Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBU6_LEIDO

TriTrypDb:

LdBPK_231410.1 , LdCL_230021200 , LDHU3_23.1890

Length:

351

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043226	organelle	2	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

A0A3Q8IBU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBU6

PDB structure(s): 7ane_d

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	5
GO:0006518	peptide metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009058	biosynthetic process	2	5
GO:0009059	macromolecule biosynthetic process	4	5
GO:0009987	cellular process	1	5
GO:0019538	protein metabolic process	3	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	5
GO:0043043	peptide biosynthetic process	5	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043603	amide metabolic process	3	5
GO:0043604	amide biosynthetic process	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044260	obsolete cellular macromolecule metabolic process	3	5
GO:0044271	cellular nitrogen compound biosynthetic process	4	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:1901566	organonitrogen compound biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	5
GO:0005198	structural molecule activity	1	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.382
CLV_NRD_NRD_1	144	146	PF00675	0.428
CLV_NRD_NRD_1	186	188	PF00675	0.361
CLV_NRD_NRD_1	329	331	PF00675	0.420
CLV_NRD_NRD_1	345	347	PF00675	0.381
CLV_NRD_NRD_1	72	74	PF00675	0.512
CLV_PCSK_KEX2_1	144	146	PF00082	0.428
CLV_PCSK_KEX2_1	328	330	PF00082	0.416
CLV_PCSK_KEX2_1	345	347	PF00082	0.417
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.432
CLV_PCSK_SKI1_1	101	105	PF00082	0.414
CLV_PCSK_SKI1_1	131	135	PF00082	0.377
CLV_PCSK_SKI1_1	153	157	PF00082	0.369
CLV_PCSK_SKI1_1	224	228	PF00082	0.432
CLV_PCSK_SKI1_1	347	351	PF00082	0.462
DOC_CYCLIN_yCln2_LP_2	244	250	PF00134	0.498
DOC_MAPK_gen_1	144	156	PF00069	0.368
DOC_MAPK_gen_1	319	326	PF00069	0.376
DOC_MAPK_MEF2A_6	149	156	PF00069	0.378
DOC_MAPK_MEF2A_6	195	202	PF00069	0.449
DOC_PP1_RVXF_1	151	157	PF00149	0.381
DOC_PP1_RVXF_1	268	274	PF00149	0.424
DOC_USP7_MATH_1	169	173	PF00917	0.395
DOC_USP7_MATH_1	286	290	PF00917	0.381
DOC_USP7_UBL2_3	343	347	PF12436	0.505
DOC_WW_Pin1_4	91	96	PF00397	0.536
LIG_14-3-3_CanoR_1	101	110	PF00244	0.414
LIG_14-3-3_CanoR_1	126	133	PF00244	0.399
LIG_Actin_WH2_2	303	321	PF00022	0.396
LIG_APCC_ABBA_1	263	268	PF00400	0.325
LIG_BIR_III_4	106	110	PF00653	0.471
LIG_BRCT_BRCA1_1	248	252	PF00533	0.492
LIG_Clathr_ClatBox_1	263	267	PF01394	0.337
LIG_Clathr_ClatBox_1	323	327	PF01394	0.375
LIG_eIF4E_1	225	231	PF01652	0.333
LIG_eIF4E_1	75	81	PF01652	0.364
LIG_FHA_1	116	122	PF00498	0.397
LIG_FHA_1	226	232	PF00498	0.392
LIG_FHA_1	306	312	PF00498	0.448
LIG_FHA_1	80	86	PF00498	0.446
LIG_FXI_DFP_1	273	277	PF00024	0.356
LIG_GBD_Chelix_1	303	311	PF00786	0.320
LIG_LIR_Gen_1	157	167	PF02991	0.440
LIG_LIR_Gen_1	172	182	PF02991	0.285
LIG_LIR_Gen_1	32	42	PF02991	0.370
LIG_LIR_Gen_1	47	56	PF02991	0.447
LIG_LIR_Nem_3	172	178	PF02991	0.369
LIG_LIR_Nem_3	272	276	PF02991	0.357
LIG_LIR_Nem_3	32	37	PF02991	0.384
LIG_LIR_Nem_3	47	53	PF02991	0.405
LIG_MAD2	83	91	PF02301	0.466
LIG_NRP_CendR_1	350	351	PF00754	0.479
LIG_PCNA_yPIPBox_3	73	85	PF02747	0.500
LIG_SH2_CRK	179	183	PF00017	0.344
LIG_SH2_GRB2like	117	120	PF00017	0.381
LIG_SH2_NCK_1	50	54	PF00017	0.378
LIG_SH2_SRC	6	9	PF00017	0.410
LIG_SH2_STAP1	117	121	PF00017	0.381
LIG_SH2_STAP1	175	179	PF00017	0.354
LIG_SH2_STAP1	75	79	PF00017	0.367
LIG_SH2_STAT3	75	78	PF00017	0.379
LIG_SH2_STAT5	117	120	PF00017	0.381
LIG_SH2_STAT5	42	45	PF00017	0.412
LIG_SH2_STAT5	6	9	PF00017	0.424
LIG_SH3_3	259	265	PF00018	0.360
LIG_SUMO_SIM_anti_2	240	245	PF11976	0.466
LIG_SUMO_SIM_par_1	322	327	PF11976	0.378
LIG_UBA3_1	68	74	PF00899	0.528
LIG_WRC_WIRS_1	287	292	PF05994	0.363
MOD_CDC14_SPxK_1	94	97	PF00782	0.508
MOD_CDK_SPxK_1	91	97	PF00069	0.509
MOD_CK1_1	163	169	PF00069	0.407
MOD_CK1_1	171	177	PF00069	0.377
MOD_CK1_1	23	29	PF00069	0.591
MOD_CK2_1	26	32	PF00069	0.383
MOD_Cter_Amidation	340	343	PF01082	0.418
MOD_GlcNHglycan	37	40	PF01048	0.385
MOD_GlcNHglycan	65	68	PF01048	0.470
MOD_GSK3_1	169	176	PF00069	0.417
MOD_GSK3_1	93	100	PF00069	0.480
MOD_N-GLC_1	237	242	PF02516	0.426
MOD_NEK2_1	127	132	PF00069	0.395
MOD_NEK2_1	140	145	PF00069	0.395
MOD_NEK2_1	35	40	PF00069	0.455
MOD_NEK2_1	99	104	PF00069	0.443
MOD_PK_1	246	252	PF00069	0.489
MOD_PKA_2	125	131	PF00069	0.400
MOD_PKA_2	35	41	PF00069	0.391
MOD_Plk_1	253	259	PF00069	0.442
MOD_Plk_4	239	245	PF00069	0.425
MOD_Plk_4	253	259	PF00069	0.381
MOD_ProDKin_1	91	97	PF00069	0.533
MOD_SUMO_for_1	133	136	PF00179	0.354
MOD_SUMO_rev_2	249	256	PF00179	0.405
MOD_SUMO_rev_2	267	271	PF00179	0.376
MOD_SUMO_rev_2	277	287	PF00179	0.429
TRG_DiLeu_BaEn_1	157	162	PF01217	0.369
TRG_DiLeu_BaEn_1	76	81	PF01217	0.342
TRG_ENDOCYTIC_2	117	120	PF00928	0.381
TRG_ENDOCYTIC_2	159	162	PF00928	0.375
TRG_ENDOCYTIC_2	175	178	PF00928	0.342
TRG_ENDOCYTIC_2	179	182	PF00928	0.324
TRG_ENDOCYTIC_2	50	53	PF00928	0.378
TRG_ER_diArg_1	328	330	PF00400	0.430
TRG_NLS_Bipartite_1	328	349	PF00514	0.422
TRG_NLS_MonoExtC_3	341	346	PF00514	0.406
TRG_NLS_MonoExtN_4	342	349	PF00514	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRD2	Leptomonas seymouri	92%	80%
A0A0S4IXC2	Bodo saltans	75%	86%
A0A1X0NX23	Trypanosomatidae	79%	79%
A0A422N7Q3	Trypanosoma rangeli	78%	78%
A4HCY8	Leishmania braziliensis	96%	100%
A4I0H3	Leishmania infantum	100%	100%
C9ZV98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	79%
E9AWD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QB37	Leishmania major	99%	100%
V5AZ95	Trypanosoma cruzi	78%	79%