Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IBS1_LEIDO

TriTrypDb:

LdBPK_251340.1 , LdCL_250019000 , LDHU3_25.1670

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.680
CLV_NRD_NRD_1	239	241	PF00675	0.486
CLV_NRD_NRD_1	3	5	PF00675	0.661
CLV_PCSK_KEX2_1	239	241	PF00082	0.486
CLV_PCSK_SKI1_1	240	244	PF00082	0.452
CLV_PCSK_SKI1_1	60	64	PF00082	0.450
DOC_CDC14_PxL_1	91	99	PF14671	0.532
DOC_USP7_MATH_1	122	126	PF00917	0.606
DOC_USP7_MATH_1	138	142	PF00917	0.723
DOC_USP7_MATH_1	150	154	PF00917	0.549
DOC_USP7_MATH_1	168	172	PF00917	0.790
DOC_USP7_MATH_1	3	7	PF00917	0.762
DOC_USP7_MATH_1	35	39	PF00917	0.717
DOC_USP7_MATH_1	8	12	PF00917	0.689
DOC_WW_Pin1_4	174	179	PF00397	0.654
LIG_BRCT_BRCA1_1	5	9	PF00533	0.727
LIG_FHA_1	99	105	PF00498	0.470
LIG_FHA_2	113	119	PF00498	0.629
LIG_FHA_2	220	226	PF00498	0.580
LIG_FHA_2	48	54	PF00498	0.581
LIG_Integrin_RGD_1	230	232	PF01839	0.546
LIG_LIR_Gen_1	80	88	PF02991	0.670
LIG_LIR_Nem_3	245	249	PF02991	0.601
LIG_LIR_Nem_3	88	94	PF02991	0.525
LIG_LYPXL_yS_3	246	249	PF13949	0.606
LIG_PALB2_WD40_1	86	94	PF16756	0.531
LIG_PDZ_Class_3	250	255	PF00595	0.723
LIG_SH2_GRB2like	55	58	PF00017	0.614
LIG_SH2_SRC	192	195	PF00017	0.565
LIG_SH2_STAT5	192	195	PF00017	0.430
LIG_SH2_STAT5	55	58	PF00017	0.478
LIG_SH3_3	241	247	PF00018	0.486
LIG_TRAF2_1	56	59	PF00917	0.478
LIG_TYR_ITIM	244	249	PF00017	0.597
MOD_CK1_1	134	140	PF00069	0.721
MOD_CK1_1	33	39	PF00069	0.659
MOD_CK1_1	77	83	PF00069	0.685
MOD_CK2_1	112	118	PF00069	0.514
MOD_CK2_1	53	59	PF00069	0.480
MOD_CK2_1	96	102	PF00069	0.495
MOD_GlcNHglycan	10	13	PF01048	0.687
MOD_GlcNHglycan	136	139	PF01048	0.730
MOD_GlcNHglycan	140	143	PF01048	0.742
MOD_GlcNHglycan	33	36	PF01048	0.676
MOD_GlcNHglycan	37	40	PF01048	0.682
MOD_GlcNHglycan	71	74	PF01048	0.687
MOD_GlcNHglycan	76	79	PF01048	0.643
MOD_GlcNHglycan	98	101	PF01048	0.470
MOD_GSK3_1	134	141	PF00069	0.755
MOD_GSK3_1	145	152	PF00069	0.658
MOD_GSK3_1	169	176	PF00069	0.737
MOD_GSK3_1	31	38	PF00069	0.697
MOD_GSK3_1	49	56	PF00069	0.530
MOD_N-GLC_1	150	155	PF02516	0.603
MOD_N-GLC_2	156	158	PF02516	0.780
MOD_NEK2_1	62	67	PF00069	0.484
MOD_NEK2_1	69	74	PF00069	0.579
MOD_NEK2_2	112	117	PF00069	0.551
MOD_PIKK_1	62	68	PF00454	0.471
MOD_PKA_2	3	9	PF00069	0.765
MOD_PKA_2	83	89	PF00069	0.647
MOD_Plk_4	93	99	PF00069	0.512
MOD_ProDKin_1	174	180	PF00069	0.646
MOD_SUMO_rev_2	53	62	PF00179	0.490
TRG_DiLeu_BaEn_2	57	63	PF01217	0.536
TRG_DiLeu_BaEn_3	188	194	PF01217	0.483
TRG_DiLeu_BaEn_4	58	64	PF01217	0.486
TRG_ENDOCYTIC_2	246	249	PF00928	0.606
TRG_ER_diArg_1	238	240	PF00400	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXL9	Leptomonas seymouri	52%	95%
A0A1X0NMN4	Trypanosomatidae	32%	100%
A4HE73	Leishmania braziliensis	80%	100%
A4I1H5	Leishmania infantum	100%	100%
C9ZJZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AXK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q9W2	Leishmania major	94%	100%