Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBW9_LEIDO

TriTrypDb:

LdBPK_211230.1 , LdCL_210017400 , LDHU3_21.1460

Length:

142

Annotations

LeishMANIAdb annotations

A single-pass helical protein with a potential mitochondrial transit signal. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IBW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	58	60	PF00675	0.433
CLV_NRD_NRD_1	73	75	PF00675	0.380
CLV_PCSK_KEX2_1	58	60	PF00082	0.434
CLV_PCSK_KEX2_1	73	75	PF00082	0.377
CLV_PCSK_SKI1_1	131	135	PF00082	0.404
CLV_PCSK_SKI1_1	60	64	PF00082	0.404
CLV_PCSK_SKI1_1	74	78	PF00082	0.425
DEG_APCC_DBOX_1	73	81	PF00400	0.691
DOC_MAPK_gen_1	122	130	PF00069	0.645
DOC_MAPK_gen_1	48	57	PF00069	0.593
DOC_MAPK_gen_1	70	80	PF00069	0.682
DOC_MAPK_MEF2A_6	48	57	PF00069	0.577
DOC_USP7_MATH_1	138	142	PF00917	0.694
DOC_WW_Pin1_4	16	21	PF00397	0.422
DOC_WW_Pin1_4	8	13	PF00397	0.402
LIG_14-3-3_CanoR_1	91	98	PF00244	0.650
LIG_APCC_ABBAyCdc20_2	50	56	PF00400	0.633
LIG_BRCT_BRCA1_1	42	46	PF00533	0.607
LIG_Clathr_ClatBox_1	77	81	PF01394	0.701
LIG_MLH1_MIPbox_1	42	46	PF16413	0.607
LIG_PALB2_WD40_1	5	13	PF16756	0.504
LIG_PDZ_Class_3	137	142	PF00595	0.729
LIG_SH2_SRC	40	43	PF00017	0.647
LIG_SH2_STAT5	4	7	PF00017	0.442
LIG_SH2_STAT5	45	48	PF00017	0.620
LIG_SH3_3	2	8	PF00018	0.442
LIG_SUMO_SIM_par_1	93	101	PF11976	0.741
LIG_UBA3_1	126	134	PF00899	0.645
MOD_CK1_1	18	24	PF00069	0.350
MOD_CK1_1	97	103	PF00069	0.739
MOD_GlcNHglycan	92	95	PF01048	0.470
MOD_GSK3_1	90	97	PF00069	0.716
MOD_NEK2_1	15	20	PF00069	0.439
MOD_PIKK_1	98	104	PF00454	0.614
MOD_PKA_2	90	96	PF00069	0.651
MOD_ProDKin_1	16	22	PF00069	0.418
MOD_ProDKin_1	8	14	PF00069	0.398
MOD_SUMO_rev_2	129	135	PF00179	0.623
TRG_ENDOCYTIC_2	23	26	PF00928	0.391
TRG_ENDOCYTIC_2	65	68	PF00928	0.600
TRG_ER_diArg_1	57	59	PF00400	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R0	Leptomonas seymouri	75%	100%
A0A1X0NYD4	Trypanosomatidae	64%	100%
A4HBV9	Leishmania braziliensis	91%	100%
D0A199	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	96%
E9AGW7	Leishmania infantum	100%	100%
E9AV83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QC97	Leishmania major	97%	100%