IQ_calmodulin-binding_motif_containing_protein_pu tative/Pfam:PF00612

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBX8_LEIDO

TriTrypDb:

LdBPK_241390.1 , LdCL_240019000 , LDHU3_24.1670

Length:

888

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.471
CLV_C14_Caspase3-7	495	499	PF00656	0.544
CLV_C14_Caspase3-7	526	530	PF00656	0.607
CLV_NRD_NRD_1	344	346	PF00675	0.676
CLV_NRD_NRD_1	492	494	PF00675	0.672
CLV_NRD_NRD_1	51	53	PF00675	0.449
CLV_NRD_NRD_1	588	590	PF00675	0.495
CLV_NRD_NRD_1	618	620	PF00675	0.614
CLV_NRD_NRD_1	637	639	PF00675	0.346
CLV_NRD_NRD_1	647	649	PF00675	0.384
CLV_NRD_NRD_1	651	653	PF00675	0.376
CLV_NRD_NRD_1	668	670	PF00675	0.368
CLV_NRD_NRD_1	682	684	PF00675	0.382
CLV_NRD_NRD_1	792	794	PF00675	0.248
CLV_NRD_NRD_1	853	855	PF00675	0.461
CLV_NRD_NRD_1	862	864	PF00675	0.474
CLV_PCSK_FUR_1	49	53	PF00082	0.440
CLV_PCSK_FUR_1	789	793	PF00082	0.261
CLV_PCSK_KEX2_1	344	346	PF00082	0.632
CLV_PCSK_KEX2_1	49	51	PF00082	0.445
CLV_PCSK_KEX2_1	588	590	PF00082	0.490
CLV_PCSK_KEX2_1	618	620	PF00082	0.566
CLV_PCSK_KEX2_1	637	639	PF00082	0.339
CLV_PCSK_KEX2_1	647	649	PF00082	0.389
CLV_PCSK_KEX2_1	667	669	PF00082	0.280
CLV_PCSK_KEX2_1	682	684	PF00082	0.400
CLV_PCSK_KEX2_1	791	793	PF00082	0.258
CLV_PCSK_KEX2_1	852	854	PF00082	0.508
CLV_PCSK_KEX2_1	862	864	PF00082	0.469
CLV_PCSK_PC1ET2_1	852	854	PF00082	0.545
CLV_PCSK_SKI1_1	107	111	PF00082	0.341
CLV_PCSK_SKI1_1	167	171	PF00082	0.520
CLV_PCSK_SKI1_1	215	219	PF00082	0.437
CLV_PCSK_SKI1_1	28	32	PF00082	0.430
CLV_PCSK_SKI1_1	308	312	PF00082	0.581
CLV_PCSK_SKI1_1	466	470	PF00082	0.641
CLV_PCSK_SKI1_1	746	750	PF00082	0.257
DEG_APCC_DBOX_1	214	222	PF00400	0.459
DEG_APCC_DBOX_1	465	473	PF00400	0.487
DEG_Nend_UBRbox_2	1	3	PF02207	0.744
DOC_ANK_TNKS_1	155	162	PF00023	0.443
DOC_CDC14_PxL_1	179	187	PF14671	0.385
DOC_CKS1_1	365	370	PF01111	0.472
DOC_MAPK_gen_1	296	305	PF00069	0.418
DOC_MAPK_gen_1	588	598	PF00069	0.526
DOC_MAPK_HePTP_8	293	305	PF00069	0.477
DOC_MAPK_MEF2A_6	296	305	PF00069	0.502
DOC_MAPK_MEF2A_6	34	41	PF00069	0.437
DOC_MAPK_MEF2A_6	592	600	PF00069	0.515
DOC_MIT_MIM_1	533	542	PF04212	0.494
DOC_PP2B_LxvP_1	113	116	PF13499	0.625
DOC_PP4_FxxP_1	511	514	PF00568	0.575
DOC_PP4_FxxP_1	566	569	PF00568	0.474
DOC_USP7_MATH_1	20	24	PF00917	0.411
DOC_USP7_MATH_1	213	217	PF00917	0.493
DOC_USP7_MATH_1	232	236	PF00917	0.436
DOC_USP7_MATH_1	245	249	PF00917	0.551
DOC_USP7_MATH_1	279	283	PF00917	0.577
DOC_USP7_MATH_1	292	296	PF00917	0.458
DOC_USP7_MATH_1	340	344	PF00917	0.652
DOC_USP7_MATH_1	427	431	PF00917	0.589
DOC_USP7_MATH_1	787	791	PF00917	0.465
DOC_USP7_MATH_1	9	13	PF00917	0.553
DOC_WW_Pin1_4	364	369	PF00397	0.548
DOC_WW_Pin1_4	437	442	PF00397	0.325
LIG_14-3-3_CanoR_1	354	364	PF00244	0.726
LIG_14-3-3_CanoR_1	459	463	PF00244	0.594
LIG_14-3-3_CanoR_1	52	62	PF00244	0.389
LIG_14-3-3_CanoR_1	538	542	PF00244	0.561
LIG_14-3-3_CanoR_1	558	566	PF00244	0.347
LIG_14-3-3_CanoR_1	661	666	PF00244	0.495
LIG_14-3-3_CanoR_1	822	829	PF00244	0.679
LIG_14-3-3_CanoR_1	878	884	PF00244	0.526
LIG_Actin_WH2_2	140	158	PF00022	0.342
LIG_APCC_ABBA_1	301	306	PF00400	0.504
LIG_APCC_ABBA_1	821	826	PF00400	0.546
LIG_APCC_ABBAyCdc20_2	300	306	PF00400	0.438
LIG_BIR_III_4	450	454	PF00653	0.455
LIG_BRCT_BRCA1_1	812	816	PF00533	0.550
LIG_CaM_IQ_9	629	645	PF13499	0.401
LIG_CaM_IQ_9	659	675	PF13499	0.419
LIG_CaM_IQ_9	699	714	PF13499	0.477
LIG_CaM_IQ_9	738	753	PF13499	0.444
LIG_CaM_IQ_9	768	784	PF13499	0.341
LIG_CaM_IQ_9	839	855	PF13499	0.454
LIG_FHA_1	130	136	PF00498	0.557
LIG_FHA_1	186	192	PF00498	0.399
LIG_FHA_1	245	251	PF00498	0.493
LIG_FHA_1	255	261	PF00498	0.440
LIG_FHA_1	365	371	PF00498	0.467
LIG_FHA_1	382	388	PF00498	0.449
LIG_FHA_1	443	449	PF00498	0.488
LIG_FHA_1	485	491	PF00498	0.693
LIG_FHA_1	554	560	PF00498	0.508
LIG_FHA_1	563	569	PF00498	0.488
LIG_FHA_1	688	694	PF00498	0.355
LIG_FHA_1	77	83	PF00498	0.496
LIG_FHA_1	878	884	PF00498	0.582
LIG_FHA_2	116	122	PF00498	0.622
LIG_FHA_2	221	227	PF00498	0.477
LIG_FHA_2	263	269	PF00498	0.520
LIG_FHA_2	419	425	PF00498	0.482
LIG_FHA_2	490	496	PF00498	0.650
LIG_LIR_Apic_2	565	569	PF02991	0.540
LIG_LIR_Gen_1	395	405	PF02991	0.396
LIG_LIR_Gen_1	429	436	PF02991	0.498
LIG_LIR_Gen_1	66	76	PF02991	0.393
LIG_LIR_Gen_1	817	828	PF02991	0.546
LIG_LIR_Gen_1	93	102	PF02991	0.337
LIG_LIR_Nem_3	100	105	PF02991	0.346
LIG_LIR_Nem_3	188	192	PF02991	0.490
LIG_LIR_Nem_3	395	400	PF02991	0.570
LIG_LIR_Nem_3	429	435	PF02991	0.444
LIG_LIR_Nem_3	64	68	PF02991	0.401
LIG_LIR_Nem_3	817	823	PF02991	0.581
LIG_LIR_Nem_3	93	98	PF02991	0.331
LIG_NRBOX	468	474	PF00104	0.417
LIG_NRBOX	538	544	PF00104	0.469
LIG_PCNA_yPIPBox_3	190	203	PF02747	0.353
LIG_PCNA_yPIPBox_3	742	756	PF02747	0.483
LIG_Pex14_2	432	436	PF04695	0.533
LIG_Pex14_2	549	553	PF04695	0.498
LIG_Pex14_2	816	820	PF04695	0.498
LIG_PTB_Apo_2	349	356	PF02174	0.621
LIG_REV1ctd_RIR_1	598	606	PF16727	0.456
LIG_RPA_C_Fungi	47	59	PF08784	0.383
LIG_SH2_CRK	106	110	PF00017	0.388
LIG_SH2_CRK	737	741	PF00017	0.300
LIG_SH2_SRC	243	246	PF00017	0.404
LIG_SH2_STAP1	274	278	PF00017	0.524
LIG_SH2_STAP1	397	401	PF00017	0.439
LIG_SH2_STAP1	44	48	PF00017	0.350
LIG_SH2_STAP1	737	741	PF00017	0.306
LIG_SH2_STAT3	769	772	PF00017	0.534
LIG_SH2_STAT5	256	259	PF00017	0.376
LIG_SH2_STAT5	304	307	PF00017	0.529
LIG_SH2_STAT5	377	380	PF00017	0.447
LIG_SH2_STAT5	635	638	PF00017	0.477
LIG_SH2_STAT5	655	658	PF00017	0.256
LIG_SH2_STAT5	68	71	PF00017	0.445
LIG_SH2_STAT5	94	97	PF00017	0.389
LIG_SH3_3	105	111	PF00018	0.461
LIG_SH3_3	365	371	PF00018	0.476
LIG_SH3_3	459	465	PF00018	0.552
LIG_SH3_3	478	484	PF00018	0.431
LIG_SH3_3	81	87	PF00018	0.492
LIG_SUMO_SIM_anti_2	216	223	PF11976	0.466
LIG_SUMO_SIM_par_1	247	254	PF11976	0.375
LIG_TRAF2_1	548	551	PF00917	0.491
LIG_TRAF2_1	641	644	PF00917	0.518
LIG_TRAF2_1	868	871	PF00917	0.529
LIG_UBA3_1	38	42	PF00899	0.395
LIG_WRC_WIRS_1	21	26	PF05994	0.477
LIG_WRC_WIRS_1	563	568	PF05994	0.506
MOD_CK1_1	234	240	PF00069	0.702
MOD_CK1_1	266	272	PF00069	0.501
MOD_CK1_1	810	816	PF00069	0.618
MOD_CK1_1	879	885	PF00069	0.527
MOD_CK2_1	205	211	PF00069	0.414
MOD_CK2_1	220	226	PF00069	0.387
MOD_CK2_1	234	240	PF00069	0.532
MOD_CK2_1	262	268	PF00069	0.454
MOD_CK2_1	353	359	PF00069	0.670
MOD_CK2_1	418	424	PF00069	0.499
MOD_CK2_1	489	495	PF00069	0.631
MOD_Cter_Amidation	645	648	PF01082	0.423
MOD_GlcNHglycan	100	105	PF01048	0.375
MOD_GlcNHglycan	11	14	PF01048	0.544
MOD_GlcNHglycan	215	218	PF01048	0.577
MOD_GlcNHglycan	226	231	PF01048	0.596
MOD_GlcNHglycan	55	58	PF01048	0.464
MOD_GlcNHglycan	560	563	PF01048	0.598
MOD_GlcNHglycan	591	595	PF01048	0.447
MOD_GlcNHglycan	809	812	PF01048	0.539
MOD_GSK3_1	177	184	PF00069	0.549
MOD_GSK3_1	259	266	PF00069	0.557
MOD_GSK3_1	279	286	PF00069	0.534
MOD_GSK3_1	330	337	PF00069	0.691
MOD_GSK3_1	558	565	PF00069	0.589
MOD_GSK3_1	807	814	PF00069	0.563
MOD_GSK3_1	9	16	PF00069	0.489
MOD_N-GLC_1	263	268	PF02516	0.382
MOD_NEK2_1	143	148	PF00069	0.370
MOD_NEK2_1	169	174	PF00069	0.470
MOD_NEK2_1	185	190	PF00069	0.475
MOD_NEK2_1	220	225	PF00069	0.405
MOD_NEK2_1	251	256	PF00069	0.364
MOD_NEK2_1	383	388	PF00069	0.520
MOD_NEK2_1	400	405	PF00069	0.467
MOD_NEK2_1	418	423	PF00069	0.343
MOD_NEK2_1	442	447	PF00069	0.457
MOD_NEK2_1	458	463	PF00069	0.445
MOD_NEK2_1	63	68	PF00069	0.483
MOD_NEK2_1	678	683	PF00069	0.479
MOD_NEK2_1	687	692	PF00069	0.509
MOD_NEK2_1	730	735	PF00069	0.608
MOD_NEK2_1	845	850	PF00069	0.529
MOD_NEK2_2	13	18	PF00069	0.466
MOD_NEK2_2	427	432	PF00069	0.453
MOD_PIKK_1	205	211	PF00454	0.565
MOD_PIKK_1	22	28	PF00454	0.465
MOD_PIKK_1	353	359	PF00454	0.721
MOD_PIKK_1	768	774	PF00454	0.532
MOD_PK_1	131	137	PF00069	0.439
MOD_PKA_2	353	359	PF00069	0.669
MOD_PKA_2	458	464	PF00069	0.526
MOD_PKA_2	484	490	PF00069	0.722
MOD_PKA_2	537	543	PF00069	0.502
MOD_PKA_2	678	684	PF00069	0.544
MOD_PKA_2	730	736	PF00069	0.545
MOD_PKA_2	877	883	PF00069	0.585
MOD_Plk_1	100	106	PF00069	0.552
MOD_Plk_1	267	273	PF00069	0.507
MOD_Plk_1	28	34	PF00069	0.406
MOD_Plk_1	612	618	PF00069	0.600
MOD_Plk_1	63	69	PF00069	0.513
MOD_Plk_1	774	780	PF00069	0.381
MOD_Plk_4	245	251	PF00069	0.407
MOD_Plk_4	267	273	PF00069	0.481
MOD_Plk_4	383	389	PF00069	0.418
MOD_Plk_4	413	419	PF00069	0.540
MOD_Plk_4	427	433	PF00069	0.382
MOD_Plk_4	43	49	PF00069	0.511
MOD_Plk_4	458	464	PF00069	0.610
MOD_Plk_4	468	474	PF00069	0.459
MOD_Plk_4	537	543	PF00069	0.519
MOD_Plk_4	612	618	PF00069	0.705
MOD_Plk_4	736	742	PF00069	0.281
MOD_ProDKin_1	364	370	PF00069	0.539
MOD_ProDKin_1	437	443	PF00069	0.326
MOD_SUMO_for_1	163	166	PF00179	0.291
MOD_SUMO_for_1	543	546	PF00179	0.589
MOD_SUMO_for_1	575	578	PF00179	0.482
MOD_SUMO_rev_2	124	132	PF00179	0.634
MOD_SUMO_rev_2	826	836	PF00179	0.536
TRG_DiLeu_BaEn_1	166	171	PF01217	0.388
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.524
TRG_DiLeu_BaLyEn_6	444	449	PF01217	0.499
TRG_DiLeu_BaLyEn_6	592	597	PF01217	0.579
TRG_ENDOCYTIC_2	106	109	PF00928	0.513
TRG_ENDOCYTIC_2	397	400	PF00928	0.444
TRG_ENDOCYTIC_2	642	645	PF00928	0.405
TRG_ENDOCYTIC_2	675	678	PF00928	0.475
TRG_ENDOCYTIC_2	68	71	PF00928	0.445
TRG_ENDOCYTIC_2	737	740	PF00928	0.300
TRG_ENDOCYTIC_2	94	97	PF00928	0.457
TRG_ER_diArg_1	298	301	PF00400	0.403
TRG_ER_diArg_1	48	51	PF00400	0.422
TRG_ER_diArg_1	617	619	PF00400	0.611
TRG_ER_diArg_1	636	638	PF00400	0.299
TRG_ER_diArg_1	647	649	PF00400	0.377
TRG_ER_diArg_1	667	669	PF00400	0.524
TRG_ER_diArg_1	789	792	PF00400	0.324
TRG_ER_diArg_1	853	855	PF00400	0.476
TRG_NES_CRM1_1	557	571	PF08389	0.553
TRG_Pf-PMV_PEXEL_1	173	178	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	608	613	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSD4	Leptomonas seymouri	49%	100%
A0A1X0NVS1	Trypanosomatidae	28%	100%
A0A422NP16	Trypanosoma rangeli	28%	100%
A4HDK7	Leishmania braziliensis	76%	100%
A4I0X4	Leishmania infantum	100%	100%
C9ZWH3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AWX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QAJ6	Leishmania major	93%	100%
V5AVI0	Trypanosoma cruzi	28%	100%