Kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinase-like protein

Gene product:

kinase-like protein (fragment)

Species:

Leishmania donovani

UniProt:

A0A3Q8IBT5_LEIDO

TriTrypDb:

LdBPK_201370.1 , LdCL_200018400 , LDHU3_20.1730

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBT5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0007165	signal transduction	2	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0046777	protein autophosphorylation	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0004674	protein serine/threonine kinase activity	4	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004683	calmodulin-dependent protein kinase activity	5	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5	1
GO:0010857	calcium-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	136	138	PF00675	0.419
CLV_NRD_NRD_1	168	170	PF00675	0.284
CLV_NRD_NRD_1	36	38	PF00675	0.344
CLV_NRD_NRD_1	46	48	PF00675	0.346
CLV_NRD_NRD_1	70	72	PF00675	0.345
CLV_PCSK_KEX2_1	136	138	PF00082	0.419
CLV_PCSK_KEX2_1	168	170	PF00082	0.284
CLV_PCSK_KEX2_1	195	197	PF00082	0.500
CLV_PCSK_KEX2_1	42	44	PF00082	0.385
CLV_PCSK_KEX2_1	70	72	PF00082	0.345
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.446
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.389
CLV_PCSK_SKI1_1	142	146	PF00082	0.500
CLV_PCSK_SKI1_1	232	236	PF00082	0.443
DEG_APCC_DBOX_1	171	179	PF00400	0.311
DEG_Nend_UBRbox_1	1	4	PF02207	0.400
DOC_CKS1_1	10	15	PF01111	0.509
DOC_CKS1_1	198	203	PF01111	0.500
DOC_MAPK_FxFP_2	113	116	PF00069	0.500
DOC_MAPK_gen_1	168	178	PF00069	0.296
DOC_MAPK_MEF2A_6	114	123	PF00069	0.311
DOC_MAPK_MEF2A_6	169	178	PF00069	0.297
DOC_MAPK_MEF2A_6	89	97	PF00069	0.412
DOC_PP1_RVXF_1	175	182	PF00149	0.500
DOC_PP2B_LxvP_1	259	262	PF13499	0.613
DOC_PP4_FxxP_1	113	116	PF00568	0.500
DOC_USP7_MATH_1	252	256	PF00917	0.587
DOC_USP7_UBL2_3	38	42	PF12436	0.348
DOC_WW_Pin1_4	197	202	PF00397	0.500
DOC_WW_Pin1_4	263	268	PF00397	0.499
DOC_WW_Pin1_4	72	77	PF00397	0.452
DOC_WW_Pin1_4	9	14	PF00397	0.500
LIG_14-3-3_CanoR_1	37	44	PF00244	0.483
LIG_14-3-3_CanoR_1	51	59	PF00244	0.241
LIG_APCC_ABBAyCdc20_2	137	143	PF00400	0.419
LIG_CSL_BTD_1	10	13	PF09270	0.610
LIG_deltaCOP1_diTrp_1	222	231	PF00928	0.500
LIG_FHA_1	21	27	PF00498	0.338
LIG_GBD_Chelix_1	175	183	PF00786	0.311
LIG_HP1_1	117	121	PF01393	0.365
LIG_LIR_Apic_2	200	206	PF02991	0.500
LIG_LIR_Gen_1	207	217	PF02991	0.432
LIG_LIR_Nem_3	20	24	PF02991	0.446
LIG_LIR_Nem_3	207	212	PF02991	0.349
LIG_LIR_Nem_3	235	241	PF02991	0.395
LIG_LIR_Nem_3	266	271	PF02991	0.491
LIG_MAD2	270	278	PF02301	0.521
LIG_SH2_STAT5	9	12	PF00017	0.533
LIG_SH3_3	195	201	PF00018	0.500
LIG_SUMO_SIM_par_1	116	122	PF11976	0.500
MOD_CDK_SPxK_1	9	15	PF00069	0.525
MOD_CDK_SPxxK_3	263	270	PF00069	0.498
MOD_CK1_1	20	26	PF00069	0.446
MOD_Cter_Amidation	166	169	PF01082	0.284
MOD_GlcNHglycan	255	258	PF01048	0.697
MOD_GlcNHglycan	52	55	PF01048	0.500
MOD_GSK3_1	222	229	PF00069	0.464
MOD_N-GLC_1	252	257	PF02516	0.474
MOD_NEK2_1	226	231	PF00069	0.500
MOD_NEK2_1	245	250	PF00069	0.388
MOD_NEK2_1	50	55	PF00069	0.284
MOD_PKA_1	42	48	PF00069	0.500
MOD_PKA_2	36	42	PF00069	0.483
MOD_PKA_2	50	56	PF00069	0.241
MOD_Plk_1	100	106	PF00069	0.417
MOD_Plk_4	226	232	PF00069	0.486
MOD_Plk_4	245	251	PF00069	0.401
MOD_ProDKin_1	197	203	PF00069	0.500
MOD_ProDKin_1	263	269	PF00069	0.496
MOD_ProDKin_1	72	78	PF00069	0.452
MOD_ProDKin_1	9	15	PF00069	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8H5	Leptomonas seymouri	28%	84%
A0A0N1HVN6	Leptomonas seymouri	26%	75%
A0A0N1HWQ2	Leptomonas seymouri	26%	93%
A0A0N1I6T8	Leptomonas seymouri	26%	94%
A0A0N1IIF9	Leptomonas seymouri	25%	100%
A0A0N1IMI0	Leptomonas seymouri	27%	99%
A0A0N1PC32	Leptomonas seymouri	27%	72%
A0A0S4IQX7	Bodo saltans	27%	72%
A0A0S4ISS4	Bodo saltans	30%	90%
A0A0S4IZY3	Bodo saltans	25%	83%
A0A0S4J8J4	Bodo saltans	26%	76%
A0A0S4JBR3	Bodo saltans	24%	89%
A0A0S4JQP6	Bodo saltans	29%	100%
A0A0S4JUJ2	Bodo saltans	28%	97%
A0A0S4JWD5	Bodo saltans	26%	71%
A0A0S4KFT7	Bodo saltans	27%	83%
A0A1X0NG10	Trypanosomatidae	28%	100%
A0A1X0NLN7	Trypanosomatidae	31%	83%
A0A1X0NQ63	Trypanosomatidae	27%	94%
A0A1X0NRZ9	Trypanosomatidae	28%	76%
A0A1X0NW24	Trypanosomatidae	27%	79%
A0A1X0NYK8	Trypanosomatidae	26%	90%
A0A1X0P5B1	Trypanosomatidae	26%	85%
A0A1X0P5F2	Trypanosomatidae	26%	85%
A0A1X0P692	Trypanosomatidae	29%	77%
A0A1X0P6V1	Trypanosomatidae	24%	100%
A0A1X0P735	Trypanosomatidae	26%	100%
A0A1X0P7V0	Trypanosomatidae	27%	83%
A0A1X0P919	Trypanosomatidae	29%	75%
A0A1X0P935	Trypanosomatidae	27%	76%
A0A1X0PAW2	Trypanosomatidae	26%	78%
A0A3Q8IB30	Leishmania donovani	28%	84%
A0A3Q8IEH3	Leishmania donovani	27%	93%
A0A3R7KMF0	Trypanosoma rangeli	25%	79%
A0A3R7M1U6	Trypanosoma rangeli	27%	75%
A0A3R7M5C7	Trypanosoma rangeli	26%	98%
A0A3R7M819	Trypanosoma rangeli	28%	79%
A0A3R7MJP3	Trypanosoma rangeli	28%	100%
A0A3R7NKI8	Trypanosoma rangeli	24%	90%
A0A3S5H606	Leishmania donovani	26%	94%
A0A3S5H789	Leishmania donovani	96%	73%
A0A3S5IRC3	Trypanosoma rangeli	31%	75%
A0A3S7WUX5	Leishmania donovani	26%	100%
A0A3S7X2W3	Leishmania donovani	26%	75%
A0A3S7X8X3	Leishmania donovani	27%	86%
A0A3S7X9R4	Leishmania donovani	26%	75%
A0A3S7X9S2	Leishmania donovani	26%	82%
A0A3S7XA45	Leishmania donovani	27%	71%
A0A422MYB4	Trypanosoma rangeli	26%	88%
A0A422N9H2	Trypanosoma rangeli	24%	74%
A0A422NJ30	Trypanosoma rangeli	28%	100%
A0A422P0J2	Trypanosoma rangeli	28%	83%
A0A422P1R5	Trypanosoma rangeli	26%	90%
A2BD05	Sus scrofa	26%	89%
A4H539	Leishmania braziliensis	26%	94%
A4H9H4	Leishmania braziliensis	26%	100%
A4H9L8	Leishmania braziliensis	28%	84%
A4HG26	Leishmania braziliensis	28%	93%
A4HG92	Leishmania braziliensis	26%	93%
A4HH03	Leishmania braziliensis	31%	73%
A4HHN1	Leishmania braziliensis	26%	75%
A4HN71	Leishmania braziliensis	27%	75%
A4HNG3	Leishmania braziliensis	26%	71%
A4HTB4	Leishmania infantum	26%	94%
A4HXU0	Leishmania infantum	26%	100%
A4HXY2	Leishmania infantum	28%	84%
A4HYX6	Leishmania infantum	96%	73%
A4I3C6	Leishmania infantum	27%	93%
A4I4U6	Leishmania infantum	26%	75%
A4IAZ7	Leishmania infantum	27%	86%
A4IBT4	Leishmania infantum	26%	73%
A4IBT9	Leishmania infantum	26%	75%
A4IC54	Leishmania infantum	27%	71%
A9S5R3	Physcomitrium patens	24%	81%
C9ZJ15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	75%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	66%
C9ZLJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	75%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	94%
C9ZW68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	79%
C9ZYF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	77%
C9ZYS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	71%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	70%
C9ZZX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZZX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A2M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	90%
D0A2R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	74%
D0A5C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	83%
D0A820	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	87%
D0N4E2	Phytophthora infestans (strain T30-4)	29%	70%
D3ZBE5	Rattus norvegicus	27%	92%
E9ACW6	Leishmania major	28%	93%
E9AED4	Leishmania major	26%	100%
E9AFM1	Leishmania major	26%	82%
E9AFX4	Leishmania major	27%	71%
E9AII8	Leishmania braziliensis	76%	100%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	94%
E9ALF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ALJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	75%
E9ARK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	84%
E9AUS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	74%
E9AZL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	93%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	73%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	73%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	75%
E9B727	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	71%
G5EDF7	Caenorhabditis elegans	27%	83%
G5EFM9	Caenorhabditis elegans	27%	92%
O01427	Caenorhabditis elegans	25%	91%
O01775	Caenorhabditis elegans	25%	78%
O14047	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	89%
O80397	Arabidopsis thaliana	29%	76%
O94768	Homo sapiens	24%	75%
P00531	Avian retrovirus MH2	25%	73%
P00532	Murine sarcoma virus 3611	24%	86%
P05986	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	70%
P06244	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	70%
P06245	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	73%
P15735	Homo sapiens	27%	69%
P31325	Rattus norvegicus	27%	69%
P34117	Dictyostelium discoideum	27%	96%
P36506	Rattus norvegicus	27%	70%
P36507	Homo sapiens	28%	70%
P51817	Homo sapiens	25%	78%
P52564	Homo sapiens	28%	84%
P59895	Rattus norvegicus	26%	89%
P70236	Mus musculus	28%	84%
Q00771	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	29%	67%
Q14012	Homo sapiens	28%	75%
Q1HG70	Canis lupus familiaris	27%	70%
Q20347	Caenorhabditis elegans	30%	77%
Q24324	Drosophila melanogaster	26%	70%
Q27687	Leishmania major	28%	84%
Q2KJ16	Bos taurus	27%	69%
Q38775	Antirrhinum majus	27%	89%
Q4QCR2	Leishmania major	94%	100%
Q4QCR3	Leishmania major	94%	73%
Q4QDX7	Leishmania major	26%	100%
Q4QIJ7	Leishmania major	26%	94%
Q54CY9	Dictyostelium discoideum	23%	89%
Q54SJ5	Dictyostelium discoideum	29%	89%
Q5E9X2	Bos taurus	27%	84%
Q5QN75	Oryza sativa subsp. japonica	29%	79%
Q62070	Mus musculus	31%	75%
Q63450	Rattus norvegicus	28%	75%
Q63932	Mus musculus	27%	70%
Q6A1A2	Homo sapiens	27%	70%
Q6ERS0	Oryza sativa subsp. japonica	30%	69%
Q869W6	Dictyostelium discoideum	26%	80%
Q8BG48	Mus musculus	23%	75%
Q8BGW6	Mus musculus	25%	70%
Q8BW96	Mus musculus	28%	72%
Q8GVC7	Phytophthora infestans	29%	70%
Q8IU85	Homo sapiens	28%	72%
Q8LPI7	Arabidopsis thaliana	27%	67%
Q8RXG3	Arabidopsis thaliana	28%	80%
Q8SR90	Encephalitozoon cuniculi (strain GB-M1)	24%	90%
Q8SRK8	Encephalitozoon cuniculi (strain GB-M1)	26%	87%
Q8TDX7	Homo sapiens	27%	92%
Q8WU08	Homo sapiens	26%	70%
Q90891	Gallus gallus	25%	70%
Q91XS8	Rattus norvegicus	23%	75%
Q91YS8	Mus musculus	28%	75%
Q93VK0	Arabidopsis thaliana	28%	100%
Q93Z18	Arabidopsis thaliana	27%	67%
Q94A06	Arabidopsis thaliana	26%	79%
Q965G5	Caenorhabditis elegans	31%	76%
Q96LW2	Homo sapiens	31%	68%
Q9DB30	Mus musculus	27%	69%
Q9DGE0	Danio rerio	29%	77%
Q9ES70	Mus musculus	26%	89%
Q9ES74	Mus musculus	27%	92%
Q9FJV0	Arabidopsis thaliana	27%	78%
Q9GM70	Oryctolagus cuniculus	24%	70%
Q9GNR4	Leishmania major	26%	75%
Q9HC98	Homo sapiens	26%	89%
Q9LPQ3	Arabidopsis thaliana	28%	91%
Q9N2N1	Leishmania major	27%	93%
Q9P1W9	Homo sapiens	30%	90%
Q9S7U9	Arabidopsis thaliana	26%	77%
Q9SPK4	Arabidopsis thaliana	27%	98%
Q9UEE5	Homo sapiens	25%	67%
Q9UQ07	Homo sapiens	25%	67%
Q9Y077	Leishmania major	26%	75%
V5B8E0	Trypanosoma cruzi	31%	79%
V5B9R6	Trypanosoma cruzi	28%	79%
V5BEK5	Trypanosoma cruzi	27%	83%
V5BG98	Trypanosoma cruzi	26%	90%
V5BJT8	Trypanosoma cruzi	30%	85%
V5BKJ3	Trypanosoma cruzi	26%	79%
V5BNV8	Trypanosoma cruzi	25%	94%
V5BPE2	Trypanosoma cruzi	30%	77%
V5BQF4	Trypanosoma cruzi	30%	75%
V5BV49	Trypanosoma cruzi	26%	90%
V5BWC2	Trypanosoma cruzi	27%	100%
V5BX61	Trypanosoma cruzi	27%	75%
V5D9M1	Trypanosoma cruzi	27%	76%
W0LYS5	Macrobrachium nipponense	29%	81%