Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBT1_LEIDO

TriTrypDb:

LdBPK_210090.1 , LdCL_210005800 , LDHU3_21.0100

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBT1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006720	isoprenoid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	412	416	PF00656	0.477
CLV_NRD_NRD_1	12	14	PF00675	0.496
CLV_NRD_NRD_1	246	248	PF00675	0.579
CLV_PCSK_KEX2_1	12	14	PF00082	0.495
CLV_PCSK_SKI1_1	158	162	PF00082	0.466
CLV_PCSK_SKI1_1	21	25	PF00082	0.451
CLV_PCSK_SKI1_1	351	355	PF00082	0.420
CLV_PCSK_SKI1_1	64	68	PF00082	0.397
DEG_APCC_DBOX_1	262	270	PF00400	0.552
DOC_ANK_TNKS_1	410	417	PF00023	0.560
DOC_CKS1_1	438	443	PF01111	0.549
DOC_CYCLIN_RxL_1	61	70	PF00134	0.461
DOC_MAPK_gen_1	247	253	PF00069	0.507
DOC_MAPK_MEF2A_6	17	26	PF00069	0.394
DOC_PP1_RVXF_1	156	163	PF00149	0.489
DOC_PP1_RVXF_1	84	90	PF00149	0.547
DOC_USP7_MATH_1	30	34	PF00917	0.464
DOC_USP7_MATH_1	90	94	PF00917	0.630
DOC_WW_Pin1_4	300	305	PF00397	0.728
DOC_WW_Pin1_4	437	442	PF00397	0.554
LIG_14-3-3_CanoR_1	189	199	PF00244	0.531
LIG_14-3-3_CanoR_1	230	235	PF00244	0.469
LIG_14-3-3_CanoR_1	263	267	PF00244	0.525
LIG_14-3-3_CanoR_1	270	278	PF00244	0.518
LIG_14-3-3_CanoR_1	308	313	PF00244	0.676
LIG_14-3-3_CanoR_1	404	410	PF00244	0.614
LIG_14-3-3_CanoR_1	437	441	PF00244	0.626
LIG_14-3-3_CanoR_1	91	95	PF00244	0.631
LIG_Actin_WH2_2	62	79	PF00022	0.478
LIG_Actin_WH2_2	99	117	PF00022	0.628
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_BRCT_BRCA1_1	255	259	PF00533	0.464
LIG_BRCT_BRCA1_1	487	491	PF00533	0.560
LIG_eIF4E_1	19	25	PF01652	0.570
LIG_eIF4E_1	365	371	PF01652	0.413
LIG_FHA_1	109	115	PF00498	0.620
LIG_FHA_1	118	124	PF00498	0.719
LIG_FHA_1	164	170	PF00498	0.540
LIG_FHA_1	185	191	PF00498	0.523
LIG_FHA_1	2	8	PF00498	0.605
LIG_FHA_1	329	335	PF00498	0.543
LIG_FHA_1	358	364	PF00498	0.483
LIG_FHA_1	366	372	PF00498	0.370
LIG_FHA_1	42	48	PF00498	0.480
LIG_FHA_1	82	88	PF00498	0.450
LIG_FHA_1	98	104	PF00498	0.571
LIG_FHA_2	29	35	PF00498	0.574
LIG_FHA_2	333	339	PF00498	0.498
LIG_FHA_2	373	379	PF00498	0.539
LIG_FXI_DFP_1	283	287	PF00024	0.513
LIG_LIR_Apic_2	436	441	PF02991	0.513
LIG_LIR_Gen_1	256	266	PF02991	0.452
LIG_LIR_Gen_1	366	373	PF02991	0.466
LIG_LIR_Nem_3	137	142	PF02991	0.473
LIG_LIR_Nem_3	256	262	PF02991	0.407
LIG_LIR_Nem_3	311	316	PF02991	0.567
LIG_LIR_Nem_3	347	353	PF02991	0.428
LIG_LIR_Nem_3	366	370	PF02991	0.270
LIG_LIR_Nem_3	387	393	PF02991	0.496
LIG_LYPXL_SIV_4	18	26	PF13949	0.594
LIG_Pex14_1	85	89	PF04695	0.427
LIG_Pex14_2	349	353	PF04695	0.491
LIG_SH2_CRK	313	317	PF00017	0.488
LIG_SH2_CRK	367	371	PF00017	0.467
LIG_SH2_SRC	313	316	PF00017	0.611
LIG_SH2_STAP1	19	23	PF00017	0.564
LIG_SH2_STAP1	365	369	PF00017	0.426
LIG_SH2_STAT5	168	171	PF00017	0.540
LIG_SH2_STAT5	315	318	PF00017	0.502
LIG_SH2_STAT5	367	370	PF00017	0.435
LIG_SH2_STAT5	390	393	PF00017	0.512
LIG_SH2_STAT5	419	422	PF00017	0.546
LIG_SH3_3	281	287	PF00018	0.500
LIG_SH3_3	301	307	PF00018	0.406
LIG_SH3_CIN85_PxpxPR_1	59	64	PF14604	0.627
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.564
LIG_SUMO_SIM_anti_2	216	224	PF11976	0.448
LIG_SxIP_EBH_1	387	400	PF03271	0.624
LIG_TRAF2_1	375	378	PF00917	0.266
LIG_UBA3_1	66	74	PF00899	0.534
LIG_WW_3	14	18	PF00397	0.397
LIG_WW_3	305	309	PF00397	0.692
MOD_CDC14_SPxK_1	305	308	PF00782	0.697
MOD_CDK_SPxK_1	302	308	PF00069	0.696
MOD_CK1_1	2	8	PF00069	0.567
MOD_CK1_1	33	39	PF00069	0.666
MOD_CK1_1	386	392	PF00069	0.556
MOD_CK1_1	422	428	PF00069	0.499
MOD_CK2_1	255	261	PF00069	0.505
MOD_CK2_1	28	34	PF00069	0.535
MOD_CK2_1	332	338	PF00069	0.570
MOD_CK2_1	372	378	PF00069	0.541
MOD_CK2_1	464	470	PF00069	0.514
MOD_GlcNHglycan	154	157	PF01048	0.458
MOD_GlcNHglycan	254	258	PF01048	0.470
MOD_GlcNHglycan	275	278	PF01048	0.404
MOD_GlcNHglycan	308	311	PF01048	0.636
MOD_GlcNHglycan	316	319	PF01048	0.493
MOD_GlcNHglycan	412	415	PF01048	0.577
MOD_GlcNHglycan	77	80	PF01048	0.529
MOD_GSK3_1	109	116	PF00069	0.641
MOD_GSK3_1	249	256	PF00069	0.450
MOD_GSK3_1	287	294	PF00069	0.504
MOD_GSK3_1	29	36	PF00069	0.583
MOD_GSK3_1	296	303	PF00069	0.625
MOD_GSK3_1	328	335	PF00069	0.487
MOD_GSK3_1	37	44	PF00069	0.590
MOD_GSK3_1	394	401	PF00069	0.596
MOD_GSK3_1	405	412	PF00069	0.523
MOD_GSK3_1	415	422	PF00069	0.552
MOD_GSK3_1	485	492	PF00069	0.563
MOD_NEK2_1	213	218	PF00069	0.510
MOD_NEK2_1	220	225	PF00069	0.452
MOD_NEK2_1	253	258	PF00069	0.470
MOD_NEK2_1	291	296	PF00069	0.509
MOD_NEK2_1	396	401	PF00069	0.571
MOD_NEK2_1	405	410	PF00069	0.571
MOD_NEK2_1	67	72	PF00069	0.490
MOD_PIKK_1	221	227	PF00454	0.462
MOD_PIKK_1	33	39	PF00454	0.660
MOD_PIKK_1	332	338	PF00454	0.493
MOD_PIKK_1	394	400	PF00454	0.660
MOD_PK_1	308	314	PF00069	0.681
MOD_PKA_2	262	268	PF00069	0.563
MOD_PKA_2	410	416	PF00069	0.630
MOD_PKA_2	422	428	PF00069	0.530
MOD_PKA_2	436	442	PF00069	0.599
MOD_PKA_2	90	96	PF00069	0.606
MOD_Plk_1	108	114	PF00069	0.678
MOD_Plk_1	127	133	PF00069	0.561
MOD_Plk_1	365	371	PF00069	0.436
MOD_Plk_4	109	115	PF00069	0.701
MOD_Plk_4	128	134	PF00069	0.583
MOD_Plk_4	255	261	PF00069	0.437
MOD_Plk_4	308	314	PF00069	0.665
MOD_Plk_4	386	392	PF00069	0.557
MOD_Plk_4	415	421	PF00069	0.633
MOD_Plk_4	422	428	PF00069	0.481
MOD_Plk_4	474	480	PF00069	0.691
MOD_ProDKin_1	300	306	PF00069	0.728
MOD_ProDKin_1	437	443	PF00069	0.557
TRG_DiLeu_BaEn_1	20	25	PF01217	0.569
TRG_DiLeu_BaEn_1	6	11	PF01217	0.604
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.631
TRG_ENDOCYTIC_2	139	142	PF00928	0.566
TRG_ENDOCYTIC_2	19	22	PF00928	0.535
TRG_ENDOCYTIC_2	313	316	PF00928	0.500
TRG_ENDOCYTIC_2	350	353	PF00928	0.384
TRG_ENDOCYTIC_2	367	370	PF00928	0.415
TRG_ENDOCYTIC_2	393	396	PF00928	0.586
TRG_ER_diArg_1	11	13	PF00400	0.505
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWC8	Leptomonas seymouri	47%	97%
A0A1X0NXR3	Trypanosomatidae	29%	92%
A0A3R7K7L8	Trypanosoma rangeli	28%	94%
A4HBK2	Leishmania braziliensis	81%	100%
A4HZL3	Leishmania infantum	99%	100%
D0A1J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	96%
E9AUX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QCL1	Leishmania major	95%	100%
V5BQ24	Trypanosoma cruzi	26%	100%