Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBX4_LEIDO

TriTrypDb:

LdBPK_090920.1 , LdCL_090014600 , LDHU3_09.1070

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	459	463	PF00656	0.686
CLV_NRD_NRD_1	117	119	PF00675	0.625
CLV_NRD_NRD_1	148	150	PF00675	0.632
CLV_NRD_NRD_1	387	389	PF00675	0.683
CLV_NRD_NRD_1	434	436	PF00675	0.622
CLV_NRD_NRD_1	453	455	PF00675	0.474
CLV_NRD_NRD_1	480	482	PF00675	0.581
CLV_NRD_NRD_1	9	11	PF00675	0.720
CLV_PCSK_KEX2_1	116	118	PF00082	0.573
CLV_PCSK_KEX2_1	148	150	PF00082	0.632
CLV_PCSK_KEX2_1	387	389	PF00082	0.683
CLV_PCSK_KEX2_1	453	455	PF00082	0.678
CLV_PCSK_KEX2_1	517	519	PF00082	0.659
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.585
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.659
CLV_PCSK_PC7_1	112	118	PF00082	0.676
CLV_PCSK_SKI1_1	117	121	PF00082	0.677
CLV_PCSK_SKI1_1	413	417	PF00082	0.664
CLV_PCSK_SKI1_1	436	440	PF00082	0.634
DEG_Nend_Nbox_1	1	3	PF02207	0.677
DEG_SCF_FBW7_1	313	319	PF00400	0.726
DEG_SPOP_SBC_1	71	75	PF00917	0.808
DOC_CKS1_1	313	318	PF01111	0.725
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.769
DOC_MAPK_gen_1	517	523	PF00069	0.682
DOC_MAPK_RevD_3	440	454	PF00069	0.683
DOC_PP2B_LxvP_1	20	23	PF13499	0.807
DOC_PP2B_LxvP_1	442	445	PF13499	0.689
DOC_PP4_FxxP_1	297	300	PF00568	0.798
DOC_PP4_FxxP_1	371	374	PF00568	0.777
DOC_PP4_MxPP_1	438	441	PF00568	0.674
DOC_USP7_MATH_1	265	269	PF00917	0.634
DOC_USP7_MATH_1	290	294	PF00917	0.793
DOC_USP7_MATH_1	334	338	PF00917	0.732
DOC_USP7_MATH_1	72	76	PF00917	0.769
DOC_WW_Pin1_4	296	301	PF00397	0.780
DOC_WW_Pin1_4	312	317	PF00397	0.821
DOC_WW_Pin1_4	320	325	PF00397	0.749
DOC_WW_Pin1_4	404	409	PF00397	0.680
LIG_14-3-3_CanoR_1	256	260	PF00244	0.709
LIG_14-3-3_CanoR_1	289	295	PF00244	0.625
LIG_14-3-3_CanoR_1	435	439	PF00244	0.610
LIG_Actin_WH2_2	85	101	PF00022	0.695
LIG_BRCT_BRCA1_1	336	340	PF00533	0.726
LIG_EVH1_1	41	45	PF00568	0.616
LIG_EVH1_1	439	443	PF00568	0.676
LIG_FHA_1	171	177	PF00498	0.531
LIG_FHA_1	289	295	PF00498	0.663
LIG_FHA_1	396	402	PF00498	0.625
LIG_FHA_1	414	420	PF00498	0.604
LIG_FHA_1	71	77	PF00498	0.811
LIG_FHA_2	139	145	PF00498	0.611
LIG_FHA_2	237	243	PF00498	0.653
LIG_FHA_2	348	354	PF00498	0.816
LIG_FHA_2	472	478	PF00498	0.601
LIG_LIR_Apic_2	369	374	PF02991	0.672
LIG_LIR_Gen_1	251	261	PF02991	0.607
LIG_LIR_Nem_3	251	257	PF02991	0.610
LIG_MYND_1	440	444	PF01753	0.689
LIG_PDZ_Class_2	518	523	PF00595	0.680
LIG_PDZ_Wminus1_1	521	523	PF00595	0.756
LIG_PTAP_UEV_1	302	307	PF05743	0.714
LIG_PTB_Apo_2	56	63	PF02174	0.809
LIG_SH2_CRK	364	368	PF00017	0.736
LIG_SH2_CRK	491	495	PF00017	0.650
LIG_SH2_CRK	95	99	PF00017	0.667
LIG_SH2_NCK_1	429	433	PF00017	0.724
LIG_SH2_PTP2	254	257	PF00017	0.612
LIG_SH2_STAP1	2	6	PF00017	0.679
LIG_SH2_STAP1	429	433	PF00017	0.627
LIG_SH2_STAT3	188	191	PF00017	0.544
LIG_SH2_STAT5	188	191	PF00017	0.576
LIG_SH2_STAT5	254	257	PF00017	0.612
LIG_SH2_STAT5	364	367	PF00017	0.655
LIG_SH2_STAT5	370	373	PF00017	0.663
LIG_SH2_STAT5	488	491	PF00017	0.629
LIG_SH3_2	441	446	PF14604	0.764
LIG_SH3_3	297	303	PF00018	0.728
LIG_SH3_3	310	316	PF00018	0.637
LIG_SH3_3	333	339	PF00018	0.693
LIG_SH3_3	380	386	PF00018	0.735
LIG_SH3_3	39	45	PF00018	0.660
LIG_SH3_3	402	408	PF00018	0.707
LIG_SH3_3	437	443	PF00018	0.756
LIG_SH3_3	506	512	PF00018	0.775
LIG_SH3_3	76	82	PF00018	0.793
LIG_SH3_CIN85_PxpxPR_1	441	446	PF14604	0.764
LIG_TRAF2_1	136	139	PF00917	0.688
LIG_TRAF2_1	200	203	PF00917	0.518
LIG_TRAF2_1	249	252	PF00917	0.632
LIG_TRAF2_1	350	353	PF00917	0.599
LIG_TYR_ITIM	362	367	PF00017	0.692
LIG_TYR_ITIM	489	494	PF00017	0.640
LIG_WRC_WIRS_1	1	6	PF05994	0.668
LIG_WW_2	440	443	PF00397	0.686
LIG_WW_3	443	447	PF00397	0.765
MOD_CK1_1	12	18	PF00069	0.692
MOD_CK1_1	207	213	PF00069	0.667
MOD_CK1_1	220	226	PF00069	0.733
MOD_CK1_1	235	241	PF00069	0.664
MOD_CK1_1	299	305	PF00069	0.769
MOD_CK1_1	5	11	PF00069	0.786
MOD_CK2_1	138	144	PF00069	0.564
MOD_CK2_1	347	353	PF00069	0.785
MOD_Cter_Amidation	515	518	PF01082	0.663
MOD_GlcNHglycan	11	14	PF01048	0.693
MOD_GlcNHglycan	17	20	PF01048	0.691
MOD_GlcNHglycan	234	237	PF01048	0.713
MOD_GlcNHglycan	303	306	PF01048	0.719
MOD_GlcNHglycan	336	339	PF01048	0.746
MOD_GlcNHglycan	374	377	PF01048	0.766
MOD_GlcNHglycan	429	432	PF01048	0.622
MOD_GSK3_1	216	223	PF00069	0.751
MOD_GSK3_1	231	238	PF00069	0.782
MOD_GSK3_1	304	311	PF00069	0.810
MOD_GSK3_1	312	319	PF00069	0.707
MOD_GSK3_1	320	327	PF00069	0.735
MOD_GSK3_1	372	379	PF00069	0.658
MOD_GSK3_1	409	416	PF00069	0.651
MOD_GSK3_1	5	12	PF00069	0.669
MOD_N-GLC_1	15	20	PF02516	0.699
MOD_N-GLC_1	497	502	PF02516	0.720
MOD_NEK2_1	204	209	PF00069	0.700
MOD_NEK2_1	460	465	PF00069	0.589
MOD_NEK2_1	489	494	PF00069	0.640
MOD_NEK2_2	72	77	PF00069	0.812
MOD_PIKK_1	170	176	PF00454	0.532
MOD_PIKK_1	304	310	PF00454	0.836
MOD_PKA_2	170	176	PF00069	0.532
MOD_PKA_2	189	195	PF00069	0.555
MOD_PKA_2	255	261	PF00069	0.708
MOD_PKA_2	288	294	PF00069	0.681
MOD_PKA_2	434	440	PF00069	0.722
MOD_PKA_2	460	466	PF00069	0.686
MOD_PKA_2	9	15	PF00069	0.626
MOD_Plk_1	102	108	PF00069	0.521
MOD_Plk_1	446	452	PF00069	0.753
MOD_Plk_2-3	471	477	PF00069	0.630
MOD_Plk_4	184	190	PF00069	0.557
MOD_Plk_4	362	368	PF00069	0.612
MOD_Plk_4	434	440	PF00069	0.722
MOD_Plk_4	460	466	PF00069	0.585
MOD_Plk_4	72	78	PF00069	0.811
MOD_ProDKin_1	296	302	PF00069	0.779
MOD_ProDKin_1	312	318	PF00069	0.823
MOD_ProDKin_1	320	326	PF00069	0.747
MOD_ProDKin_1	404	410	PF00069	0.678
MOD_SUMO_for_1	126	129	PF00179	0.579
MOD_SUMO_rev_2	33	37	PF00179	0.783
MOD_SUMO_rev_2	477	484	PF00179	0.696
TRG_ENDOCYTIC_2	254	257	PF00928	0.612
TRG_ENDOCYTIC_2	364	367	PF00928	0.738
TRG_ENDOCYTIC_2	491	494	PF00928	0.650
TRG_ENDOCYTIC_2	95	98	PF00928	0.618
TRG_ER_diArg_1	148	150	PF00400	0.637
TRG_ER_diArg_1	285	288	PF00400	0.773
TRG_ER_diArg_1	386	388	PF00400	0.683
TRG_ER_diArg_1	452	454	PF00400	0.690
TRG_NLS_MonoCore_2	114	119	PF00514	0.598
TRG_NLS_MonoExtN_4	112	119	PF00514	0.633
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J5	Leptomonas seymouri	45%	100%
A4H5N6	Leishmania braziliensis	74%	100%
A4HU08	Leishmania infantum	100%	100%
E9AMT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QHT7	Leishmania major	92%	100%