Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBS2_LEIDO

TriTrypDb:

LdBPK_210360.1 , LdCL_210008400 , LDHU3_21.0380

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IBS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	223	225	PF00675	0.472
CLV_PCSK_KEX2_1	223	225	PF00082	0.472
CLV_PCSK_SKI1_1	63	67	PF00082	0.385
CLV_Separin_Metazoa	133	137	PF03568	0.371
DEG_SPOP_SBC_1	187	191	PF00917	0.597
DEG_SPOP_SBC_1	21	25	PF00917	0.622
DOC_MAPK_MEF2A_6	50	57	PF00069	0.687
DOC_USP7_MATH_1	188	192	PF00917	0.646
DOC_USP7_MATH_1	21	25	PF00917	0.691
DOC_USP7_MATH_1	28	32	PF00917	0.711
DOC_WW_Pin1_4	234	239	PF00397	0.692
DOC_WW_Pin1_4	3	8	PF00397	0.659
DOC_WW_Pin1_4	42	47	PF00397	0.644
DOC_WW_Pin1_4	65	70	PF00397	0.520
LIG_14-3-3_CanoR_1	223	228	PF00244	0.726
LIG_14-3-3_CanoR_1	38	43	PF00244	0.631
LIG_BRCT_BRCA1_1	43	47	PF00533	0.702
LIG_BRCT_BRCA1_1	60	64	PF00533	0.525
LIG_BRCT_BRCA1_2	60	66	PF00533	0.523
LIG_DLG_GKlike_1	223	231	PF00625	0.689
LIG_FHA_1	130	136	PF00498	0.415
LIG_FHA_1	168	174	PF00498	0.295
LIG_FHA_1	188	194	PF00498	0.559
LIG_FHA_1	80	86	PF00498	0.291
LIG_LIR_Gen_1	88	99	PF02991	0.319
LIG_LIR_Nem_3	170	175	PF02991	0.289
LIG_LIR_Nem_3	237	243	PF02991	0.647
LIG_LIR_Nem_3	61	67	PF02991	0.587
LIG_LIR_Nem_3	88	94	PF02991	0.338
LIG_LYPXL_yS_3	118	121	PF13949	0.440
LIG_Pex14_2	91	95	PF04695	0.340
LIG_PTB_Apo_2	72	79	PF02174	0.557
LIG_SH2_CRK	116	120	PF00017	0.391
LIG_SH2_CRK	179	183	PF00017	0.585
LIG_SH2_CRK	67	71	PF00017	0.575
LIG_SH2_NCK_1	227	231	PF00017	0.723
LIG_SH2_STAP1	100	104	PF00017	0.395
LIG_SH2_STAT5	131	134	PF00017	0.418
LIG_SH2_STAT5	67	70	PF00017	0.605
LIG_SH3_1	235	241	PF00018	0.663
LIG_SH3_3	235	241	PF00018	0.689
LIG_SH3_3	54	60	PF00018	0.602
LIG_SUMO_SIM_par_1	164	171	PF11976	0.340
LIG_UBA3_1	94	103	PF00899	0.436
LIG_WRC_WIRS_1	169	174	PF05994	0.340
MOD_CDK_SPxK_1	65	71	PF00069	0.533
MOD_CDK_SPxxK_3	3	10	PF00069	0.656
MOD_CK1_1	22	28	PF00069	0.745
MOD_CK2_1	37	43	PF00069	0.632
MOD_CMANNOS	8	11	PF00535	0.450
MOD_GlcNHglycan	157	160	PF01048	0.388
MOD_GlcNHglycan	190	193	PF01048	0.499
MOD_GlcNHglycan	196	199	PF01048	0.481
MOD_GlcNHglycan	218	221	PF01048	0.468
MOD_GlcNHglycan	26	29	PF01048	0.540
MOD_GlcNHglycan	3	6	PF01048	0.441
MOD_GlcNHglycan	60	63	PF01048	0.420
MOD_GSK3_1	145	152	PF00069	0.389
MOD_GSK3_1	19	26	PF00069	0.725
MOD_GSK3_1	209	216	PF00069	0.720
MOD_GSK3_1	37	44	PF00069	0.733
MOD_GSK3_1	79	86	PF00069	0.492
MOD_N-GLC_2	52	54	PF02516	0.391
MOD_NEK2_1	1	6	PF00069	0.645
MOD_NEK2_1	167	172	PF00069	0.300
MOD_NEK2_1	37	42	PF00069	0.633
MOD_PKA_1	223	229	PF00069	0.727
MOD_PKA_2	223	229	PF00069	0.727
MOD_PKA_2	37	43	PF00069	0.632
MOD_Plk_4	168	174	PF00069	0.340
MOD_Plk_4	94	100	PF00069	0.398
MOD_ProDKin_1	234	240	PF00069	0.695
MOD_ProDKin_1	3	9	PF00069	0.656
MOD_ProDKin_1	42	48	PF00069	0.642
MOD_ProDKin_1	65	71	PF00069	0.520
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.612
TRG_ENDOCYTIC_2	118	121	PF00928	0.440
TRG_ENDOCYTIC_2	179	182	PF00928	0.572
TRG_ENDOCYTIC_2	67	70	PF00928	0.635
TRG_ER_diArg_1	30	33	PF00400	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7KF63	Trypanosoma rangeli	34%	100%
A4HBM8	Leishmania braziliensis	73%	100%
A4HZB7	Leishmania infantum	100%	100%
E9AUZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QCI5	Leishmania major	93%	100%