LeishMANIAdb
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LEM3 (Ligand-effect modulator 3) family / CDC50 family, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
LEM3 (Ligand-effect modulator 3) family / CDC50 family, putative
Gene product:
LEM3 (ligand-effect modulator 3) family / CDC50 family, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IBY5_LEIDO
TriTrypDb:
LdBPK_091080.1 * , LdCL_090017400 , LDHU3_09.1300
Length:
595

Annotations

LeishMANIAdb annotations

Homologous to animal CDC50 family phospholipid flippase (ATPase) proteins.. This family has expanded in kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19
GO:0005783 endoplasmic reticulum 5 2
GO:0005794 Golgi apparatus 5 2
GO:0005886 plasma membrane 3 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A0A3Q8IBY5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBY5

Function

Biological processes
Term Name Level Count
GO:0033036 macromolecule localization 2 19
GO:0051179 localization 1 19
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 66 70 PF00656 0.796
CLV_NRD_NRD_1 322 324 PF00675 0.418
CLV_NRD_NRD_1 447 449 PF00675 0.445
CLV_NRD_NRD_1 478 480 PF00675 0.483
CLV_NRD_NRD_1 558 560 PF00675 0.378
CLV_NRD_NRD_1 569 571 PF00675 0.359
CLV_PCSK_FUR_1 104 108 PF00082 0.359
CLV_PCSK_FUR_1 528 532 PF00082 0.312
CLV_PCSK_FUR_1 556 560 PF00082 0.372
CLV_PCSK_KEX2_1 106 108 PF00082 0.459
CLV_PCSK_KEX2_1 530 532 PF00082 0.454
CLV_PCSK_KEX2_1 536 538 PF00082 0.426
CLV_PCSK_KEX2_1 558 560 PF00082 0.345
CLV_PCSK_PC1ET2_1 106 108 PF00082 0.355
CLV_PCSK_PC1ET2_1 530 532 PF00082 0.424
CLV_PCSK_PC1ET2_1 536 538 PF00082 0.398
CLV_PCSK_SKI1_1 107 111 PF00082 0.347
CLV_PCSK_SKI1_1 300 304 PF00082 0.523
CLV_PCSK_SKI1_1 323 327 PF00082 0.515
CLV_PCSK_SKI1_1 392 396 PF00082 0.462
DEG_ODPH_VHL_1 309 321 PF01847 0.277
DEG_SPOP_SBC_1 26 30 PF00917 0.595
DEG_SPOP_SBC_1 345 349 PF00917 0.308
DOC_CDC14_PxL_1 335 343 PF14671 0.193
DOC_CYCLIN_yCln2_LP_2 155 161 PF00134 0.341
DOC_CYCLIN_yCln2_LP_2 267 273 PF00134 0.198
DOC_MAPK_FxFP_2 140 143 PF00069 0.614
DOC_MAPK_gen_1 387 396 PF00069 0.309
DOC_MAPK_gen_1 448 458 PF00069 0.235
DOC_MAPK_gen_1 477 484 PF00069 0.311
DOC_MAPK_MEF2A_6 216 223 PF00069 0.245
DOC_MAPK_MEF2A_6 449 458 PF00069 0.193
DOC_MAPK_MEF2A_6 493 501 PF00069 0.237
DOC_PP1_RVXF_1 385 392 PF00149 0.267
DOC_PP2B_LxvP_1 155 158 PF13499 0.324
DOC_PP4_FxxP_1 140 143 PF00568 0.614
DOC_PP4_FxxP_1 23 26 PF00568 0.775
DOC_USP7_MATH_1 190 194 PF00917 0.311
DOC_USP7_MATH_1 26 30 PF00917 0.599
DOC_USP7_MATH_1 428 432 PF00917 0.240
DOC_USP7_MATH_1 535 539 PF00917 0.602
DOC_USP7_MATH_1 56 60 PF00917 0.639
DOC_USP7_MATH_1 77 81 PF00917 0.674
DOC_USP7_MATH_1 91 95 PF00917 0.678
DOC_USP7_UBL2_3 106 110 PF12436 0.552
DOC_WW_Pin1_4 141 146 PF00397 0.531
DOC_WW_Pin1_4 280 285 PF00397 0.289
DOC_WW_Pin1_4 29 34 PF00397 0.631
DOC_WW_Pin1_4 3 8 PF00397 0.591
DOC_WW_Pin1_4 323 328 PF00397 0.314
DOC_WW_Pin1_4 346 351 PF00397 0.292
DOC_WW_Pin1_4 35 40 PF00397 0.621
DOC_WW_Pin1_4 51 56 PF00397 0.597
LIG_14-3-3_CanoR_1 300 305 PF00244 0.369
LIG_14-3-3_CanoR_1 392 397 PF00244 0.286
LIG_14-3-3_CanoR_1 440 450 PF00244 0.228
LIG_14-3-3_CanoR_1 477 483 PF00244 0.288
LIG_14-3-3_CanoR_1 62 68 PF00244 0.633
LIG_Actin_WH2_2 554 572 PF00022 0.623
LIG_AP2alpha_1 315 319 PF02296 0.234
LIG_EH1_1 514 522 PF00400 0.315
LIG_FHA_1 316 322 PF00498 0.242
LIG_FHA_1 346 352 PF00498 0.325
LIG_FHA_1 460 466 PF00498 0.337
LIG_FHA_1 512 518 PF00498 0.340
LIG_FHA_2 215 221 PF00498 0.226
LIG_FHA_2 284 290 PF00498 0.290
LIG_FHA_2 324 330 PF00498 0.296
LIG_FHA_2 393 399 PF00498 0.218
LIG_FHA_2 407 413 PF00498 0.277
LIG_Integrin_isoDGR_2 249 251 PF01839 0.501
LIG_LIR_Apic_2 402 408 PF02991 0.273
LIG_LIR_Gen_1 144 154 PF02991 0.424
LIG_LIR_Gen_1 172 180 PF02991 0.352
LIG_LIR_Gen_1 215 223 PF02991 0.315
LIG_LIR_Gen_1 468 476 PF02991 0.333
LIG_LIR_Nem_3 144 149 PF02991 0.413
LIG_LIR_Nem_3 172 176 PF02991 0.278
LIG_LIR_Nem_3 177 183 PF02991 0.269
LIG_LIR_Nem_3 215 221 PF02991 0.280
LIG_LIR_Nem_3 272 276 PF02991 0.218
LIG_LIR_Nem_3 317 322 PF02991 0.208
LIG_LIR_Nem_3 388 394 PF02991 0.249
LIG_LIR_Nem_3 398 404 PF02991 0.218
LIG_LIR_Nem_3 444 450 PF02991 0.248
LIG_LIR_Nem_3 468 474 PF02991 0.234
LIG_LIR_Nem_3 538 542 PF02991 0.597
LIG_LIR_Nem_3 546 552 PF02991 0.538
LIG_Pex14_1 400 404 PF04695 0.223
LIG_Pex14_2 315 319 PF04695 0.234
LIG_Pex14_2 443 447 PF04695 0.230
LIG_PTB_Apo_2 413 420 PF02174 0.200
LIG_PTB_Phospho_1 413 419 PF10480 0.202
LIG_SH2_CRK 186 190 PF00017 0.300
LIG_SH2_CRK 271 275 PF00017 0.315
LIG_SH2_CRK 322 326 PF00017 0.288
LIG_SH2_CRK 451 455 PF00017 0.276
LIG_SH2_CRK 471 475 PF00017 0.333
LIG_SH2_CRK 529 533 PF00017 0.517
LIG_SH2_NCK_1 471 475 PF00017 0.315
LIG_SH2_NCK_1 88 92 PF00017 0.588
LIG_SH2_SRC 186 189 PF00017 0.296
LIG_SH2_STAP1 433 437 PF00017 0.239
LIG_SH2_STAT3 540 543 PF00017 0.614
LIG_SH2_STAT5 153 156 PF00017 0.355
LIG_SH2_STAT5 188 191 PF00017 0.336
LIG_SH2_STAT5 266 269 PF00017 0.296
LIG_SH2_STAT5 271 274 PF00017 0.274
LIG_SH2_STAT5 301 304 PF00017 0.315
LIG_SH2_STAT5 413 416 PF00017 0.263
LIG_SH2_STAT5 419 422 PF00017 0.263
LIG_SH2_STAT5 463 466 PF00017 0.251
LIG_SH2_STAT5 540 543 PF00017 0.553
LIG_SH3_3 292 298 PF00018 0.309
LIG_SH3_3 454 460 PF00018 0.318
LIG_SH3_3 538 544 PF00018 0.646
LIG_SUMO_SIM_anti_2 346 355 PF11976 0.265
LIG_SUMO_SIM_par_1 282 289 PF11976 0.218
LIG_SUMO_SIM_par_1 462 469 PF11976 0.267
LIG_TRFH_1 146 150 PF08558 0.388
LIG_TYR_ITIM 320 325 PF00017 0.315
LIG_WRC_WIRS_1 473 478 PF05994 0.221
MOD_CDC14_SPxK_1 32 35 PF00782 0.624
MOD_CDK_SPxK_1 29 35 PF00069 0.627
MOD_CK1_1 100 106 PF00069 0.647
MOD_CK1_1 132 138 PF00069 0.625
MOD_CK1_1 191 197 PF00069 0.211
MOD_CK1_1 29 35 PF00069 0.743
MOD_CK1_1 42 48 PF00069 0.697
MOD_CK1_1 442 448 PF00069 0.231
MOD_CK1_1 50 56 PF00069 0.764
MOD_CK1_1 6 12 PF00069 0.689
MOD_CK1_1 60 66 PF00069 0.795
MOD_CK2_1 214 220 PF00069 0.226
MOD_CK2_1 323 329 PF00069 0.293
MOD_CK2_1 392 398 PF00069 0.250
MOD_CK2_1 406 412 PF00069 0.313
MOD_CK2_1 67 73 PF00069 0.797
MOD_Cter_Amidation 477 480 PF01082 0.477
MOD_GlcNHglycan 15 18 PF01048 0.569
MOD_GlcNHglycan 335 338 PF01048 0.490
MOD_GlcNHglycan 367 370 PF01048 0.491
MOD_GlcNHglycan 41 44 PF01048 0.540
MOD_GlcNHglycan 49 52 PF01048 0.575
MOD_GlcNHglycan 79 82 PF01048 0.563
MOD_GlcNHglycan 93 96 PF01048 0.541
MOD_GSK3_1 2 9 PF00069 0.746
MOD_GSK3_1 21 28 PF00069 0.748
MOD_GSK3_1 345 352 PF00069 0.258
MOD_GSK3_1 35 42 PF00069 0.765
MOD_GSK3_1 365 372 PF00069 0.240
MOD_GSK3_1 47 54 PF00069 0.716
MOD_GSK3_1 56 63 PF00069 0.814
MOD_N-GLC_1 191 196 PF02516 0.645
MOD_N-GLC_1 221 226 PF02516 0.498
MOD_N-GLC_1 315 320 PF02516 0.442
MOD_N-GLC_1 333 338 PF02516 0.333
MOD_N-GLC_1 355 360 PF02516 0.440
MOD_N-GLC_1 392 397 PF02516 0.515
MOD_N-GLC_1 56 61 PF02516 0.425
MOD_N-GLC_2 374 376 PF02516 0.402
MOD_NEK2_1 315 320 PF00069 0.242
MOD_NEK2_1 367 372 PF00069 0.202
MOD_NEK2_1 379 384 PF00069 0.202
MOD_NEK2_1 439 444 PF00069 0.247
MOD_NEK2_1 511 516 PF00069 0.353
MOD_NEK2_2 121 126 PF00069 0.631
MOD_PIKK_1 129 135 PF00454 0.626
MOD_PIKK_1 251 257 PF00454 0.218
MOD_PIKK_1 290 296 PF00454 0.258
MOD_PKA_2 100 106 PF00069 0.711
MOD_PKA_2 439 445 PF00069 0.256
MOD_PKA_2 478 484 PF00069 0.256
MOD_PKA_2 61 67 PF00069 0.656
MOD_PKB_1 390 398 PF00069 0.163
MOD_Plk_1 178 184 PF00069 0.362
MOD_Plk_1 191 197 PF00069 0.235
MOD_Plk_1 315 321 PF00069 0.249
MOD_Plk_1 392 398 PF00069 0.315
MOD_Plk_4 315 321 PF00069 0.216
MOD_Plk_4 349 355 PF00069 0.188
MOD_Plk_4 459 465 PF00069 0.352
MOD_Plk_4 478 484 PF00069 0.262
MOD_Plk_4 505 511 PF00069 0.343
MOD_ProDKin_1 141 147 PF00069 0.529
MOD_ProDKin_1 280 286 PF00069 0.289
MOD_ProDKin_1 29 35 PF00069 0.633
MOD_ProDKin_1 3 9 PF00069 0.593
MOD_ProDKin_1 323 329 PF00069 0.314
MOD_ProDKin_1 346 352 PF00069 0.292
MOD_ProDKin_1 51 57 PF00069 0.598
TRG_DiLeu_BaEn_1 575 580 PF01217 0.468
TRG_ENDOCYTIC_2 153 156 PF00928 0.408
TRG_ENDOCYTIC_2 173 176 PF00928 0.198
TRG_ENDOCYTIC_2 180 183 PF00928 0.240
TRG_ENDOCYTIC_2 186 189 PF00928 0.247
TRG_ENDOCYTIC_2 234 237 PF00928 0.239
TRG_ENDOCYTIC_2 273 276 PF00928 0.218
TRG_ENDOCYTIC_2 322 325 PF00928 0.315
TRG_ENDOCYTIC_2 451 454 PF00928 0.300
TRG_ENDOCYTIC_2 471 474 PF00928 0.286
TRG_ENDOCYTIC_2 529 532 PF00928 0.643
TRG_ENDOCYTIC_2 552 555 PF00928 0.535
TRG_ER_diArg_1 476 479 PF00400 0.269
TRG_ER_diArg_1 555 558 PF00400 0.620
TRG_NLS_MonoExtN_4 107 114 PF00514 0.621
TRG_Pf-PMV_PEXEL_1 530 534 PF00026 0.373

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0U8 Leptomonas seymouri 65% 95%
A0A0S4IMK4 Bodo saltans 32% 100%
A0A0S4JQR9 Bodo saltans 37% 100%
A0A1X0NHQ5 Trypanosomatidae 46% 100%
A0A1X0P5L3 Trypanosomatidae 34% 100%
A0A3R7LIN7 Trypanosoma rangeli 47% 100%
A0A3S7X9N4 Leishmania donovani 35% 100%
A0A422NR22 Trypanosoma rangeli 33% 100%
A4H5T1 Leishmania braziliensis 79% 100%
A4HN07 Leishmania braziliensis 36% 100%
A4HU24 Leishmania infantum 99% 100%
A4IBN0 Leishmania infantum 35% 100%
D0A9K3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AFG4 Leishmania major 35% 100%
E9AMV4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9B6L9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
P42838 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
Q4QHS2 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS