RNA-binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBV6_LEIDO

TriTrypDb:

LdBPK_201710.1 , LdCL_200021900 , LDHU3_20.2080

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.485
CLV_NRD_NRD_1	24	26	PF00675	0.473
CLV_NRD_NRD_1	245	247	PF00675	0.538
CLV_PCSK_FUR_1	243	247	PF00082	0.549
CLV_PCSK_KEX2_1	122	124	PF00082	0.547
CLV_PCSK_KEX2_1	171	173	PF00082	0.475
CLV_PCSK_KEX2_1	24	26	PF00082	0.473
CLV_PCSK_KEX2_1	245	247	PF00082	0.557
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.606
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.475
CLV_PCSK_PC7_1	167	173	PF00082	0.533
CLV_PCSK_SKI1_1	7	11	PF00082	0.694
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DEG_SPOP_SBC_1	99	103	PF00917	0.693
DOC_MAPK_gen_1	171	180	PF00069	0.529
DOC_MAPK_gen_1	292	299	PF00069	0.556
DOC_MAPK_RevD_3	158	172	PF00069	0.626
DOC_MAPK_RevD_3	280	295	PF00069	0.497
DOC_USP7_MATH_1	99	103	PF00917	0.681
DOC_WW_Pin1_4	170	175	PF00397	0.608
DOC_WW_Pin1_4	49	54	PF00397	0.565
LIG_14-3-3_CanoR_1	98	105	PF00244	0.697
LIG_Actin_WH2_2	187	204	PF00022	0.509
LIG_APCC_ABBA_1	262	267	PF00400	0.336
LIG_BIR_III_2	184	188	PF00653	0.504
LIG_Clathr_ClatBox_1	71	75	PF01394	0.478
LIG_FHA_1	106	112	PF00498	0.602
LIG_FHA_2	58	64	PF00498	0.530
LIG_FHA_2	87	93	PF00498	0.527
LIG_FXI_DFP_1	272	276	PF00024	0.452
LIG_LIR_Gen_1	231	239	PF02991	0.358
LIG_LIR_Nem_3	130	134	PF02991	0.521
LIG_LIR_Nem_3	231	235	PF02991	0.346
LIG_LIR_Nem_3	260	265	PF02991	0.416
LIG_LIR_Nem_3	45	51	PF02991	0.582
LIG_NRBOX	39	45	PF00104	0.551
LIG_SH2_STAP1	109	113	PF00017	0.445
LIG_SH2_STAP1	265	269	PF00017	0.369
LIG_SH2_STAT5	109	112	PF00017	0.506
LIG_SH2_STAT5	136	139	PF00017	0.405
LIG_SH2_STAT5	232	235	PF00017	0.476
LIG_SH2_STAT5	281	284	PF00017	0.349
LIG_SH3_3	207	213	PF00018	0.457
LIG_SH3_3	279	285	PF00018	0.353
LIG_SUMO_SIM_anti_2	145	151	PF11976	0.379
LIG_SUMO_SIM_anti_2	203	211	PF11976	0.510
LIG_SUMO_SIM_anti_2	219	225	PF11976	0.515
LIG_SUMO_SIM_anti_2	286	292	PF11976	0.462
LIG_SUMO_SIM_par_1	70	76	PF11976	0.533
LIG_UBA3_1	287	295	PF00899	0.502
LIG_WRC_WIRS_1	48	53	PF05994	0.478
MOD_CDK_SPK_2	170	175	PF00069	0.582
MOD_CK1_1	100	106	PF00069	0.671
MOD_CK1_1	205	211	PF00069	0.432
MOD_CK1_1	33	39	PF00069	0.555
MOD_CK2_1	57	63	PF00069	0.472
MOD_GlcNHglycan	218	221	PF01048	0.533
MOD_GlcNHglycan	32	35	PF01048	0.470
MOD_GlcNHglycan	53	56	PF01048	0.416
MOD_GSK3_1	201	208	PF00069	0.439
MOD_GSK3_1	212	219	PF00069	0.402
MOD_GSK3_1	47	54	PF00069	0.619
MOD_GSK3_1	99	106	PF00069	0.740
MOD_NEK2_1	1	6	PF00069	0.588
MOD_NEK2_1	201	206	PF00069	0.461
MOD_NEK2_1	35	40	PF00069	0.537
MOD_NEK2_2	57	62	PF00069	0.417
MOD_PIKK_1	257	263	PF00454	0.480
MOD_PIKK_1	35	41	PF00454	0.466
MOD_PIKK_1	75	81	PF00454	0.568
MOD_PIKK_1	91	97	PF00454	0.700
MOD_PK_1	202	208	PF00069	0.559
MOD_PKA_2	86	92	PF00069	0.550
MOD_PKA_2	97	103	PF00069	0.642
MOD_Plk_1	202	208	PF00069	0.457
MOD_Plk_2-3	70	76	PF00069	0.470
MOD_Plk_4	109	115	PF00069	0.584
MOD_Plk_4	127	133	PF00069	0.565
MOD_Plk_4	202	208	PF00069	0.490
MOD_Plk_4	228	234	PF00069	0.459
MOD_Plk_4	283	289	PF00069	0.497
MOD_ProDKin_1	170	176	PF00069	0.596
MOD_ProDKin_1	49	55	PF00069	0.566
TRG_ENDOCYTIC_2	131	134	PF00928	0.434
TRG_ENDOCYTIC_2	232	235	PF00928	0.369
TRG_ER_diArg_1	123	126	PF00400	0.495
TRG_ER_diArg_1	23	25	PF00400	0.474
TRG_ER_diArg_1	242	245	PF00400	0.540
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB90	Leptomonas seymouri	62%	100%
A0A1X0NW23	Trypanosomatidae	40%	100%
A0A422NTN5	Trypanosoma rangeli	41%	88%
A4HZ03	Leishmania infantum	100%	100%
C9ZIL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	81%
E9AIM2	Leishmania braziliensis	83%	100%
E9AUV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QCM8	Leishmania major	94%	100%
V5BHE7	Trypanosoma cruzi	39%	80%