Succinyl-CoA:3-ketoacid-coenzyme A transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

succinyl-coa:3-ketoacid-coenzyme a transferase- like protein (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IC07_LEIDO

TriTrypDb:

LdBPK_301910.1 , LdCL_300024400 , LDHU3_30.2630

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A0A3Q8IC07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC07

Function

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Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009987	cellular process	1	12
GO:0016042	lipid catabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044281	small molecule metabolic process	2	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008260	succinyl-CoA:3-oxo-acid CoA-transferase activity	5	12
GO:0008410	CoA-transferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016782	transferase activity, transferring sulphur-containing groups	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.611
CLV_C14_Caspase3-7	283	287	PF00656	0.609
CLV_NRD_NRD_1	248	250	PF00675	0.635
CLV_NRD_NRD_1	256	258	PF00675	0.596
CLV_NRD_NRD_1	278	280	PF00675	0.366
CLV_NRD_NRD_1	3	5	PF00675	0.646
CLV_PCSK_KEX2_1	189	191	PF00082	0.452
CLV_PCSK_KEX2_1	248	250	PF00082	0.630
CLV_PCSK_KEX2_1	278	280	PF00082	0.366
CLV_PCSK_KEX2_1	3	5	PF00082	0.628

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P584	Leptomonas seymouri	52%	100%
A0A0N1I0F3	Leptomonas seymouri	45%	100%
A0A0S4JH09	Bodo saltans	53%	100%
A0A1X0NIU4	Trypanosomatidae	48%	100%
A0A1X0P425	Trypanosomatidae	48%	100%
A0A3Q8IMK1	Leishmania donovani	45%	100%
A0A3R7LBN6	Trypanosoma rangeli	49%	100%
A0A3S7X3G0	Leishmania donovani	83%	100%
A4HLU7	Leishmania braziliensis	45%	100%
A4I5L8	Leishmania infantum	100%	100%

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