Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglucomutase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBZ3_LEIDO

TriTrypDb:

LdBPK_210700.1 , LdCL_210011900 , LDHU3_21.0760

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8IBZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBZ3

PDB structure(s): 4qg5_A , 4qg5_B , 4qg5_C , 4qg5_D

Function

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Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11

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Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	11
GO:0003824	catalytic activity	1	11
GO:0004614	phosphoglucomutase activity	5	11
GO:0005488	binding	1	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0016868	intramolecular transferase activity, phosphotransferases	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.510
CLV_NRD_NRD_1	101	103	PF00675	0.427
CLV_NRD_NRD_1	106	108	PF00675	0.427
CLV_NRD_NRD_1	18	20	PF00675	0.409
CLV_NRD_NRD_1	581	583	PF00675	0.651
CLV_NRD_NRD_1	79	81	PF00675	0.503
CLV_PCSK_FUR_1	99	103	PF00082	0.405
CLV_PCSK_KEX2_1	425	427	PF00082	0.521
CLV_PCSK_KEX2_1	79	81	PF00082	0.451
CLV_PCSK_KEX2_1	99	101	PF00082	0.435

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD7	Leptomonas seymouri	78%	99%
A0A0S4IYR2	Bodo saltans	60%	100%
A0A1X0NXZ7	Trypanosomatidae	64%	100%
A0A3S5IR70	Trypanosoma rangeli	61%	100%
A4HBR1	Leishmania braziliensis	90%	100%
A4HZ63	Leishmania infantum	100%	100%
D3ZVR9	Rattus norvegicus	43%	100%
E9AV30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O02606	Paramecium tetraurelia	48%	100%
O15820	Entamoeba histolytica	45%	100%

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