Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBW5_LEIDO

TriTrypDb:

LdBPK_210710.1 , LdCL_210012000 , LDHU3_21.0770

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBW5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.704
CLV_C14_Caspase3-7	343	347	PF00656	0.460
CLV_NRD_NRD_1	230	232	PF00675	0.552
CLV_NRD_NRD_1	237	239	PF00675	0.485
CLV_NRD_NRD_1	310	312	PF00675	0.381
CLV_NRD_NRD_1	589	591	PF00675	0.419
CLV_NRD_NRD_1	604	606	PF00675	0.585
CLV_NRD_NRD_1	630	632	PF00675	0.403
CLV_PCSK_FUR_1	235	239	PF00082	0.519
CLV_PCSK_KEX2_1	230	232	PF00082	0.522
CLV_PCSK_KEX2_1	237	239	PF00082	0.443
CLV_PCSK_KEX2_1	247	249	PF00082	0.407
CLV_PCSK_KEX2_1	310	312	PF00082	0.381
CLV_PCSK_KEX2_1	589	591	PF00082	0.419
CLV_PCSK_KEX2_1	604	606	PF00082	0.397
CLV_PCSK_KEX2_1	629	631	PF00082	0.415
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.525
CLV_PCSK_PC7_1	585	591	PF00082	0.383
CLV_PCSK_SKI1_1	127	131	PF00082	0.622
CLV_PCSK_SKI1_1	137	141	PF00082	0.420
CLV_PCSK_SKI1_1	301	305	PF00082	0.481
CLV_PCSK_SKI1_1	310	314	PF00082	0.420
CLV_PCSK_SKI1_1	351	355	PF00082	0.368
CLV_PCSK_SKI1_1	364	368	PF00082	0.417
CLV_PCSK_SKI1_1	488	492	PF00082	0.403
CLV_PCSK_SKI1_1	498	502	PF00082	0.482
CLV_PCSK_SKI1_1	614	618	PF00082	0.457
CLV_PCSK_SKI1_1	630	634	PF00082	0.407
DEG_APCC_DBOX_1	236	244	PF00400	0.489
DEG_APCC_DBOX_1	363	371	PF00400	0.427
DEG_APCC_DBOX_1	497	505	PF00400	0.505
DOC_CKS1_1	128	133	PF01111	0.622
DOC_CKS1_1	326	331	PF01111	0.449
DOC_MAPK_gen_1	16	24	PF00069	0.364
DOC_MAPK_gen_1	310	318	PF00069	0.383
DOC_MAPK_MEF2A_6	310	318	PF00069	0.423
DOC_MAPK_MEF2A_6	79	87	PF00069	0.492
DOC_PP1_RVXF_1	236	243	PF00149	0.444
DOC_PP2B_LxvP_1	541	544	PF13499	0.477
DOC_PP2B_PxIxI_1	32	38	PF00149	0.354
DOC_PP4_FxxP_1	481	484	PF00568	0.456
DOC_USP7_MATH_1	110	114	PF00917	0.738
DOC_USP7_MATH_1	129	133	PF00917	0.346
DOC_USP7_MATH_1	195	199	PF00917	0.709
DOC_USP7_MATH_1	3	7	PF00917	0.486
DOC_USP7_MATH_1	382	386	PF00917	0.739
DOC_USP7_MATH_1	398	402	PF00917	0.609
DOC_USP7_MATH_1	420	424	PF00917	0.542
DOC_USP7_MATH_1	490	494	PF00917	0.432
DOC_USP7_MATH_1	503	507	PF00917	0.595
DOC_WW_Pin1_4	127	132	PF00397	0.684
DOC_WW_Pin1_4	158	163	PF00397	0.417
DOC_WW_Pin1_4	208	213	PF00397	0.678
DOC_WW_Pin1_4	224	229	PF00397	0.494
DOC_WW_Pin1_4	310	315	PF00397	0.483
DOC_WW_Pin1_4	325	330	PF00397	0.376
DOC_WW_Pin1_4	522	527	PF00397	0.603
DOC_WW_Pin1_4	551	556	PF00397	0.640
LIG_14-3-3_CanoR_1	301	307	PF00244	0.501
LIG_14-3-3_CanoR_1	351	357	PF00244	0.457
LIG_14-3-3_CanoR_1	433	440	PF00244	0.548
LIG_14-3-3_CanoR_1	492	502	PF00244	0.454
LIG_Actin_WH2_2	113	129	PF00022	0.484
LIG_Actin_WH2_2	167	185	PF00022	0.356
LIG_BIR_II_1	1	5	PF00653	0.357
LIG_BRCT_BRCA1_1	529	533	PF00533	0.463
LIG_deltaCOP1_diTrp_1	576	584	PF00928	0.392
LIG_eIF4E_1	489	495	PF01652	0.488
LIG_EVH1_1	501	505	PF00568	0.510
LIG_FHA_1	311	317	PF00498	0.449
LIG_FHA_1	352	358	PF00498	0.510
LIG_FHA_1	387	393	PF00498	0.756
LIG_FHA_1	434	440	PF00498	0.617
LIG_FHA_1	489	495	PF00498	0.536
LIG_FHA_2	253	259	PF00498	0.454
LIG_FHA_2	535	541	PF00498	0.363
LIG_Integrin_RGD_1	394	396	PF01839	0.457
LIG_LIR_Gen_1	401	410	PF02991	0.416
LIG_LIR_Nem_3	401	405	PF02991	0.407
LIG_LIR_Nem_3	423	429	PF02991	0.522
LIG_LIR_Nem_3	485	489	PF02991	0.461
LIG_MYND_1	499	503	PF01753	0.519
LIG_SH2_CRK	427	431	PF00017	0.497
LIG_SH2_CRK	479	483	PF00017	0.524
LIG_SH2_NCK_1	550	554	PF00017	0.574
LIG_SH2_STAP1	534	538	PF00017	0.417
LIG_SH2_STAT5	414	417	PF00017	0.523
LIG_SH3_1	552	558	PF00018	0.468
LIG_SH3_2	523	528	PF14604	0.599
LIG_SH3_3	128	134	PF00018	0.669
LIG_SH3_3	206	212	PF00018	0.595
LIG_SH3_3	290	296	PF00018	0.524
LIG_SH3_3	496	502	PF00018	0.548
LIG_SH3_3	504	510	PF00018	0.650
LIG_SH3_3	520	526	PF00018	0.498
LIG_SH3_3	552	558	PF00018	0.635
LIG_SH3_CIN85_PxpxPR_1	160	165	PF14604	0.499
LIG_Sin3_3	567	574	PF02671	0.463
LIG_SUMO_SIM_anti_2	315	320	PF11976	0.485
LIG_SUMO_SIM_anti_2	537	543	PF11976	0.333
LIG_SUMO_SIM_par_1	82	91	PF11976	0.479
LIG_TRAF2_1	211	214	PF00917	0.455
LIG_TRAF2_1	23	26	PF00917	0.465
LIG_TRAF2_1	255	258	PF00917	0.572
LIG_TRAF2_1	609	612	PF00917	0.476
LIG_WRC_WIRS_1	4	9	PF05994	0.334
LIG_WRC_WIRS_1	92	97	PF05994	0.429
LIG_WW_3	554	558	PF00397	0.619
MOD_CDC14_SPxK_1	227	230	PF00782	0.512
MOD_CDC14_SPxK_1	525	528	PF00782	0.601
MOD_CDC14_SPxK_1	554	557	PF00782	0.617
MOD_CDK_SPxK_1	224	230	PF00069	0.495
MOD_CDK_SPxK_1	522	528	PF00069	0.602
MOD_CDK_SPxK_1	551	557	PF00069	0.637
MOD_CDK_SPxxK_3	130	137	PF00069	0.342
MOD_CDK_SPxxK_3	158	165	PF00069	0.385
MOD_CDK_SPxxK_3	224	231	PF00069	0.499
MOD_CK1_1	103	109	PF00069	0.460
MOD_CK1_1	111	117	PF00069	0.738
MOD_CK1_1	2	8	PF00069	0.397
MOD_CK1_1	273	279	PF00069	0.405
MOD_CK1_1	289	295	PF00069	0.513
MOD_CK1_1	359	365	PF00069	0.392
MOD_CK1_1	432	438	PF00069	0.551
MOD_CK1_1	493	499	PF00069	0.454
MOD_CK1_1	527	533	PF00069	0.495
MOD_CK1_1	91	97	PF00069	0.476
MOD_CK2_1	208	214	PF00069	0.668
MOD_CK2_1	252	258	PF00069	0.547
MOD_CK2_1	534	540	PF00069	0.368
MOD_CK2_1	87	93	PF00069	0.539
MOD_CMANNOS	146	149	PF00535	0.347
MOD_Cter_Amidation	461	464	PF01082	0.287
MOD_GlcNHglycan	1	4	PF01048	0.457
MOD_GlcNHglycan	110	113	PF01048	0.715
MOD_GlcNHglycan	141	144	PF01048	0.376
MOD_GlcNHglycan	202	205	PF01048	0.680
MOD_GlcNHglycan	232	235	PF01048	0.532
MOD_GlcNHglycan	272	275	PF01048	0.466
MOD_GlcNHglycan	288	291	PF01048	0.565
MOD_GlcNHglycan	376	380	PF01048	0.551
MOD_GlcNHglycan	384	387	PF01048	0.583
MOD_GlcNHglycan	518	521	PF01048	0.694
MOD_GlcNHglycan	529	532	PF01048	0.596
MOD_GSK3_1	100	107	PF00069	0.496
MOD_GSK3_1	196	203	PF00069	0.683
MOD_GSK3_1	208	215	PF00069	0.595
MOD_GSK3_1	282	289	PF00069	0.503
MOD_GSK3_1	302	309	PF00069	0.527
MOD_GSK3_1	328	335	PF00069	0.560
MOD_GSK3_1	352	359	PF00069	0.461
MOD_GSK3_1	382	389	PF00069	0.697
MOD_GSK3_1	428	435	PF00069	0.633
MOD_GSK3_1	87	94	PF00069	0.394
MOD_N-GLC_1	386	391	PF02516	0.631
MOD_NEK2_1	102	107	PF00069	0.522
MOD_NEK2_1	141	146	PF00069	0.370
MOD_NEK2_1	306	311	PF00069	0.427
MOD_NEK2_1	429	434	PF00069	0.685
MOD_NEK2_1	598	603	PF00069	0.433
MOD_NEK2_1	95	100	PF00069	0.424
MOD_PIKK_1	100	106	PF00454	0.539
MOD_PIKK_1	141	147	PF00454	0.364
MOD_PIKK_1	368	374	PF00454	0.521
MOD_PKA_1	230	236	PF00069	0.593
MOD_PKA_1	589	595	PF00069	0.400
MOD_PKA_2	230	236	PF00069	0.610
MOD_PKA_2	359	365	PF00069	0.417
MOD_PKA_2	368	374	PF00069	0.456
MOD_PKA_2	432	438	PF00069	0.524
MOD_PKA_2	58	64	PF00069	0.379
MOD_PKA_2	589	595	PF00069	0.422
MOD_Plk_1	213	219	PF00069	0.431
MOD_Plk_1	238	244	PF00069	0.532
MOD_Plk_1	332	338	PF00069	0.533
MOD_Plk_1	88	94	PF00069	0.543
MOD_Plk_4	196	202	PF00069	0.635
MOD_Plk_4	238	244	PF00069	0.481
MOD_Plk_4	3	9	PF00069	0.339
MOD_Plk_4	352	358	PF00069	0.544
MOD_Plk_4	410	416	PF00069	0.509
MOD_Plk_4	435	441	PF00069	0.555
MOD_Plk_4	534	540	PF00069	0.291
MOD_Plk_4	598	604	PF00069	0.497
MOD_Plk_4	91	97	PF00069	0.430
MOD_ProDKin_1	127	133	PF00069	0.671
MOD_ProDKin_1	158	164	PF00069	0.416
MOD_ProDKin_1	208	214	PF00069	0.670
MOD_ProDKin_1	224	230	PF00069	0.495
MOD_ProDKin_1	310	316	PF00069	0.481
MOD_ProDKin_1	325	331	PF00069	0.378
MOD_ProDKin_1	522	528	PF00069	0.602
MOD_ProDKin_1	551	557	PF00069	0.637
TRG_DiLeu_BaEn_4	257	263	PF01217	0.421
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.481
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.507
TRG_ENDOCYTIC_2	427	430	PF00928	0.497
TRG_ENDOCYTIC_2	478	481	PF00928	0.508
TRG_ER_diArg_1	177	180	PF00400	0.418
TRG_ER_diArg_1	230	232	PF00400	0.620
TRG_ER_diArg_1	248	251	PF00400	0.570
TRG_ER_diArg_1	310	312	PF00400	0.477
TRG_ER_diArg_1	588	590	PF00400	0.402
TRG_ER_diArg_1	603	605	PF00400	0.361
TRG_ER_diArg_1	628	631	PF00400	0.407
TRG_NES_CRM1_1	442	455	PF08389	0.554
TRG_NLS_Bipartite_1	230	251	PF00514	0.571
TRG_NLS_MonoExtN_4	244	251	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	310	315	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAU6	Leptomonas seymouri	51%	100%
A0A1X0NYZ1	Trypanosomatidae	24%	100%
A0A422NHB0	Trypanosoma rangeli	25%	100%
A4HBR2	Leishmania braziliensis	77%	100%
A4HZ64	Leishmania infantum	100%	100%
D0A1H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AV31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QCF0	Leishmania major	94%	100%
V5BIF6	Trypanosoma cruzi	26%	100%