Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBT7_LEIDO

TriTrypDb:

LdBPK_231290.1 , LdCL_230020000 , LDHU3_23.1690

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.599
CLV_NRD_NRD_1	309	311	PF00675	0.564
CLV_PCSK_KEX2_1	105	107	PF00082	0.588
CLV_PCSK_KEX2_1	309	311	PF00082	0.564
CLV_PCSK_KEX2_1	44	46	PF00082	0.491
CLV_PCSK_KEX2_1	444	446	PF00082	0.473
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.451
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.473
CLV_PCSK_SKI1_1	129	133	PF00082	0.427
CLV_PCSK_SKI1_1	194	198	PF00082	0.577
CLV_PCSK_SKI1_1	309	313	PF00082	0.557
CLV_PCSK_SKI1_1	444	448	PF00082	0.408
DEG_APCC_DBOX_1	193	201	PF00400	0.456
DEG_SPOP_SBC_1	246	250	PF00917	0.562
DEG_SPOP_SBC_1	376	380	PF00917	0.660
DOC_CKS1_1	257	262	PF01111	0.620
DOC_CYCLIN_RxL_1	189	198	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	415	418	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	68	74	PF00134	0.531
DOC_MAPK_gen_1	227	236	PF00069	0.528
DOC_MAPK_gen_1	395	403	PF00069	0.557
DOC_PP1_RVXF_1	342	349	PF00149	0.499
DOC_PP2B_LxvP_1	415	418	PF13499	0.451
DOC_PP2B_LxvP_1	68	71	PF13499	0.556
DOC_PP2B_PxIxI_1	120	126	PF00149	0.404
DOC_PP4_FxxP_1	14	17	PF00568	0.366
DOC_PP4_FxxP_1	403	406	PF00568	0.550
DOC_PP4_FxxP_1	83	86	PF00568	0.376
DOC_USP7_MATH_1	287	291	PF00917	0.613
DOC_USP7_MATH_1	325	329	PF00917	0.572
DOC_USP7_MATH_1	381	385	PF00917	0.630
DOC_USP7_MATH_1	53	57	PF00917	0.458
DOC_WW_Pin1_4	13	18	PF00397	0.371
DOC_WW_Pin1_4	256	261	PF00397	0.602
DOC_WW_Pin1_4	283	288	PF00397	0.624
DOC_WW_Pin1_4	292	297	PF00397	0.674
DOC_WW_Pin1_4	314	319	PF00397	0.578
DOC_WW_Pin1_4	66	71	PF00397	0.602
LIG_14-3-3_CanoR_1	136	141	PF00244	0.358
LIG_14-3-3_CanoR_1	170	175	PF00244	0.383
LIG_14-3-3_CanoR_1	395	405	PF00244	0.542
LIG_14-3-3_CanoR_1	51	61	PF00244	0.499
LIG_14-3-3_CanoR_1	98	102	PF00244	0.521
LIG_Actin_WH2_2	143	158	PF00022	0.458
LIG_Actin_WH2_2	285	303	PF00022	0.508
LIG_EVH1_2	407	411	PF00568	0.393
LIG_FHA_1	233	239	PF00498	0.430
LIG_FHA_1	246	252	PF00498	0.548
LIG_FHA_1	317	323	PF00498	0.604
LIG_FHA_1	372	378	PF00498	0.578
LIG_FHA_1	386	392	PF00498	0.523
LIG_FHA_1	423	429	PF00498	0.444
LIG_FHA_1	79	85	PF00498	0.505
LIG_FHA_2	125	131	PF00498	0.383
LIG_FHA_2	319	325	PF00498	0.598
LIG_FHA_2	437	443	PF00498	0.505
LIG_FXI_DFP_1	6	10	PF00024	0.322
LIG_LIR_Apic_2	12	17	PF02991	0.355
LIG_LIR_Apic_2	402	406	PF02991	0.556
LIG_LIR_Apic_2	81	86	PF02991	0.448
LIG_LIR_Gen_1	135	146	PF02991	0.436
LIG_LIR_Gen_1	205	213	PF02991	0.485
LIG_LIR_Gen_1	294	305	PF02991	0.459
LIG_LIR_Nem_3	12	18	PF02991	0.430
LIG_LIR_Nem_3	135	141	PF02991	0.433
LIG_LIR_Nem_3	205	211	PF02991	0.525
LIG_LIR_Nem_3	294	300	PF02991	0.479
LIG_PDZ_Class_1	448	453	PF00595	0.505
LIG_SH2_CRK	177	181	PF00017	0.449
LIG_SH2_CRK	297	301	PF00017	0.447
LIG_SH2_CRK	62	66	PF00017	0.550
LIG_SH2_NCK_1	208	212	PF00017	0.435
LIG_SH2_STAP1	186	190	PF00017	0.378
LIG_SH2_STAT5	124	127	PF00017	0.327
LIG_SH2_STAT5	133	136	PF00017	0.382
LIG_SH2_STAT5	208	211	PF00017	0.429
LIG_SH3_2	71	76	PF14604	0.464
LIG_SH3_3	115	121	PF00018	0.493
LIG_SH3_3	15	21	PF00018	0.458
LIG_SH3_3	402	408	PF00018	0.510
LIG_SH3_3	411	417	PF00018	0.313
LIG_SH3_3	68	74	PF00018	0.467
LIG_TRAF2_1	202	205	PF00917	0.445
LIG_TRAF2_1	439	442	PF00917	0.501
LIG_TYR_ITIM	206	211	PF00017	0.528
LIG_UBA3_1	87	96	PF00899	0.366
LIG_WRC_WIRS_1	233	238	PF05994	0.419
MOD_CK1_1	247	253	PF00069	0.632
MOD_CK1_1	291	297	PF00069	0.616
MOD_CK1_1	316	322	PF00069	0.572
MOD_CK1_1	426	432	PF00069	0.466
MOD_CK1_1	64	70	PF00069	0.500
MOD_CK2_1	318	324	PF00069	0.614
MOD_CK2_1	436	442	PF00069	0.495
MOD_GlcNHglycan	219	222	PF01048	0.576
MOD_GlcNHglycan	30	33	PF01048	0.475
MOD_GlcNHglycan	327	330	PF01048	0.527
MOD_GlcNHglycan	352	355	PF01048	0.597
MOD_GlcNHglycan	381	384	PF01048	0.602
MOD_GlcNHglycan	428	431	PF01048	0.475
MOD_GlcNHglycan	55	58	PF01048	0.441
MOD_GSK3_1	232	239	PF00069	0.399
MOD_GSK3_1	252	259	PF00069	0.752
MOD_GSK3_1	271	278	PF00069	0.748
MOD_GSK3_1	283	290	PF00069	0.576
MOD_GSK3_1	291	298	PF00069	0.431
MOD_GSK3_1	312	319	PF00069	0.610
MOD_GSK3_1	371	378	PF00069	0.681
MOD_GSK3_1	381	388	PF00069	0.552
MOD_GSK3_1	422	429	PF00069	0.511
MOD_GSK3_1	9	16	PF00069	0.345
MOD_N-GLC_1	448	453	PF02516	0.451
MOD_NEK2_1	236	241	PF00069	0.459
MOD_NEK2_1	312	317	PF00069	0.597
MOD_NEK2_1	348	353	PF00069	0.598
MOD_NEK2_1	447	452	PF00069	0.436
MOD_NEK2_1	9	14	PF00069	0.338
MOD_PK_1	423	429	PF00069	0.466
MOD_PKA_2	422	428	PF00069	0.512
MOD_PKA_2	97	103	PF00069	0.527
MOD_Plk_1	342	348	PF00069	0.500
MOD_Plk_1	78	84	PF00069	0.466
MOD_Plk_4	295	301	PF00069	0.471
MOD_Plk_4	423	429	PF00069	0.466
MOD_Plk_4	78	84	PF00069	0.424
MOD_Plk_4	9	15	PF00069	0.340
MOD_ProDKin_1	13	19	PF00069	0.374
MOD_ProDKin_1	256	262	PF00069	0.595
MOD_ProDKin_1	283	289	PF00069	0.621
MOD_ProDKin_1	292	298	PF00069	0.663
MOD_ProDKin_1	314	320	PF00069	0.578
MOD_ProDKin_1	66	72	PF00069	0.594
MOD_SUMO_rev_2	320	328	PF00179	0.587
MOD_SUMO_rev_2	441	446	PF00179	0.521
TRG_DiLeu_BaEn_2	78	84	PF01217	0.466
TRG_DiLeu_BaEn_4	442	448	PF01217	0.408
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.437
TRG_ENDOCYTIC_2	208	211	PF00928	0.550
TRG_ENDOCYTIC_2	297	300	PF00928	0.453
TRG_ENDOCYTIC_2	62	65	PF00928	0.494
TRG_ER_diArg_1	105	107	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R2	Leptomonas seymouri	46%	100%
A4HCX8	Leishmania braziliensis	72%	100%
A4I0G1	Leishmania infantum	100%	100%
E9AWC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QB48	Leishmania major	94%	100%