Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBS8_LEIDO

TriTrypDb:

LdBPK_231110.1 , LdCL_230018400 , LDHU3_23.1470

Length:

157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8IBS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.631
CLV_NRD_NRD_1	39	41	PF00675	0.358
CLV_NRD_NRD_1	46	48	PF00675	0.338
CLV_PCSK_FUR_1	121	125	PF00082	0.581
CLV_PCSK_KEX2_1	123	125	PF00082	0.583
CLV_PCSK_KEX2_1	140	142	PF00082	0.557
CLV_PCSK_KEX2_1	39	41	PF00082	0.368
CLV_PCSK_KEX2_1	46	48	PF00082	0.351
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.583
CLV_PCSK_SKI1_1	100	104	PF00082	0.677
CLV_PCSK_SKI1_1	24	28	PF00082	0.366
CLV_PCSK_SKI1_1	93	97	PF00082	0.670
DEG_APCC_DBOX_1	99	107	PF00400	0.497
DEG_APCC_KENBOX_2	95	99	PF00400	0.505
DEG_Nend_Nbox_1	1	3	PF02207	0.729
DOC_CYCLIN_yCln2_LP_2	83	86	PF00134	0.484
DOC_MAPK_gen_1	43	51	PF00069	0.597
DOC_PP2B_LxvP_1	83	86	PF13499	0.458
DOC_USP7_MATH_1	7	11	PF00917	0.661
LIG_eIF4E_1	28	34	PF01652	0.595
LIG_FHA_1	18	24	PF00498	0.655
LIG_FHA_2	108	114	PF00498	0.371
LIG_FHA_2	92	98	PF00498	0.474
LIG_LIR_Gen_1	73	84	PF02991	0.378
LIG_LIR_Nem_3	22	28	PF02991	0.583
LIG_LIR_Nem_3	29	34	PF02991	0.515
LIG_LIR_Nem_3	73	79	PF02991	0.378
LIG_NRBOX	148	154	PF00104	0.471
LIG_PCNA_TLS_4	48	55	PF02747	0.640
LIG_PDZ_Class_1	152	157	PF00595	0.335
LIG_SH2_STAP1	28	32	PF00017	0.624
LIG_SH2_STAT5	28	31	PF00017	0.622
LIG_SH2_STAT5	32	35	PF00017	0.623
LIG_SH2_STAT5	75	78	PF00017	0.355
LIG_SH3_3	79	85	PF00018	0.594
LIG_TRFH_1	32	36	PF08558	0.621
LIG_TYR_ITSM	71	78	PF00017	0.378
MOD_CK2_1	107	113	PF00069	0.369
MOD_CK2_1	91	97	PF00069	0.458
MOD_GSK3_1	70	77	PF00069	0.370
MOD_NEK2_1	1	6	PF00069	0.684
MOD_NEK2_1	152	157	PF00069	0.440
MOD_NEK2_1	70	75	PF00069	0.361
MOD_PKA_2	56	62	PF00069	0.586
MOD_Plk_1	91	97	PF00069	0.469
MOD_Plk_4	26	32	PF00069	0.567
MOD_Plk_4	56	62	PF00069	0.563
MOD_Plk_4	70	76	PF00069	0.291
MOD_SUMO_for_1	122	125	PF00179	0.378
TRG_DiLeu_BaEn_1	101	106	PF01217	0.494
TRG_DiLeu_BaEn_4	144	150	PF01217	0.470
TRG_ENDOCYTIC_2	117	120	PF00928	0.466
TRG_ENDOCYTIC_2	75	78	PF00928	0.335
TRG_ER_diArg_1	139	141	PF00400	0.454
TRG_ER_diArg_1	38	40	PF00400	0.584
TRG_ER_diArg_1	45	47	PF00400	0.558
TRG_ER_diArg_1	8	11	PF00400	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZH6	Leptomonas seymouri	77%	100%
A0A0S4JBZ8	Bodo saltans	39%	99%
A0A1X0NWU3	Trypanosomatidae	56%	100%
A0A422N7L6	Trypanosoma rangeli	56%	100%
A4HCW3	Leishmania braziliensis	88%	100%
A4I0E3	Leishmania infantum	100%	100%
C9ZV92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AWA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4QB69	Leishmania major	99%	100%