0.371
LIG_LIR_Gen_1	170	177	PF02991	0.541
LIG_LIR_Gen_1	300	309	PF02991	0.363
LIG_LIR_Gen_1	35	46	PF02991	0.720
LIG_LIR_Gen_1	63	74	PF02991	0.628
LIG_LIR_Nem_3	197	202	PF02991	0.367
LIG_LIR_Nem_3	300	306	PF02991	0.350
LIG_LIR_Nem_3	63	69	PF02991	0.558
LIG_Pex14_2	60	64	PF04695	0.499
LIG_SH2_CRK	66	70	PF00017	0.537
LIG_SH2_GRB2like	66	69	PF00017	0.725
LIG_SH2_NCK_1	66	70	PF00017	0.509
LIG_SH2_STAP1	172	176	PF00017	0.560
LIG_SH2_STAP1	25	29	PF00017	0.613
LIG_SH2_STAP1	298	302	PF00017	0.402
LIG_SH2_STAT3	73	76	PF00017	0.549
LIG_SH2_STAT5	140	143	PF00017	0.446
LIG_SH2_STAT5	266	269	PF00017	0.402
LIG_SH2_STAT5	298	301	PF00017	0.282
LIG_SH2_STAT5	303	306	PF00017	0.257
LIG_SH2_STAT5	73	76	PF00017	0.645
LIG_SH3_3	116	122	PF00018	0.617
LIG_SH3_3	125	131	PF00018	0.555
LIG_SH3_3	143	149	PF00018	0.482
LIG_SH3_3	182	188	PF00018	0.429
LIG_SH3_3	26	32	PF00018	0.676
LIG_SH3_3	66	72	PF00018	0.598
LIG_SH3_3	84	90	PF00018	0.627
LIG_SH3_4	236	243	PF00018	0.388
LIG_SUMO_SIM_par_1	187	192	PF11976	0.519
LIG_SUMO_SIM_par_1	277	283	PF11976	0.415
LIG_TRAF2_1	176	179	PF00917	0.598
LIG_TRAF2_1	220	223	PF00917	0.720
MOD_CK1_1	105	111	PF00069	0.697
MOD_CK1_1	126	132	PF00069	0.662
MOD_CK1_1	16	22	PF00069	0.536
MOD_CK1_1	162	168	PF00069	0.370
MOD_CK1_1	218	224	PF00069	0.726
MOD_CK1_1	44	50	PF00069	0.713
MOD_CK1_1	67	73	PF00069	0.616
MOD_CK1_1	77	83	PF00069	0.636
MOD_CK2_1	217	223	PF00069	0.707
MOD_CK2_1	243	249	PF00069	0.408
MOD_Cter_Amidation	337	340	PF01082	0.688
MOD_Cter_Amidation	344	347	PF01082	0.647
MOD_GlcNHglycan	11	14	PF01048	0.660
MOD_GlcNHglycan	202	205	PF01048	0.450
MOD_GlcNHglycan	245	248	PF01048	0.399
MOD_GlcNHglycan	46	49	PF01048	0.552
MOD_GSK3_1	102	109	PF00069	0.730
MOD_GSK3_1	211	218	PF00069	0.683
MOD_GSK3_1	274	281	PF00069	0.488
MOD_GSK3_1	292	299	PF00069	0.332
MOD_GSK3_1	37	44	PF00069	0.696
MOD_GSK3_1	5	12	PF00069	0.685
MOD_GSK3_1	60	67	PF00069	0.602
MOD_GSK3_1	68	75	PF00069	0.531
MOD_N-GLC_1	67	72	PF02516	0.722
MOD_NEK2_1	124	129	PF00069	0.682
MOD_NEK2_1	14	19	PF00069	0.591
MOD_NEK2_1	64	69	PF00069	0.617
MOD_NEK2_1	74	79	PF00069	0.645
MOD_PIKK_1	72	78	PF00454	0.606
MOD_PKA_1	292	298	PF00069	0.371
MOD_PKA_2	124	130	PF00069	0.588
MOD_PKA_2	159	165	PF00069	0.511
MOD_PKA_2	296	302	PF00069	0.439
MOD_PKA_2	327	333	PF00069	0.574
MOD_Plk_1	153	159	PF00069	0.463
MOD_Plk_1	162	168	PF00069	0.471
MOD_Plk_1	307	313	PF00069	0.402
MOD_Plk_1	32	38	PF00069	0.681
MOD_Plk_4	162	168	PF00069	0.482
MOD_Plk_4	170	176	PF00069	0.544
MOD_Plk_4	37	43	PF00069	0.639
MOD_Plk_4	60	66	PF00069	0.638
MOD_ProDKin_1	100	106	PF00069	0.603
MOD_ProDKin_1	215	221	PF00069	0.687
MOD_ProDKin_1	227	233	PF00069	0.647
MOD_ProDKin_1	41	47	PF00069	0.675
MOD_ProDKin_1	48	54	PF00069	0.678
MOD_ProDKin_1	68	74	PF00069	0.425
MOD_ProDKin_1	92	98	PF00069	0.612
MOD_SUMO_for_1	206	209	PF00179	0.611
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.442
TRG_ENDOCYTIC_2	172	175	PF00928	0.520
TRG_ENDOCYTIC_2	303	306	PF00928	0.286
TRG_ENDOCYTIC_2	66	69	PF00928	0.651
TRG_ER_diArg_1	337	340	PF00400	0.593
TRG_ER_diArg_1	87	89	PF00400	0.675
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT9	Leptomonas seymouri	61%	95%
A0A0S4JEW1	Bodo saltans	29%	100%
A0A1X0NQL8	Trypanosomatidae	30%	91%
A0A3Q8IJZ1	Leishmania donovani	25%	100%
A0A3Q8ILM8	Leishmania donovani	31%	100%
A0A3R7KIC4	Trypanosoma rangeli	31%	92%
A4HUB9	Leishmania infantum	100%	100%
A4IC69	Leishmania infantum	25%	100%
E9AI38	Leishmania braziliensis	83%	100%
E9AN18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AUD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q051	Leishmania major	32%	100%
Q4QHK8	Leishmania major	95%	100%
V5DA19	Trypanosoma cruzi	38%	92%