SET domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IBR8_LEIDO

TriTrypDb:

LdBPK_230990.1 , LdCL_230016500 , LDHU3_23.1340

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IBR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IBR8

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	383	387	PF00656	0.456
CLV_C14_Caspase3-7	82	86	PF00656	0.548
CLV_NRD_NRD_1	290	292	PF00675	0.374
CLV_NRD_NRD_1	424	426	PF00675	0.391
CLV_PCSK_FUR_1	422	426	PF00082	0.391
CLV_PCSK_KEX2_1	290	292	PF00082	0.374
CLV_PCSK_KEX2_1	424	426	PF00082	0.355
CLV_PCSK_SKI1_1	221	225	PF00082	0.513
CLV_PCSK_SKI1_1	267	271	PF00082	0.359
CLV_PCSK_SKI1_1	32	36	PF00082	0.401
DEG_Nend_UBRbox_2	1	3	PF02207	0.473
DEG_SPOP_SBC_1	166	170	PF00917	0.489
DOC_CKS1_1	63	68	PF01111	0.389
DOC_CYCLIN_RxL_1	264	272	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	63	69	PF00134	0.423
DOC_MAPK_gen_1	290	296	PF00069	0.373
DOC_MAPK_gen_1	397	407	PF00069	0.437
DOC_PP1_RVXF_1	179	186	PF00149	0.300
DOC_PP4_FxxP_1	111	114	PF00568	0.320
DOC_USP7_MATH_1	154	158	PF00917	0.691
DOC_USP7_MATH_1	216	220	PF00917	0.574
DOC_USP7_MATH_1	36	40	PF00917	0.385
DOC_USP7_MATH_1	380	384	PF00917	0.476
DOC_USP7_MATH_1	442	446	PF00917	0.407
DOC_USP7_MATH_1	51	55	PF00917	0.246
DOC_USP7_MATH_1	56	60	PF00917	0.249
DOC_USP7_MATH_1	91	95	PF00917	0.685
DOC_USP7_MATH_2	347	353	PF00917	0.582
DOC_WW_Pin1_4	110	115	PF00397	0.329
DOC_WW_Pin1_4	244	249	PF00397	0.436
DOC_WW_Pin1_4	54	59	PF00397	0.465
DOC_WW_Pin1_4	62	67	PF00397	0.514
DOC_WW_Pin1_4	85	90	PF00397	0.679
LIG_14-3-3_CanoR_1	125	134	PF00244	0.300
LIG_14-3-3_CanoR_1	189	193	PF00244	0.392
LIG_14-3-3_CanoR_1	221	226	PF00244	0.434
LIG_14-3-3_CanoR_1	290	295	PF00244	0.586
LIG_Actin_WH2_2	348	363	PF00022	0.322
LIG_Actin_WH2_2	378	396	PF00022	0.466
LIG_APCC_ABBA_1	44	49	PF00400	0.340
LIG_BRCT_BRCA1_1	63	67	PF00533	0.399
LIG_FHA_1	153	159	PF00498	0.587
LIG_FHA_1	185	191	PF00498	0.383
LIG_FHA_1	225	231	PF00498	0.502
LIG_FHA_1	234	240	PF00498	0.392
LIG_FHA_1	274	280	PF00498	0.378
LIG_FHA_1	321	327	PF00498	0.453
LIG_FHA_1	35	41	PF00498	0.363
LIG_FHA_1	386	392	PF00498	0.440
LIG_FHA_1	394	400	PF00498	0.478
LIG_FHA_2	168	174	PF00498	0.522
LIG_FHA_2	25	31	PF00498	0.553
LIG_FHA_2	82	88	PF00498	0.619
LIG_LIR_Apic_2	109	114	PF02991	0.316
LIG_LIR_Apic_2	342	346	PF02991	0.510
LIG_LIR_Apic_2	54	58	PF02991	0.364
LIG_LIR_Gen_1	229	240	PF02991	0.385
LIG_LIR_Gen_1	353	363	PF02991	0.513
LIG_LIR_Gen_1	41	52	PF02991	0.386
LIG_LIR_Nem_3	13	18	PF02991	0.407
LIG_LIR_Nem_3	229	235	PF02991	0.381
LIG_LIR_Nem_3	353	359	PF02991	0.528
LIG_LIR_Nem_3	406	412	PF02991	0.422
LIG_LIR_Nem_3	41	47	PF02991	0.392
LIG_NRBOX	265	271	PF00104	0.462
LIG_NRBOX	364	370	PF00104	0.514
LIG_PCNA_PIPBox_1	423	432	PF02747	0.429
LIG_PCNA_yPIPBox_3	419	430	PF02747	0.403
LIG_PTB_Apo_2	425	432	PF02174	0.480
LIG_SH2_CRK	366	370	PF00017	0.514
LIG_SH2_PTP2	343	346	PF00017	0.469
LIG_SH2_PTP2	409	412	PF00017	0.359
LIG_SH2_STAT3	208	211	PF00017	0.412
LIG_SH2_STAT5	110	113	PF00017	0.375
LIG_SH2_STAT5	192	195	PF00017	0.284
LIG_SH2_STAT5	208	211	PF00017	0.335
LIG_SH2_STAT5	343	346	PF00017	0.540
LIG_SH2_STAT5	409	412	PF00017	0.344
LIG_SH2_STAT5	429	432	PF00017	0.206
LIG_SH3_3	235	241	PF00018	0.332
LIG_SH3_3	302	308	PF00018	0.446
LIG_SH3_3	341	347	PF00018	0.514
LIG_SH3_3	50	56	PF00018	0.291
LIG_SUMO_SIM_par_1	403	408	PF11976	0.466
LIG_SUMO_SIM_par_1	59	65	PF11976	0.499
LIG_TRAF2_1	39	42	PF00917	0.286
LIG_TRFH_1	343	347	PF08558	0.486
LIG_TYR_ITIM	407	412	PF00017	0.484
MOD_CK1_1	102	108	PF00069	0.319
MOD_CK1_1	157	163	PF00069	0.704
MOD_CK1_1	164	170	PF00069	0.644
MOD_CK1_1	172	178	PF00069	0.312
MOD_CK1_1	226	232	PF00069	0.527
MOD_CK1_1	258	264	PF00069	0.490
MOD_CK1_1	322	328	PF00069	0.431
MOD_CK1_1	367	373	PF00069	0.501
MOD_CK1_1	54	60	PF00069	0.390
MOD_CK1_1	73	79	PF00069	0.271
MOD_CK1_1	90	96	PF00069	0.700
MOD_CK2_1	167	173	PF00069	0.550
MOD_CK2_1	24	30	PF00069	0.533
MOD_CK2_1	36	42	PF00069	0.368
MOD_CK2_1	415	421	PF00069	0.428
MOD_CK2_1	77	83	PF00069	0.660
MOD_GlcNHglycan	142	146	PF01048	0.685
MOD_GlcNHglycan	159	162	PF01048	0.737
MOD_GlcNHglycan	218	221	PF01048	0.671
MOD_GlcNHglycan	27	30	PF01048	0.487
MOD_GlcNHglycan	281	284	PF01048	0.386
MOD_GlcNHglycan	444	447	PF01048	0.452
MOD_GlcNHglycan	79	82	PF01048	0.667
MOD_GlcNHglycan	93	96	PF01048	0.587
MOD_GSK3_1	102	109	PF00069	0.332
MOD_GSK3_1	150	157	PF00069	0.686
MOD_GSK3_1	160	167	PF00069	0.622
MOD_GSK3_1	168	175	PF00069	0.359
MOD_GSK3_1	184	191	PF00069	0.368
MOD_GSK3_1	240	247	PF00069	0.468
MOD_GSK3_1	381	388	PF00069	0.431
MOD_GSK3_1	442	449	PF00069	0.569
MOD_GSK3_1	6	13	PF00069	0.308
MOD_GSK3_1	73	80	PF00069	0.516
MOD_GSK3_1	81	88	PF00069	0.599
MOD_N-GLC_1	372	377	PF02516	0.214
MOD_NEK2_1	126	131	PF00069	0.479
MOD_NEK2_1	152	157	PF00069	0.663
MOD_NEK2_1	165	170	PF00069	0.516
MOD_NEK2_1	279	284	PF00069	0.351
MOD_NEK2_1	372	377	PF00069	0.450
MOD_NEK2_1	393	398	PF00069	0.474
MOD_NEK2_1	405	410	PF00069	0.380
MOD_NEK2_1	61	66	PF00069	0.436
MOD_NEK2_1	72	77	PF00069	0.416
MOD_NEK2_2	429	434	PF00069	0.360
MOD_OFUCOSY	371	376	PF10250	0.266
MOD_PIKK_1	152	158	PF00454	0.545
MOD_PIKK_1	233	239	PF00454	0.485
MOD_PIKK_1	273	279	PF00454	0.304
MOD_PIKK_1	99	105	PF00454	0.366
MOD_PKA_1	290	296	PF00069	0.373
MOD_PKA_2	134	140	PF00069	0.439
MOD_PKA_2	188	194	PF00069	0.399
MOD_PKA_2	290	296	PF00069	0.445
MOD_Plk_1	172	178	PF00069	0.424
MOD_Plk_1	372	378	PF00069	0.478
MOD_Plk_4	10	16	PF00069	0.455
MOD_Plk_4	106	112	PF00069	0.339
MOD_Plk_4	188	194	PF00069	0.408
MOD_Plk_4	226	232	PF00069	0.367
MOD_Plk_4	258	264	PF00069	0.343
MOD_Plk_4	290	296	PF00069	0.562
MOD_Plk_4	306	312	PF00069	0.387
MOD_Plk_4	364	370	PF00069	0.466
MOD_Plk_4	56	62	PF00069	0.440
MOD_ProDKin_1	110	116	PF00069	0.327
MOD_ProDKin_1	244	250	PF00069	0.450
MOD_ProDKin_1	54	60	PF00069	0.462
MOD_ProDKin_1	62	68	PF00069	0.504
MOD_ProDKin_1	85	91	PF00069	0.677
MOD_SUMO_rev_2	144	153	PF00179	0.646
MOD_SUMO_rev_2	28	34	PF00179	0.421
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.402
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.333
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.369
TRG_ENDOCYTIC_2	232	235	PF00928	0.385
TRG_ENDOCYTIC_2	366	369	PF00928	0.514
TRG_ENDOCYTIC_2	409	412	PF00928	0.359
TRG_ER_diArg_1	289	291	PF00400	0.257
TRG_ER_diArg_1	422	425	PF00400	0.263
TRG_NES_CRM1_1	10	23	PF08389	0.459
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	327	332	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL96	Leptomonas seymouri	55%	100%
A0A0S4IN59	Bodo saltans	32%	100%
A0A1X0NWW3	Trypanosomatidae	39%	100%
A0A422N8X4	Trypanosoma rangeli	39%	100%
A4HCV2	Leishmania braziliensis	78%	100%
A4I0D3	Leishmania infantum	99%	100%
C9ZV37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AW97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QB81	Leishmania major	92%	100%
Q5ZIZ2	Gallus gallus	26%	100%
Q6GMV2	Homo sapiens	26%	100%
V5BBM7	Trypanosoma cruzi	37%	100%