Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBZ6_LEIDO

TriTrypDb:

LdBPK_301730.1 , LdCL_300022600 , LDHU3_30.2410

Length:

391

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.558
CLV_NRD_NRD_1	199	201	PF00675	0.674
CLV_NRD_NRD_1	358	360	PF00675	0.561
CLV_NRD_NRD_1	54	56	PF00675	0.763
CLV_PCSK_KEX2_1	199	201	PF00082	0.784
CLV_PCSK_KEX2_1	54	56	PF00082	0.763
CLV_PCSK_SKI1_1	171	175	PF00082	0.654
CLV_PCSK_SKI1_1	301	305	PF00082	0.569
DEG_APCC_KENBOX_2	128	132	PF00400	0.522
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DOC_CYCLIN_RxL_1	117	130	PF00134	0.464
DOC_CYCLIN_RxL_1	217	228	PF00134	0.651
DOC_MAPK_MEF2A_6	374	383	PF00069	0.560
DOC_PP1_RVXF_1	121	128	PF00149	0.576
DOC_USP7_MATH_1	113	117	PF00917	0.488
DOC_USP7_MATH_1	162	166	PF00917	0.561
DOC_USP7_MATH_1	202	206	PF00917	0.733
DOC_USP7_MATH_1	48	52	PF00917	0.698
DOC_USP7_MATH_2	175	181	PF00917	0.524
DOC_WW_Pin1_4	171	176	PF00397	0.540
DOC_WW_Pin1_4	183	188	PF00397	0.665
DOC_WW_Pin1_4	211	216	PF00397	0.610
LIG_14-3-3_CanoR_1	110	118	PF00244	0.558
LIG_14-3-3_CanoR_1	121	126	PF00244	0.480
LIG_14-3-3_CanoR_1	226	233	PF00244	0.710
LIG_14-3-3_CanoR_1	294	298	PF00244	0.606
LIG_14-3-3_CanoR_1	301	310	PF00244	0.471
LIG_14-3-3_CanoR_1	352	357	PF00244	0.575
LIG_14-3-3_CanoR_1	37	43	PF00244	0.644
LIG_AP2alpha_2	9	11	PF02296	0.503
LIG_BIR_III_2	35	39	PF00653	0.619
LIG_BRCT_BRCA1_1	123	127	PF00533	0.535
LIG_BRCT_BRCA1_1	237	241	PF00533	0.491
LIG_BRCT_BRCA1_2	123	129	PF00533	0.536
LIG_CtBP_PxDLS_1	215	219	PF00389	0.593
LIG_FHA_1	176	182	PF00498	0.708
LIG_FHA_1	269	275	PF00498	0.758
LIG_FHA_1	340	346	PF00498	0.510
LIG_FHA_1	351	357	PF00498	0.591
LIG_FHA_1	48	54	PF00498	0.757
LIG_FHA_2	172	178	PF00498	0.611
LIG_FHA_2	212	218	PF00498	0.634
LIG_FHA_2	278	284	PF00498	0.696
LIG_FHA_2	309	315	PF00498	0.565
LIG_FHA_2	353	359	PF00498	0.505
LIG_LIR_Gen_1	17	24	PF02991	0.552
LIG_LIR_Gen_1	238	247	PF02991	0.457
LIG_LIR_Gen_1	385	390	PF02991	0.366
LIG_LIR_Nem_3	17	23	PF02991	0.526
LIG_LIR_Nem_3	238	244	PF02991	0.471
LIG_LIR_Nem_3	385	389	PF02991	0.362
LIG_PCNA_yPIPBox_3	196	210	PF02747	0.613
LIG_SH2_CRK	386	390	PF00017	0.368
LIG_SH2_NCK_1	7	11	PF00017	0.504
LIG_SH2_SRC	20	23	PF00017	0.648
LIG_SH2_SRC	7	10	PF00017	0.603
LIG_SH2_STAP1	20	24	PF00017	0.604
LIG_SH2_STAP1	386	390	PF00017	0.368
LIG_SH2_STAP1	90	94	PF00017	0.426
LIG_SH3_3	184	190	PF00018	0.695
LIG_SH3_3	285	291	PF00018	0.697
LIG_SUMO_SIM_anti_2	154	161	PF11976	0.391
LIG_SUMO_SIM_par_1	214	219	PF11976	0.573
LIG_TRAF2_1	152	155	PF00917	0.490
LIG_TRAF2_1	311	314	PF00917	0.502
LIG_TYR_ITIM	18	23	PF00017	0.524
LIG_Vh1_VBS_1	146	164	PF01044	0.542
MOD_CK1_1	225	231	PF00069	0.704
MOD_CK1_1	234	240	PF00069	0.603
MOD_CK1_1	268	274	PF00069	0.643
MOD_CK1_1	293	299	PF00069	0.604
MOD_CK2_1	101	107	PF00069	0.536
MOD_CK2_1	113	119	PF00069	0.421
MOD_CK2_1	148	154	PF00069	0.557
MOD_CK2_1	171	177	PF00069	0.721
MOD_CK2_1	211	217	PF00069	0.634
MOD_CK2_1	277	283	PF00069	0.704
MOD_CK2_1	308	314	PF00069	0.569
MOD_GlcNHglycan	150	153	PF01048	0.604
MOD_GlcNHglycan	165	168	PF01048	0.505
MOD_GlcNHglycan	2	5	PF01048	0.637
MOD_GlcNHglycan	211	214	PF01048	0.524
MOD_GlcNHglycan	386	389	PF01048	0.421
MOD_GlcNHglycan	50	53	PF01048	0.741
MOD_GlcNHglycan	61	64	PF01048	0.568
MOD_GlcNHglycan	79	82	PF01048	0.617
MOD_GSK3_1	109	116	PF00069	0.494
MOD_GSK3_1	117	124	PF00069	0.478
MOD_GSK3_1	171	178	PF00069	0.573
MOD_GSK3_1	218	225	PF00069	0.700
MOD_GSK3_1	231	238	PF00069	0.595
MOD_GSK3_1	274	281	PF00069	0.609
MOD_GSK3_1	289	296	PF00069	0.566
MOD_GSK3_1	38	45	PF00069	0.709
MOD_GSK3_1	71	78	PF00069	0.708
MOD_N-GLC_1	202	207	PF02516	0.588
MOD_NEK2_1	101	106	PF00069	0.387
MOD_NEK2_1	176	181	PF00069	0.700
MOD_NEK2_1	209	214	PF00069	0.724
MOD_NEK2_1	216	221	PF00069	0.566
MOD_NEK2_1	222	227	PF00069	0.526
MOD_NEK2_1	332	337	PF00069	0.511
MOD_NEK2_2	71	76	PF00069	0.728
MOD_PIKK_1	194	200	PF00454	0.690
MOD_PIKK_1	296	302	PF00454	0.686
MOD_PIKK_1	315	321	PF00454	0.428
MOD_PIKK_1	332	338	PF00454	0.551
MOD_PKA_1	54	60	PF00069	0.590
MOD_PKA_2	109	115	PF00069	0.521
MOD_PKA_2	162	168	PF00069	0.446
MOD_PKA_2	225	231	PF00069	0.765
MOD_PKA_2	293	299	PF00069	0.641
MOD_PKA_2	38	44	PF00069	0.642
MOD_PKA_2	53	59	PF00069	0.652
MOD_PKB_1	121	129	PF00069	0.454
MOD_PKB_1	350	358	PF00069	0.519
MOD_Plk_1	176	182	PF00069	0.721
MOD_Plk_1	202	208	PF00069	0.565
MOD_Plk_2-3	177	183	PF00069	0.529
MOD_Plk_4	265	271	PF00069	0.685
MOD_Plk_4	71	77	PF00069	0.604
MOD_ProDKin_1	171	177	PF00069	0.545
MOD_ProDKin_1	183	189	PF00069	0.667
MOD_ProDKin_1	211	217	PF00069	0.609
MOD_SUMO_rev_2	366	376	PF00179	0.513
MOD_SUMO_rev_2	95	104	PF00179	0.454
TRG_DiLeu_BaEn_1	155	160	PF01217	0.573
TRG_DiLeu_BaEn_3	155	161	PF01217	0.500
TRG_DiLeu_BaEn_3	370	376	PF01217	0.334
TRG_ENDOCYTIC_2	20	23	PF00928	0.531
TRG_ENDOCYTIC_2	386	389	PF00928	0.362
TRG_ER_diArg_1	142	145	PF00400	0.583
TRG_ER_diArg_1	351	354	PF00400	0.575
TRG_ER_diArg_1	53	55	PF00400	0.591
TRG_NLS_MonoExtN_4	359	364	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	325	330	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I207	Leptomonas seymouri	41%	100%
A0A1X0P1T9	Trypanosomatidae	26%	100%
A0A422P3J4	Trypanosoma rangeli	28%	100%
A4HIB6	Leishmania braziliensis	68%	100%
A4I5K0	Leishmania infantum	100%	100%
E9B0U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q7C1	Leishmania major	90%	100%
V5B8Y5	Trypanosoma cruzi	28%	100%