Ras-related protein Rab-21

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-related protein Rab21, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IC02_LEIDO

TriTrypDb:

LdBPK_210870.1 , LdCL_210013600 , LDHU3_21.0970

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005768	endosome	7	1
GO:0005769	early endosome	8	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A0A3Q8IC02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IC02

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0007165	signal transduction	2	6
GO:0007264	small GTPase mediated signal transduction	4	6
GO:0007265	Ras protein signal transduction	5	6
GO:0008104	protein localization	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0032482	Rab protein signal transduction	6	6
GO:0033036	macromolecule localization	2	6
GO:0035556	intracellular signal transduction	3	6
GO:0045184	establishment of protein localization	3	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0065007	biological regulation	1	6
GO:0070727	cellular macromolecule localization	3	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6
GO:0006886	intracellular protein transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0003924	GTPase activity	7	9
GO:0005488	binding	1	9
GO:0005525	GTP binding	5	9
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0019001	guanyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032561	guanyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.536
CLV_C14_Caspase3-7	99	103	PF00656	0.332
CLV_NRD_NRD_1	106	108	PF00675	0.369
CLV_NRD_NRD_1	222	224	PF00675	0.651
CLV_PCSK_FUR_1	220	224	PF00082	0.669
CLV_PCSK_KEX2_1	222	224	PF00082	0.651
CLV_PCSK_PC7_1	218	224	PF00082	0.664
CLV_PCSK_SKI1_1	11	15	PF00082	0.334
CLV_PCSK_SKI1_1	126	130	PF00082	0.348
CLV_PCSK_SKI1_1	185	189	PF00082	0.601
DEG_APCC_DBOX_1	221	229	PF00400	0.698
DEG_Nend_UBRbox_2	1	3	PF02207	0.596
DEG_SCF_FBW7_1	235	240	PF00400	0.697
DOC_MAPK_gen_1	218	227	PF00069	0.663
DOC_PP1_RVXF_1	4	11	PF00149	0.542
DOC_USP7_MATH_1	196	200	PF00917	0.750
DOC_USP7_MATH_1	216	220	PF00917	0.712
DOC_USP7_MATH_1	237	241	PF00917	0.728
DOC_USP7_MATH_1	281	285	PF00917	0.697
DOC_WW_Pin1_4	133	138	PF00397	0.408
DOC_WW_Pin1_4	212	217	PF00397	0.763
DOC_WW_Pin1_4	233	238	PF00397	0.670
DOC_WW_Pin1_4	249	254	PF00397	0.771
DOC_WW_Pin1_4	272	277	PF00397	0.679
LIG_14-3-3_CanoR_1	107	113	PF00244	0.411
LIG_14-3-3_CanoR_1	19	29	PF00244	0.329
LIG_Actin_WH2_2	93	109	PF00022	0.383
LIG_BRCT_BRCA1_1	157	161	PF00533	0.424
LIG_FHA_1	177	183	PF00498	0.305
LIG_FHA_1	21	27	PF00498	0.314
LIG_FHA_2	137	143	PF00498	0.396
LIG_FHA_2	99	105	PF00498	0.320
LIG_LIR_Gen_1	115	125	PF02991	0.387
LIG_LIR_Gen_1	172	182	PF02991	0.365
LIG_LIR_Gen_1	78	88	PF02991	0.329
LIG_LIR_Nem_3	115	120	PF02991	0.387
LIG_LIR_Nem_3	7	13	PF02991	0.441
LIG_LIR_Nem_3	78	83	PF02991	0.329
LIG_MLH1_MIPbox_1	157	161	PF16413	0.387
LIG_SH2_CRK	117	121	PF00017	0.411
LIG_SH2_CRK	208	212	PF00017	0.777
LIG_SH2_CRK	248	252	PF00017	0.725
LIG_SH2_NCK_1	117	121	PF00017	0.411
LIG_SH2_STAP1	47	51	PF00017	0.299
LIG_SH2_STAT5	29	32	PF00017	0.405
LIG_SUMO_SIM_par_1	11	17	PF11976	0.329
LIG_SUMO_SIM_par_1	266	271	PF11976	0.707
LIG_TRAF2_1	75	78	PF00917	0.329
LIG_WW_3	252	256	PF00397	0.707
MOD_CDK_SPxK_1	212	218	PF00069	0.763
MOD_CDK_SPxK_1	233	239	PF00069	0.692
MOD_CDK_SPxK_1	249	255	PF00069	0.716
MOD_CK1_1	163	169	PF00069	0.363
MOD_CK1_1	199	205	PF00069	0.711
MOD_CK1_1	24	30	PF00069	0.363
MOD_CK1_1	240	246	PF00069	0.721
MOD_CK1_1	261	267	PF00069	0.721
MOD_CK1_1	45	51	PF00069	0.411
MOD_CK2_1	136	142	PF00069	0.335
MOD_CK2_1	238	244	PF00069	0.726
MOD_GlcNHglycan	162	165	PF01048	0.329
MOD_GlcNHglycan	174	177	PF01048	0.329
MOD_GlcNHglycan	199	202	PF01048	0.689
MOD_GlcNHglycan	261	264	PF01048	0.722
MOD_GlcNHglycan	270	273	PF01048	0.772
MOD_GlcNHglycan	284	287	PF01048	0.612
MOD_GlcNHglycan	58	61	PF01048	0.350
MOD_GSK3_1	172	179	PF00069	0.325
MOD_GSK3_1	181	188	PF00069	0.429
MOD_GSK3_1	196	203	PF00069	0.552
MOD_GSK3_1	20	27	PF00069	0.359
MOD_GSK3_1	212	219	PF00069	0.545
MOD_GSK3_1	233	240	PF00069	0.694
MOD_GSK3_1	268	275	PF00069	0.733
MOD_GSK3_1	38	45	PF00069	0.218
MOD_GSK3_1	98	105	PF00069	0.329
MOD_N-GLC_1	282	287	PF02516	0.574
MOD_NEK2_1	155	160	PF00069	0.317
MOD_NEK2_1	46	51	PF00069	0.363
MOD_NEK2_1	71	76	PF00069	0.411
MOD_PIKK_1	176	182	PF00454	0.465
MOD_PKB_1	183	191	PF00069	0.649
MOD_PKB_1	212	220	PF00069	0.587
MOD_PKB_1	4	12	PF00069	0.414
MOD_Plk_1	37	43	PF00069	0.395
MOD_Plk_1	6	12	PF00069	0.552
MOD_Plk_4	21	27	PF00069	0.329
MOD_Plk_4	42	48	PF00069	0.313
MOD_ProDKin_1	133	139	PF00069	0.408
MOD_ProDKin_1	212	218	PF00069	0.763
MOD_ProDKin_1	233	239	PF00069	0.674
MOD_ProDKin_1	249	255	PF00069	0.773
MOD_ProDKin_1	272	278	PF00069	0.678
TRG_ENDOCYTIC_2	117	120	PF00928	0.411
TRG_ENDOCYTIC_2	208	211	PF00928	0.790
TRG_ENDOCYTIC_2	248	251	PF00928	0.731
TRG_ER_diArg_1	182	185	PF00400	0.506
TRG_ER_diArg_1	211	214	PF00400	0.656
TRG_ER_diArg_1	220	223	PF00400	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I1	Leptomonas seymouri	34%	100%
A0A0N1HU31	Leptomonas seymouri	29%	100%
A0A0N1PBC8	Leptomonas seymouri	74%	100%
A0A0N1PE58	Leptomonas seymouri	25%	100%
A0A0S4IJB7	Bodo saltans	30%	100%
A0A0S4IRD6	Bodo saltans	29%	100%
A0A0S4IWD9	Bodo saltans	33%	85%
A0A0S4IY79	Bodo saltans	33%	100%
A0A0S4J9T5	Bodo saltans	32%	100%
A0A0S4JBJ9	Bodo saltans	38%	100%
A0A0S4JDW3	Bodo saltans	36%	100%
A0A0S4JKI9	Bodo saltans	45%	100%
A0A0S4JR87	Bodo saltans	34%	100%
A0A0S4JVK4	Bodo saltans	34%	100%
A0A0S4KHE5	Bodo saltans	37%	100%
A0A1X0NKS6	Trypanosomatidae	27%	100%
A0A1X0NLK7	Trypanosomatidae	34%	100%
A0A1X0NLM1	Trypanosomatidae	35%	100%
A0A1X0NN55	Trypanosomatidae	27%	100%
A0A1X0NQ87	Trypanosomatidae	30%	78%
A0A1X0NQG4	Trypanosomatidae	27%	100%
A0A1X0NR18	Trypanosomatidae	30%	100%
A0A1X0NXM2	Trypanosomatidae	50%	85%
A0A1X0P706	Trypanosomatidae	33%	100%
A0A3Q8I8T8	Leishmania donovani	29%	100%
A0A3Q8ICX9	Leishmania donovani	32%	100%
A0A3Q8ID64	Leishmania donovani	35%	100%
A0A3Q8IE68	Leishmania donovani	35%	100%
A0A3Q8IK84	Leishmania donovani	33%	100%
A0A3R7KA22	Trypanosoma rangeli	31%	100%
A0A3R7LXW6	Trypanosoma rangeli	35%	100%
A0A3R7ME44	Trypanosoma rangeli	32%	100%
A0A3R7N3U0	Trypanosoma rangeli	29%	100%
A0A3R7N9V4	Trypanosoma rangeli	30%	100%
A0A3R7RHV7	Trypanosoma rangeli	29%	100%
A0A3R7RKC1	Trypanosoma rangeli	33%	100%
A0A3S5H4Z2	Leishmania donovani	37%	100%
A0A3S5H5Y5	Leishmania donovani	35%	100%
A0A3S5H6H3	Leishmania donovani	29%	100%
A0A3S7WRA9	Leishmania donovani	37%	100%
A0A3S7WUY8	Leishmania donovani	34%	100%
A0A3S7WV84	Leishmania donovani	39%	100%
A0A3S7X3D1	Leishmania donovani	31%	100%
A0A3S7X5J2	Leishmania donovani	32%	100%
A0A422P0L6	Trypanosoma rangeli	38%	100%
A1KXP5	Leishmania donovani	42%	100%
A4H506	Leishmania braziliensis	33%	100%
A4H679	Leishmania braziliensis	34%	100%
A4H6A4	Leishmania braziliensis	29%	100%
A4H6A5	Leishmania braziliensis	29%	100%
A4H9M3	Leishmania braziliensis	38%	100%
A4HBS6	Leishmania braziliensis	86%	99%
A4HEE8	Leishmania braziliensis	29%	100%
A4HFK0	Leishmania braziliensis	35%	100%
A4HHR8	Leishmania braziliensis	40%	100%
A4HIB4	Leishmania braziliensis	31%	100%
A4HK33	Leishmania braziliensis	33%	100%
A4HKH2	Leishmania braziliensis	31%	100%
A4HKJ3	Leishmania braziliensis	34%	100%
A4HLP5	Leishmania braziliensis	34%	100%
A4HRM3	Leishmania infantum	37%	100%
A4HT72	Leishmania infantum	35%	100%
A4HUK3	Leishmania infantum	37%	100%
A4HUM8	Leishmania infantum	29%	100%
A4HUM9	Leishmania infantum	29%	100%
A4HVF7	Leishmania infantum	42%	100%
A4HXY7	Leishmania infantum	39%	100%
A4HZ80	Leishmania infantum	100%	100%
A4I1I6	Leishmania infantum	30%	100%
A4I5J8	Leishmania infantum	31%	100%
A4I7N3	Leishmania infantum	32%	100%
A4I7Z9	Leishmania infantum	32%	100%
A4I825	Leishmania infantum	35%	100%
A4I946	Leishmania infantum	34%	100%
A5D7F5	Bos taurus	29%	100%
B1A5Z4	Leishmania donovani	30%	100%
B6DT76	Bodo saltans	34%	100%
C9ZQX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZVR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A3U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A5C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A6V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A9H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0AA91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E2RQ15	Canis lupus familiaris	34%	100%
E9AD53	Leishmania major	35%	100%
E9AGQ4	Leishmania infantum	34%	100%
E9AHE8	Leishmania infantum	35%	100%
E9AL68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ANA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9ANC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ANC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AP56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9ARQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AV47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AXM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AYX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B0U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B2H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B2W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B2Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B420	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
F1PTE3	Canis lupus familiaris	34%	100%
G4MYS1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	31%	100%
I1RMF2	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
O00194	Homo sapiens	35%	100%
O01803	Caenorhabditis elegans	34%	100%
P01123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P05714	Rattus norvegicus	30%	100%
P11620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P20338	Homo sapiens	30%	100%
P22125	Diplobatis ommata	33%	100%
P31582	Arabidopsis thaliana	39%	100%
P31583	Nicotiana plumbaginifolia	40%	100%
P33723	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	35%	100%
P34140	Dictyostelium discoideum	34%	100%
P35276	Mus musculus	33%	100%
P35280	Rattus norvegicus	29%	100%
P35282	Mus musculus	42%	100%
P35285	Mus musculus	37%	100%
P35286	Rattus norvegicus	34%	100%
P35288	Mus musculus	29%	100%
P35293	Mus musculus	36%	100%
P35294	Mus musculus	31%	100%
P36018	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P36862	Volvox carteri	34%	100%
P36863	Volvox carteri	29%	100%
P38555	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P46629	Oryctolagus cuniculus	35%	100%
P51146	Rattus norvegicus	32%	100%
P51996	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P55258	Mus musculus	29%	100%
P55745	Canis lupus familiaris	41%	100%
P56371	Mus musculus	31%	100%
P61017	Canis lupus familiaris	32%	100%
P61018	Homo sapiens	32%	100%
P61020	Homo sapiens	42%	100%
P61021	Mus musculus	42%	100%
P61028	Mus musculus	29%	100%
P62820	Homo sapiens	33%	100%
P62821	Mus musculus	33%	100%
P62822	Canis lupus familiaris	33%	100%
P70550	Rattus norvegicus	29%	100%
P92963	Arabidopsis thaliana	32%	100%
P93267	Mesembryanthemum crystallinum	32%	100%
Q01387	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	100%
Q01971	Oryctolagus cuniculus	30%	100%
Q14964	Homo sapiens	28%	100%
Q17QU4	Bos taurus	30%	100%
Q17R06	Bos taurus	41%	100%
Q2HJI8	Bos taurus	29%	100%
Q2TBH7	Bos taurus	31%	100%
Q38922	Arabidopsis thaliana	32%	100%
Q39570	Chlamydomonas reinhardtii	29%	100%
Q40191	Lotus japonicus	30%	100%
Q40194	Lotus japonicus	36%	100%
Q4Q404	Leishmania major	34%	100%
Q4Q573	Leishmania major	35%	100%
Q4Q595	Leishmania major	32%	100%
Q4Q5N4	Leishmania major	33%	100%
Q4Q7C3	Leishmania major	30%	100%
Q4Q9V1	Leishmania major	30%	100%
Q4QCD4	Leishmania major	95%	100%
Q4QDS9	Leishmania major	39%	100%
Q4QGD2	Leishmania major	42%	100%
Q4QH97	Leishmania major	29%	100%
Q4QH98	Leishmania major	29%	100%
Q4QHC3	Leishmania major	35%	100%
Q4QIN6	Leishmania major	35%	100%
Q52NJ2	Sus scrofa	33%	100%
Q5EB77	Rattus norvegicus	36%	100%
Q5KTJ6	Mesocricetus auratus	34%	100%
Q5M7U5	Rattus norvegicus	31%	100%
Q5R4W9	Pongo abelii	34%	100%
Q5RBG1	Pongo abelii	42%	100%
Q5RDE5	Pongo abelii	29%	100%
Q5ZHW4	Gallus gallus	41%	100%
Q63942	Rattus norvegicus	33%	100%
Q68EK7	Danio rerio	32%	100%
Q6AXT5	Rattus norvegicus	42%	100%
Q6GQP4	Rattus norvegicus	38%	100%
Q6IML7	Rattus norvegicus	28%	100%
Q6NYB7	Rattus norvegicus	33%	100%
Q6PHI9	Danio rerio	30%	100%
Q8BHC1	Mus musculus	32%	100%
Q8BHD0	Mus musculus	28%	100%
Q8CFP6	Mus musculus	28%	100%
Q8MXQ2	Dictyostelium discoideum	28%	100%
Q8WQ53	Geodia cydonium	40%	100%
Q91ZR1	Mus musculus	32%	100%
Q921E2	Mus musculus	38%	100%
Q948K6	Arabidopsis thaliana	32%	100%
Q96DA2	Homo sapiens	32%	100%
Q99P58	Mus musculus	36%	100%
Q9DD03	Mus musculus	34%	100%
Q9LNW1	Arabidopsis thaliana	31%	100%
Q9NP90	Homo sapiens	34%	100%
Q9NZQ0	Homo sapiens	29%	100%
Q9SMQ6	Arabidopsis thaliana	32%	100%
Q9UL25	Homo sapiens	41%	100%
Q9UL26	Homo sapiens	37%	100%
Q9ULC3	Homo sapiens	30%	100%
Q9XI98	Arabidopsis thaliana	35%	100%
Q9ZRE2	Arabidopsis thaliana	34%	100%
V5C2R1	Trypanosoma cruzi	33%	79%
V5D027	Trypanosoma cruzi	35%	100%
V5D9W7	Trypanosoma cruzi	39%	100%
V5DKQ7	Trypanosoma cruzi	30%	91%