Cysteine peptidase, Clan CA, family C2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calpain-like cysteine peptidase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBS3_LEIDO

TriTrypDb:

LdBPK_040430.1 , LdBPK_201210.1 , LdCL_200016600 , LDHU3_20.1510

Length:

910

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 16

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 20

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 98
NetGPI	no	yes: 0, no: 100

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	3
GO:0005930	axoneme	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005856	cytoskeleton	5	1
GO:0020016	ciliary pocket	2	1
GO:0020038	subpellicular network	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IBS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBS3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	101
GO:0006807	nitrogen compound metabolic process	2	101
GO:0008152	metabolic process	1	101
GO:0019538	protein metabolic process	3	101
GO:0043170	macromolecule metabolic process	3	101
GO:0044238	primary metabolic process	2	101
GO:0071704	organic substance metabolic process	2	101
GO:1901564	organonitrogen compound metabolic process	3	101

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	101
GO:0004175	endopeptidase activity	4	101
GO:0004197	cysteine-type endopeptidase activity	5	101
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	101
GO:0008233	peptidase activity	3	101
GO:0008234	cysteine-type peptidase activity	4	101
GO:0016787	hydrolase activity	2	101
GO:0140096	catalytic activity, acting on a protein	2	101

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.410
CLV_C14_Caspase3-7	392	396	PF00656	0.478
CLV_C14_Caspase3-7	467	471	PF00656	0.444
CLV_C14_Caspase3-7	706	710	PF00656	0.527
CLV_NRD_NRD_1	373	375	PF00675	0.460
CLV_NRD_NRD_1	710	712	PF00675	0.395
CLV_PCSK_KEX2_1	373	375	PF00082	0.423
CLV_PCSK_KEX2_1	763	765	PF00082	0.412
CLV_PCSK_KEX2_1	863	865	PF00082	0.486
CLV_PCSK_KEX2_1	893	895	PF00082	0.473
CLV_PCSK_PC1ET2_1	763	765	PF00082	0.422
CLV_PCSK_PC1ET2_1	863	865	PF00082	0.495
CLV_PCSK_PC1ET2_1	893	895	PF00082	0.515
CLV_PCSK_SKI1_1	216	220	PF00082	0.596
CLV_PCSK_SKI1_1	374	378	PF00082	0.555
CLV_PCSK_SKI1_1	429	433	PF00082	0.258
CLV_PCSK_SKI1_1	520	524	PF00082	0.321
CLV_PCSK_SKI1_1	536	540	PF00082	0.198
CLV_PCSK_SKI1_1	658	662	PF00082	0.254
CLV_PCSK_SKI1_1	805	809	PF00082	0.462
DEG_SCF_FBW7_2	245	250	PF00400	0.523
DEG_SIAH_1	206	214	PF03145	0.397
DOC_CKS1_1	26	31	PF01111	0.508
DOC_PP1_RVXF_1	508	514	PF00149	0.478
DOC_PP1_RVXF_1	666	673	PF00149	0.523
DOC_PP4_FxxP_1	278	281	PF00568	0.297
DOC_PP4_FxxP_1	411	414	PF00568	0.522
DOC_PP4_FxxP_1	491	494	PF00568	0.481
DOC_USP7_MATH_1	136	140	PF00917	0.666
DOC_USP7_MATH_1	478	482	PF00917	0.480
DOC_USP7_MATH_2	444	450	PF00917	0.534
DOC_USP7_UBL2_3	554	558	PF12436	0.476
DOC_USP7_UBL2_3	708	712	PF12436	0.506
DOC_WW_Pin1_4	117	122	PF00397	0.772
DOC_WW_Pin1_4	138	143	PF00397	0.800
DOC_WW_Pin1_4	202	207	PF00397	0.757
DOC_WW_Pin1_4	22	27	PF00397	0.673
DOC_WW_Pin1_4	243	248	PF00397	0.482
DOC_WW_Pin1_4	614	619	PF00397	0.481
DOC_WW_Pin1_4	747	752	PF00397	0.392
LIG_14-3-3_CanoR_1	216	222	PF00244	0.650
LIG_14-3-3_CanoR_1	373	381	PF00244	0.530
LIG_14-3-3_CanoR_1	510	514	PF00244	0.458
LIG_14-3-3_CanoR_1	800	809	PF00244	0.515
LIG_Actin_WH2_2	346	363	PF00022	0.321
LIG_Actin_WH2_2	521	538	PF00022	0.562
LIG_BIR_II_1	1	5	PF00653	0.757
LIG_BIR_III_2	684	688	PF00653	0.383
LIG_BRCT_BRCA1_1	858	862	PF00533	0.467
LIG_Clathr_ClatBox_1	882	886	PF01394	0.561
LIG_CtBP_PxDLS_1	444	448	PF00389	0.386
LIG_deltaCOP1_diTrp_1	671	676	PF00928	0.482
LIG_deltaCOP1_diTrp_1	804	808	PF00928	0.430
LIG_eIF4E_1	633	639	PF01652	0.496
LIG_FHA_1	213	219	PF00498	0.581
LIG_FHA_1	355	361	PF00498	0.334
LIG_FHA_1	375	381	PF00498	0.479
LIG_FHA_1	734	740	PF00498	0.427
LIG_FHA_1	753	759	PF00498	0.462
LIG_FHA_2	11	17	PF00498	0.777
LIG_FHA_2	341	347	PF00498	0.413
LIG_FHA_2	390	396	PF00498	0.535
LIG_FHA_2	643	649	PF00498	0.501
LIG_FHA_2	679	685	PF00498	0.577
LIG_LIR_Apic_2	276	281	PF02991	0.285
LIG_LIR_Gen_1	553	564	PF02991	0.480
LIG_LIR_Gen_1	579	586	PF02991	0.512
LIG_LIR_Gen_1	597	608	PF02991	0.486
LIG_LIR_Gen_1	631	639	PF02991	0.497
LIG_LIR_Gen_1	752	758	PF02991	0.363
LIG_LIR_Gen_1	803	814	PF02991	0.424
LIG_LIR_Gen_1	9	20	PF02991	0.749
LIG_LIR_Nem_3	294	298	PF02991	0.303
LIG_LIR_Nem_3	525	530	PF02991	0.504
LIG_LIR_Nem_3	546	551	PF02991	0.465
LIG_LIR_Nem_3	553	559	PF02991	0.472
LIG_LIR_Nem_3	562	566	PF02991	0.464
LIG_LIR_Nem_3	597	603	PF02991	0.453
LIG_LIR_Nem_3	631	636	PF02991	0.464
LIG_LIR_Nem_3	752	757	PF02991	0.389
LIG_LIR_Nem_3	770	775	PF02991	0.431
LIG_LIR_Nem_3	786	791	PF02991	0.476
LIG_LIR_Nem_3	803	809	PF02991	0.443
LIG_LIR_Nem_3	859	865	PF02991	0.387
LIG_LIR_Nem_3	873	878	PF02991	0.461
LIG_LIR_Nem_3	9	15	PF02991	0.526
LIG_Pex14_2	703	707	PF04695	0.474
LIG_SH2_CRK	175	179	PF00017	0.807
LIG_SH2_CRK	556	560	PF00017	0.469
LIG_SH2_CRK	563	567	PF00017	0.469
LIG_SH2_CRK	611	615	PF00017	0.487
LIG_SH2_CRK	633	637	PF00017	0.481
LIG_SH2_CRK	772	776	PF00017	0.417
LIG_SH2_CRK	788	792	PF00017	0.485
LIG_SH2_GRB2like	369	372	PF00017	0.542
LIG_SH2_GRB2like	713	716	PF00017	0.442
LIG_SH2_NCK_1	175	179	PF00017	0.513
LIG_SH2_NCK_1	182	186	PF00017	0.524
LIG_SH2_NCK_1	633	637	PF00017	0.492
LIG_SH2_PTP2	825	828	PF00017	0.393
LIG_SH2_SRC	527	530	PF00017	0.491
LIG_SH2_STAP1	159	163	PF00017	0.809
LIG_SH2_STAP1	182	186	PF00017	0.835
LIG_SH2_STAP1	304	308	PF00017	0.318
LIG_SH2_STAP1	537	541	PF00017	0.507
LIG_SH2_STAP1	727	731	PF00017	0.340
LIG_SH2_STAT5	145	148	PF00017	0.777
LIG_SH2_STAT5	334	337	PF00017	0.360
LIG_SH2_STAT5	527	530	PF00017	0.481
LIG_SH2_STAT5	611	614	PF00017	0.487
LIG_SH2_STAT5	644	647	PF00017	0.452
LIG_SH2_STAT5	713	716	PF00017	0.474
LIG_SH2_STAT5	825	828	PF00017	0.340
LIG_SH2_STAT5	843	846	PF00017	0.343
LIG_SH3_1	23	29	PF00018	0.503
LIG_SH3_3	181	187	PF00018	0.682
LIG_SH3_3	23	29	PF00018	0.837
LIG_SH3_3	336	342	PF00018	0.319
LIG_SH3_3	411	417	PF00018	0.520
LIG_SH3_3	427	433	PF00018	0.533
LIG_SH3_3	745	751	PF00018	0.378
LIG_SH3_3	834	840	PF00018	0.573
LIG_SH3_3	87	93	PF00018	0.842
LIG_SH3_3	882	888	PF00018	0.453
LIG_SH3_5	725	729	PF00018	0.406
LIG_SUMO_SIM_anti_2	813	818	PF11976	0.375
LIG_SUMO_SIM_par_1	741	747	PF11976	0.397
LIG_SUMO_SIM_par_1	773	778	PF11976	0.378
LIG_TRAF2_1	158	161	PF00917	0.818
LIG_TRAF2_1	163	166	PF00917	0.738
LIG_TRAF2_1	19	22	PF00917	0.514
LIG_TRAF2_1	40	43	PF00917	0.702
LIG_TRAF2_1	53	56	PF00917	0.505
LIG_TRAF2_1	66	69	PF00917	0.492
LIG_TRAF2_1	93	96	PF00917	0.527
LIG_TRAF2_2	29	34	PF00917	0.517
LIG_TRAF2_2	78	83	PF00917	0.507
LIG_TYR_ITIM	283	288	PF00017	0.331
LIG_UBA3_1	283	291	PF00899	0.349
LIG_UBA3_1	702	708	PF00899	0.383
LIG_UBA3_1	816	824	PF00899	0.448
LIG_WRPW_2	431	434	PF00400	0.383
MOD_CDK_SPxK_1	614	620	PF00069	0.490
MOD_CK1_1	476	482	PF00069	0.496
MOD_CK1_1	856	862	PF00069	0.404
MOD_CK2_1	10	16	PF00069	0.829
MOD_CK2_1	232	238	PF00069	0.484
MOD_CK2_1	340	346	PF00069	0.469
MOD_CK2_1	476	482	PF00069	0.476
MOD_CK2_1	642	648	PF00069	0.524
MOD_CK2_1	775	781	PF00069	0.376
MOD_CMANNOS	704	707	PF00535	0.273
MOD_GlcNHglycan	207	210	PF01048	0.651
MOD_GlcNHglycan	406	409	PF01048	0.510
MOD_GlcNHglycan	530	533	PF01048	0.320
MOD_GlcNHglycan	539	542	PF01048	0.326
MOD_GlcNHglycan	567	570	PF01048	0.281
MOD_GlcNHglycan	671	675	PF01048	0.333
MOD_GlcNHglycan	740	743	PF01048	0.492
MOD_GlcNHglycan	794	797	PF01048	0.426
MOD_GSK3_1	239	246	PF00069	0.494
MOD_GSK3_1	576	583	PF00069	0.474
MOD_GSK3_1	609	616	PF00069	0.487
MOD_GSK3_1	752	759	PF00069	0.424
MOD_N-GLC_1	298	303	PF02516	0.323
MOD_N-GLC_1	322	327	PF02516	0.341
MOD_N-GLC_1	61	66	PF02516	0.505
MOD_N-GLC_1	767	772	PF02516	0.612
MOD_N-GLC_1	792	797	PF02516	0.426
MOD_NEK2_1	239	244	PF00069	0.506
MOD_NEK2_1	321	326	PF00069	0.277
MOD_NEK2_1	349	354	PF00069	0.404
MOD_NEK2_1	468	473	PF00069	0.487
MOD_NEK2_1	523	528	PF00069	0.515
MOD_NEK2_1	559	564	PF00069	0.482
MOD_NEK2_1	586	591	PF00069	0.538
MOD_NEK2_1	703	708	PF00069	0.493
MOD_NEK2_1	792	797	PF00069	0.443
MOD_NEK2_1	94	99	PF00069	0.741
MOD_NEK2_2	580	585	PF00069	0.564
MOD_OFUCOSY	270	277	PF10250	0.193
MOD_PIKK_1	112	118	PF00454	0.704
MOD_PIKK_1	446	452	PF00454	0.541
MOD_PIKK_1	756	762	PF00454	0.358
MOD_PIKK_1	900	906	PF00454	0.546
MOD_PIKK_1	94	100	PF00454	0.761
MOD_PKA_2	509	515	PF00069	0.457
MOD_PKA_2	799	805	PF00069	0.312
MOD_Plk_1	258	264	PF00069	0.631
MOD_Plk_1	298	304	PF00069	0.330
MOD_Plk_1	321	327	PF00069	0.287
MOD_Plk_1	586	592	PF00069	0.514
MOD_Plk_1	812	818	PF00069	0.385
MOD_Plk_1	856	862	PF00069	0.435
MOD_Plk_2-3	588	594	PF00069	0.524
MOD_Plk_2-3	83	89	PF00069	0.519
MOD_Plk_4	258	264	PF00069	0.591
MOD_Plk_4	468	474	PF00069	0.482
MOD_Plk_4	523	529	PF00069	0.508
MOD_Plk_4	609	615	PF00069	0.509
MOD_Plk_4	642	648	PF00069	0.498
MOD_Plk_4	812	818	PF00069	0.446
MOD_ProDKin_1	117	123	PF00069	0.773
MOD_ProDKin_1	138	144	PF00069	0.799
MOD_ProDKin_1	202	208	PF00069	0.749
MOD_ProDKin_1	22	28	PF00069	0.675
MOD_ProDKin_1	243	249	PF00069	0.482
MOD_ProDKin_1	614	620	PF00069	0.481
MOD_ProDKin_1	747	753	PF00069	0.393
MOD_SUMO_for_1	876	879	PF00179	0.430
MOD_SUMO_rev_2	587	596	PF00179	0.481
MOD_SUMO_rev_2	648	657	PF00179	0.534
MOD_SUMO_rev_2	770	775	PF00179	0.465
MOD_SUMO_rev_2	83	90	PF00179	0.726
TRG_DiLeu_BaEn_2	343	349	PF01217	0.257
TRG_ENDOCYTIC_2	182	185	PF00928	0.722
TRG_ENDOCYTIC_2	285	288	PF00928	0.325
TRG_ENDOCYTIC_2	527	530	PF00928	0.500
TRG_ENDOCYTIC_2	556	559	PF00928	0.475
TRG_ENDOCYTIC_2	563	566	PF00928	0.474
TRG_ENDOCYTIC_2	611	614	PF00928	0.471
TRG_ENDOCYTIC_2	633	636	PF00928	0.493
TRG_ENDOCYTIC_2	644	647	PF00928	0.495
TRG_ENDOCYTIC_2	772	775	PF00928	0.390
TRG_ENDOCYTIC_2	788	791	PF00928	0.421
TRG_ENDOCYTIC_2	825	828	PF00928	0.335
TRG_ER_diArg_1	213	216	PF00400	0.646
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T6	Leptomonas seymouri	34%	100%
A0A0N1I8N2	Leptomonas seymouri	29%	92%
A0A0N1IGQ2	Leptomonas seymouri	32%	100%
A0A0N1ILF1	Leptomonas seymouri	40%	100%
A0A0N1IMH1	Leptomonas seymouri	34%	100%
A0A0N1P9P1	Leptomonas seymouri	40%	100%
A0A0N1PCA9	Leptomonas seymouri	35%	100%
A0A0N1PE91	Leptomonas seymouri	27%	100%
A0A0N1PFI4	Leptomonas seymouri	35%	100%
A0A0S4JLK6	Bodo saltans	28%	100%
A0A0S4KGT2	Bodo saltans	40%	100%
A0A1X0NJ19	Trypanosomatidae	29%	74%
A0A1X0NJK2	Trypanosomatidae	31%	100%
A0A1X0NJX8	Trypanosomatidae	36%	100%
A0A1X0NKT7	Trypanosomatidae	32%	100%
A0A1X0NKX8	Trypanosomatidae	32%	100%
A0A1X0NMT3	Trypanosomatidae	41%	100%
A0A1X0NW84	Trypanosomatidae	39%	100%
A0A1X0NW85	Trypanosomatidae	38%	100%
A0A1X0NW89	Trypanosomatidae	55%	100%
A0A1X0NWA6	Trypanosomatidae	30%	100%
A0A1X0NWW1	Trypanosomatidae	40%	100%
A0A3Q8IDD4	Leishmania donovani	34%	100%
A0A3Q8IJT4	Leishmania donovani	26%	100%
A0A3S5H5A5	Leishmania donovani	41%	100%
A0A3S5ISG2	Trypanosoma rangeli	32%	100%
A0A3S7WW13	Leishmania donovani	27%	82%
A0A3S7WW18	Leishmania donovani	99%	100%
A0A3S7WW41	Leishmania donovani	35%	100%
A0A3S7WW71	Leishmania donovani	40%	100%
A0A3S7X430	Leishmania donovani	34%	100%
A0A3S7X438	Leishmania donovani	30%	97%
A0A3S7X460	Leishmania donovani	35%	100%
A0A3S7X463	Leishmania donovani	28%	97%
A0A3S7X470	Leishmania donovani	35%	100%
A0A422MYU1	Trypanosoma rangeli	52%	99%
A0A422MYX0	Trypanosoma rangeli	38%	100%
A4H3W4	Leishmania braziliensis	41%	100%
A4HE81	Leishmania braziliensis	34%	100%
A4HJ14	Leishmania braziliensis	34%	100%
A4HJ22	Leishmania braziliensis	32%	100%
A4HJ24	Leishmania braziliensis	34%	100%
A4HS39	Leishmania infantum	41%	100%
A4HYN0	Leishmania infantum	99%	100%
A4HYW1	Leishmania infantum	97%	100%
A4HYW2	Leishmania infantum	40%	100%
A4HYW3	Leishmania infantum	35%	100%
A4HYW4	Leishmania infantum	28%	100%
A4I1J4	Leishmania infantum	34%	100%
A4I6E4	Leishmania infantum	35%	100%
A4I6E6	Leishmania infantum	35%	100%
A4I6F0	Leishmania infantum	30%	100%
A4I6K4	Leishmania infantum	34%	100%
A4I6K5	Leishmania infantum	28%	100%
A4I6K6	Leishmania infantum	26%	100%
C9ZIE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	84%
C9ZIE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZIE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZN52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZN53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZWY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZY36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E8NHG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AIH1	Leishmania braziliensis	85%	100%
E9AIH3	Leishmania braziliensis	40%	100%
E9AIH4	Leishmania braziliensis	35%	100%
E9AK26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AUQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AUQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AUR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AXM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9B1J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B1J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B1J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4Q6L7	Leishmania major	35%	100%
Q4Q6L9	Leishmania major	35%	100%
Q4Q6M0	Leishmania major	31%	100%
Q4Q6M2	Leishmania major	26%	100%
Q4Q6M3	Leishmania major	27%	100%
Q4Q6M4	Leishmania major	33%	100%
Q4Q9U3	Leishmania major	34%	100%
Q4QCS6	Leishmania major	36%	100%
Q4QCS7	Leishmania major	40%	100%
Q4QCS8	Leishmania major	95%	100%
Q4QCS9	Leishmania major	92%	100%
Q9U0T9	Leishmania major	41%	100%
V5AYJ1	Trypanosoma cruzi	31%	100%
V5B5I4	Trypanosoma cruzi	54%	100%
V5BA05	Trypanosoma cruzi	41%	100%
V5BEL3	Trypanosoma cruzi	37%	100%
V5BII7	Trypanosoma cruzi	29%	74%
V5BN20	Trypanosoma cruzi	35%	100%
V5D9Y2	Trypanosoma cruzi	41%	100%
V5DES7	Trypanosoma cruzi	32%	100%