PlsC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBV5_LEIDO

TriTrypDb:

LdBPK_090540.1 , LdCL_090010500 , LDHU3_09.0670

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3Q8IBV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBV5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.711
CLV_NRD_NRD_1	188	190	PF00675	0.473
CLV_NRD_NRD_1	209	211	PF00675	0.500
CLV_NRD_NRD_1	380	382	PF00675	0.428
CLV_PCSK_KEX2_1	188	190	PF00082	0.471
CLV_PCSK_KEX2_1	380	382	PF00082	0.427
CLV_PCSK_SKI1_1	246	250	PF00082	0.371
CLV_PCSK_SKI1_1	38	42	PF00082	0.449
CLV_PCSK_SKI1_1	399	403	PF00082	0.477
CLV_PCSK_SKI1_1	69	73	PF00082	0.367
CLV_PCSK_SKI1_1	81	85	PF00082	0.308
DEG_APCC_DBOX_1	37	45	PF00400	0.475
DEG_APCC_DBOX_1	68	76	PF00400	0.376
DEG_APCC_DBOX_1	80	88	PF00400	0.503
DEG_Nend_UBRbox_2	1	3	PF02207	0.663
DEG_ODPH_VHL_1	72	85	PF01847	0.446
DEG_SIAH_1	94	102	PF03145	0.660
DOC_CYCLIN_RxL_1	35	42	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.612
DOC_MAPK_gen_1	113	122	PF00069	0.569
DOC_MAPK_gen_1	188	195	PF00069	0.661
DOC_MAPK_gen_1	380	388	PF00069	0.600
DOC_MAPK_MEF2A_6	380	388	PF00069	0.600
DOC_PP1_RVXF_1	169	175	PF00149	0.582
DOC_PP1_RVXF_1	79	86	PF00149	0.560
DOC_PP2B_LxvP_1	249	252	PF13499	0.601
DOC_PP2B_LxvP_1	351	354	PF13499	0.582
DOC_PP2B_LxvP_1	71	74	PF13499	0.363
DOC_USP7_MATH_1	108	112	PF00917	0.757
DOC_USP7_MATH_1	259	263	PF00917	0.693
DOC_USP7_MATH_1	332	336	PF00917	0.694
DOC_USP7_MATH_1	337	341	PF00917	0.627
DOC_USP7_MATH_1	407	411	PF00917	0.603
DOC_WW_Pin1_4	276	281	PF00397	0.658
DOC_WW_Pin1_4	311	316	PF00397	0.623
DOC_WW_Pin1_4	330	335	PF00397	0.575
DOC_WW_Pin1_4	405	410	PF00397	0.683
LIG_14-3-3_CanoR_1	188	194	PF00244	0.565
LIG_14-3-3_CanoR_1	210	219	PF00244	0.642
LIG_14-3-3_CanoR_1	346	352	PF00244	0.640
LIG_14-3-3_CanoR_1	38	48	PF00244	0.420
LIG_14-3-3_CanoR_1	381	387	PF00244	0.670
LIG_BRCT_BRCA1_1	191	195	PF00533	0.616
LIG_BRCT_BRCA1_1	313	317	PF00533	0.700
LIG_BRCT_BRCA1_1	41	45	PF00533	0.433
LIG_DLG_GKlike_1	189	196	PF00625	0.658
LIG_EH1_1	84	92	PF00400	0.607
LIG_FHA_1	188	194	PF00498	0.582
LIG_FHA_1	298	304	PF00498	0.699
LIG_FHA_1	311	317	PF00498	0.594
LIG_FHA_1	50	56	PF00498	0.394
LIG_FHA_2	334	340	PF00498	0.673
LIG_Integrin_isoDGR_2	244	246	PF01839	0.451
LIG_LIR_Apic_2	274	280	PF02991	0.642
LIG_LIR_Gen_1	127	137	PF02991	0.582
LIG_LIR_Gen_1	291	302	PF02991	0.717
LIG_LIR_Gen_1	42	51	PF02991	0.484
LIG_LIR_LC3C_4	119	122	PF02991	0.600
LIG_LIR_Nem_3	127	132	PF02991	0.586
LIG_LIR_Nem_3	2	7	PF02991	0.654
LIG_LIR_Nem_3	291	297	PF02991	0.714
LIG_LIR_Nem_3	42	48	PF02991	0.441
LIG_LIR_Nem_3	54	60	PF02991	0.344
LIG_NRBOX	66	72	PF00104	0.404
LIG_NRBOX	79	85	PF00104	0.464
LIG_Pex14_2	294	298	PF04695	0.721
LIG_SH2_CRK	142	146	PF00017	0.579
LIG_SH2_CRK	277	281	PF00017	0.679
LIG_SH2_NCK_1	277	281	PF00017	0.653
LIG_SH2_STAT3	221	224	PF00017	0.578
LIG_SH2_STAT5	186	189	PF00017	0.621
LIG_SH2_STAT5	60	63	PF00017	0.373
LIG_SH3_3	169	175	PF00018	0.554
LIG_SH3_3	17	23	PF00018	0.682
LIG_SH3_3	312	318	PF00018	0.612
LIG_SH3_3	89	95	PF00018	0.628
LIG_SH3_4	100	107	PF00018	0.781
LIG_SUMO_SIM_par_1	46	54	PF11976	0.388
LIG_TYR_ITIM	61	66	PF00017	0.262
LIG_Vh1_VBS_1	40	58	PF01044	0.449
MOD_CK1_1	109	115	PF00069	0.715
MOD_CK1_1	158	164	PF00069	0.727
MOD_CK1_1	262	268	PF00069	0.659
MOD_CK1_1	335	341	PF00069	0.614
MOD_CK1_1	342	348	PF00069	0.686
MOD_CK2_1	157	163	PF00069	0.740
MOD_CK2_1	285	291	PF00069	0.581
MOD_CMANNOS	181	184	PF00535	0.374
MOD_GlcNHglycan	107	111	PF01048	0.592
MOD_GlcNHglycan	155	160	PF01048	0.501
MOD_GlcNHglycan	202	205	PF01048	0.434
MOD_GlcNHglycan	229	232	PF01048	0.404
MOD_GlcNHglycan	257	260	PF01048	0.442
MOD_GlcNHglycan	263	267	PF01048	0.324
MOD_GlcNHglycan	341	344	PF01048	0.503
MOD_GlcNHglycan	351	354	PF01048	0.367
MOD_GlcNHglycan	372	375	PF01048	0.531
MOD_GlcNHglycan	41	44	PF01048	0.421
MOD_GSK3_1	184	191	PF00069	0.588
MOD_GSK3_1	255	262	PF00069	0.625
MOD_GSK3_1	285	292	PF00069	0.616
MOD_GSK3_1	316	323	PF00069	0.626
MOD_GSK3_1	333	340	PF00069	0.550
MOD_GSK3_1	401	408	PF00069	0.655
MOD_N-GLC_1	289	294	PF02516	0.371
MOD_NEK2_1	297	302	PF00069	0.635
MOD_NEK2_1	304	309	PF00069	0.630
MOD_NEK2_1	370	375	PF00069	0.755
MOD_NEK2_1	39	44	PF00069	0.383
MOD_NEK2_1	401	406	PF00069	0.673
MOD_NEK2_1	83	88	PF00069	0.582
MOD_PIKK_1	175	181	PF00454	0.558
MOD_PK_1	28	34	PF00069	0.581
MOD_PKA_1	188	194	PF00069	0.565
MOD_PKA_1	210	216	PF00069	0.668
MOD_PKA_2	187	193	PF00069	0.633
MOD_PKA_2	324	330	PF00069	0.625
MOD_Plk_1	148	154	PF00069	0.627
MOD_Plk_1	289	295	PF00069	0.629
MOD_Plk_1	320	326	PF00069	0.605
MOD_Plk_4	124	130	PF00069	0.520
MOD_Plk_4	289	295	PF00069	0.601
MOD_Plk_4	51	57	PF00069	0.398
MOD_ProDKin_1	276	282	PF00069	0.660
MOD_ProDKin_1	311	317	PF00069	0.622
MOD_ProDKin_1	330	336	PF00069	0.583
MOD_ProDKin_1	405	411	PF00069	0.690
MOD_SUMO_rev_2	335	343	PF00179	0.720
MOD_SUMO_rev_2	385	394	PF00179	0.677
TRG_DiLeu_BaEn_2	389	395	PF01217	0.610
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.410
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.397
TRG_ENDOCYTIC_2	142	145	PF00928	0.579
TRG_ENDOCYTIC_2	398	401	PF00928	0.656
TRG_ENDOCYTIC_2	63	66	PF00928	0.359
TRG_ER_diArg_1	379	381	PF00400	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK56	Leptomonas seymouri	63%	100%
A0A0S4IZ96	Bodo saltans	30%	100%
A0A1X0NMQ7	Trypanosomatidae	30%	97%
A0A3S5IRZ0	Trypanosoma rangeli	33%	100%
A4H5M6	Leishmania braziliensis	78%	98%
A4HTW3	Leishmania infantum	99%	100%
D0A9C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AMQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QHX5	Leishmania major	92%	100%
V5BIH4	Trypanosoma cruzi	32%	100%