Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endomembrane protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBT4_LEIDO

TriTrypDb:

LdBPK_131280.1 , LdCL_130018300 , LDHU3_13.1560

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3Q8IBT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBT4

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	418	420	PF00675	0.263
CLV_NRD_NRD_1	423	425	PF00675	0.259
CLV_NRD_NRD_1	440	442	PF00675	0.338
CLV_PCSK_KEX2_1	418	420	PF00082	0.262
CLV_PCSK_KEX2_1	422	424	PF00082	0.260
CLV_PCSK_PC7_1	414	420	PF00082	0.275
CLV_PCSK_SKI1_1	414	418	PF00082	0.271
CLV_PCSK_SKI1_1	441	445	PF00082	0.340
CLV_PCSK_SKI1_1	447	451	PF00082	0.428
CLV_PCSK_SKI1_1	66	70	PF00082	0.513
CLV_PCSK_SKI1_1	78	82	PF00082	0.454
DEG_APCC_DBOX_1	115	123	PF00400	0.156
DEG_APCC_DBOX_1	208	216	PF00400	0.325
DEG_SPOP_SBC_1	323	327	PF00917	0.245
DOC_AGCK_PIF_1	462	467	PF00069	0.362
DOC_CYCLIN_RxL_1	441	453	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	360	366	PF00134	0.323
DOC_MAPK_gen_1	350	359	PF00069	0.470
DOC_MAPK_MEF2A_6	389	397	PF00069	0.333
DOC_PP2B_LxvP_1	360	363	PF13499	0.463
DOC_PP2B_LxvP_1	443	446	PF13499	0.527
DOC_PP2B_PxIxI_1	456	462	PF00149	0.426
DOC_PP4_FxxP_1	271	274	PF00568	0.541
DOC_PP4_FxxP_1	342	345	PF00568	0.570
DOC_PP4_MxPP_1	343	346	PF00568	0.412
DOC_USP7_MATH_1	21	25	PF00917	0.548
DOC_USP7_MATH_1	346	350	PF00917	0.507
DOC_USP7_MATH_1	496	500	PF00917	0.424
DOC_WW_Pin1_4	165	170	PF00397	0.339
DOC_WW_Pin1_4	368	373	PF00397	0.245
LIG_14-3-3_CanoR_1	196	201	PF00244	0.332
LIG_14-3-3_CanoR_1	204	212	PF00244	0.315
LIG_14-3-3_CanoR_1	235	244	PF00244	0.490
LIG_14-3-3_CanoR_1	307	317	PF00244	0.313
LIG_14-3-3_CanoR_1	418	426	PF00244	0.525
LIG_14-3-3_CanoR_1	78	83	PF00244	0.310
LIG_APCC_ABBA_1	459	464	PF00400	0.426
LIG_BRCT_BRCA1_1	182	186	PF00533	0.261
LIG_BRCT_BRCA1_1	197	201	PF00533	0.261
LIG_BRCT_BRCA1_1	465	469	PF00533	0.323
LIG_BRCT_BRCA1_1	517	521	PF00533	0.351
LIG_BRCT_BRCA1_1	553	557	PF00533	0.271
LIG_FHA_1	147	153	PF00498	0.336
LIG_FHA_1	179	185	PF00498	0.299
LIG_FHA_1	201	207	PF00498	0.353
LIG_FHA_1	216	222	PF00498	0.334
LIG_FHA_1	286	292	PF00498	0.431
LIG_FHA_1	295	301	PF00498	0.408
LIG_FHA_1	314	320	PF00498	0.363
LIG_FHA_1	323	329	PF00498	0.282
LIG_FHA_1	356	362	PF00498	0.325
LIG_FHA_1	371	377	PF00498	0.293
LIG_FHA_1	493	499	PF00498	0.365
LIG_FHA_1	501	507	PF00498	0.314
LIG_FHA_2	121	127	PF00498	0.309
LIG_FHA_2	197	203	PF00498	0.316
LIG_FHA_2	67	73	PF00498	0.338
LIG_GBD_Chelix_1	212	220	PF00786	0.353
LIG_GBD_Chelix_1	229	237	PF00786	0.227
LIG_LIR_Apic_2	269	274	PF02991	0.513
LIG_LIR_Gen_1	179	188	PF02991	0.298
LIG_LIR_Gen_1	277	284	PF02991	0.511
LIG_LIR_Gen_1	297	303	PF02991	0.136
LIG_LIR_Gen_1	316	324	PF02991	0.465
LIG_LIR_Gen_1	333	343	PF02991	0.289
LIG_LIR_Gen_1	358	366	PF02991	0.361
LIG_LIR_Gen_1	373	380	PF02991	0.429
LIG_LIR_Gen_1	464	472	PF02991	0.416
LIG_LIR_Gen_1	50	61	PF02991	0.277
LIG_LIR_Gen_1	503	510	PF02991	0.326
LIG_LIR_Gen_1	529	539	PF02991	0.311
LIG_LIR_Gen_1	554	565	PF02991	0.311
LIG_LIR_Nem_3	149	154	PF02991	0.335
LIG_LIR_Nem_3	179	185	PF02991	0.279
LIG_LIR_Nem_3	260	266	PF02991	0.466
LIG_LIR_Nem_3	277	283	PF02991	0.457
LIG_LIR_Nem_3	297	302	PF02991	0.165
LIG_LIR_Nem_3	316	320	PF02991	0.365
LIG_LIR_Nem_3	358	362	PF02991	0.344
LIG_LIR_Nem_3	464	468	PF02991	0.414
LIG_LIR_Nem_3	47	51	PF02991	0.318
LIG_LIR_Nem_3	487	493	PF02991	0.324
LIG_LIR_Nem_3	503	507	PF02991	0.322
LIG_LIR_Nem_3	529	535	PF02991	0.296
LIG_LIR_Nem_3	554	558	PF02991	0.353
LIG_MYND_1	433	437	PF01753	0.445
LIG_NRBOX	2	8	PF00104	0.562
LIG_NRBOX	219	225	PF00104	0.416
LIG_NRBOX	69	75	PF00104	0.332
LIG_Pex14_1	263	267	PF04695	0.475
LIG_Pex14_1	351	355	PF04695	0.541
LIG_Pex14_2	197	201	PF04695	0.255
LIG_Pex14_2	355	359	PF04695	0.426
LIG_Pex14_2	370	374	PF04695	0.426
LIG_Pex14_2	458	462	PF04695	0.407
LIG_Pex14_2	465	469	PF04695	0.366
LIG_Pex14_2	535	539	PF04695	0.401
LIG_PTB_Apo_2	158	165	PF02174	0.212
LIG_SH2_CRK	182	186	PF00017	0.313
LIG_SH2_CRK	366	370	PF00017	0.245
LIG_SH2_CRK	481	485	PF00017	0.275
LIG_SH2_CRK	53	57	PF00017	0.281
LIG_SH2_CRK	555	559	PF00017	0.403
LIG_SH2_GRB2like	193	196	PF00017	0.341
LIG_SH2_NCK_1	182	186	PF00017	0.313
LIG_SH2_NCK_1	267	271	PF00017	0.541
LIG_SH2_NCK_1	366	370	PF00017	0.364
LIG_SH2_PTP2	151	154	PF00017	0.332
LIG_SH2_PTP2	491	494	PF00017	0.386
LIG_SH2_SRC	267	270	PF00017	0.475
LIG_SH2_STAP1	105	109	PF00017	0.313
LIG_SH2_STAP1	120	124	PF00017	0.215
LIG_SH2_STAP1	178	182	PF00017	0.269
LIG_SH2_STAP1	193	197	PF00017	0.237
LIG_SH2_STAP1	267	271	PF00017	0.525
LIG_SH2_STAP1	366	370	PF00017	0.364
LIG_SH2_STAP1	528	532	PF00017	0.343
LIG_SH2_STAP1	553	557	PF00017	0.281
LIG_SH2_STAT3	112	115	PF00017	0.248
LIG_SH2_STAT5	112	115	PF00017	0.245
LIG_SH2_STAT5	118	121	PF00017	0.214
LIG_SH2_STAT5	151	154	PF00017	0.276
LIG_SH2_STAT5	178	181	PF00017	0.271
LIG_SH2_STAT5	205	208	PF00017	0.314
LIG_SH2_STAT5	28	31	PF00017	0.391
LIG_SH2_STAT5	322	325	PF00017	0.397
LIG_SH2_STAT5	331	334	PF00017	0.385
LIG_SH2_STAT5	366	369	PF00017	0.448
LIG_SH2_STAT5	415	418	PF00017	0.498
LIG_SH2_STAT5	448	451	PF00017	0.411
LIG_SH2_STAT5	491	494	PF00017	0.370
LIG_SH2_STAT5	528	531	PF00017	0.306
LIG_SH2_STAT5	53	56	PF00017	0.295
LIG_SH2_STAT5	537	540	PF00017	0.326
LIG_SH2_STAT5	555	558	PF00017	0.162
LIG_SH2_STAT5	572	575	PF00017	0.426
LIG_SH2_STAT5	577	580	PF00017	0.540
LIG_SH3_1	434	440	PF00018	0.461
LIG_SH3_2	437	442	PF14604	0.513
LIG_SH3_3	182	188	PF00018	0.281
LIG_SH3_3	366	372	PF00018	0.245
LIG_SH3_3	398	404	PF00018	0.362
LIG_SH3_3	434	440	PF00018	0.476
LIG_SUMO_SIM_anti_2	218	225	PF11976	0.420
LIG_SUMO_SIM_anti_2	227	234	PF11976	0.434
LIG_SUMO_SIM_anti_2	288	294	PF11976	0.420
LIG_SUMO_SIM_par_1	221	227	PF11976	0.363
LIG_SUMO_SIM_par_1	288	294	PF11976	0.457
LIG_SUMO_SIM_par_1	448	453	PF11976	0.389
LIG_TRAF2_1	60	63	PF00917	0.309
LIG_TRFH_1	359	363	PF08558	0.459
LIG_TRFH_1	53	57	PF08558	0.245
LIG_TYR_ITIM	364	369	PF00017	0.245
LIG_TYR_ITIM	489	494	PF00017	0.444
LIG_TYR_ITSM	147	154	PF00017	0.413
LIG_WRC_WIRS_1	177	182	PF05994	0.362
LIG_WRC_WIRS_1	314	319	PF05994	0.445
LIG_WRC_WIRS_1	501	506	PF05994	0.459
LIG_WW_3	438	442	PF00397	0.426
MOD_CDC14_SPxK_1	168	171	PF00782	0.426
MOD_CDK_SPxK_1	165	171	PF00069	0.426
MOD_CK1_1	207	213	PF00069	0.462
MOD_CK1_1	24	30	PF00069	0.491
MOD_CK1_1	301	307	PF00069	0.426
MOD_CK1_1	471	477	PF00069	0.459
MOD_CK1_1	5	11	PF00069	0.568
MOD_CK2_1	120	126	PF00069	0.352
MOD_CK2_1	135	141	PF00069	0.221
MOD_CK2_1	186	192	PF00069	0.450
MOD_CK2_1	196	202	PF00069	0.387
MOD_CK2_1	66	72	PF00069	0.422
MOD_GlcNHglycan	21	24	PF01048	0.546
MOD_GlcNHglycan	259	263	PF01048	0.387
MOD_GlcNHglycan	332	335	PF01048	0.350
MOD_GlcNHglycan	452	455	PF01048	0.426
MOD_GlcNHglycan	8	11	PF01048	0.442
MOD_GSK3_1	1	8	PF00069	0.598
MOD_GSK3_1	160	167	PF00069	0.450
MOD_GSK3_1	176	183	PF00069	0.214
MOD_GSK3_1	196	203	PF00069	0.319
MOD_GSK3_1	207	214	PF00069	0.367
MOD_GSK3_1	294	301	PF00069	0.245
MOD_GSK3_1	32	39	PF00069	0.319
MOD_GSK3_1	364	371	PF00069	0.245
MOD_GSK3_1	463	470	PF00069	0.419
MOD_GSK3_1	47	54	PF00069	0.438
MOD_GSK3_1	492	499	PF00069	0.313
MOD_N-GLC_1	160	165	PF02516	0.335
MOD_N-GLC_1	216	221	PF02516	0.420
MOD_N-GLC_1	90	95	PF02516	0.317
MOD_NEK2_1	1	6	PF00069	0.620
MOD_NEK2_1	146	151	PF00069	0.392
MOD_NEK2_1	164	169	PF00069	0.264
MOD_NEK2_1	180	185	PF00069	0.194
MOD_NEK2_1	215	220	PF00069	0.385
MOD_NEK2_1	224	229	PF00069	0.353
MOD_NEK2_1	231	236	PF00069	0.308
MOD_NEK2_1	291	296	PF00069	0.374
MOD_NEK2_1	324	329	PF00069	0.393
MOD_NEK2_1	355	360	PF00069	0.311
MOD_NEK2_1	450	455	PF00069	0.359
MOD_NEK2_1	467	472	PF00069	0.217
MOD_NEK2_1	484	489	PF00069	0.205
MOD_NEK2_1	521	526	PF00069	0.315
MOD_NEK2_1	538	543	PF00069	0.315
MOD_NEK2_1	551	556	PF00069	0.320
MOD_NEK2_1	573	578	PF00069	0.453
MOD_PIKK_1	285	291	PF00454	0.420
MOD_PK_1	515	521	PF00069	0.413
MOD_PKA_2	195	201	PF00069	0.426
MOD_PKA_2	274	280	PF00069	0.413
MOD_PKA_2	306	312	PF00069	0.391
MOD_PKA_2	417	423	PF00069	0.403
MOD_PKB_1	209	217	PF00069	0.387
MOD_Plk_1	120	126	PF00069	0.405
MOD_Plk_1	140	146	PF00069	0.129
MOD_Plk_1	160	166	PF00069	0.276
MOD_Plk_1	216	222	PF00069	0.420
MOD_Plk_1	32	38	PF00069	0.428
MOD_Plk_1	463	469	PF00069	0.362
MOD_Plk_2-3	135	141	PF00069	0.284
MOD_Plk_2-3	187	193	PF00069	0.459
MOD_Plk_4	140	146	PF00069	0.413
MOD_Plk_4	173	179	PF00069	0.359
MOD_Plk_4	180	186	PF00069	0.342
MOD_Plk_4	196	202	PF00069	0.315
MOD_Plk_4	2	8	PF00069	0.589
MOD_Plk_4	211	217	PF00069	0.254
MOD_Plk_4	24	30	PF00069	0.576
MOD_Plk_4	294	300	PF00069	0.465
MOD_Plk_4	32	38	PF00069	0.353
MOD_Plk_4	355	361	PF00069	0.403
MOD_Plk_4	365	371	PF00069	0.403
MOD_Plk_4	468	474	PF00069	0.342
MOD_Plk_4	496	502	PF00069	0.381
MOD_Plk_4	51	57	PF00069	0.370
MOD_Plk_4	568	574	PF00069	0.313
MOD_ProDKin_1	165	171	PF00069	0.424
MOD_ProDKin_1	368	374	PF00069	0.245
MOD_SUMO_for_1	170	173	PF00179	0.459
MOD_SUMO_for_1	242	245	PF00179	0.459
MOD_SUMO_rev_2	63	68	PF00179	0.362
TRG_DiLeu_BaEn_2	140	146	PF01217	0.284
TRG_DiLeu_BaEn_4	63	69	PF01217	0.245
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.322
TRG_ENDOCYTIC_2	151	154	PF00928	0.413
TRG_ENDOCYTIC_2	182	185	PF00928	0.387
TRG_ENDOCYTIC_2	267	270	PF00928	0.325
TRG_ENDOCYTIC_2	335	338	PF00928	0.358
TRG_ENDOCYTIC_2	366	369	PF00928	0.409
TRG_ENDOCYTIC_2	448	451	PF00928	0.433
TRG_ENDOCYTIC_2	481	484	PF00928	0.320
TRG_ENDOCYTIC_2	491	494	PF00928	0.325
TRG_ENDOCYTIC_2	53	56	PF00928	0.339
TRG_ENDOCYTIC_2	532	535	PF00928	0.331
TRG_ENDOCYTIC_2	555	558	PF00928	0.343
TRG_ER_diArg_1	209	212	PF00400	0.360
TRG_ER_diArg_1	417	419	PF00400	0.315
TRG_ER_diArg_1	422	424	PF00400	0.313
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	24%	88%
A0A0N1I2B1	Leptomonas seymouri	26%	93%
A0A0N1I6Y7	Leptomonas seymouri	23%	95%
A0A0N1IME8	Leptomonas seymouri	61%	100%
A0A0S4IV41	Bodo saltans	27%	92%
A0A0S4J9X2	Bodo saltans	23%	91%
A0A0S4JBB1	Bodo saltans	29%	92%
A0A0S4JCH7	Bodo saltans	25%	86%
A0A0S4JEU5	Bodo saltans	25%	92%
A0A0S4JIF4	Bodo saltans	27%	92%
A0A0S4JWZ9	Bodo saltans	23%	96%
A0A0S4JZ31	Bodo saltans	30%	100%
A0A1X0NJN3	Trypanosomatidae	37%	99%
A0A1X0NK64	Trypanosomatidae	24%	94%
A0A1X0NLM6	Trypanosomatidae	27%	100%
A0A1X0NZX5	Trypanosomatidae	24%	91%
A0A1X0P2G3	Trypanosomatidae	26%	93%
A0A1X0P6M4	Trypanosomatidae	23%	77%
A0A1X0PA12	Trypanosomatidae	24%	93%
A0A3Q8IFM1	Leishmania donovani	27%	92%
A0A3Q8IHT3	Leishmania donovani	23%	92%
A0A3R7MBZ3	Trypanosoma rangeli	24%	94%
A0A3S7X2L7	Leishmania donovani	25%	86%
A0A422NED2	Trypanosoma rangeli	22%	91%
A0A422NMS9	Trypanosoma rangeli	23%	90%
A0A422P482	Trypanosoma rangeli	35%	98%
A4H7C1	Leishmania braziliensis	71%	100%
A4HB85	Leishmania braziliensis	23%	100%
A4HHH4	Leishmania braziliensis	25%	87%
A4HHY3	Leishmania braziliensis	28%	92%
A4HVR6	Leishmania infantum	100%	100%
A4I4M3	Leishmania infantum	26%	87%
A4I563	Leishmania infantum	27%	92%
A4IAD3	Leishmania infantum	23%	100%
A4IFE9	Bos taurus	28%	97%
A5D7E2	Bos taurus	29%	92%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	81%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	93%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	94%
D0A6H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	97%
E9AE21	Leishmania major	25%	87%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	87%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	90%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
F4HW17	Arabidopsis thaliana	28%	100%
F4JRE0	Arabidopsis thaliana	27%	90%
F4KIB2	Arabidopsis thaliana	25%	91%
O15321	Homo sapiens	28%	97%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	88%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	83%
P58021	Mus musculus	27%	89%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	88%
Q4KLL4	Rattus norvegicus	29%	92%
Q4Q2H8	Leishmania major	22%	97%
Q4Q7S3	Leishmania major	26%	100%
Q4QG16	Leishmania major	86%	100%
Q54ZW0	Dictyostelium discoideum	26%	100%
Q55FP0	Dictyostelium discoideum	25%	92%
Q5R8F1	Pongo abelii	28%	97%
Q5R8Y6	Pongo abelii	26%	89%
Q5RDY2	Pongo abelii	29%	92%
Q66HF2	Rattus norvegicus	27%	100%
Q66HG5	Rattus norvegicus	26%	89%
Q7YTA6	Dictyostelium discoideum	25%	90%
Q8BH24	Mus musculus	29%	92%
Q8RWW1	Arabidopsis thaliana	25%	92%
Q92544	Homo sapiens	29%	92%
Q940G0	Arabidopsis thaliana	32%	100%
Q940S0	Arabidopsis thaliana	29%	99%
Q99805	Homo sapiens	26%	89%
Q9C5N2	Arabidopsis thaliana	28%	91%
Q9C720	Arabidopsis thaliana	29%	92%
Q9DBU0	Mus musculus	28%	97%
Q9ET30	Mus musculus	30%	100%
Q9FHT4	Arabidopsis thaliana	28%	99%
Q9FYQ8	Arabidopsis thaliana	29%	90%
Q9HD45	Homo sapiens	31%	100%
Q9LIC2	Arabidopsis thaliana	30%	92%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	94%
Q9ZPS7	Arabidopsis thaliana	29%	99%
V5BCD5	Trypanosoma cruzi	24%	93%
V5D9U0	Trypanosoma cruzi	26%	91%
V5DII3	Trypanosoma cruzi	35%	98%