Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IBT9_LEIDO

TriTrypDb:

LdBPK_240600.1 , LdCL_240010800 , LDHU3_24.0710

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IBT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.579
CLV_MEL_PAP_1	332	338	PF00089	0.582
CLV_NRD_NRD_1	173	175	PF00675	0.654
CLV_NRD_NRD_1	381	383	PF00675	0.656
CLV_NRD_NRD_1	437	439	PF00675	0.565
CLV_NRD_NRD_1	599	601	PF00675	0.583
CLV_NRD_NRD_1	679	681	PF00675	0.656
CLV_PCSK_KEX2_1	173	175	PF00082	0.654
CLV_PCSK_KEX2_1	201	203	PF00082	0.672
CLV_PCSK_KEX2_1	381	383	PF00082	0.656
CLV_PCSK_KEX2_1	437	439	PF00082	0.644
CLV_PCSK_KEX2_1	599	601	PF00082	0.583
CLV_PCSK_KEX2_1	679	681	PF00082	0.656
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.672
CLV_PCSK_PC7_1	377	383	PF00082	0.647
CLV_PCSK_SKI1_1	176	180	PF00082	0.659
CLV_PCSK_SKI1_1	225	229	PF00082	0.651
CLV_Separin_Metazoa	386	390	PF03568	0.610
DEG_APCC_DBOX_1	334	342	PF00400	0.572
DEG_ODPH_VHL_1	350	363	PF01847	0.443
DEG_SCF_FBW7_1	216	222	PF00400	0.643
DEG_SCF_FBW7_2	206	212	PF00400	0.660
DEG_SCF_TRCP1_1	22	27	PF00400	0.559
DOC_CDC14_PxL_1	611	619	PF14671	0.525
DOC_CKS1_1	206	211	PF01111	0.622
DOC_CKS1_1	216	221	PF01111	0.577
DOC_CKS1_1	28	33	PF01111	0.718
DOC_CKS1_1	631	636	PF01111	0.534
DOC_CYCLIN_RxL_1	11	23	PF00134	0.618
DOC_MAPK_DCC_7	364	373	PF00069	0.548
DOC_MAPK_gen_1	229	238	PF00069	0.632
DOC_MAPK_gen_1	679	685	PF00069	0.760
DOC_MAPK_HePTP_8	361	373	PF00069	0.552
DOC_MAPK_MEF2A_6	304	313	PF00069	0.616
DOC_MAPK_MEF2A_6	335	342	PF00069	0.573
DOC_MAPK_MEF2A_6	364	373	PF00069	0.601
DOC_MAPK_MEF2A_6	429	436	PF00069	0.601
DOC_PP1_RVXF_1	260	266	PF00149	0.653
DOC_PP1_RVXF_1	623	629	PF00149	0.604
DOC_PP2B_LxvP_1	519	522	PF13499	0.606
DOC_PP2B_LxvP_1	565	568	PF13499	0.679
DOC_USP7_MATH_1	166	170	PF00917	0.656
DOC_USP7_MATH_1	221	225	PF00917	0.606
DOC_USP7_MATH_1	284	288	PF00917	0.648
DOC_USP7_MATH_1	651	655	PF00917	0.648
DOC_USP7_MATH_1	80	84	PF00917	0.590
DOC_USP7_MATH_1	97	101	PF00917	0.495
DOC_WW_Pin1_4	205	210	PF00397	0.679
DOC_WW_Pin1_4	215	220	PF00397	0.592
DOC_WW_Pin1_4	22	27	PF00397	0.679
DOC_WW_Pin1_4	396	401	PF00397	0.657
DOC_WW_Pin1_4	630	635	PF00397	0.517
LIG_14-3-3_CanoR_1	176	185	PF00244	0.670
LIG_14-3-3_CanoR_1	202	207	PF00244	0.644
LIG_14-3-3_CanoR_1	262	268	PF00244	0.660
LIG_14-3-3_CanoR_1	343	352	PF00244	0.567
LIG_14-3-3_CanoR_1	364	368	PF00244	0.533
LIG_14-3-3_CanoR_1	650	656	PF00244	0.650
LIG_Actin_WH2_2	455	473	PF00022	0.575
LIG_APCC_ABBA_1	416	421	PF00400	0.609
LIG_APCC_ABBAyCdc20_2	415	421	PF00400	0.615
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BIR_III_4	472	476	PF00653	0.613
LIG_BIR_III_4	586	590	PF00653	0.521
LIG_BRCT_BRCA1_1	223	227	PF00533	0.675
LIG_FHA_1	107	113	PF00498	0.702
LIG_FHA_1	118	124	PF00498	0.575
LIG_FHA_1	23	29	PF00498	0.649
LIG_FHA_1	345	351	PF00498	0.616
LIG_FHA_1	53	59	PF00498	0.582
LIG_FHA_2	109	115	PF00498	0.644
LIG_FHA_2	273	279	PF00498	0.630
LIG_Integrin_RGD_1	665	667	PF01839	0.686
LIG_LIR_Gen_1	148	157	PF02991	0.576
LIG_LIR_Gen_1	266	274	PF02991	0.579
LIG_LIR_Gen_1	303	313	PF02991	0.617
LIG_LIR_Gen_1	444	453	PF02991	0.567
LIG_LIR_Gen_1	458	468	PF02991	0.422
LIG_LIR_Gen_1	492	503	PF02991	0.637
LIG_LIR_LC3C_4	151	155	PF02991	0.624
LIG_LIR_Nem_3	139	144	PF02991	0.626
LIG_LIR_Nem_3	148	153	PF02991	0.532
LIG_LIR_Nem_3	266	270	PF02991	0.588
LIG_LIR_Nem_3	303	308	PF02991	0.619
LIG_LIR_Nem_3	401	406	PF02991	0.621
LIG_LIR_Nem_3	444	448	PF02991	0.568
LIG_LIR_Nem_3	458	463	PF02991	0.407
LIG_LIR_Nem_3	480	486	PF02991	0.625
LIG_LIR_Nem_3	492	498	PF02991	0.516
LIG_LIR_Nem_3	505	509	PF02991	0.505
LIG_LYPXL_S_1	430	434	PF13949	0.597
LIG_LYPXL_yS_3	431	434	PF13949	0.601
LIG_PDZ_Class_2	682	687	PF00595	0.656
LIG_RPA_C_Fungi	377	389	PF08784	0.630
LIG_SH2_CRK	305	309	PF00017	0.614
LIG_SH2_CRK	506	510	PF00017	0.562
LIG_SH2_GRB2like	539	542	PF00017	0.606
LIG_SH2_NCK_1	506	510	PF00017	0.562
LIG_SH2_PTP2	403	406	PF00017	0.593
LIG_SH2_SRC	403	406	PF00017	0.545
LIG_SH2_SRC	453	456	PF00017	0.545
LIG_SH2_STAP1	254	258	PF00017	0.673
LIG_SH2_STAP1	486	490	PF00017	0.591
LIG_SH2_STAP1	618	622	PF00017	0.605
LIG_SH2_STAT5	217	220	PF00017	0.692
LIG_SH2_STAT5	264	267	PF00017	0.664
LIG_SH2_STAT5	312	315	PF00017	0.571
LIG_SH2_STAT5	403	406	PF00017	0.593
LIG_SH2_STAT5	486	489	PF00017	0.590
LIG_SH2_STAT5	494	497	PF00017	0.527
LIG_SH2_STAT5	50	53	PF00017	0.638
LIG_SH2_STAT5	506	509	PF00017	0.510
LIG_SH2_STAT5	630	633	PF00017	0.557
LIG_SH3_3	203	209	PF00018	0.611
LIG_SH3_3	213	219	PF00018	0.572
LIG_SH3_3	240	246	PF00018	0.677
LIG_SH3_3	333	339	PF00018	0.652
LIG_SH3_3	346	352	PF00018	0.479
LIG_SH3_3	463	469	PF00018	0.672
LIG_SH3_3	609	615	PF00018	0.600
LIG_SH3_3	628	634	PF00018	0.408
LIG_SH3_3	71	77	PF00018	0.654
LIG_SH3_5	502	506	PF00018	0.642
LIG_WRC_WIRS_1	617	622	PF05994	0.534
MOD_CDK_SPK_2	215	220	PF00069	0.646
MOD_CDK_SPxK_1	396	402	PF00069	0.571
MOD_CK1_1	205	211	PF00069	0.680
MOD_CK1_1	231	237	PF00069	0.582
MOD_CK2_1	145	151	PF00069	0.579
MOD_CK2_1	272	278	PF00069	0.631
MOD_CK2_1	438	444	PF00069	0.545
MOD_CK2_1	80	86	PF00069	0.654
MOD_Cter_Amidation	597	600	PF01082	0.601
MOD_GlcNHglycan	147	150	PF01048	0.580
MOD_GlcNHglycan	22	25	PF01048	0.491
MOD_GlcNHglycan	3	6	PF01048	0.573
MOD_GlcNHglycan	559	562	PF01048	0.641
MOD_GSK3_1	20	27	PF00069	0.567
MOD_GSK3_1	201	208	PF00069	0.626
MOD_GSK3_1	215	222	PF00069	0.559
MOD_GSK3_1	34	41	PF00069	0.490
MOD_GSK3_1	626	633	PF00069	0.487
MOD_N-GLC_1	38	43	PF02516	0.504
MOD_NEK2_1	1	6	PF00069	0.589
MOD_NEK2_1	20	25	PF00069	0.490
MOD_NEK2_1	341	346	PF00069	0.638
MOD_NEK2_1	363	368	PF00069	0.556
MOD_NEK2_1	373	378	PF00069	0.599
MOD_NEK2_1	38	43	PF00069	0.504
MOD_NEK2_1	448	453	PF00069	0.561
MOD_NEK2_1	626	631	PF00069	0.561
MOD_OFUCOSY	93	99	PF10250	0.641
MOD_PIKK_1	128	134	PF00454	0.521
MOD_PIKK_1	176	182	PF00454	0.637
MOD_PIKK_1	320	326	PF00454	0.624
MOD_PIKK_1	356	362	PF00454	0.595
MOD_PIKK_1	666	672	PF00454	0.664
MOD_PK_1	202	208	PF00069	0.603
MOD_PKA_1	201	207	PF00069	0.626
MOD_PKA_1	437	443	PF00069	0.549
MOD_PKA_2	201	207	PF00069	0.643
MOD_PKA_2	228	234	PF00069	0.606
MOD_PKA_2	356	362	PF00069	0.562
MOD_PKA_2	363	369	PF00069	0.508
MOD_PKA_2	437	443	PF00069	0.549
MOD_PKB_1	174	182	PF00069	0.661
MOD_Plk_1	117	123	PF00069	0.616
MOD_Plk_1	38	44	PF00069	0.521
MOD_Plk_1	504	510	PF00069	0.566
MOD_Plk_1	80	86	PF00069	0.654
MOD_Plk_2-3	114	120	PF00069	0.559
MOD_Plk_4	210	216	PF00069	0.697
MOD_Plk_4	237	243	PF00069	0.682
MOD_Plk_4	24	30	PF00069	0.698
MOD_Plk_4	363	369	PF00069	0.496
MOD_Plk_4	616	622	PF00069	0.531
MOD_Plk_4	651	657	PF00069	0.649
MOD_ProDKin_1	205	211	PF00069	0.680
MOD_ProDKin_1	215	221	PF00069	0.590
MOD_ProDKin_1	22	28	PF00069	0.681
MOD_ProDKin_1	396	402	PF00069	0.661
MOD_ProDKin_1	630	636	PF00069	0.525
MOD_SUMO_for_1	546	549	PF00179	0.622
MOD_SUMO_rev_2	224	234	PF00179	0.559
MOD_SUMO_rev_2	619	626	PF00179	0.521
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.622
TRG_ENDOCYTIC_2	194	197	PF00928	0.667
TRG_ENDOCYTIC_2	267	270	PF00928	0.591
TRG_ENDOCYTIC_2	305	308	PF00928	0.618
TRG_ENDOCYTIC_2	403	406	PF00928	0.593
TRG_ENDOCYTIC_2	431	434	PF00928	0.601
TRG_ENDOCYTIC_2	494	497	PF00928	0.638
TRG_ENDOCYTIC_2	506	509	PF00928	0.515
TRG_ER_diArg_1	173	176	PF00400	0.649
TRG_ER_diArg_1	380	382	PF00400	0.602
TRG_ER_diArg_1	388	391	PF00400	0.538
TRG_ER_diArg_1	436	438	PF00400	0.551
TRG_ER_diArg_1	599	601	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HDB7	Leishmania braziliensis	72%	100%
A4I0P7	Leishmania infantum	99%	100%
E9AWP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QAS4	Leishmania major	92%	100%