2'-phosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphotransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBU9_LEIDO

TriTrypDb:

LdBPK_240830.1 , LdCL_240013300 , LDHU3_24.0960

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBU9

Function

Biological processes
Term	Name	Level	Count
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000215	tRNA 2'-phosphotransferase activity	5	11
GO:0003676	nucleic acid binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.667
CLV_C14_Caspase3-7	308	312	PF00656	0.703
CLV_C14_Caspase3-7	7	11	PF00656	0.579
CLV_NRD_NRD_1	252	254	PF00675	0.515
CLV_NRD_NRD_1	267	269	PF00675	0.577
CLV_NRD_NRD_1	33	35	PF00675	0.741
CLV_NRD_NRD_1	405	407	PF00675	0.467
CLV_NRD_NRD_1	509	511	PF00675	0.283
CLV_NRD_NRD_1	71	73	PF00675	0.317
CLV_PCSK_KEX2_1	252	254	PF00082	0.487
CLV_PCSK_KEX2_1	267	269	PF00082	0.577
CLV_PCSK_KEX2_1	33	35	PF00082	0.738
CLV_PCSK_KEX2_1	71	73	PF00082	0.317
CLV_PCSK_SKI1_1	102	106	PF00082	0.231
CLV_PCSK_SKI1_1	166	170	PF00082	0.270
CLV_PCSK_SKI1_1	241	245	PF00082	0.221
CLV_PCSK_SKI1_1	456	460	PF00082	0.430
CLV_PCSK_SKI1_1	89	93	PF00082	0.305
DEG_ODPH_VHL_1	50	63	PF01847	0.444
DOC_CKS1_1	179	184	PF01111	0.552
DOC_CKS1_1	18	23	PF01111	0.701
DOC_CKS1_1	539	544	PF01111	0.331
DOC_CYCLIN_yClb5_NLxxxL_5	241	247	PF00134	0.504
DOC_MAPK_gen_1	192	200	PF00069	0.526
DOC_MAPK_gen_1	252	259	PF00069	0.443
DOC_MAPK_gen_1	406	412	PF00069	0.469
DOC_MAPK_gen_1	510	517	PF00069	0.283
DOC_MAPK_MEF2A_6	252	261	PF00069	0.442
DOC_MAPK_MEF2A_6	510	519	PF00069	0.306
DOC_PP1_RVXF_1	378	385	PF00149	0.433
DOC_PP2B_LxvP_1	225	228	PF13499	0.545
DOC_PP2B_PxIxI_1	81	87	PF00149	0.421
DOC_PP4_FxxP_1	330	333	PF00568	0.486
DOC_USP7_MATH_1	151	155	PF00917	0.493
DOC_USP7_MATH_1	19	23	PF00917	0.776
DOC_USP7_MATH_1	282	286	PF00917	0.474
DOC_USP7_MATH_1	292	296	PF00917	0.672
DOC_USP7_MATH_1	38	42	PF00917	0.702
DOC_USP7_MATH_1	387	391	PF00917	0.384
DOC_USP7_UBL2_3	367	371	PF12436	0.427
DOC_USP7_UBL2_3	553	557	PF12436	0.464
DOC_WW_Pin1_4	17	22	PF00397	0.733
DOC_WW_Pin1_4	178	183	PF00397	0.554
DOC_WW_Pin1_4	297	302	PF00397	0.646
DOC_WW_Pin1_4	538	543	PF00397	0.331
DOC_WW_Pin1_4	89	94	PF00397	0.504
LIG_14-3-3_CanoR_1	111	119	PF00244	0.574
LIG_14-3-3_CanoR_1	241	250	PF00244	0.453
LIG_14-3-3_CanoR_1	323	329	PF00244	0.709
LIG_14-3-3_CanoR_1	33	37	PF00244	0.619
LIG_14-3-3_CanoR_1	385	395	PF00244	0.419
LIG_14-3-3_CanoR_1	456	462	PF00244	0.430
LIG_Actin_WH2_2	239	254	PF00022	0.504
LIG_AP2alpha_2	128	130	PF02296	0.552
LIG_APCC_ABBA_1	515	520	PF00400	0.325
LIG_BIR_III_2	148	152	PF00653	0.550
LIG_BIR_III_2	281	285	PF00653	0.653
LIG_BRCT_BRCA1_1	326	330	PF00533	0.545
LIG_BRCT_BRCA1_1	357	361	PF00533	0.613
LIG_BRCT_BRCA1_1	43	47	PF00533	0.693
LIG_FHA_1	242	248	PF00498	0.421
LIG_FHA_1	332	338	PF00498	0.585
LIG_FHA_1	539	545	PF00498	0.312
LIG_FHA_2	157	163	PF00498	0.461
LIG_FHA_2	284	290	PF00498	0.599
LIG_FHA_2	306	312	PF00498	0.705
LIG_FHA_2	457	463	PF00498	0.378
LIG_FHA_2	64	70	PF00498	0.435
LIG_Integrin_isoDGR_2	563	565	PF01839	0.398
LIG_LIR_Apic_2	327	333	PF02991	0.517
LIG_LIR_Gen_1	154	162	PF02991	0.493
LIG_LIR_Gen_1	390	400	PF02991	0.384
LIG_LIR_Gen_1	56	65	PF02991	0.306
LIG_LIR_Nem_3	128	133	PF02991	0.461
LIG_LIR_Nem_3	154	158	PF02991	0.493
LIG_LIR_Nem_3	390	396	PF02991	0.384
LIG_LIR_Nem_3	44	50	PF02991	0.554
LIG_LIR_Nem_3	56	61	PF02991	0.293
LIG_LIR_Nem_3	80	84	PF02991	0.461
LIG_LIR_Nem_3	96	100	PF02991	0.461
LIG_LYPXL_SIV_4	430	438	PF13949	0.433
LIG_MYND_1	211	215	PF01753	0.480
LIG_NRBOX	246	252	PF00104	0.385
LIG_PDZ_Class_2	565	570	PF00595	0.562
LIG_RPA_C_Fungi	336	348	PF08784	0.543
LIG_SH2_CRK	155	159	PF00017	0.430
LIG_SH2_PTP2	100	103	PF00017	0.306
LIG_SH2_PTP2	393	396	PF00017	0.384
LIG_SH2_PTP2	58	61	PF00017	0.313
LIG_SH2_SRC	518	521	PF00017	0.325
LIG_SH2_STAT5	100	103	PF00017	0.306
LIG_SH2_STAT5	134	137	PF00017	0.448
LIG_SH2_STAT5	155	158	PF00017	0.374
LIG_SH2_STAT5	393	396	PF00017	0.350
LIG_SH2_STAT5	439	442	PF00017	0.306
LIG_SH2_STAT5	484	487	PF00017	0.344
LIG_SH2_STAT5	518	521	PF00017	0.325
LIG_SH2_STAT5	554	557	PF00017	0.377
LIG_SH2_STAT5	58	61	PF00017	0.313
LIG_SH3_3	101	107	PF00018	0.349
LIG_SH3_3	209	215	PF00018	0.396
LIG_SH3_3	295	301	PF00018	0.697
LIG_SUMO_SIM_par_1	255	260	PF11976	0.427
LIG_SUMO_SIM_par_1	333	338	PF11976	0.510
LIG_SUMO_SIM_par_1	82	87	PF11976	0.308
LIG_TRAF2_1	343	346	PF00917	0.536
LIG_TRAF2_1	460	463	PF00917	0.423
LIG_TRAF2_1	66	69	PF00917	0.217
LIG_WW_3	300	304	PF00397	0.742
MOD_CDC14_SPxK_1	300	303	PF00782	0.578
MOD_CDK_SPxK_1	17	23	PF00069	0.700
MOD_CDK_SPxK_1	297	303	PF00069	0.573
MOD_CK1_1	41	47	PF00069	0.700
MOD_CK1_1	486	492	PF00069	0.320
MOD_CK2_1	456	462	PF00069	0.344
MOD_CK2_1	63	69	PF00069	0.313
MOD_CMANNOS	473	476	PF00535	0.430
MOD_GlcNHglycan	124	127	PF01048	0.466
MOD_GlcNHglycan	175	178	PF01048	0.430
MOD_GlcNHglycan	203	206	PF01048	0.443
MOD_GlcNHglycan	215	218	PF01048	0.440
MOD_GlcNHglycan	234	237	PF01048	0.232
MOD_GlcNHglycan	26	29	PF01048	0.795
MOD_GlcNHglycan	294	297	PF01048	0.762
MOD_GlcNHglycan	319	322	PF01048	0.783
MOD_GlcNHglycan	40	43	PF01048	0.731
MOD_GlcNHglycan	506	509	PF01048	0.311
MOD_GSK3_1	107	114	PF00069	0.306
MOD_GSK3_1	13	20	PF00069	0.725
MOD_GSK3_1	297	304	PF00069	0.771
MOD_GSK3_1	367	374	PF00069	0.334
MOD_GSK3_1	38	45	PF00069	0.748
MOD_GSK3_1	559	566	PF00069	0.460
MOD_N-GLC_1	201	206	PF02516	0.366
MOD_N-GLC_1	241	246	PF02516	0.249
MOD_NEK2_1	13	18	PF00069	0.701
MOD_NEK2_1	173	178	PF00069	0.396
MOD_NEK2_1	348	353	PF00069	0.631
MOD_NEK2_1	372	377	PF00069	0.396
MOD_NEK2_1	531	536	PF00069	0.328
MOD_PIKK_1	117	123	PF00454	0.340
MOD_PIKK_1	193	199	PF00454	0.488
MOD_PIKK_1	4	10	PF00454	0.629
MOD_PKA_2	173	179	PF00069	0.430
MOD_PKA_2	213	219	PF00069	0.249
MOD_PKA_2	32	38	PF00069	0.762
MOD_PKA_2	419	425	PF00069	0.419
MOD_Plk_1	14	20	PF00069	0.548
MOD_Plk_1	241	247	PF00069	0.467
MOD_Plk_1	257	263	PF00069	0.483
MOD_Plk_4	164	170	PF00069	0.325
MOD_Plk_4	331	337	PF00069	0.537
MOD_Plk_4	372	378	PF00069	0.377
MOD_Plk_4	468	474	PF00069	0.306
MOD_ProDKin_1	17	23	PF00069	0.736
MOD_ProDKin_1	178	184	PF00069	0.436
MOD_ProDKin_1	297	303	PF00069	0.650
MOD_ProDKin_1	538	544	PF00069	0.331
MOD_ProDKin_1	89	95	PF00069	0.366
MOD_SUMO_rev_2	162	168	PF00179	0.306
MOD_SUMO_rev_2	362	369	PF00179	0.573
TRG_DiLeu_BaEn_2	135	141	PF01217	0.430
TRG_ENDOCYTIC_2	155	158	PF00928	0.350
TRG_ENDOCYTIC_2	393	396	PF00928	0.384
TRG_ENDOCYTIC_2	518	521	PF00928	0.325
TRG_ENDOCYTIC_2	58	61	PF00928	0.306
TRG_ER_diArg_1	251	253	PF00400	0.491
TRG_ER_diArg_1	266	268	PF00400	0.545
TRG_ER_diArg_1	71	73	PF00400	0.392
TRG_NES_CRM1_1	220	230	PF08389	0.437
TRG_NLS_MonoExtN_4	313	320	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWH5	Leptomonas seymouri	58%	92%
A0A0S4J7G0	Bodo saltans	42%	88%
A0A422MZ86	Trypanosoma rangeli	44%	100%
A4HDD9	Leishmania braziliensis	77%	99%
A4I0S0	Leishmania infantum	100%	100%
D0A750	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AWS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QAQ2	Leishmania major	90%	100%
V5C0L6	Trypanosoma cruzi	46%	89%