NIMA-related kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBZ9_LEIDO

TriTrypDb:

LdBPK_211870.1 , LdCL_210024400 , LDHU3_21.2240

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBZ9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.552
CLV_C14_Caspase3-7	514	518	PF00656	0.748
CLV_C14_Caspase3-7	693	697	PF00656	0.662
CLV_NRD_NRD_1	122	124	PF00675	0.425
CLV_NRD_NRD_1	276	278	PF00675	0.638
CLV_NRD_NRD_1	294	296	PF00675	0.598
CLV_NRD_NRD_1	300	302	PF00675	0.486
CLV_NRD_NRD_1	332	334	PF00675	0.612
CLV_NRD_NRD_1	340	342	PF00675	0.494
CLV_NRD_NRD_1	352	354	PF00675	0.349
CLV_NRD_NRD_1	364	366	PF00675	0.505
CLV_NRD_NRD_1	400	402	PF00675	0.586
CLV_NRD_NRD_1	439	441	PF00675	0.565
CLV_NRD_NRD_1	492	494	PF00675	0.680
CLV_NRD_NRD_1	512	514	PF00675	0.462
CLV_NRD_NRD_1	518	520	PF00675	0.654
CLV_NRD_NRD_1	588	590	PF00675	0.783
CLV_NRD_NRD_1	658	660	PF00675	0.547
CLV_NRD_NRD_1	677	679	PF00675	0.419
CLV_PCSK_KEX2_1	122	124	PF00082	0.425
CLV_PCSK_KEX2_1	245	247	PF00082	0.398
CLV_PCSK_KEX2_1	276	278	PF00082	0.666
CLV_PCSK_KEX2_1	294	296	PF00082	0.566
CLV_PCSK_KEX2_1	300	302	PF00082	0.498
CLV_PCSK_KEX2_1	331	333	PF00082	0.615
CLV_PCSK_KEX2_1	340	342	PF00082	0.537
CLV_PCSK_KEX2_1	354	356	PF00082	0.400
CLV_PCSK_KEX2_1	399	401	PF00082	0.569
CLV_PCSK_KEX2_1	439	441	PF00082	0.565
CLV_PCSK_KEX2_1	512	514	PF00082	0.623
CLV_PCSK_KEX2_1	657	659	PF00082	0.482
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.438
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.534
CLV_PCSK_SKI1_1	103	107	PF00082	0.322
CLV_PCSK_SKI1_1	122	126	PF00082	0.314
CLV_PCSK_SKI1_1	127	131	PF00082	0.316
CLV_PCSK_SKI1_1	214	218	PF00082	0.319
CLV_PCSK_SKI1_1	259	263	PF00082	0.457
CLV_PCSK_SKI1_1	354	358	PF00082	0.556
CLV_PCSK_SKI1_1	493	497	PF00082	0.706
CLV_PCSK_SKI1_1	520	524	PF00082	0.665
CLV_PCSK_SKI1_1	680	684	PF00082	0.727
CLV_PCSK_SKI1_1	699	703	PF00082	0.502
CLV_PCSK_SKI1_1	726	730	PF00082	0.419
DEG_APCC_DBOX_1	258	266	PF00400	0.366
DEG_Nend_UBRbox_2	1	3	PF02207	0.452
DEG_SCF_FBW7_1	480	487	PF00400	0.757
DEG_SCF_FBW7_2	630	635	PF00400	0.769
DEG_SPOP_SBC_1	484	488	PF00917	0.765
DOC_CKS1_1	481	486	PF01111	0.760
DOC_CYCLIN_yCln2_LP_2	612	615	PF00134	0.549
DOC_MAPK_gen_1	127	136	PF00069	0.306
DOC_MAPK_gen_1	273	282	PF00069	0.636
DOC_MAPK_gen_1	340	350	PF00069	0.595
DOC_MAPK_MEF2A_6	721	729	PF00069	0.445
DOC_MAPK_MEF2A_6	73	80	PF00069	0.323
DOC_PP2B_LxvP_1	569	572	PF13499	0.665
DOC_PP2B_LxvP_1	602	605	PF13499	0.520
DOC_PP2B_LxvP_1	612	615	PF13499	0.584
DOC_PP4_FxxP_1	707	710	PF00568	0.609
DOC_USP7_MATH_1	247	251	PF00917	0.321
DOC_USP7_MATH_1	485	489	PF00917	0.757
DOC_USP7_MATH_1	547	551	PF00917	0.804
DOC_USP7_MATH_1	564	568	PF00917	0.772
DOC_USP7_MATH_1	694	698	PF00917	0.703
DOC_USP7_MATH_1	710	714	PF00917	0.619
DOC_USP7_MATH_1	789	793	PF00917	0.652
DOC_USP7_MATH_2	42	48	PF00917	0.306
DOC_USP7_UBL2_3	373	377	PF12436	0.672
DOC_USP7_UBL2_3	581	585	PF12436	0.772
DOC_USP7_UBL2_3	675	679	PF12436	0.642
DOC_USP7_UBL2_3	8	12	PF12436	0.396
DOC_WW_Pin1_4	163	168	PF00397	0.306
DOC_WW_Pin1_4	411	416	PF00397	0.735
DOC_WW_Pin1_4	480	485	PF00397	0.654
DOC_WW_Pin1_4	493	498	PF00397	0.651
DOC_WW_Pin1_4	543	548	PF00397	0.712
DOC_WW_Pin1_4	591	596	PF00397	0.705
DOC_WW_Pin1_4	603	608	PF00397	0.605
DOC_WW_Pin1_4	628	633	PF00397	0.713
DOC_WW_Pin1_4	647	652	PF00397	0.719
LIG_14-3-3_CanoR_1	154	158	PF00244	0.313
LIG_14-3-3_CanoR_1	233	239	PF00244	0.438
LIG_14-3-3_CanoR_1	246	255	PF00244	0.321
LIG_14-3-3_CanoR_1	276	280	PF00244	0.650
LIG_14-3-3_CanoR_1	534	543	PF00244	0.618
LIG_14-3-3_CanoR_1	678	683	PF00244	0.662
LIG_Actin_WH2_2	145	162	PF00022	0.306
LIG_Actin_WH2_2	204	219	PF00022	0.321
LIG_Actin_WH2_2	28	43	PF00022	0.396
LIG_AP2alpha_1	682	686	PF02296	0.672
LIG_APCC_ABBA_1	725	730	PF00400	0.417
LIG_APCC_ABBAyCdc20_2	122	128	PF00400	0.298
LIG_BRCT_BRCA1_1	504	508	PF00533	0.715
LIG_FHA_1	129	135	PF00498	0.321
LIG_FHA_1	154	160	PF00498	0.320
LIG_FHA_1	62	68	PF00498	0.306
LIG_FHA_1	704	710	PF00498	0.516
LIG_FHA_1	713	719	PF00498	0.468
LIG_FHA_2	494	500	PF00498	0.676
LIG_FHA_2	535	541	PF00498	0.771
LIG_FHA_2	650	656	PF00498	0.643
LIG_LIR_Apic_2	166	172	PF02991	0.306
LIG_LIR_Apic_2	706	710	PF02991	0.618
LIG_LIR_Gen_1	2	10	PF02991	0.330
LIG_LIR_Gen_1	660	670	PF02991	0.453
LIG_LIR_Gen_1	75	83	PF02991	0.341
LIG_LIR_Nem_3	2	7	PF02991	0.306
LIG_LIR_Nem_3	660	666	PF02991	0.467
LIG_LIR_Nem_3	87	92	PF02991	0.306
LIG_LYPXL_S_1	219	223	PF13949	0.321
LIG_LYPXL_yS_3	220	223	PF13949	0.306
LIG_MAD2	214	222	PF02301	0.306
LIG_PCNA_yPIPBox_3	209	220	PF02747	0.327
LIG_PDZ_Class_2	795	800	PF00595	0.521
LIG_Pex14_2	15	19	PF04695	0.306
LIG_Pex14_2	682	686	PF04695	0.672
LIG_SH2_CRK	4	8	PF00017	0.365
LIG_SH2_CRK	89	93	PF00017	0.306
LIG_SH2_GRB2like	82	85	PF00017	0.341
LIG_SH2_SRC	66	69	PF00017	0.306
LIG_SH2_SRC	82	85	PF00017	0.306
LIG_SH2_STAP1	227	231	PF00017	0.331
LIG_SH2_STAT5	169	172	PF00017	0.306
LIG_SH2_STAT5	4	7	PF00017	0.311
LIG_SH2_STAT5	490	493	PF00017	0.699
LIG_SH2_STAT5	66	69	PF00017	0.306
LIG_SH3_3	216	222	PF00018	0.341
LIG_SH3_3	472	478	PF00018	0.684
LIG_SH3_3	530	536	PF00018	0.584
LIG_SH3_3	557	563	PF00018	0.723
LIG_SH3_3	608	614	PF00018	0.761
LIG_SH3_4	581	588	PF00018	0.702
LIG_SUMO_SIM_par_1	250	256	PF11976	0.320
LIG_SUMO_SIM_par_1	278	284	PF11976	0.661
LIG_TRAF2_1	281	284	PF00917	0.581
LIG_TRAF2_1	349	352	PF00917	0.572
LIG_TRAF2_1	496	499	PF00917	0.663
LIG_TRAF2_1	576	579	PF00917	0.683
LIG_UBA3_1	238	245	PF00899	0.365
LIG_WW_3	479	483	PF00397	0.754
MOD_CK1_1	14	20	PF00069	0.306
MOD_CK1_1	229	235	PF00069	0.336
MOD_CK1_1	278	284	PF00069	0.635
MOD_CK1_1	546	552	PF00069	0.778
MOD_CK1_1	556	562	PF00069	0.724
MOD_CK1_1	791	797	PF00069	0.698
MOD_CK2_1	278	284	PF00069	0.629
MOD_CK2_1	427	433	PF00069	0.636
MOD_CK2_1	493	499	PF00069	0.685
MOD_CK2_1	534	540	PF00069	0.775
MOD_CK2_1	647	653	PF00069	0.651
MOD_CK2_1	748	754	PF00069	0.656
MOD_GlcNHglycan	16	19	PF01048	0.307
MOD_GlcNHglycan	428	432	PF01048	0.607
MOD_GlcNHglycan	46	49	PF01048	0.306
MOD_GlcNHglycan	468	473	PF01048	0.716
MOD_GlcNHglycan	537	540	PF01048	0.733
MOD_GlcNHglycan	553	556	PF01048	0.751
MOD_GlcNHglycan	573	576	PF01048	0.628
MOD_GlcNHglycan	712	715	PF01048	0.650
MOD_GlcNHglycan	748	751	PF01048	0.628
MOD_GlcNHglycan	760	763	PF01048	0.612
MOD_GlcNHglycan	791	794	PF01048	0.704
MOD_GlcNHglycan	795	798	PF01048	0.527
MOD_GSK3_1	159	166	PF00069	0.312
MOD_GSK3_1	225	232	PF00069	0.330
MOD_GSK3_1	407	414	PF00069	0.778
MOD_GSK3_1	480	487	PF00069	0.760
MOD_GSK3_1	489	496	PF00069	0.749
MOD_GSK3_1	543	550	PF00069	0.777
MOD_GSK3_1	591	598	PF00069	0.740
MOD_GSK3_1	787	794	PF00069	0.648
MOD_N-GLC_1	181	186	PF02516	0.306
MOD_N-GLC_1	229	234	PF02516	0.341
MOD_N-GLC_1	247	252	PF02516	0.341
MOD_N-GLC_1	61	66	PF02516	0.306
MOD_N-GLC_1	710	715	PF02516	0.613
MOD_N-GLC_1	746	751	PF02516	0.602
MOD_NEK2_1	114	119	PF00069	0.442
MOD_NEK2_1	147	152	PF00069	0.306
MOD_NEK2_1	159	164	PF00069	0.321
MOD_NEK2_1	203	208	PF00069	0.430
MOD_NEK2_1	226	231	PF00069	0.376
MOD_NEK2_1	234	239	PF00069	0.338
MOD_NEK2_1	253	258	PF00069	0.407
MOD_NEK2_1	54	59	PF00069	0.438
MOD_NEK2_2	450	455	PF00069	0.656
MOD_PIKK_1	107	113	PF00454	0.321
MOD_PIKK_1	128	134	PF00454	0.306
MOD_PIKK_1	2	8	PF00454	0.387
MOD_PIKK_1	247	253	PF00454	0.341
MOD_PIKK_1	459	465	PF00454	0.734
MOD_PIKK_1	502	508	PF00454	0.696
MOD_PK_1	553	559	PF00069	0.585
MOD_PKA_1	678	684	PF00069	0.593
MOD_PKA_2	153	159	PF00069	0.306
MOD_PKA_2	275	281	PF00069	0.642
MOD_PKA_2	44	50	PF00069	0.312
MOD_PKA_2	450	456	PF00069	0.710
MOD_Plk_1	194	200	PF00069	0.306
MOD_Plk_1	229	235	PF00069	0.396
MOD_Plk_1	247	253	PF00069	0.341
MOD_Plk_1	468	474	PF00069	0.579
MOD_Plk_1	61	67	PF00069	0.315
MOD_Plk_1	695	701	PF00069	0.641
MOD_Plk_4	114	120	PF00069	0.451
MOD_Plk_4	148	154	PF00069	0.322
MOD_Plk_4	234	240	PF00069	0.349
MOD_Plk_4	253	259	PF00069	0.416
MOD_Plk_4	450	456	PF00069	0.726
MOD_Plk_4	665	671	PF00069	0.470
MOD_Plk_4	72	78	PF00069	0.345
MOD_ProDKin_1	163	169	PF00069	0.306
MOD_ProDKin_1	411	417	PF00069	0.729
MOD_ProDKin_1	480	486	PF00069	0.658
MOD_ProDKin_1	493	499	PF00069	0.647
MOD_ProDKin_1	543	549	PF00069	0.713
MOD_ProDKin_1	591	597	PF00069	0.704
MOD_ProDKin_1	603	609	PF00069	0.603
MOD_ProDKin_1	628	634	PF00069	0.707
MOD_ProDKin_1	647	653	PF00069	0.713
MOD_SUMO_rev_2	347	356	PF00179	0.598
MOD_SUMO_rev_2	372	378	PF00179	0.551
MOD_SUMO_rev_2	573	583	PF00179	0.705
MOD_SUMO_rev_2	672	681	PF00179	0.507
MOD_SUMO_rev_2	68	75	PF00179	0.442
MOD_SUMO_rev_2	697	707	PF00179	0.635
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.440
TRG_ENDOCYTIC_2	220	223	PF00928	0.312
TRG_ENDOCYTIC_2	4	7	PF00928	0.310
TRG_ENDOCYTIC_2	435	438	PF00928	0.575
TRG_ENDOCYTIC_2	663	666	PF00928	0.432
TRG_ENDOCYTIC_2	742	745	PF00928	0.456
TRG_ENDOCYTIC_2	89	92	PF00928	0.337
TRG_ER_diArg_1	122	124	PF00400	0.423
TRG_ER_diArg_1	299	301	PF00400	0.549
TRG_ER_diArg_1	331	333	PF00400	0.617
TRG_ER_diArg_1	340	342	PF00400	0.595
TRG_ER_diArg_1	399	401	PF00400	0.603
TRG_ER_diArg_1	438	440	PF00400	0.574
TRG_ER_diArg_1	511	513	PF00400	0.602
TRG_ER_diArg_1	657	659	PF00400	0.603
TRG_NES_CRM1_1	260	275	PF08389	0.476
TRG_NES_CRM1_1	716	730	PF08389	0.451
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W7	Leptomonas seymouri	65%	100%
A0A0S4JKY4	Bodo saltans	45%	100%
A0A1X0NHD4	Trypanosomatidae	48%	100%
A0A3R7M6Z7	Trypanosoma rangeli	47%	100%
A4HC09	Leishmania braziliensis	84%	100%
A4HZM2	Leishmania infantum	100%	100%
D0A118	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AVE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QC33	Leishmania major	96%	100%
V5BLW4	Trypanosoma cruzi	49%	100%