NTF2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBY3_LEIDO

TriTrypDb:

LdBPK_210490.1 , LdCL_210009700 , LDHU3_21.0530

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IBY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBY3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.399
CLV_NRD_NRD_1	167	169	PF00675	0.490
CLV_NRD_NRD_1	174	176	PF00675	0.493
CLV_NRD_NRD_1	255	257	PF00675	0.730
CLV_NRD_NRD_1	267	269	PF00675	0.611
CLV_NRD_NRD_1	306	308	PF00675	0.724
CLV_NRD_NRD_1	332	334	PF00675	0.683
CLV_NRD_NRD_1	336	338	PF00675	0.654
CLV_NRD_NRD_1	78	80	PF00675	0.417
CLV_PCSK_KEX2_1	110	112	PF00082	0.399
CLV_PCSK_KEX2_1	166	168	PF00082	0.504
CLV_PCSK_KEX2_1	174	176	PF00082	0.491
CLV_PCSK_KEX2_1	336	338	PF00082	0.789
CLV_PCSK_SKI1_1	110	114	PF00082	0.387
CLV_PCSK_SKI1_1	175	179	PF00082	0.541
CLV_PCSK_SKI1_1	352	356	PF00082	0.496
CLV_PCSK_SKI1_1	372	376	PF00082	0.361
CLV_PCSK_SKI1_1	401	405	PF00082	0.533
DOC_ANK_TNKS_1	292	299	PF00023	0.791
DOC_CYCLIN_RxL_1	172	179	PF00134	0.546
DOC_MAPK_gen_1	107	116	PF00069	0.409
DOC_MAPK_gen_1	174	180	PF00069	0.548
DOC_MAPK_gen_1	79	86	PF00069	0.423
DOC_MAPK_MEF2A_6	107	116	PF00069	0.462
DOC_PP1_RVXF_1	370	377	PF00149	0.611
DOC_PP4_FxxP_1	348	351	PF00568	0.416
DOC_USP7_MATH_1	221	225	PF00917	0.731
DOC_USP7_MATH_1	289	293	PF00917	0.753
DOC_USP7_MATH_1	34	38	PF00917	0.459
DOC_USP7_UBL2_3	400	404	PF12436	0.430
DOC_WW_Pin1_4	287	292	PF00397	0.788
DOC_WW_Pin1_4	323	328	PF00397	0.745
DOC_WW_Pin1_4	5	10	PF00397	0.479
LIG_14-3-3_CanoR_1	125	130	PF00244	0.446
LIG_14-3-3_CanoR_1	220	229	PF00244	0.665
LIG_14-3-3_CanoR_1	43	49	PF00244	0.443
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BRCT_BRCA1_1	364	368	PF00533	0.599
LIG_CaM_IQ_9	177	192	PF13499	0.614
LIG_FHA_1	126	132	PF00498	0.422
LIG_FHA_1	340	346	PF00498	0.658
LIG_FHA_1	86	92	PF00498	0.465
LIG_FHA_2	45	51	PF00498	0.455
LIG_LIR_Gen_1	133	139	PF02991	0.471
LIG_LIR_Gen_1	25	34	PF02991	0.458
LIG_LIR_Gen_1	365	375	PF02991	0.540
LIG_LIR_Gen_1	42	51	PF02991	0.459
LIG_LIR_Nem_3	108	112	PF02991	0.479
LIG_LIR_Nem_3	133	138	PF02991	0.401
LIG_LIR_Nem_3	17	22	PF02991	0.404
LIG_LIR_Nem_3	25	30	PF02991	0.381
LIG_LIR_Nem_3	365	371	PF02991	0.539
LIG_LIR_Nem_3	42	48	PF02991	0.451
LIG_Pex14_2	113	117	PF04695	0.356
LIG_Rb_pABgroove_1	34	42	PF01858	0.455
LIG_SH2_CRK	109	113	PF00017	0.454
LIG_SH2_CRK	45	49	PF00017	0.437
LIG_SH2_STAP1	24	28	PF00017	0.438
LIG_SH2_STAT5	105	108	PF00017	0.483
LIG_SH2_STAT5	135	138	PF00017	0.401
LIG_SH2_STAT5	161	164	PF00017	0.552
LIG_SH3_2	241	246	PF14604	0.722
LIG_SH3_3	226	232	PF00018	0.629
LIG_SH3_3	238	244	PF00018	0.732
LIG_SH3_3	255	261	PF00018	0.571
LIG_SH3_3	267	273	PF00018	0.611
LIG_SH3_3	288	294	PF00018	0.635
LIG_SH3_3	86	92	PF00018	0.465
LIG_SUMO_SIM_par_1	82	88	PF11976	0.484
LIG_TRFH_1	117	121	PF08558	0.378
LIG_WW_3	243	247	PF00397	0.729
MOD_CDC14_SPxK_1	290	293	PF00782	0.784
MOD_CDK_SPxK_1	287	293	PF00069	0.789
MOD_CK1_1	216	222	PF00069	0.743
MOD_CK1_1	339	345	PF00069	0.684
MOD_CK1_1	44	50	PF00069	0.377
MOD_CK2_1	138	144	PF00069	0.542
MOD_CK2_1	386	392	PF00069	0.537
MOD_Cter_Amidation	297	300	PF01082	0.800
MOD_GlcNHglycan	223	226	PF01048	0.742
MOD_GlcNHglycan	338	341	PF01048	0.721
MOD_GlcNHglycan	380	383	PF01048	0.493
MOD_GlcNHglycan	388	391	PF01048	0.466
MOD_GSK3_1	11	18	PF00069	0.459
MOD_GSK3_1	119	126	PF00069	0.435
MOD_GSK3_1	223	230	PF00069	0.669
MOD_GSK3_1	319	326	PF00069	0.746
MOD_GSK3_1	362	369	PF00069	0.595
MOD_NEK2_1	162	167	PF00069	0.558
MOD_NEK2_1	72	77	PF00069	0.463
MOD_PIKK_1	362	368	PF00454	0.591
MOD_PKA_1	336	342	PF00069	0.759
MOD_PKA_2	216	222	PF00069	0.710
MOD_PKA_2	336	342	PF00069	0.636
MOD_PKA_2	34	40	PF00069	0.448
MOD_PKA_2	378	384	PF00069	0.566
MOD_Plk_1	41	47	PF00069	0.395
MOD_Plk_1	72	78	PF00069	0.467
MOD_Plk_2-3	82	88	PF00069	0.484
MOD_Plk_4	15	21	PF00069	0.440
MOD_Plk_4	44	50	PF00069	0.383
MOD_ProDKin_1	287	293	PF00069	0.789
MOD_ProDKin_1	323	329	PF00069	0.746
MOD_ProDKin_1	5	11	PF00069	0.474
MOD_SUMO_for_1	359	362	PF00179	0.531
MOD_SUMO_rev_2	263	270	PF00179	0.739
MOD_SUMO_rev_2	272	279	PF00179	0.758
MOD_SUMO_rev_2	357	361	PF00179	0.484
MOD_SUMO_rev_2	365	374	PF00179	0.495
MOD_SUMO_rev_2	396	403	PF00179	0.540
TRG_ENDOCYTIC_2	109	112	PF00928	0.466
TRG_ENDOCYTIC_2	135	138	PF00928	0.401
TRG_ENDOCYTIC_2	24	27	PF00928	0.372
TRG_ENDOCYTIC_2	45	48	PF00928	0.436
TRG_ER_diArg_1	109	111	PF00400	0.466
TRG_ER_diArg_1	166	168	PF00400	0.485
TRG_ER_diArg_1	183	186	PF00400	0.539
TRG_ER_diArg_1	335	337	PF00400	0.740
TRG_NLS_Bipartite_1	336	356	PF00514	0.659
TRG_NLS_MonoExtN_4	349	356	PF00514	0.548
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P850	Leptomonas seymouri	59%	88%
A0A422MZN2	Trypanosoma rangeli	32%	84%
A4HBP1	Leishmania braziliensis	82%	99%
A4HZ42	Leishmania infantum	99%	99%
E9AV10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
Q4QCH2	Leishmania major	89%	95%