Exosome_complex_exonuclease_putative/GeneDB:LmjF. 14.0010

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome complex exonuclease, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBV3_LEIDO

TriTrypDb:

LdBPK_140010.1 , LdCL_140005000 , LDHU3_14.0030

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	11
GO:0032991	protein-containing complex	1	11
GO:1902494	catalytic complex	2	11
GO:1905354	exoribonuclease complex	3	11
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IBV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBV3

Function

Biological processes
Term	Name	Level	Count
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	1
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006399	tRNA metabolic process	7	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0016073	snRNA metabolic process	7	1
GO:0016074	sno(s)RNA metabolic process	7	1
GO:0016075	rRNA catabolic process	7	1
GO:0016078	tRNA catabolic process	7	1
GO:0016180	snRNA processing	8	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0031126	sno(s)RNA 3'-end processing	9	1
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	9	1
GO:0034470	ncRNA processing	7	1
GO:0034472	snRNA 3'-end processing	8	1
GO:0034475	U4 snRNA 3'-end processing	9	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034660	ncRNA metabolic process	6	1
GO:0034661	ncRNA catabolic process	6	1
GO:0043144	sno(s)RNA processing	8	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0043633	polyadenylation-dependent RNA catabolic process	6	1
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	1
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	9	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071025	RNA surveillance	6	1
GO:0071027	nuclear RNA surveillance	7	1
GO:0071029	nuclear ncRNA surveillance	7	1
GO:0071034	CUT catabolic process	7	1
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	1
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	1
GO:0071043	CUT metabolic process	7	1
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	1
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	10	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:0106354	tRNA surveillance	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	9
GO:0004527	exonuclease activity	5	9
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.518
CLV_NRD_NRD_1	124	126	PF00675	0.431
CLV_NRD_NRD_1	294	296	PF00675	0.543
CLV_PCSK_KEX2_1	123	125	PF00082	0.436
CLV_PCSK_KEX2_1	184	186	PF00082	0.225
CLV_PCSK_KEX2_1	294	296	PF00082	0.537
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.226
CLV_PCSK_SKI1_1	134	138	PF00082	0.372
CLV_PCSK_SKI1_1	184	188	PF00082	0.226
CLV_PCSK_SKI1_1	278	282	PF00082	0.400
DOC_ANK_TNKS_1	148	155	PF00023	0.405
DOC_MAPK_MEF2A_6	197	204	PF00069	0.495
DOC_MAPK_RevD_3	110	125	PF00069	0.432
DOC_MAPK_RevD_3	280	295	PF00069	0.365
DOC_PP1_SILK_1	119	124	PF00149	0.470
DOC_PP2B_PxIxI_1	171	177	PF00149	0.235
DOC_USP7_MATH_1	215	219	PF00917	0.550
DOC_WW_Pin1_4	148	153	PF00397	0.410
LIG_14-3-3_CanoR_1	31	37	PF00244	0.356
LIG_14-3-3_CanoR_1	67	72	PF00244	0.348
LIG_BIR_II_1	1	5	PF00653	0.480
LIG_FHA_1	196	202	PF00498	0.535
LIG_FHA_1	63	69	PF00498	0.373
LIG_FHA_2	21	27	PF00498	0.542
LIG_GBD_Chelix_1	259	267	PF00786	0.380
LIG_Integrin_RGD_1	127	129	PF01839	0.536
LIG_LIR_Nem_3	164	169	PF02991	0.392
LIG_PCNA_yPIPBox_3	72	86	PF02747	0.470
LIG_PDZ_Class_1	302	307	PF00595	0.530
LIG_SH2_CRK	166	170	PF00017	0.354
LIG_SH2_STAT3	196	199	PF00017	0.459
LIG_SH2_STAT5	29	32	PF00017	0.413
LIG_SH3_3	112	118	PF00018	0.373
LIG_SUMO_SIM_anti_2	107	114	PF11976	0.342
LIG_SUMO_SIM_anti_2	2	11	PF11976	0.431
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.494
LIG_SUMO_SIM_par_1	2	11	PF11976	0.473
LIG_SUMO_SIM_par_1	89	94	PF11976	0.451
LIG_TRAF2_1	24	27	PF00917	0.390
LIG_WRC_WIRS_1	33	38	PF05994	0.461
MOD_CK1_1	104	110	PF00069	0.367
MOD_CK1_1	113	119	PF00069	0.369
MOD_CK1_1	157	163	PF00069	0.350
MOD_CK1_1	22	28	PF00069	0.420
MOD_CK2_1	111	117	PF00069	0.455
MOD_CK2_1	20	26	PF00069	0.517
MOD_CK2_1	215	221	PF00069	0.607
MOD_GlcNHglycan	169	172	PF01048	0.391
MOD_GlcNHglycan	215	218	PF01048	0.582
MOD_GlcNHglycan	301	304	PF01048	0.715
MOD_GlcNHglycan	58	61	PF01048	0.440
MOD_GlcNHglycan	92	96	PF01048	0.429
MOD_GSK3_1	174	181	PF00069	0.531
MOD_GSK3_1	209	216	PF00069	0.595
MOD_GSK3_1	220	227	PF00069	0.542
MOD_GSK3_1	251	258	PF00069	0.444
MOD_N-GLC_1	102	107	PF02516	0.440
MOD_NEK2_1	1	6	PF00069	0.404
MOD_NEK2_1	110	115	PF00069	0.281
MOD_NEK2_1	270	275	PF00069	0.471
MOD_NEK2_1	91	96	PF00069	0.436
MOD_NEK2_2	154	159	PF00069	0.321
MOD_NEK2_2	265	270	PF00069	0.334
MOD_PIKK_1	102	108	PF00454	0.387
MOD_PIKK_1	195	201	PF00454	0.459
MOD_PK_1	67	73	PF00069	0.348
MOD_PKA_2	178	184	PF00069	0.484
MOD_Plk_1	255	261	PF00069	0.337
MOD_Plk_1	270	276	PF00069	0.376
MOD_Plk_4	1	7	PF00069	0.400
MOD_Plk_4	178	184	PF00069	0.449
MOD_Plk_4	265	271	PF00069	0.471
MOD_ProDKin_1	148	154	PF00069	0.409
MOD_SUMO_rev_2	16	22	PF00179	0.476
TRG_DiLeu_BaEn_1	164	169	PF01217	0.300
TRG_ENDOCYTIC_2	166	169	PF00928	0.336
TRG_ER_diArg_1	122	125	PF00400	0.446
TRG_ER_diArg_1	294	296	PF00400	0.650
TRG_NES_CRM1_1	279	292	PF08389	0.397
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I616	Leptomonas seymouri	77%	100%
A0A0S4ISJ0	Bodo saltans	43%	79%
A0A1X0NQG9	Trypanosomatidae	53%	100%
A0A422NXH9	Trypanosoma rangeli	52%	100%
A4H7G3	Leishmania braziliensis	83%	100%
A4HVU3	Leishmania infantum	100%	100%
A5UJS0	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	23%	100%
C9ZT82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	95%
E9APJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O29758	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	30%	100%
O59221	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	26%	100%
P38792	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	86%
Q09704	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	93%
Q13868	Homo sapiens	39%	100%
Q2KID0	Bos taurus	39%	100%
Q4QFY3	Leishmania major	92%	100%
Q8VBV3	Mus musculus	39%	100%
Q9V120	Pyrococcus abyssi (strain GE5 / Orsay)	26%	100%
Q9ZVT7	Arabidopsis thaliana	33%	95%