SNARE domain family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

syntaxin, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBW4_LEIDO

TriTrypDb:

LdBPK_210080.1 , LdCL_210005700 , LDHU3_21.0090

Length:

233

Annotations

Annotations by Jardim et al.

Vesicle mediated transport, syntaxin

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0012505	endomembrane system	2	2
GO:0031201	SNARE complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0098796	membrane protein complex	2	2
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3Q8IBW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBW4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	4
GO:0006886	intracellular protein transport	4	2
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0022406	membrane docking	2	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2
GO:0006887	exocytosis	4	1
GO:0016192	vesicle-mediated transport	4	3
GO:0032940	secretion by cell	3	1
GO:0046903	secretion	4	1
GO:0140352	export from cell	2	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.608
CLV_PCSK_SKI1_1	43	47	PF00082	0.409
CLV_PCSK_SKI1_1	57	61	PF00082	0.394
CLV_Separin_Metazoa	58	62	PF03568	0.550
DEG_Nend_Nbox_1	1	3	PF02207	0.735
DEG_SPOP_SBC_1	33	37	PF00917	0.505
DOC_MAPK_gen_1	160	169	PF00069	0.660
DOC_MAPK_MEF2A_6	185	194	PF00069	0.519
DOC_PP1_RVXF_1	152	158	PF00149	0.573
DOC_USP7_MATH_1	122	126	PF00917	0.708
DOC_USP7_MATH_1	206	210	PF00917	0.474
DOC_USP7_UBL2_3	69	73	PF12436	0.656
DOC_WW_Pin1_4	118	123	PF00397	0.617
LIG_14-3-3_CanoR_1	154	158	PF00244	0.618
LIG_Actin_WH2_2	148	165	PF00022	0.606
LIG_Actin_WH2_2	180	197	PF00022	0.519
LIG_AP2alpha_2	5	7	PF02296	0.558
LIG_APCC_ABBA_1	167	172	PF00400	0.701
LIG_BRCT_BRCA1_1	3	7	PF00533	0.552
LIG_CaM_IQ_9	187	202	PF13499	0.496
LIG_FHA_1	154	160	PF00498	0.633
LIG_FHA_1	173	179	PF00498	0.730
LIG_FHA_1	219	225	PF00498	0.362
LIG_FHA_2	46	52	PF00498	0.613
LIG_LIR_Gen_1	221	230	PF02991	0.319
LIG_LIR_Gen_1	99	109	PF02991	0.675
LIG_LIR_Nem_3	221	225	PF02991	0.344
LIG_LIR_Nem_3	99	104	PF02991	0.575
LIG_PCNA_yPIPBox_3	193	205	PF02747	0.456
LIG_Pex14_2	222	226	PF04695	0.339
LIG_SH2_NCK_1	101	105	PF00017	0.527
LIG_SH2_STAP1	101	105	PF00017	0.556
LIG_SH3_3	116	122	PF00018	0.741
LIG_TRAF2_1	38	41	PF00917	0.680
LIG_TRAF2_1	48	51	PF00917	0.591
LIG_UBA3_1	204	213	PF00899	0.464
LIG_UBA3_1	52	57	PF00899	0.629
LIG_WRC_WIRS_1	219	224	PF05994	0.413
MOD_CK1_1	35	41	PF00069	0.622
MOD_CK2_1	118	124	PF00069	0.729
MOD_CK2_1	34	40	PF00069	0.599
MOD_CK2_1	45	51	PF00069	0.570
MOD_CK2_1	7	13	PF00069	0.603
MOD_CK2_1	73	79	PF00069	0.586
MOD_CK2_1	96	102	PF00069	0.632
MOD_GlcNHglycan	106	109	PF01048	0.407
MOD_GlcNHglycan	134	137	PF01048	0.496
MOD_GlcNHglycan	186	190	PF01048	0.319
MOD_GlcNHglycan	75	78	PF01048	0.395
MOD_GSK3_1	118	125	PF00069	0.698
MOD_N-GLC_1	7	12	PF02516	0.351
MOD_NEK2_1	162	167	PF00069	0.610
MOD_NEK2_1	204	209	PF00069	0.516
MOD_NEK2_1	7	12	PF00069	0.551
MOD_PIKK_1	172	178	PF00454	0.725
MOD_PIKK_1	26	32	PF00454	0.645
MOD_PKA_2	153	159	PF00069	0.616
MOD_PKA_2	162	168	PF00069	0.632
MOD_Plk_1	7	13	PF00069	0.555
MOD_Plk_2-3	96	102	PF00069	0.609
MOD_Plk_4	218	224	PF00069	0.302
MOD_ProDKin_1	118	124	PF00069	0.619
MOD_SUMO_rev_2	143	147	PF00179	0.694
MOD_SUMO_rev_2	38	48	PF00179	0.601
TRG_DiLeu_BaEn_3	50	56	PF01217	0.601
TRG_ENDOCYTIC_2	101	104	PF00928	0.630
TRG_ER_diArg_1	111	114	PF00400	0.695
TRG_ER_diArg_1	192	195	PF00400	0.500
TRG_NES_CRM1_1	50	65	PF08389	0.558
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.451
TRG_Pf-PMV_PEXEL_1	88	93	PF00026	0.351
TRG_PTS2	1	28	PF00400	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C8	Leptomonas seymouri	74%	98%
A0A0N1IK90	Leptomonas seymouri	31%	90%
A0A0S4J237	Bodo saltans	28%	81%
A0A0S4JJL1	Bodo saltans	30%	95%
A0A1X0NXA4	Trypanosomatidae	44%	100%
A0A3Q8IDN9	Leishmania donovani	30%	93%
A0A3R7M3G3	Trypanosoma rangeli	42%	100%
A4HBK1	Leishmania braziliensis	84%	100%
A4HZL4	Leishmania infantum	100%	100%
A4I201	Leishmania infantum	31%	100%
D0A1J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AUX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q9C5	Leishmania major	32%	100%
Q4QCL2	Leishmania major	95%	100%