RET2, RNA editing complex MP57

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing 3' terminal uridylyl transferase 2

Species:

Leishmania donovani

UniProt:

A0A3Q8IC11_LEIDO

TriTrypDb:

LdBPK_260380.1 , LdCL_260009300 , LDHU3_26.0490

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	22
GO:0110165	cellular anatomical entity	1	23
GO:0016020	membrane	2	3
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3Q8IC11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC11

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	24
GO:0006396	RNA processing	6	24
GO:0006725	cellular aromatic compound metabolic process	3	24
GO:0006807	nitrogen compound metabolic process	2	24
GO:0008152	metabolic process	1	24
GO:0009987	cellular process	1	24
GO:0016070	RNA metabolic process	5	24
GO:0031123	RNA 3'-end processing	7	24
GO:0034641	cellular nitrogen compound metabolic process	3	24
GO:0043170	macromolecule metabolic process	3	24
GO:0044237	cellular metabolic process	2	24
GO:0044238	primary metabolic process	2	24
GO:0046483	heterocycle metabolic process	3	24
GO:0071076	RNA 3' uridylation	8	24
GO:0071704	organic substance metabolic process	2	24
GO:0090304	nucleic acid metabolic process	4	24
GO:1901360	organic cyclic compound metabolic process	3	24
GO:0006378	mRNA polyadenylation	7	1
GO:0006397	mRNA processing	7	1
GO:0016071	mRNA metabolic process	6	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0043631	RNA polyadenylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	24
GO:0005488	binding	1	24
GO:0016740	transferase activity	2	24
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	24
GO:0016779	nucleotidyltransferase activity	4	24
GO:0043167	ion binding	2	24
GO:0043169	cation binding	3	24
GO:0046872	metal ion binding	4	24
GO:0050265	RNA uridylyltransferase activity	4	24
GO:0070569	uridylyltransferase activity	5	24
GO:0140098	catalytic activity, acting on RNA	3	24
GO:0140640	catalytic activity, acting on a nucleic acid	2	24
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	4
GO:0070566	adenylyltransferase activity	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.518
CLV_NRD_NRD_1	193	195	PF00675	0.284
CLV_NRD_NRD_1	495	497	PF00675	0.529
CLV_PCSK_KEX2_1	138	140	PF00082	0.260
CLV_PCSK_KEX2_1	148	150	PF00082	0.336
CLV_PCSK_KEX2_1	495	497	PF00082	0.494
CLV_PCSK_KEX2_1	71	73	PF00082	0.418
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.244
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.341
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.492
CLV_PCSK_SKI1_1	272	276	PF00082	0.344
CLV_PCSK_SKI1_1	489	493	PF00082	0.355
CLV_PCSK_SKI1_1	63	67	PF00082	0.379
DEG_APCC_DBOX_1	155	163	PF00400	0.344
DEG_APCC_DBOX_1	196	204	PF00400	0.284
DEG_COP1_1	273	283	PF00400	0.284
DEG_SPOP_SBC_1	36	40	PF00917	0.688
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.366
DOC_PP1_RVXF_1	353	360	PF00149	0.378
DOC_PP4_FxxP_1	126	129	PF00568	0.470
DOC_USP7_MATH_1	131	135	PF00917	0.461
DOC_USP7_MATH_1	23	27	PF00917	0.618
DOC_USP7_MATH_1	36	40	PF00917	0.627
DOC_USP7_UBL2_3	138	142	PF12436	0.455
DOC_USP7_UBL2_3	322	326	PF12436	0.316
DOC_WW_Pin1_4	164	169	PF00397	0.354
DOC_WW_Pin1_4	2	7	PF00397	0.673
DOC_WW_Pin1_4	30	35	PF00397	0.718
DOC_WW_Pin1_4	375	380	PF00397	0.372
DOC_WW_Pin1_4	94	99	PF00397	0.457
LIG_14-3-3_CanoR_1	15	25	PF00244	0.550
LIG_14-3-3_CanoR_1	182	188	PF00244	0.455
LIG_14-3-3_CanoR_1	194	203	PF00244	0.229
LIG_14-3-3_CanoR_1	232	236	PF00244	0.288
LIG_14-3-3_CanoR_1	414	420	PF00244	0.310
LIG_14-3-3_CanoR_1	473	479	PF00244	0.450
LIG_Actin_WH2_2	4	20	PF00022	0.616
LIG_AP2alpha_2	361	363	PF02296	0.335
LIG_CaMK_CASK_1	226	232	PF00069	0.300
LIG_Clathr_ClatBox_1	438	442	PF01394	0.252
LIG_CtBP_PxDLS_1	385	389	PF00389	0.316
LIG_deltaCOP1_diTrp_1	422	427	PF00928	0.284
LIG_eIF4E_1	103	109	PF01652	0.528
LIG_FHA_1	12	18	PF00498	0.634
LIG_FHA_1	138	144	PF00498	0.457
LIG_FHA_1	165	171	PF00498	0.358
LIG_FHA_1	352	358	PF00498	0.378
LIG_FHA_2	187	193	PF00498	0.424
LIG_FHA_2	197	203	PF00498	0.424
LIG_FHA_2	242	248	PF00498	0.346
LIG_LIR_Apic_2	422	428	PF02991	0.271
LIG_LIR_Gen_1	141	152	PF02991	0.484
LIG_LIR_Gen_1	434	441	PF02991	0.313
LIG_LIR_Gen_1	442	453	PF02991	0.324
LIG_LIR_Gen_1	5	13	PF02991	0.468
LIG_LIR_Nem_3	141	147	PF02991	0.518
LIG_LIR_Nem_3	289	295	PF02991	0.259
LIG_LIR_Nem_3	344	350	PF02991	0.337
LIG_LIR_Nem_3	376	380	PF02991	0.326
LIG_LIR_Nem_3	434	438	PF02991	0.305
LIG_LIR_Nem_3	442	448	PF02991	0.262
LIG_LIR_Nem_3	5	11	PF02991	0.469
LIG_NRBOX	387	393	PF00104	0.300
LIG_Pex14_1	288	292	PF04695	0.296
LIG_Pex14_2	284	288	PF04695	0.304
LIG_Pex14_2	377	381	PF04695	0.246
LIG_SH2_CRK	185	189	PF00017	0.443
LIG_SH2_GRB2like	174	177	PF00017	0.446
LIG_SH2_NCK_1	445	449	PF00017	0.300
LIG_SH2_PTP2	10	13	PF00017	0.480
LIG_SH2_SRC	445	448	PF00017	0.300
LIG_SH2_SRC	481	484	PF00017	0.521
LIG_SH2_SRC	8	11	PF00017	0.471
LIG_SH2_STAP1	270	274	PF00017	0.284
LIG_SH2_STAP1	341	345	PF00017	0.297
LIG_SH2_STAP1	399	403	PF00017	0.255
LIG_SH2_STAP1	405	409	PF00017	0.230
LIG_SH2_STAP1	47	51	PF00017	0.496
LIG_SH2_STAT3	150	153	PF00017	0.253
LIG_SH2_STAT5	103	106	PF00017	0.473
LIG_SH2_STAT5	174	177	PF00017	0.292
LIG_SH2_STAT5	185	188	PF00017	0.390
LIG_SH2_STAT5	215	218	PF00017	0.275
LIG_SH2_STAT5	270	273	PF00017	0.284
LIG_SH2_STAT5	279	282	PF00017	0.294
LIG_SH2_STAT5	301	304	PF00017	0.298
LIG_SH2_STAT5	306	309	PF00017	0.346
LIG_SH2_STAT5	350	353	PF00017	0.353
LIG_SH2_STAT5	437	440	PF00017	0.321
LIG_SH2_STAT5	481	484	PF00017	0.493
LIG_SH2_STAT5	8	11	PF00017	0.495
LIG_SH3_3	19	25	PF00018	0.733
LIG_SH3_3	366	372	PF00018	0.337
LIG_SUMO_SIM_par_1	158	164	PF11976	0.289
LIG_SUMO_SIM_par_1	408	413	PF11976	0.319
LIG_TRAF2_1	189	192	PF00917	0.284
MOD_CDK_SPxxK_3	164	171	PF00069	0.347
MOD_CDK_SPxxK_3	94	101	PF00069	0.284
MOD_CK1_1	107	113	PF00069	0.284
MOD_CK1_1	196	202	PF00069	0.422
MOD_CK1_1	32	38	PF00069	0.640
MOD_CK1_1	39	45	PF00069	0.607
MOD_CK1_1	418	424	PF00069	0.298
MOD_CK1_1	46	52	PF00069	0.602
MOD_CK2_1	186	192	PF00069	0.284
MOD_CK2_1	241	247	PF00069	0.305
MOD_CK2_1	37	43	PF00069	0.716
MOD_GlcNHglycan	19	22	PF01048	0.667
MOD_GlcNHglycan	26	29	PF01048	0.640
MOD_GlcNHglycan	327	330	PF01048	0.356
MOD_GlcNHglycan	34	37	PF01048	0.530
MOD_GlcNHglycan	39	42	PF01048	0.753
MOD_GSK3_1	160	167	PF00069	0.378
MOD_GSK3_1	32	39	PF00069	0.669
MOD_GSK3_1	337	344	PF00069	0.330
MOD_GSK3_1	427	434	PF00069	0.366
MOD_NEK2_1	17	22	PF00069	0.660
MOD_NEK2_1	337	342	PF00069	0.335
MOD_NEK2_1	351	356	PF00069	0.340
MOD_NEK2_1	78	83	PF00069	0.344
MOD_NEK2_2	415	420	PF00069	0.435
MOD_PK_1	142	148	PF00069	0.487
MOD_PKA_2	17	23	PF00069	0.532
MOD_PKA_2	183	189	PF00069	0.496
MOD_PKA_2	193	199	PF00069	0.355
MOD_PKA_2	231	237	PF00069	0.288
MOD_PKA_2	415	421	PF00069	0.328
MOD_Plk_1	131	137	PF00069	0.488
MOD_Plk_1	230	236	PF00069	0.340
MOD_Plk_1	288	294	PF00069	0.349
MOD_Plk_1	487	493	PF00069	0.352
MOD_Plk_2-3	115	121	PF00069	0.271
MOD_Plk_4	104	110	PF00069	0.317
MOD_Plk_4	183	189	PF00069	0.533
MOD_Plk_4	196	202	PF00069	0.440
MOD_Plk_4	297	303	PF00069	0.253
MOD_Plk_4	341	347	PF00069	0.308
MOD_Plk_4	487	493	PF00069	0.409
MOD_ProDKin_1	164	170	PF00069	0.349
MOD_ProDKin_1	2	8	PF00069	0.676
MOD_ProDKin_1	30	36	PF00069	0.719
MOD_ProDKin_1	375	381	PF00069	0.380
MOD_ProDKin_1	94	100	PF00069	0.302
MOD_SUMO_for_1	467	470	PF00179	0.365
MOD_SUMO_rev_2	190	196	PF00179	0.288
MOD_SUMO_rev_2	94	102	PF00179	0.284
TRG_DiLeu_BaEn_1	387	392	PF01217	0.354
TRG_ENDOCYTIC_2	185	188	PF00928	0.414
TRG_ENDOCYTIC_2	445	448	PF00928	0.289
TRG_ENDOCYTIC_2	8	11	PF00928	0.510
TRG_ER_diArg_1	182	185	PF00400	0.371
TRG_ER_diArg_1	203	206	PF00400	0.391
TRG_ER_diArg_1	414	417	PF00400	0.300
TRG_ER_diArg_1	494	496	PF00400	0.483
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.514

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P857	Leptomonas seymouri	25%	97%
A0A0N1IJQ4	Leptomonas seymouri	76%	100%
A0A0S4JJR1	Bodo saltans	70%	100%
A0A0S4JJT6	Bodo saltans	27%	87%
A0A1X0NSS0	Trypanosomatidae	76%	100%
A0A1X0NZU6	Trypanosomatidae	29%	97%
A0A3Q8IHZ8	Leishmania donovani	26%	100%
A0A3R7K3P5	Trypanosoma rangeli	29%	97%
A0A3R7KH85	Trypanosoma rangeli	26%	71%
A0A422NVH7	Trypanosoma rangeli	74%	100%
A4HEP5	Leishmania braziliensis	88%	100%
A4HGC0	Leishmania braziliensis	25%	100%
A4I1X5	Leishmania infantum	100%	100%
A4I3F3	Leishmania infantum	26%	100%
C9ZS45	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
D0A7Y7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	97%
E9AY21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AZP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4Q8J1	Leishmania major	26%	100%
Q4Q9F2	Leishmania major	97%	100%
Q86MV5	Trypanosoma brucei brucei	73%	100%
V5BG78	Trypanosoma cruzi	29%	97%
V5BQ07	Trypanosoma cruzi	74%	100%