p22_protein_precursor_putative/GeneDB:LmjF.30.097 0

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

p22 protein precursor, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBW7_LEIDO

TriTrypDb:

LdBPK_301030.1 , LdCL_300015500 , LDHU3_30.1350

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 18
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	20
GO:0031974	membrane-enclosed lumen	2	20
GO:0043233	organelle lumen	3	20
GO:0070013	intracellular organelle lumen	4	20
GO:0110165	cellular anatomical entity	1	20

Expansion

Sequence features

A0A3Q8IBW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBW7

PDB structure(s): 1yqf_A , 1yqf_B , 1yqf_C , 1yqf_D , 1yqf_E , 1yqf_F

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.650
CLV_C14_Caspase3-7	51	55	PF00656	0.469
CLV_NRD_NRD_1	2	4	PF00675	0.581
CLV_NRD_NRD_1	49	51	PF00675	0.571
CLV_NRD_NRD_1	62	64	PF00675	0.515
CLV_NRD_NRD_1	87	89	PF00675	0.471
CLV_PCSK_KEX2_1	171	173	PF00082	0.301
CLV_PCSK_KEX2_1	198	200	PF00082	0.358
CLV_PCSK_KEX2_1	2	4	PF00082	0.577
CLV_PCSK_KEX2_1	49	51	PF00082	0.570
CLV_PCSK_KEX2_1	62	64	PF00082	0.512
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.344
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.358
DEG_Nend_UBRbox_1	1	4	PF02207	0.548
DEG_SPOP_SBC_1	36	40	PF00917	0.491
DOC_CKS1_1	77	82	PF01111	0.602
DOC_MAPK_gen_1	2	10	PF00069	0.627
DOC_PP2B_LxvP_1	45	48	PF13499	0.556
DOC_USP7_MATH_1	28	32	PF00917	0.691
DOC_USP7_MATH_1	37	41	PF00917	0.718
DOC_USP7_MATH_1	48	52	PF00917	0.672
DOC_WW_Pin1_4	76	81	PF00397	0.582
LIG_14-3-3_CanoR_1	2	6	PF00244	0.632
LIG_14-3-3_CanoR_1	35	45	PF00244	0.586
LIG_14-3-3_CanoR_1	49	57	PF00244	0.434
LIG_CtBP_PxDLS_1	103	109	PF00389	0.511
LIG_deltaCOP1_diTrp_1	222	231	PF00928	0.473
LIG_FHA_1	175	181	PF00498	0.520
LIG_FHA_1	92	98	PF00498	0.484
LIG_FHA_2	110	116	PF00498	0.593
LIG_FHA_2	162	168	PF00498	0.498
LIG_FHA_2	192	198	PF00498	0.470
LIG_FHA_2	59	65	PF00498	0.471
LIG_GBD_Chelix_1	180	188	PF00786	0.358
LIG_LIR_Apic_2	174	179	PF02991	0.480
LIG_LIR_Gen_1	183	193	PF02991	0.558
LIG_LIR_Gen_1	207	216	PF02991	0.533
LIG_LIR_Gen_1	31	41	PF02991	0.766
LIG_LIR_Gen_1	4	13	PF02991	0.696
LIG_LIR_LC3C_4	104	108	PF02991	0.506
LIG_LIR_Nem_3	123	128	PF02991	0.487
LIG_LIR_Nem_3	183	189	PF02991	0.506
LIG_LIR_Nem_3	207	211	PF02991	0.521
LIG_LIR_Nem_3	31	36	PF02991	0.780
LIG_LIR_Nem_3	4	8	PF02991	0.675
LIG_LRP6_Inhibitor_1	147	153	PF00058	0.358
LIG_PTB_Apo_2	148	155	PF02174	0.518
LIG_SH2_CRK	176	180	PF00017	0.505
LIG_SH2_CRK	186	190	PF00017	0.505
LIG_SH2_NCK_1	155	159	PF00017	0.560
LIG_SH2_SRC	155	158	PF00017	0.548
LIG_SH2_STAP1	155	159	PF00017	0.585
LIG_SH2_STAP1	212	216	PF00017	0.486
LIG_SH2_STAP1	221	225	PF00017	0.456
LIG_SH2_STAT3	127	130	PF00017	0.558
LIG_SH2_STAT5	127	130	PF00017	0.522
LIG_SH2_STAT5	176	179	PF00017	0.558
LIG_SH2_STAT5	195	198	PF00017	0.445
LIG_SH3_3	72	78	PF00018	0.513
LIG_SH3_3	84	90	PF00018	0.474
LIG_TRAF2_1	141	144	PF00917	0.547
LIG_TYR_ITIM	184	189	PF00017	0.540
LIG_WRC_WIRS_1	211	216	PF05994	0.553
MOD_CK1_1	40	46	PF00069	0.694
MOD_CK2_1	138	144	PF00069	0.532
MOD_CK2_1	161	167	PF00069	0.505
MOD_CK2_1	191	197	PF00069	0.528
MOD_CK2_1	58	64	PF00069	0.416
MOD_GlcNHglycan	10	13	PF01048	0.595
MOD_GlcNHglycan	163	167	PF01048	0.325
MOD_GlcNHglycan	26	29	PF01048	0.661
MOD_GlcNHglycan	30	33	PF01048	0.634
MOD_GlcNHglycan	39	42	PF01048	0.562
MOD_GlcNHglycan	50	53	PF01048	0.454
MOD_GSK3_1	109	116	PF00069	0.612
MOD_GSK3_1	128	135	PF00069	0.463
MOD_GSK3_1	24	31	PF00069	0.627
MOD_GSK3_1	36	43	PF00069	0.568
MOD_GSK3_1	91	98	PF00069	0.439
MOD_NEK2_1	1	6	PF00069	0.590
MOD_NEK2_1	8	13	PF00069	0.574
MOD_NEK2_1	95	100	PF00069	0.418
MOD_PIKK_1	126	132	PF00454	0.564
MOD_PKA_2	1	7	PF00069	0.653
MOD_PKA_2	108	114	PF00069	0.522
MOD_PKA_2	48	54	PF00069	0.637
MOD_Plk_1	138	144	PF00069	0.571
MOD_Plk_4	191	197	PF00069	0.478
MOD_Plk_4	210	216	PF00069	0.558
MOD_ProDKin_1	76	82	PF00069	0.586
MOD_SUMO_rev_2	197	205	PF00179	0.558
TRG_DiLeu_BaEn_1	102	107	PF01217	0.528
TRG_DiLeu_BaEn_1	143	148	PF01217	0.528
TRG_ENDOCYTIC_2	186	189	PF00928	0.540
TRG_ER_diArg_1	1	3	PF00400	0.589
TRG_ER_diArg_1	48	50	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P990	Leptomonas seymouri	79%	100%
A0A0N1HS24	Leptomonas seymouri	24%	91%
A0A0S4ITN8	Bodo saltans	39%	100%
A0A1X0NTH7	Trypanosomatidae	25%	89%
A0A1X0P207	Trypanosomatidae	45%	100%
A0A3Q8IFM4	Leishmania donovani	27%	91%
A0A422P4Z7	Trypanosoma rangeli	41%	100%
A4HCI6	Leishmania braziliensis	28%	100%
A4HI52	Leishmania braziliensis	94%	100%
A4I007	Leishmania infantum	27%	100%
A4I5C8	Leishmania infantum	100%	100%
C9ZQR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZSQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	90%
E9AVY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q7K6	Leishmania major	98%	100%
Q4QBJ9	Leishmania major	27%	100%
V5BDB3	Trypanosoma cruzi	26%	89%