Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IBZ0_LEIDO

TriTrypDb:

LdBPK_211620.1 , LdCL_210021800 , LDHU3_21.1920

Length:

1049

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IBZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.714
CLV_C14_Caspase3-7	558	562	PF00656	0.698
CLV_C14_Caspase3-7	717	721	PF00656	0.679
CLV_NRD_NRD_1	140	142	PF00675	0.438
CLV_NRD_NRD_1	4	6	PF00675	0.475
CLV_NRD_NRD_1	495	497	PF00675	0.509
CLV_NRD_NRD_1	75	77	PF00675	0.574
CLV_NRD_NRD_1	891	893	PF00675	0.521
CLV_NRD_NRD_1	984	986	PF00675	0.480
CLV_PCSK_KEX2_1	140	142	PF00082	0.438
CLV_PCSK_KEX2_1	494	496	PF00082	0.509
CLV_PCSK_KEX2_1	75	77	PF00082	0.549
CLV_PCSK_KEX2_1	891	893	PF00082	0.521
CLV_PCSK_KEX2_1	925	927	PF00082	0.423
CLV_PCSK_KEX2_1	984	986	PF00082	0.478
CLV_PCSK_PC1ET2_1	925	927	PF00082	0.423
CLV_PCSK_SKI1_1	1013	1017	PF00082	0.514
CLV_PCSK_SKI1_1	140	144	PF00082	0.482
CLV_PCSK_SKI1_1	19	23	PF00082	0.447
CLV_PCSK_SKI1_1	232	236	PF00082	0.482
CLV_PCSK_SKI1_1	261	265	PF00082	0.460
CLV_PCSK_SKI1_1	424	428	PF00082	0.472
CLV_PCSK_SKI1_1	802	806	PF00082	0.545
CLV_PCSK_SKI1_1	929	933	PF00082	0.400
DEG_Nend_UBRbox_2	1	3	PF02207	0.739
DEG_SCF_FBW7_1	158	165	PF00400	0.636
DEG_SCF_FBW7_1	354	361	PF00400	0.753
DEG_SCF_FBW7_1	853	860	PF00400	0.713
DEG_SCF_FBW7_2	334	341	PF00400	0.671
DEG_SPOP_SBC_1	453	457	PF00917	0.660
DEG_SPOP_SBC_1	754	758	PF00917	0.670
DEG_SPOP_SBC_1	768	772	PF00917	0.665
DOC_CDC14_PxL_1	64	72	PF14671	0.469
DOC_CKS1_1	1007	1012	PF01111	0.714
DOC_CKS1_1	159	164	PF01111	0.635
DOC_CKS1_1	335	340	PF01111	0.672
DOC_CYCLIN_RxL_1	432	442	PF00134	0.715
DOC_CYCLIN_RxL_1	925	936	PF00134	0.596
DOC_CYCLIN_yClb1_LxF_4	800	805	PF00134	0.662
DOC_MAPK_gen_1	140	146	PF00069	0.651
DOC_MAPK_gen_1	217	225	PF00069	0.618
DOC_MAPK_gen_1	258	268	PF00069	0.597
DOC_MAPK_gen_1	75	84	PF00069	0.272
DOC_MAPK_gen_1	799	808	PF00069	0.666
DOC_MAPK_gen_1	925	935	PF00069	0.613
DOC_MAPK_gen_1	989	998	PF00069	0.638
DOC_MAPK_HePTP_8	72	84	PF00069	0.358
DOC_MAPK_JIP1_4	799	805	PF00069	0.662
DOC_MAPK_MEF2A_6	19	27	PF00069	0.662
DOC_MAPK_MEF2A_6	258	266	PF00069	0.594
DOC_MAPK_MEF2A_6	75	84	PF00069	0.272
DOC_MAPK_MEF2A_6	802	810	PF00069	0.668
DOC_MAPK_MEF2A_6	926	935	PF00069	0.571
DOC_MAPK_NFAT4_5	261	269	PF00069	0.600
DOC_MAPK_RevD_3	62	76	PF00069	0.411
DOC_PP1_RVXF_1	800	806	PF00149	0.666
DOC_PP2B_LxvP_1	332	335	PF13499	0.676
DOC_PP4_FxxP_1	351	354	PF00568	0.744
DOC_PP4_FxxP_1	781	784	PF00568	0.673
DOC_PP4_FxxP_1	924	927	PF00568	0.612
DOC_USP7_MATH_1	1008	1012	PF00917	0.656
DOC_USP7_MATH_1	162	166	PF00917	0.743
DOC_USP7_MATH_1	179	183	PF00917	0.628
DOC_USP7_MATH_1	289	293	PF00917	0.674
DOC_USP7_MATH_1	294	298	PF00917	0.657
DOC_USP7_MATH_1	358	362	PF00917	0.704
DOC_USP7_MATH_1	37	41	PF00917	0.616
DOC_USP7_MATH_1	501	505	PF00917	0.664
DOC_USP7_MATH_1	598	602	PF00917	0.715
DOC_USP7_MATH_1	610	614	PF00917	0.692
DOC_USP7_MATH_1	643	647	PF00917	0.657
DOC_USP7_MATH_1	653	657	PF00917	0.673
DOC_USP7_MATH_1	754	758	PF00917	0.747
DOC_USP7_MATH_1	857	861	PF00917	0.722
DOC_USP7_MATH_1	882	886	PF00917	0.704
DOC_USP7_MATH_2	716	722	PF00917	0.663
DOC_USP7_UBL2_3	925	929	PF12436	0.605
DOC_WW_Pin1_4	1006	1011	PF00397	0.727
DOC_WW_Pin1_4	158	163	PF00397	0.637
DOC_WW_Pin1_4	334	339	PF00397	0.727
DOC_WW_Pin1_4	354	359	PF00397	0.757
DOC_WW_Pin1_4	483	488	PF00397	0.693
DOC_WW_Pin1_4	581	586	PF00397	0.705
DOC_WW_Pin1_4	764	769	PF00397	0.685
DOC_WW_Pin1_4	853	858	PF00397	0.741
DOC_WW_Pin1_4	883	888	PF00397	0.739
DOC_WW_Pin1_4	892	897	PF00397	0.693
LIG_14-3-3_CanoR_1	1022	1028	PF00244	0.698
LIG_14-3-3_CanoR_1	1035	1039	PF00244	0.602
LIG_14-3-3_CanoR_1	106	116	PF00244	0.633
LIG_14-3-3_CanoR_1	140	145	PF00244	0.679
LIG_14-3-3_CanoR_1	154	159	PF00244	0.632
LIG_14-3-3_CanoR_1	172	176	PF00244	0.580
LIG_14-3-3_CanoR_1	261	267	PF00244	0.646
LIG_14-3-3_CanoR_1	314	320	PF00244	0.720
LIG_14-3-3_CanoR_1	424	433	PF00244	0.721
LIG_14-3-3_CanoR_1	494	501	PF00244	0.675
LIG_APCC_ABBA_1	633	638	PF00400	0.622
LIG_APCC_ABBAyCdc20_2	1043	1049	PF00400	0.568
LIG_BIR_III_4	15	19	PF00653	0.620
LIG_BRCT_BRCA1_1	264	268	PF00533	0.601
LIG_BRCT_BRCA1_1	296	300	PF00533	0.636
LIG_BRCT_BRCA1_1	626	630	PF00533	0.568
LIG_BRCT_BRCA1_1	676	680	PF00533	0.653
LIG_Clathr_ClatBox_1	634	638	PF01394	0.624
LIG_deltaCOP1_diTrp_1	218	221	PF00928	0.605
LIG_DLG_GKlike_1	785	793	PF00625	0.669
LIG_FHA_1	137	143	PF00498	0.701
LIG_FHA_1	20	26	PF00498	0.679
LIG_FHA_1	210	216	PF00498	0.618
LIG_FHA_1	345	351	PF00498	0.778
LIG_FHA_1	373	379	PF00498	0.750
LIG_FHA_1	508	514	PF00498	0.688
LIG_FHA_1	52	58	PF00498	0.321
LIG_FHA_1	630	636	PF00498	0.608
LIG_FHA_1	665	671	PF00498	0.588
LIG_FHA_1	896	902	PF00498	0.653
LIG_FHA_2	133	139	PF00498	0.612
LIG_FHA_2	159	165	PF00498	0.665
LIG_FHA_2	355	361	PF00498	0.734
LIG_FHA_2	697	703	PF00498	0.646
LIG_FHA_2	739	745	PF00498	0.620
LIG_FHA_2	834	840	PF00498	0.709
LIG_FHA_2	912	918	PF00498	0.569
LIG_Integrin_RGD_1	742	744	PF01839	0.456
LIG_IRF3_LxIS_1	249	255	PF10401	0.613
LIG_IRF3_LxIS_1	541	548	PF10401	0.673
LIG_LIR_Apic_2	348	354	PF02991	0.740
LIG_LIR_Apic_2	921	927	PF02991	0.605
LIG_LIR_Gen_1	265	276	PF02991	0.605
LIG_LIR_Gen_1	47	57	PF02991	0.296
LIG_LIR_Gen_1	627	637	PF02991	0.596
LIG_LIR_Nem_3	1041	1045	PF02991	0.581
LIG_LIR_Nem_3	218	222	PF02991	0.599
LIG_LIR_Nem_3	265	271	PF02991	0.604
LIG_LIR_Nem_3	47	52	PF02991	0.296
LIG_LIR_Nem_3	627	633	PF02991	0.595
LIG_LIR_Nem_3	677	683	PF02991	0.638
LIG_MLH1_MIPbox_1	264	268	PF16413	0.601
LIG_MYND_3	899	903	PF01753	0.631
LIG_NRBOX	221	227	PF00104	0.627
LIG_Pex14_2	45	49	PF04695	0.270
LIG_PTAP_UEV_1	321	326	PF05743	0.699
LIG_PTB_Apo_2	38	45	PF02174	0.610
LIG_SH2_PTP2	71	74	PF00017	0.361
LIG_SH2_PTP2	81	84	PF00017	0.325
LIG_SH2_STAP1	657	661	PF00017	0.654
LIG_SH2_STAT3	649	652	PF00017	0.588
LIG_SH2_STAT3	99	102	PF00017	0.443
LIG_SH2_STAT5	125	128	PF00017	0.604
LIG_SH2_STAT5	267	270	PF00017	0.600
LIG_SH2_STAT5	665	668	PF00017	0.626
LIG_SH2_STAT5	687	690	PF00017	0.661
LIG_SH2_STAT5	71	74	PF00017	0.358
LIG_SH2_STAT5	710	713	PF00017	0.654
LIG_SH2_STAT5	81	84	PF00017	0.304
LIG_SH3_1	156	162	PF00018	0.660
LIG_SH3_1	710	716	PF00018	0.642
LIG_SH3_3	156	162	PF00018	0.660
LIG_SH3_3	20	26	PF00018	0.662
LIG_SH3_3	234	240	PF00018	0.686
LIG_SH3_3	319	325	PF00018	0.740
LIG_SH3_3	332	338	PF00018	0.731
LIG_SH3_3	388	394	PF00018	0.738
LIG_SH3_3	406	412	PF00018	0.644
LIG_SH3_3	606	612	PF00018	0.686
LIG_SH3_3	62	68	PF00018	0.325
LIG_SH3_3	710	716	PF00018	0.650
LIG_SH3_3	732	738	PF00018	0.666
LIG_SH3_3	806	812	PF00018	0.714
LIG_SH3_3	81	87	PF00018	0.369
LIG_SUMO_SIM_anti_2	928	934	PF11976	0.560
LIG_SUMO_SIM_anti_2	995	1000	PF11976	0.638
LIG_SxIP_EBH_1	492	506	PF03271	0.682
LIG_TRAF2_1	161	164	PF00917	0.687
LIG_TRAF2_1	370	373	PF00917	0.729
LIG_TRAF2_1	416	419	PF00917	0.681
LIG_UBA3_1	222	228	PF00899	0.600
LIG_UBA3_1	284	291	PF00899	0.620
LIG_UBA3_1	30	34	PF00899	0.632
LIG_UBA3_1	685	692	PF00899	0.633
LIG_WRC_WIRS_1	268	273	PF05994	0.605
LIG_WRC_WIRS_1	786	791	PF05994	0.653
LIG_WW_1	68	71	PF00397	0.346
MOD_CDK_SPK_2	585	590	PF00069	0.687
MOD_CDK_SPxK_1	769	775	PF00069	0.695
MOD_CDK_SPxxK_3	1006	1013	PF00069	0.699
MOD_CDK_SPxxK_3	585	592	PF00069	0.676
MOD_CK1_1	1023	1029	PF00069	0.699
MOD_CK1_1	171	177	PF00069	0.713
MOD_CK1_1	349	355	PF00069	0.720
MOD_CK1_1	376	382	PF00069	0.744
MOD_CK1_1	40	46	PF00069	0.633
MOD_CK1_1	403	409	PF00069	0.721
MOD_CK1_1	459	465	PF00069	0.747
MOD_CK1_1	482	488	PF00069	0.663
MOD_CK1_1	584	590	PF00069	0.705
MOD_CK1_1	672	678	PF00069	0.657
MOD_CK1_1	757	763	PF00069	0.679
MOD_CK1_1	767	773	PF00069	0.685
MOD_CK1_1	855	861	PF00069	0.736
MOD_CK1_1	895	901	PF00069	0.694
MOD_CK1_1	959	965	PF00069	0.811
MOD_CK1_1	966	972	PF00069	0.704
MOD_CK2_1	132	138	PF00069	0.635
MOD_CK2_1	158	164	PF00069	0.675
MOD_CK2_1	342	348	PF00069	0.754
MOD_CK2_1	354	360	PF00069	0.724
MOD_CK2_1	454	460	PF00069	0.749
MOD_CK2_1	696	702	PF00069	0.646
MOD_CK2_1	833	839	PF00069	0.702
MOD_CK2_1	882	888	PF00069	0.736
MOD_CK2_1	911	917	PF00069	0.561
MOD_Cter_Amidation	492	495	PF01082	0.473
MOD_DYRK1A_RPxSP_1	892	896	PF00069	0.639
MOD_GlcNHglycan	1004	1007	PF01048	0.442
MOD_GlcNHglycan	109	112	PF01048	0.402
MOD_GlcNHglycan	163	167	PF01048	0.492
MOD_GlcNHglycan	183	186	PF01048	0.462
MOD_GlcNHglycan	297	300	PF01048	0.486
MOD_GlcNHglycan	322	325	PF01048	0.492
MOD_GlcNHglycan	366	369	PF01048	0.536
MOD_GlcNHglycan	418	423	PF01048	0.589
MOD_GlcNHglycan	429	432	PF01048	0.478
MOD_GlcNHglycan	456	459	PF01048	0.518
MOD_GlcNHglycan	481	484	PF01048	0.526
MOD_GlcNHglycan	547	550	PF01048	0.486
MOD_GlcNHglycan	557	560	PF01048	0.476
MOD_GlcNHglycan	605	608	PF01048	0.506
MOD_GlcNHglycan	641	644	PF01048	0.425
MOD_GlcNHglycan	658	662	PF01048	0.548
MOD_GlcNHglycan	839	843	PF01048	0.501
MOD_GlcNHglycan	848	851	PF01048	0.518
MOD_GlcNHglycan	859	862	PF01048	0.456
MOD_GlcNHglycan	871	874	PF01048	0.500
MOD_GSK3_1	1002	1009	PF00069	0.774
MOD_GSK3_1	121	128	PF00069	0.586
MOD_GSK3_1	132	139	PF00069	0.670
MOD_GSK3_1	154	161	PF00069	0.664
MOD_GSK3_1	179	186	PF00069	0.672
MOD_GSK3_1	262	269	PF00069	0.614
MOD_GSK3_1	342	349	PF00069	0.707
MOD_GSK3_1	354	361	PF00069	0.731
MOD_GSK3_1	372	379	PF00069	0.705
MOD_GSK3_1	397	404	PF00069	0.668
MOD_GSK3_1	40	47	PF00069	0.617
MOD_GSK3_1	452	459	PF00069	0.833
MOD_GSK3_1	462	469	PF00069	0.712
MOD_GSK3_1	479	486	PF00069	0.642
MOD_GSK3_1	495	502	PF00069	0.691
MOD_GSK3_1	539	546	PF00069	0.676
MOD_GSK3_1	562	569	PF00069	0.745
MOD_GSK3_1	581	588	PF00069	0.633
MOD_GSK3_1	639	646	PF00069	0.622
MOD_GSK3_1	653	660	PF00069	0.570
MOD_GSK3_1	670	677	PF00069	0.581
MOD_GSK3_1	714	721	PF00069	0.694
MOD_GSK3_1	738	745	PF00069	0.710
MOD_GSK3_1	749	756	PF00069	0.714
MOD_GSK3_1	764	771	PF00069	0.673
MOD_GSK3_1	833	840	PF00069	0.685
MOD_GSK3_1	851	858	PF00069	0.632
MOD_GSK3_1	87	94	PF00069	0.369
MOD_GSK3_1	916	923	PF00069	0.632
MOD_GSK3_1	938	945	PF00069	0.683
MOD_GSK3_1	959	966	PF00069	0.786
MOD_LATS_1	312	318	PF00433	0.709
MOD_LATS_1	740	746	PF00433	0.654
MOD_N-GLC_1	358	363	PF02516	0.561
MOD_N-GLC_1	578	583	PF02516	0.530
MOD_N-GLC_1	823	828	PF02516	0.435
MOD_N-GLC_1	883	888	PF02516	0.506
MOD_NEK2_1	1	6	PF00069	0.737
MOD_NEK2_1	183	188	PF00069	0.730
MOD_NEK2_1	252	257	PF00069	0.647
MOD_NEK2_1	262	267	PF00069	0.589
MOD_NEK2_1	271	276	PF00069	0.541
MOD_NEK2_1	287	292	PF00069	0.632
MOD_NEK2_1	342	347	PF00069	0.714
MOD_NEK2_1	44	49	PF00069	0.486
MOD_NEK2_1	466	471	PF00069	0.715
MOD_NEK2_1	545	550	PF00069	0.688
MOD_NEK2_1	674	679	PF00069	0.639
MOD_NEK2_1	686	691	PF00069	0.601
MOD_NEK2_1	728	733	PF00069	0.635
MOD_NEK2_1	830	835	PF00069	0.685
MOD_NEK2_1	838	843	PF00069	0.682
MOD_NEK2_1	845	850	PF00069	0.659
MOD_NEK2_2	612	617	PF00069	0.635
MOD_PIKK_1	373	379	PF00454	0.750
MOD_PIKK_1	956	962	PF00454	0.710
MOD_PKA_1	140	146	PF00069	0.651
MOD_PKA_1	494	500	PF00069	0.705
MOD_PKA_1	925	931	PF00069	0.594
MOD_PKA_2	1034	1040	PF00069	0.651
MOD_PKA_2	140	146	PF00069	0.651
MOD_PKA_2	171	177	PF00069	0.676
MOD_PKA_2	313	319	PF00069	0.749
MOD_PKA_2	494	500	PF00069	0.707
MOD_PKA_2	596	602	PF00069	0.701
MOD_PKA_2	762	768	PF00069	0.704
MOD_PKA_2	774	780	PF00069	0.639
MOD_PKA_2	868	874	PF00069	0.743
MOD_PKA_2	925	931	PF00069	0.626
MOD_PKB_1	362	370	PF00069	0.734
MOD_PKB_1	867	875	PF00069	0.720
MOD_Plk_1	459	465	PF00069	0.721
MOD_Plk_1	670	676	PF00069	0.672
MOD_Plk_1	728	734	PF00069	0.668
MOD_Plk_1	823	829	PF00069	0.687
MOD_Plk_1	916	922	PF00069	0.585
MOD_Plk_2-3	714	720	PF00069	0.770
MOD_Plk_2-3	938	944	PF00069	0.750
MOD_Plk_4	121	127	PF00069	0.587
MOD_Plk_4	262	268	PF00069	0.597
MOD_Plk_4	315	321	PF00069	0.750
MOD_Plk_4	346	352	PF00069	0.681
MOD_Plk_4	40	46	PF00069	0.612
MOD_Plk_4	48	54	PF00069	0.271
MOD_Plk_4	495	501	PF00069	0.670
MOD_Plk_4	562	568	PF00069	0.647
MOD_Plk_4	629	635	PF00069	0.598
MOD_Plk_4	785	791	PF00069	0.645
MOD_Plk_4	87	93	PF00069	0.297
MOD_Plk_4	94	100	PF00069	0.299
MOD_ProDKin_1	1006	1012	PF00069	0.728
MOD_ProDKin_1	158	164	PF00069	0.636
MOD_ProDKin_1	334	340	PF00069	0.727
MOD_ProDKin_1	354	360	PF00069	0.759
MOD_ProDKin_1	483	489	PF00069	0.693
MOD_ProDKin_1	581	587	PF00069	0.704
MOD_ProDKin_1	764	770	PF00069	0.685
MOD_ProDKin_1	853	859	PF00069	0.743
MOD_ProDKin_1	883	889	PF00069	0.739
MOD_ProDKin_1	892	898	PF00069	0.689
MOD_SUMO_for_1	33	36	PF00179	0.620
MOD_SUMO_rev_2	442	450	PF00179	0.703
MOD_SUMO_rev_2	971	981	PF00179	0.708
TRG_DiLeu_BaEn_1	218	223	PF01217	0.603
TRG_DiLeu_BaEn_3	204	210	PF01217	0.665
TRG_DiLeu_BaEn_4	714	720	PF01217	0.677
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.304
TRG_ENDOCYTIC_2	71	74	PF00928	0.373
TRG_ENDOCYTIC_2	81	84	PF00928	0.284
TRG_ENDOCYTIC_2	98	101	PF00928	0.304
TRG_ER_diArg_1	140	142	PF00400	0.638
TRG_ER_diArg_1	494	496	PF00400	0.711
TRG_ER_diArg_1	74	76	PF00400	0.380
TRG_ER_diArg_1	867	870	PF00400	0.679
TRG_ER_diArg_1	890	892	PF00400	0.710
TRG_ER_diArg_1	988	991	PF00400	0.689
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	621	625	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	985	990	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUS5	Leptomonas seymouri	36%	100%
A4HBZ5	Leishmania braziliensis	57%	99%
A4HZD5	Leishmania infantum	99%	100%
E9AVC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QC58	Leishmania major	87%	100%