Calcium-binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcium-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBX6_LEIDO

TriTrypDb:

LdCL_300018200 , LDHU3_30.1680

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3Q8IBX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBX6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.456
CLV_NRD_NRD_1	330	332	PF00675	0.574
CLV_NRD_NRD_1	338	340	PF00675	0.554
CLV_NRD_NRD_1	420	422	PF00675	0.439
CLV_PCSK_KEX2_1	15	17	PF00082	0.469
CLV_PCSK_KEX2_1	243	245	PF00082	0.461
CLV_PCSK_KEX2_1	338	340	PF00082	0.482
CLV_PCSK_KEX2_1	78	80	PF00082	0.490
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.449
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.475
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.449
CLV_PCSK_SKI1_1	105	109	PF00082	0.545
CLV_PCSK_SKI1_1	151	155	PF00082	0.452
CLV_PCSK_SKI1_1	18	22	PF00082	0.428
CLV_PCSK_SKI1_1	243	247	PF00082	0.576
CLV_PCSK_SKI1_1	339	343	PF00082	0.544
CLV_PCSK_SKI1_1	367	371	PF00082	0.629
CLV_PCSK_SKI1_1	423	427	PF00082	0.497
CLV_PCSK_SKI1_1	467	471	PF00082	0.440
CLV_PCSK_SKI1_1	78	82	PF00082	0.465
DEG_APCC_DBOX_1	366	374	PF00400	0.513
DEG_Nend_UBRbox_1	1	4	PF02207	0.494
DOC_CYCLIN_RxL_1	12	26	PF00134	0.429
DOC_MAPK_gen_1	11	22	PF00069	0.435
DOC_MAPK_gen_1	128	137	PF00069	0.486
DOC_MAPK_gen_1	243	252	PF00069	0.579
DOC_MAPK_gen_1	421	428	PF00069	0.531
DOC_MAPK_gen_1	467	475	PF00069	0.440
DOC_MAPK_MEF2A_6	15	24	PF00069	0.431
DOC_MAPK_MEF2A_6	243	252	PF00069	0.544
DOC_MAPK_NFAT4_5	17	25	PF00069	0.426
DOC_PP1_SILK_1	509	514	PF00149	0.508
DOC_PP2B_LxvP_1	231	234	PF13499	0.595
DOC_PP2B_LxvP_1	283	286	PF13499	0.749
DOC_PP2B_LxvP_1	80	83	PF13499	0.447
DOC_PP2B_PxIxI_1	318	324	PF00149	0.536
DOC_SPAK_OSR1_1	244	248	PF12202	0.574
DOC_USP7_MATH_1	201	205	PF00917	0.703
DOC_USP7_MATH_1	36	40	PF00917	0.459
DOC_USP7_MATH_1	44	48	PF00917	0.469
DOC_USP7_MATH_1	74	78	PF00917	0.438
DOC_USP7_UBL2_3	11	15	PF12436	0.444
DOC_USP7_UBL2_3	513	517	PF12436	0.511
DOC_WW_Pin1_4	294	299	PF00397	0.434
LIG_14-3-3_CanoR_1	105	114	PF00244	0.673
LIG_14-3-3_CanoR_1	23	28	PF00244	0.418
LIG_14-3-3_CanoR_1	331	340	PF00244	0.538
LIG_APCC_ABBA_1	485	490	PF00400	0.452
LIG_BRCT_BRCA1_1	352	356	PF00533	0.453
LIG_EH1_1	222	230	PF00400	0.576
LIG_eIF4E_1	50	56	PF01652	0.487
LIG_FHA_1	214	220	PF00498	0.589
LIG_FHA_1	255	261	PF00498	0.628
LIG_FHA_1	388	394	PF00498	0.665
LIG_FHA_1	513	519	PF00498	0.550
LIG_FHA_1	60	66	PF00498	0.435
LIG_FHA_2	439	445	PF00498	0.577
LIG_FHA_2	90	96	PF00498	0.548
LIG_Integrin_RGD_1	131	133	PF01839	0.525
LIG_LIR_Apic_2	190	195	PF02991	0.523
LIG_LIR_Apic_2	514	519	PF02991	0.560
LIG_LIR_Gen_1	121	129	PF02991	0.551
LIG_LIR_Gen_1	133	142	PF02991	0.443
LIG_LIR_Gen_1	378	389	PF02991	0.498
LIG_LIR_Gen_1	405	413	PF02991	0.434
LIG_LIR_Gen_1	427	434	PF02991	0.439
LIG_LIR_Nem_3	121	126	PF02991	0.572
LIG_LIR_Nem_3	133	137	PF02991	0.448
LIG_LIR_Nem_3	378	384	PF02991	0.484
LIG_LIR_Nem_3	405	409	PF02991	0.452
LIG_LIR_Nem_3	427	432	PF02991	0.433
LIG_LIR_Nem_3	489	494	PF02991	0.457
LIG_LIR_Nem_3	505	511	PF02991	0.398
LIG_PDZ_Class_3	521	526	PF00595	0.407
LIG_Pex14_1	161	165	PF04695	0.462
LIG_Pex14_1	521	525	PF04695	0.603
LIG_Pex14_2	472	476	PF04695	0.438
LIG_PTB_Apo_2	172	179	PF02174	0.645
LIG_PTB_Phospho_1	172	178	PF10480	0.644
LIG_SH2_CRK	495	499	PF00017	0.466
LIG_SH2_GRB2like	494	497	PF00017	0.438
LIG_SH2_SRC	310	313	PF00017	0.589
LIG_SH2_STAP1	123	127	PF00017	0.651
LIG_SH2_STAP1	406	410	PF00017	0.429
LIG_SH2_STAP1	488	492	PF00017	0.448
LIG_SH2_STAT5	134	137	PF00017	0.547
LIG_SH2_STAT5	152	155	PF00017	0.448
LIG_SH2_STAT5	165	168	PF00017	0.439
LIG_SH2_STAT5	178	181	PF00017	0.538
LIG_SH2_STAT5	192	195	PF00017	0.413
LIG_SH2_STAT5	218	221	PF00017	0.572
LIG_SH2_STAT5	310	313	PF00017	0.446
LIG_SH2_STAT5	412	415	PF00017	0.452
LIG_SH2_STAT5	488	491	PF00017	0.560
LIG_SH3_1	182	188	PF00018	0.512
LIG_SH3_3	182	188	PF00018	0.512
LIG_SH3_3	227	233	PF00018	0.591
LIG_SH3_3	389	395	PF00018	0.651
LIG_SUMO_SIM_par_1	246	251	PF11976	0.573
LIG_SUMO_SIM_par_1	296	304	PF11976	0.554
LIG_SUMO_SIM_par_1	453	460	PF11976	0.495
LIG_TRAF2_1	385	388	PF00917	0.604
LIG_TRAF2_1	395	398	PF00917	0.686
LIG_TRAF2_1	399	402	PF00917	0.609
LIG_TRFH_1	483	487	PF08558	0.471
LIG_WRC_WIRS_1	65	70	PF05994	0.436
MOD_CK1_1	121	127	PF00069	0.617
MOD_CK1_1	204	210	PF00069	0.631
MOD_CK1_1	51	57	PF00069	0.485
MOD_CK1_1	61	67	PF00069	0.433
MOD_CK2_1	4	10	PF00069	0.496
MOD_CK2_1	89	95	PF00069	0.504
MOD_Cter_Amidation	336	339	PF01082	0.524
MOD_GlcNHglycan	142	145	PF01048	0.624
MOD_GlcNHglycan	203	206	PF01048	0.691
MOD_GlcNHglycan	211	214	PF01048	0.718
MOD_GlcNHglycan	381	384	PF01048	0.496
MOD_GlcNHglycan	498	501	PF01048	0.435
MOD_GSK3_1	108	115	PF00069	0.631
MOD_GSK3_1	2	9	PF00069	0.505
MOD_GSK3_1	209	216	PF00069	0.716
MOD_GSK3_1	23	30	PF00069	0.415
MOD_GSK3_1	246	253	PF00069	0.498
MOD_GSK3_1	254	261	PF00069	0.494
MOD_GSK3_1	275	282	PF00069	0.644
MOD_GSK3_1	44	51	PF00069	0.504
MOD_GSK3_1	81	88	PF00069	0.526
MOD_GSK3_1	91	98	PF00069	0.501
MOD_LATS_1	254	260	PF00433	0.621
MOD_N-GLC_1	213	218	PF02516	0.627
MOD_N-GLC_1	268	273	PF02516	0.581
MOD_N-GLC_1	438	443	PF02516	0.586
MOD_N-GLC_1	519	524	PF02516	0.604
MOD_NEK2_1	118	123	PF00069	0.590
MOD_NEK2_1	268	273	PF00069	0.626
MOD_NEK2_1	279	284	PF00069	0.596
MOD_NEK2_1	363	368	PF00069	0.540
MOD_NEK2_1	48	53	PF00069	0.486
MOD_NEK2_1	512	517	PF00069	0.526
MOD_NEK2_1	73	78	PF00069	0.475
MOD_NEK2_1	96	101	PF00069	0.576
MOD_NEK2_2	438	443	PF00069	0.586
MOD_PIKK_1	146	152	PF00454	0.557
MOD_PIKK_1	301	307	PF00454	0.533
MOD_PIKK_1	48	54	PF00454	0.442
MOD_PK_1	112	118	PF00069	0.515
MOD_PK_1	23	29	PF00069	0.417
MOD_PK_1	246	252	PF00069	0.575
MOD_PK_1	4	10	PF00069	0.477
MOD_PKA_1	112	118	PF00069	0.511
MOD_PKA_1	331	337	PF00069	0.655
MOD_PKA_2	146	152	PF00069	0.650
MOD_PKA_2	350	356	PF00069	0.438
MOD_PKB_1	103	111	PF00069	0.555
MOD_Plk_1	118	124	PF00069	0.585
MOD_Plk_1	213	219	PF00069	0.596
MOD_Plk_1	250	256	PF00069	0.473
MOD_Plk_1	268	274	PF00069	0.402
MOD_Plk_1	438	444	PF00069	0.582
MOD_Plk_1	519	525	PF00069	0.595
MOD_Plk_4	118	124	PF00069	0.585
MOD_Plk_4	214	220	PF00069	0.510
MOD_Plk_4	275	281	PF00069	0.713
MOD_Plk_4	376	382	PF00069	0.559
MOD_Plk_4	44	50	PF00069	0.486
MOD_Plk_4	51	57	PF00069	0.454
MOD_Plk_4	61	67	PF00069	0.402
MOD_ProDKin_1	294	300	PF00069	0.432
MOD_SUMO_rev_2	109	114	PF00179	0.482
TRG_DiLeu_BaEn_3	167	173	PF01217	0.616
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.441
TRG_ENDOCYTIC_2	123	126	PF00928	0.575
TRG_ENDOCYTIC_2	134	137	PF00928	0.487
TRG_ENDOCYTIC_2	178	181	PF00928	0.647
TRG_ENDOCYTIC_2	406	409	PF00928	0.421
TRG_ENDOCYTIC_2	488	491	PF00928	0.467
TRG_ENDOCYTIC_2	495	498	PF00928	0.455
TRG_ER_diArg_1	103	106	PF00400	0.558
TRG_ER_diArg_1	16	18	PF00400	0.469
TRG_ER_diArg_1	338	340	PF00400	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBZ1	Leptomonas seymouri	76%	100%
A0A1X0P2M2	Trypanosomatidae	49%	100%
A0A422P525	Trypanosoma rangeli	50%	100%
A4HI76	Leishmania braziliensis	87%	100%
A4I676	Leishmania infantum	99%	100%
C9ZQU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B0Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q7I0	Leishmania major	88%	100%
V5BU66	Trypanosoma cruzi	50%	100%