Carboxypeptidase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carboxypeptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBW2_LEIDO

TriTrypDb:

LdBPK_140180.1 , LdCL_140006700 , LDHU3_14.0240

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 9

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBW2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0019538	protein metabolic process	3	25
GO:0043170	macromolecule metabolic process	3	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004180	carboxypeptidase activity	5	25
GO:0004181	metallocarboxypeptidase activity	6	25
GO:0008233	peptidase activity	3	25
GO:0008235	metalloexopeptidase activity	5	25
GO:0008237	metallopeptidase activity	4	25
GO:0008238	exopeptidase activity	4	25
GO:0016787	hydrolase activity	2	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:0016853	isomerase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.305
CLV_NRD_NRD_1	11	13	PF00675	0.173
CLV_NRD_NRD_1	190	192	PF00675	0.173
CLV_NRD_NRD_1	336	338	PF00675	0.386
CLV_NRD_NRD_1	497	499	PF00675	0.258
CLV_PCSK_KEX2_1	101	103	PF00082	0.387
CLV_PCSK_KEX2_1	497	499	PF00082	0.258
CLV_PCSK_SKI1_1	18	22	PF00082	0.275
CLV_PCSK_SKI1_1	185	189	PF00082	0.411
CLV_PCSK_SKI1_1	259	263	PF00082	0.341
CLV_PCSK_SKI1_1	280	284	PF00082	0.382
CLV_PCSK_SKI1_1	35	39	PF00082	0.343
CLV_PCSK_SKI1_1	59	63	PF00082	0.369
CLV_PCSK_SKI1_1	65	69	PF00082	0.342
CLV_Separin_Metazoa	84	88	PF03568	0.211
CLV_Separin_Metazoa	98	102	PF03568	0.192
DEG_APCC_DBOX_1	102	110	PF00400	0.173
DEG_APCC_DBOX_1	399	407	PF00400	0.237
DEG_APCC_DBOX_1	78	86	PF00400	0.265
DEG_Nend_UBRbox_3	1	3	PF02207	0.512
DEG_SCF_FBW7_2	317	322	PF00400	0.162
DOC_CKS1_1	201	206	PF01111	0.271
DOC_CKS1_1	316	321	PF01111	0.328
DOC_CYCLIN_RxL_1	256	264	PF00134	0.322
DOC_CYCLIN_yClb5_NLxxxL_5	13	21	PF00134	0.209
DOC_MAPK_gen_1	388	395	PF00069	0.297
DOC_PP4_MxPP_1	31	34	PF00568	0.244
DOC_USP7_MATH_1	145	149	PF00917	0.287
DOC_WW_Pin1_4	148	153	PF00397	0.333
DOC_WW_Pin1_4	200	205	PF00397	0.271
DOC_WW_Pin1_4	250	255	PF00397	0.241
DOC_WW_Pin1_4	315	320	PF00397	0.324
LIG_14-3-3_CanoR_1	103	113	PF00244	0.371
LIG_14-3-3_CanoR_1	215	224	PF00244	0.237
LIG_14-3-3_CanoR_1	247	251	PF00244	0.442
LIG_Actin_WH2_2	129	146	PF00022	0.264
LIG_BRCT_BRCA1_1	309	313	PF00533	0.257
LIG_Clathr_ClatBox_1	133	137	PF01394	0.237
LIG_CSL_BTD_1	125	128	PF09270	0.323
LIG_deltaCOP1_diTrp_1	220	226	PF00928	0.353
LIG_deltaCOP1_diTrp_1	408	416	PF00928	0.297
LIG_FHA_1	256	262	PF00498	0.423
LIG_FHA_1	296	302	PF00498	0.277
LIG_FHA_1	316	322	PF00498	0.321
LIG_FHA_1	444	450	PF00498	0.233
LIG_FHA_1	472	478	PF00498	0.287
LIG_FHA_2	127	133	PF00498	0.355
LIG_FHA_2	262	268	PF00498	0.365
LIG_FHA_2	348	354	PF00498	0.216
LIG_GBD_Chelix_1	60	68	PF00786	0.343
LIG_HP1_1	58	62	PF01393	0.199
LIG_LIR_Apic_2	249	254	PF02991	0.250
LIG_LIR_Apic_2	315	319	PF02991	0.297
LIG_LIR_Gen_1	151	159	PF02991	0.421
LIG_LIR_Gen_1	170	181	PF02991	0.290
LIG_LIR_Gen_1	244	251	PF02991	0.162
LIG_LIR_Nem_3	151	156	PF02991	0.442
LIG_LIR_Nem_3	170	176	PF02991	0.266
LIG_LIR_Nem_3	310	316	PF02991	0.281
LIG_LIR_Nem_3	391	395	PF02991	0.271
LIG_LIR_Nem_3	418	422	PF02991	0.289
LIG_NRBOX	16	22	PF00104	0.237
LIG_NRBOX	467	473	PF00104	0.189
LIG_Pex14_1	411	415	PF04695	0.380
LIG_SH2_CRK	153	157	PF00017	0.237
LIG_SH2_NCK_1	231	235	PF00017	0.237
LIG_SH2_SRC	173	176	PF00017	0.312
LIG_SH2_SRC	231	234	PF00017	0.241
LIG_SH2_STAP1	153	157	PF00017	0.282
LIG_SH2_STAP1	257	261	PF00017	0.458
LIG_SH2_STAP1	357	361	PF00017	0.332
LIG_SH2_STAT5	245	248	PF00017	0.423
LIG_SH2_STAT5	257	260	PF00017	0.425
LIG_SH2_STAT5	316	319	PF00017	0.419
LIG_SH2_STAT5	347	350	PF00017	0.328
LIG_SH2_STAT5	422	425	PF00017	0.306
LIG_SH2_STAT5	499	502	PF00017	0.523
LIG_SH3_3	376	382	PF00018	0.216
LIG_SH3_3	482	488	PF00018	0.300
LIG_SUMO_SIM_par_1	132	137	PF11976	0.237
LIG_SUMO_SIM_par_1	19	25	PF11976	0.297
LIG_TRAF2_1	129	132	PF00917	0.288
LIG_TRAF2_1	3	6	PF00917	0.269
MOD_CDK_SPxxK_3	200	207	PF00069	0.237
MOD_CK1_1	148	154	PF00069	0.304
MOD_CK2_1	126	132	PF00069	0.326
MOD_CK2_1	194	200	PF00069	0.307
MOD_CK2_1	261	267	PF00069	0.430
MOD_GlcNHglycan	147	150	PF01048	0.275
MOD_GlcNHglycan	291	294	PF01048	0.413
MOD_GlcNHglycan	309	312	PF01048	0.239
MOD_GSK3_1	101	108	PF00069	0.285
MOD_GSK3_1	144	151	PF00069	0.245
MOD_GSK3_1	196	203	PF00069	0.258
MOD_GSK3_1	246	253	PF00069	0.434
MOD_GSK3_1	261	268	PF00069	0.453
MOD_GSK3_1	343	350	PF00069	0.403
MOD_N-GLC_1	255	260	PF02516	0.400
MOD_NEK2_1	261	266	PF00069	0.314
MOD_PIKK_1	295	301	PF00454	0.361
MOD_PIKK_1	443	449	PF00454	0.189
MOD_PIKK_1	90	96	PF00454	0.472
MOD_PKA_1	101	107	PF00069	0.318
MOD_PKA_2	101	107	PF00069	0.358
MOD_PKA_2	246	252	PF00069	0.287
MOD_PKB_1	103	111	PF00069	0.173
MOD_PKB_1	142	150	PF00069	0.362
MOD_Plk_4	175	181	PF00069	0.310
MOD_Plk_4	246	252	PF00069	0.341
MOD_Plk_4	27	33	PF00069	0.299
MOD_Plk_4	297	303	PF00069	0.268
MOD_Plk_4	343	349	PF00069	0.362
MOD_ProDKin_1	148	154	PF00069	0.333
MOD_ProDKin_1	200	206	PF00069	0.271
MOD_ProDKin_1	250	256	PF00069	0.241
MOD_ProDKin_1	315	321	PF00069	0.324
MOD_SUMO_for_1	271	274	PF00179	0.223
MOD_SUMO_for_1	70	73	PF00179	0.462
MOD_SUMO_rev_2	170	178	PF00179	0.341
MOD_SUMO_rev_2	380	389	PF00179	0.266
MOD_SUMO_rev_2	5	10	PF00179	0.209
TRG_DiLeu_BaEn_1	297	302	PF01217	0.237
TRG_DiLeu_BaEn_1	473	478	PF01217	0.274
TRG_DiLeu_BaEn_4	5	11	PF01217	0.199
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.322
TRG_ENDOCYTIC_2	153	156	PF00928	0.288
TRG_ENDOCYTIC_2	173	176	PF00928	0.322
TRG_ENDOCYTIC_2	184	187	PF00928	0.219
TRG_ENDOCYTIC_2	245	248	PF00928	0.175
TRG_ENDOCYTIC_2	392	395	PF00928	0.291
TRG_ENDOCYTIC_2	4	7	PF00928	0.343
TRG_ER_diArg_1	100	103	PF00400	0.385
TRG_ER_diArg_1	497	499	PF00400	0.259
TRG_NES_CRM1_1	315	328	PF08389	0.237
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.305
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.258
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.189
TRG_Pf-PMV_PEXEL_1	498	503	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ28	Bodo saltans	45%	100%
A0A1X0NY67	Trypanosomatidae	52%	100%
A0A1X0P441	Trypanosomatidae	56%	100%
A0A1X0P598	Trypanosomatidae	57%	100%
A0A3Q8IJY8	Leishmania donovani	89%	100%
A0A3Q8IU74	Leishmania donovani	52%	100%
A0A3S7WSA3	Leishmania donovani	53%	100%
A0A422P042	Trypanosoma rangeli	52%	100%
A0A422P4R1	Trypanosoma rangeli	52%	100%
A4H716	Leishmania braziliensis	54%	100%
A4HLW4	Leishmania braziliensis	52%	99%
A4HVE5	Leishmania infantum	53%	100%
A4HVW0	Leishmania infantum	99%	100%
A4I993	Leishmania infantum	52%	100%
A4IC85	Leishmania infantum	87%	100%
D0A656	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AP43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9B493	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
P42663	Thermus aquaticus	32%	99%
P50848	Bacillus subtilis (strain 168)	31%	100%
Q4Q0D4	Leishmania major	93%	100%
Q4Q3T3	Leishmania major	51%	100%
Q4QFW7	Leishmania major	96%	100%
Q4QGE5	Leishmania major	53%	100%
Q5SLM3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	32%	99%
Q8U3L0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	30%	100%
V5DQA0	Trypanosoma cruzi	54%	100%