Phosphopantothenoylcysteine_decarboxylase_putativ e/GeneDB:LmjF.30.1540

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphopantothenoylcysteine decarboxylase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBY6_LEIDO

TriTrypDb:

LdBPK_301550.1 , LdCL_300020900 , LDHU3_30.2030

Length:

323

Annotations

Annotations by Jardim et al.

Coenzyme/cofactor biosynthesis, phosphopantothenoylcysteine decarboxylase Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0071513	phosphopantothenoylcysteine decarboxylase complex	3	1
GO:1902494	catalytic complex	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBY6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006163	purine nucleotide metabolic process	5	1
GO:0006164	purine nucleotide biosynthetic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009150	purine ribonucleotide metabolic process	6	1
GO:0009152	purine ribonucleotide biosynthetic process	7	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009259	ribonucleotide metabolic process	5	1
GO:0009260	ribonucleotide biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0015936	coenzyme A metabolic process	6	1
GO:0015937	coenzyme A biosynthetic process	7	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0033865	nucleoside bisphosphate metabolic process	5	1
GO:0033866	nucleoside bisphosphate biosynthetic process	6	1
GO:0033875	ribonucleoside bisphosphate metabolic process	6	1
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	1
GO:0034032	purine nucleoside bisphosphate metabolic process	5	1
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046390	ribose phosphate biosynthetic process	5	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004633	phosphopantothenoylcysteine decarboxylase activity	5	4
GO:0016829	lyase activity	2	4
GO:0016830	carbon-carbon lyase activity	3	4
GO:0016831	carboxy-lyase activity	4	4
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0010181	FMN binding	4	1
GO:0032553	ribonucleotide binding	3	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	295	297	PF00675	0.634
CLV_NRD_NRD_1	304	306	PF00675	0.665
CLV_NRD_NRD_1	62	64	PF00675	0.447
CLV_NRD_NRD_1	99	101	PF00675	0.376
CLV_PCSK_KEX2_1	261	263	PF00082	0.470
CLV_PCSK_KEX2_1	294	296	PF00082	0.624
CLV_PCSK_KEX2_1	304	306	PF00082	0.665
CLV_PCSK_KEX2_1	62	64	PF00082	0.493
CLV_PCSK_KEX2_1	99	101	PF00082	0.376
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.470
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.624
CLV_PCSK_PC7_1	291	297	PF00082	0.622
CLV_PCSK_SKI1_1	117	121	PF00082	0.493
CLV_PCSK_SKI1_1	55	59	PF00082	0.400
DOC_MAPK_DCC_7	240	248	PF00069	0.564
DOC_MAPK_gen_1	99	107	PF00069	0.376
DOC_MAPK_MEF2A_6	16	24	PF00069	0.492
DOC_MAPK_MEF2A_6	240	248	PF00069	0.588
DOC_USP7_MATH_1	194	198	PF00917	0.796
DOC_USP7_MATH_1	212	216	PF00917	0.707
DOC_USP7_MATH_1	64	68	PF00917	0.421
DOC_USP7_MATH_1	7	11	PF00917	0.708
DOC_USP7_MATH_1	72	76	PF00917	0.475
DOC_WW_Pin1_4	192	197	PF00397	0.668
DOC_WW_Pin1_4	3	8	PF00397	0.779
LIG_14-3-3_CanoR_1	174	183	PF00244	0.605
LIG_14-3-3_CanoR_1	284	288	PF00244	0.527
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_BIR_III_1	1	5	PF00653	0.653
LIG_BIR_III_3	1	5	PF00653	0.815
LIG_deltaCOP1_diTrp_1	79	86	PF00928	0.385
LIG_eIF4E_1	17	23	PF01652	0.561
LIG_FHA_1	151	157	PF00498	0.402
LIG_FHA_1	178	184	PF00498	0.539
LIG_FHA_1	215	221	PF00498	0.713
LIG_FHA_1	25	31	PF00498	0.387
LIG_FHA_1	284	290	PF00498	0.485
LIG_FHA_1	310	316	PF00498	0.796
LIG_FHA_1	33	39	PF00498	0.395
LIG_FHA_2	245	251	PF00498	0.619
LIG_GBD_Chelix_1	118	126	PF00786	0.435
LIG_GBD_Chelix_1	279	287	PF00786	0.570
LIG_Integrin_isoDGR_2	208	210	PF01839	0.647
LIG_LIR_Apic_2	149	155	PF02991	0.376
LIG_LIR_Apic_2	166	171	PF02991	0.376
LIG_LIR_Gen_1	250	258	PF02991	0.429
LIG_LIR_Gen_1	84	94	PF02991	0.511
LIG_LIR_LC3C_4	103	106	PF02991	0.493
LIG_LIR_Nem_3	14	20	PF02991	0.637
LIG_LIR_Nem_3	250	256	PF02991	0.444
LIG_LYPXL_yS_3	17	20	PF13949	0.590
LIG_SH2_CRK	253	257	PF00017	0.412
LIG_SH2_STAT5	168	171	PF00017	0.518
LIG_SH3_3	1	7	PF00018	0.681
LIG_SH3_3	103	109	PF00018	0.424
LIG_SH3_3	239	245	PF00018	0.738
LIG_SH3_3	252	258	PF00018	0.392
LIG_SH3_3	312	318	PF00018	0.773
LIG_SUMO_SIM_anti_2	103	108	PF11976	0.435
LIG_SUMO_SIM_par_1	21	27	PF11976	0.376
LIG_SUMO_SIM_par_1	244	251	PF11976	0.568
LIG_SxIP_EBH_1	63	77	PF03271	0.493
LIG_TRAF2_1	12	15	PF00917	0.716
LIG_TRAF2_1	275	278	PF00917	0.525
LIG_TRAF2_1	318	321	PF00917	0.868
LIG_WW_2	242	245	PF00397	0.593
MOD_CDC14_SPxK_1	195	198	PF00782	0.680
MOD_CDK_SPxK_1	192	198	PF00069	0.672
MOD_CK1_1	10	16	PF00069	0.719
MOD_CK1_1	175	181	PF00069	0.516
MOD_CK1_1	192	198	PF00069	0.597
MOD_CK1_1	204	210	PF00069	0.897
MOD_CK1_1	215	221	PF00069	0.782
MOD_CK1_1	223	229	PF00069	0.698
MOD_CK1_1	3	9	PF00069	0.852
MOD_CK1_1	75	81	PF00069	0.509
MOD_CK2_1	244	250	PF00069	0.626
MOD_CK2_1	272	278	PF00069	0.567
MOD_CMANNOS	83	86	PF00535	0.376
MOD_GlcNHglycan	203	206	PF01048	0.725
MOD_GlcNHglycan	213	217	PF01048	0.727
MOD_GlcNHglycan	225	228	PF01048	0.720
MOD_GSK3_1	146	153	PF00069	0.394
MOD_GSK3_1	215	222	PF00069	0.832
MOD_GSK3_1	223	230	PF00069	0.812
MOD_GSK3_1	244	251	PF00069	0.592
MOD_GSK3_1	3	10	PF00069	0.801
MOD_N-GLC_1	220	225	PF02516	0.736
MOD_NEK2_1	126	131	PF00069	0.472
MOD_NEK2_1	182	187	PF00069	0.535
MOD_NEK2_1	24	29	PF00069	0.431
MOD_NEK2_1	248	253	PF00069	0.599
MOD_OFUCOSY	169	176	PF10250	0.559
MOD_PIKK_1	309	315	PF00454	0.736
MOD_PK_1	16	22	PF00069	0.491
MOD_PKA_2	248	254	PF00069	0.575
MOD_PKA_2	283	289	PF00069	0.524
MOD_Plk_4	126	132	PF00069	0.472
MOD_Plk_4	248	254	PF00069	0.566
MOD_Plk_4	72	78	PF00069	0.529
MOD_ProDKin_1	192	198	PF00069	0.672
MOD_ProDKin_1	3	9	PF00069	0.779
MOD_SUMO_rev_2	10	18	PF00179	0.701
TRG_ENDOCYTIC_2	17	20	PF00928	0.590
TRG_ENDOCYTIC_2	253	256	PF00928	0.454
TRG_ER_diArg_1	303	305	PF00400	0.570
TRG_ER_diArg_1	61	63	PF00400	0.493
TRG_ER_diArg_1	98	100	PF00400	0.376
TRG_NES_CRM1_1	277	293	PF08389	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGH1	Leptomonas seymouri	64%	100%
A0A3R7KRR4	Trypanosoma rangeli	51%	100%
A4HI99	Leishmania braziliensis	79%	100%
A4I5I3	Leishmania infantum	100%	100%
C9ZQW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B0S8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7F0	Leishmania major	95%	100%
V5B8Z6	Trypanosoma cruzi	48%	100%